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Home › Dataset Library › Effects of ACE2 on BMPR2 mutation-mediated defects in gene expression

Dataset: Effects of ACE2 on BMPR2 mutation-mediated defects in gene expression

BMPR2 mutation causes pulmonary arterial hypertension (PAH); ACE2 treatment can resolve established BMPR2-mediated PAH. The purpose of...

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BMPR2 mutation causes pulmonary arterial hypertension (PAH); ACE2 treatment can resolve established BMPR2-mediated PAH. The purpose of this study was to uncover the molecular mechanism behind this. Four groups: +/- ACE2 and +/- BMPR2 transgene, two arrays each, each array a pool of three animals.

Species:
mouse

Samples:
8

Source:
E-GEOD-21583

Updated:
Dec.12, 2014

Registered:
Nov.11, 2014


Factors: (via ArrayExpress)
Sample GENOTYPE TREATMENT
GSM538875 heterozygous for Rosa26-rtTA2 transgene none
GSM538875 heterozygous for Rosa26-rtTA2 transgene none
GSM538877 heterozygous for Rosa26-rtTA2 transgene ACE2
GSM538877 heterozygous for Rosa26-rtTA2 transgene ACE2
GSM538879 heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes ACE2
GSM538879 heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes ACE2
GSM53888 heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes none
GSM53888 heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes none

Tags

  • hypertension

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