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Home › Dataset Library › Time course for bladder UCC development in UPII-SV40Tag mice

Dataset: Time course for bladder UCC development in UPII-SV40Tag mice

We have identified genes that are differentially expressed between the bladders of UPII-SV40Tag mice and their age-matched wild-type...

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We have identified genes that are differentially expressed between the bladders of UPII-SV40Tag mice and their age-matched wild-type littermates at 3, 6, 20, and 30 weeks of age. These are ages that correspond to premalignant, carcinoma in situ, and early-stage and later stage invasive UCC, respectively Analysis of the microarray data sets has revealed ∼1,900 unique genes differentially expressed (≥3-fold difference at one or more time points) between wild-type and UPII-SV40Tag urothelium during the time course of tumor development. RNA from the urothelium of duplicate UPII-SV40Tag hemizygous and age-matched wild type littermate mice was isolated at 3, 6, 20, and 30 weeks of age and gene expression profiles were obtained.

Species:
mouse

Samples:
15

Source:
E-GEOD-23845

PubMed:
20501863

Updated:
Dec.12, 2014

Registered:
Nov.11, 2014


Factors: (via ArrayExpress)
Sample AGE GENOTYPE
GSM587889 3wk wild type littermates
GSM587889 3wk wild type littermates
GSM58789 3wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM58789 3wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM587893 6wk wild type littermates
GSM587894 6wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM587894 6wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM587896 20wk wild type littermates
GSM587896 20wk wild type littermates
GSM587898 20wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM587898 20wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM587900 30wk wild type littermates
GSM587900 30wk wild type littermates
GSM587902 30wk Transgenic, uroplakin II promoter driving expression of SV40Tag
GSM587902 30wk Transgenic, uroplakin II promoter driving expression of SV40Tag

Tags

  • carcinoma
  • urothelium

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