Dataset: Effects of ACE2 on BMPR2 mutation-mediated defects in gene expression
BMPR2 mutation causes pulmonary arterial hypertension (PAH); ACE2 treatment can resolve established BMPR2-mediated PAH. The purpose of...
BMPR2 mutation causes pulmonary arterial hypertension (PAH); ACE2 treatment can resolve established BMPR2-mediated PAH. The purpose of this study was to uncover the molecular mechanism behind this. Four groups: +/- ACE2 and +/- BMPR2 transgene, two arrays each, each array a pool of three animals.
- Species:
- mouse
- Samples:
- 8
- Source:
- E-GEOD-21583
- Updated:
- Dec.12, 2014
- Registered:
- Nov.11, 2014
Factors:
(via ArrayExpress)
Sample | GENOTYPE | TREATMENT |
---|---|---|
GSM538875 | heterozygous for Rosa26-rtTA2 transgene | none |
GSM538875 | heterozygous for Rosa26-rtTA2 transgene | none |
GSM538877 | heterozygous for Rosa26-rtTA2 transgene | ACE2 |
GSM538877 | heterozygous for Rosa26-rtTA2 transgene | ACE2 |
GSM538879 | heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes | ACE2 |
GSM538879 | heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes | ACE2 |
GSM53888 | heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes | none |
GSM53888 | heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes | none |