ArrayExpress Uploaderarrayexpress_sid6240Mouse 293HighliverMouse 297HighliverMouse 319HighliverMouse 447HighliverMouse 492HighliverMouse 516HighliverMouse 525HighliverMouse 540HighliverMouse 258LowliverMouse 260LowliverMouse 342LowliverMouse 425LowliverMouse 434LowliverMouse 521LowliverMouse 639LowliverMouse 532LowliverMouse 293HighpancreasMouse 297HighpancreasMouse 319HighpancreasMouse 447HighpancreasMouse 492HighpancreasMouse 516HighpancreasMouse 525HighpancreasMouse 540HighpancreasMouse 258LowpancreasMouse 260LowpancreasMouse 342LowpancreasMouse 425LowpancreasMouse 434LowpancreasMouse 521LowpancreasMouse 639LowpancreasMouse 532LowpancreasMouse 293HighmuscleMouse 297HighmuscleMouse 319HighmuscleMouse 447HighmuscleMouse 492HighmuscleMouse 516HighmuscleMouse 525HighmuscleMouse 540HighmuscleMouse 258LowmuscleMouse 260LowmuscleMouse 342LowmuscleMouse 425LowmuscleMouse 434LowmuscleMouse 521LowmuscleMouse 639LowmuscleMouse 532LowmuscleMouse 293HighAdiposeMouse 297HighAdiposeMouse 319HighAdiposeMouse 447HighAdiposeMouse 492HighAdiposeMouse 516HighAdiposeMouse 525HighAdiposeMouse 540HighAdiposeMouse 258LowAdiposeMouse 260LowAdiposeMouse 342LowAdiposeMouse 425LowAdiposeMouse 434LowAdiposeMouse 521LowAdiposeMouse 639LowAdiposeMouse 532LowAdipose06Type 2 diabetes (T2D) is the most common form of diabetes in humans and is closely associated with dyslipidemia and obesity that...E-GEOD-24637/profile/8773/arrayexpressuploader364adipose tissuebodygenomeglucosehyperglycemiahyperinsulinemiainsulinlipidlivermuscleobesitypancreasDec.12, 2014Falsegenetic-and-genomic-analysis-of-hyperlipidemia-obeE-GEOD-24637_A-AFFY-45Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using TALLYHO x C57BL6 F2 miceNov.11, 2014Type 2 diabetes (T2D) is the most common form of diabetes in humans and is closely associated with dyslipidemia and obesity that magnifies the mortality and morbidity related to T2D. The TALLYHO/JngJ (TH) mouse is a polygenic model for T2D characterized by obesity, hyperinsulinemia, impaired glucose uptake and tolerance, hyperlipidemia, and hyperglycemia. To determine the genetic factors that contribute to these T2D related characteristics in TH mice, we interbred TH mice with C57BL/6J (B6) mice. The parental, F1, and F2 mice were phenotyped at 8, 12, 16, 20, and 24 weeks of age for 4-hour fasting plasma triglyceride, cholesterol, insulin, and glucose levels, as well as body weights. Fat pad and carcass weights were measured at 24 weeks after sacrificing the mice. The F2 mice were genotyped genome-wide for 68 markers. Of 393 genotyped F2 mice, 16 were chosen from the extremes of the triglyceride distribution (8 high and 8 low), and liver, pancreas, muscle and adipose tissue were measured for gene expression. Gene expression quantitative trait locus (eQTL) analysis aided in selection of candidates underlying hyperlipidemia, diabetes and obesity QTLs. We identified several genetic loci that affected quantitative variation in plasma lipid and glucose levels and obesity traits. 16 (8 high and 8 low) out of 393 F2 mice were chosen from the extremes of the triglyceride distribution, excluding overtly diabetic mice, and liver, pancreas, muscle and adipose tissue were measured for gene expression. In addition to data from the 64 microarrays on the 16 mice, a supplemental file with phenotypes and marker genotypes is provided for all mice as a supplementary file on the Series record (below). Mouse identification numbers are included to connect the data files.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24637mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24637/samples/