Dataset: Transcription profiling by array of human chronic lymphocytic leukemia cells after treatment with LMP-420

[original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and minimal toxicity for normal hematopoietic cells. LMP-420 induces cytotoxicity and apoptosis to CLL cells in vitro without any negative effects to normal immune cells. This gene expression experiment compares CLL cells treated with LMP-420 versus media alone to investigate the mechanism of action of LMP-420. CLL cells from 13 patients were treated with LMP-420 or media for 24 hours, then RNA was extracted and assayed on U133Plus2 GeneChips.

Species:

human

Samples:

26

Source:

E-GEOD-20211

PubMed:

20613784

Updated:

Dec.12, 2014

Registered:

Sep.15, 2014