Dataset: tTA/TDP Mice Expression Array

Transgenic (Tg) mice expressing nuclear or cytoplasmic human TDP-43 were generated. Tg mice had motor spasticity and forebrain neurodegeneration. Human TDP-43 reduced mouse TDP-43 in nuclei of affected neurons. Tg mice showed alterations in transcripts related to chromatin assembly. Cerebral cortex from 21 transgenic mice and controls were assayed after two weeks off doxycyline diet as described in Igaz et al.

Species:

mouse

Samples:

21

Source:

E-GEOD-25182

Updated:

Dec.12, 2014

Registered:

Nov.24, 2014