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Home › Dataset Library › Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using TALLYHO x C57BL6 F2 mice

Dataset: Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using TALLYHO x C57BL6 F2 mice

Type 2 diabetes (T2D) is the most common form of diabetes in humans and is closely associated with dyslipidemia and obesity that...

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Type 2 diabetes (T2D) is the most common form of diabetes in humans and is closely associated with dyslipidemia and obesity that magnifies the mortality and morbidity related to T2D. The TALLYHO/JngJ (TH) mouse is a polygenic model for T2D characterized by obesity, hyperinsulinemia, impaired glucose uptake and tolerance, hyperlipidemia, and hyperglycemia. To determine the genetic factors that contribute to these T2D related characteristics in TH mice, we interbred TH mice with C57BL/6J (B6) mice. The parental, F1, and F2 mice were phenotyped at 8, 12, 16, 20, and 24 weeks of age for 4-hour fasting plasma triglyceride, cholesterol, insulin, and glucose levels, as well as body weights. Fat pad and carcass weights were measured at 24 weeks after sacrificing the mice. The F2 mice were genotyped genome-wide for 68 markers. Of 393 genotyped F2 mice, 16 were chosen from the extremes of the triglyceride distribution (8 high and 8 low), and liver, pancreas, muscle and adipose tissue were measured for gene expression. Gene expression quantitative trait locus (eQTL) analysis aided in selection of candidates underlying hyperlipidemia, diabetes and obesity QTLs. We identified several genetic loci that affected quantitative variation in plasma lipid and glucose levels and obesity traits. 16 (8 high and 8 low) out of 393 F2 mice were chosen from the extremes of the triglyceride distribution, excluding overtly diabetic mice, and liver, pancreas, muscle and adipose tissue were measured for gene expression. In addition to data from the 64 microarrays on the 16 mice, a supplemental file with phenotypes and marker genotypes is provided for all mice as a supplementary file on the Series record (below). Mouse identification numbers are included to connect the data files.

Species:
mouse

Samples:
64

Source:
E-GEOD-24637

Updated:
Dec.12, 2014

Registered:
Nov.11, 2014


Factors: (via ArrayExpress)
Sample MOUSE NUMBER TRIGYCERIDE TISSUE
GSM607572 Mouse 293 High liver
GSM607573 Mouse 297 High liver
GSM607574 Mouse 319 High liver
GSM607575 Mouse 447 High liver
GSM607576 Mouse 492 High liver
GSM607577 Mouse 516 High liver
GSM607578 Mouse 525 High liver
GSM607579 Mouse 540 High liver
GSM607580 Mouse 258 Low liver
GSM60758 Mouse 260 Low liver
GSM607582 Mouse 342 Low liver
GSM607583 Mouse 425 Low liver
GSM607584 Mouse 434 Low liver
GSM607585 Mouse 521 Low liver
GSM607586 Mouse 639 Low liver
GSM607587 Mouse 532 Low liver
GSM607588 Mouse 293 High pancreas
GSM607589 Mouse 297 High pancreas
GSM607590 Mouse 319 High pancreas
GSM60759 Mouse 447 High pancreas
GSM607592 Mouse 492 High pancreas
GSM607593 Mouse 516 High pancreas
GSM607594 Mouse 525 High pancreas
GSM607595 Mouse 540 High pancreas
GSM607596 Mouse 258 Low pancreas
GSM607597 Mouse 260 Low pancreas
GSM607598 Mouse 342 Low pancreas
GSM607599 Mouse 425 Low pancreas
GSM607600 Mouse 434 Low pancreas
GSM60760 Mouse 521 Low pancreas
GSM607602 Mouse 639 Low pancreas
GSM607603 Mouse 532 Low pancreas
GSM607604 Mouse 293 High muscle
GSM607605 Mouse 297 High muscle
GSM607606 Mouse 319 High muscle
GSM607607 Mouse 447 High muscle
GSM607608 Mouse 492 High muscle
GSM607609 Mouse 516 High muscle
GSM607610 Mouse 525 High muscle
GSM6076 Mouse 540 High muscle
GSM607612 Mouse 258 Low muscle
GSM607613 Mouse 260 Low muscle
GSM607614 Mouse 342 Low muscle
GSM607615 Mouse 425 Low muscle
GSM607616 Mouse 434 Low muscle
GSM607617 Mouse 521 Low muscle
GSM607618 Mouse 639 Low muscle
GSM607619 Mouse 532 Low muscle
GSM607620 Mouse 293 High Adipose
GSM60762 Mouse 297 High Adipose
GSM607622 Mouse 319 High Adipose
GSM607623 Mouse 447 High Adipose
GSM607624 Mouse 492 High Adipose
GSM607625 Mouse 516 High Adipose
GSM607626 Mouse 525 High Adipose
GSM607627 Mouse 540 High Adipose
GSM607628 Mouse 258 Low Adipose
GSM607629 Mouse 260 Low Adipose
GSM607630 Mouse 342 Low Adipose
GSM60763 Mouse 425 Low Adipose
GSM607632 Mouse 434 Low Adipose
GSM607633 Mouse 521 Low Adipose
GSM607634 Mouse 639 Low Adipose
GSM607635 Mouse 532 Low Adipose

Tags

  • adipose tissue
  • body
  • genome
  • glucose
  • hyperglycemia
  • hyperinsulinemia
  • insulin
  • lipid
  • liver
  • muscle
  • obesity
  • pancreas

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