Dataset: Comparison of post-mortem tissue from brain BA10 region between schizophrenic and control patients.

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function....

Registered by ArrayExpress Uploader

View Dataset

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some environmental influences on aetiology. To gain further insight into disease mechanism, we used microarray technology to determine the expression of over 30 000 mRNA transcripts in post-mortem tissue from a brain region associated with the pathophysiology of the disease (Brodmann area 10: anterior prefrontal cortex) in 28 schizophrenic and 23 control patients. Post-mortem derived BA10 tissue from 28 schizophrenic and 23 control patients were compared. Age, gender, post-mortem delay and pH of brain lysates data were also captured.

Species:: human
Samples:: 51
Source:: E-GEOD-17612
PubMed:: 19255580
Updated:: Dec.12, 2014
Registered:: Sep.12, 2014

Factors: (via ArrayExpress)

Sample	GENDER	PH	POST-MORTEM DELAY	AGE
GSM439778	Male	6	4.5h	74
GSM439779	Male	6.8	12h	72
GSM439780	Female	6.5	5h	89
GSM43978	Female	5.9	3.5h	85
GSM439782	Male	6.2	16.5h	61
GSM439783	Female	6.5	4h	54
GSM439784	Male	6.3	8h	41
GSM439785	Male	6	6.5h	71
GSM439786	Male	6.1	3h	77
GSM439787	Female	5.7	12.5h	90
GSM439788	not specified	6.3	4.5h	91
GSM439789	Male	6.6	12h	54
GSM439790	Female	6.1	3h	65
GSM43979	Male	6.3	9h	75
GSM439792	Female	6.7	8h	78
GSM439793	Male	6.2	6.75h	90
GSM439794	Male	6.4	16.5h	56
GSM439795	Female	not specified	22h	81
GSM439796	Male	6	11h	82
GSM439797	Male	6.3	9.5h	91
GSM439798	Male	6.4	11h	82
GSM439799	Male	6.5	15h	58
GSM439800	Female	6.3	11h	28
GSM43980	Male	6	3.5h	87
GSM439802	Female	6.5	14.5h	87
GSM439803	Male	6.6	20h	72
GSM439804	Male	6.9	17h	25
GSM439805	Female	5.9	8.5h	82
GSM439806	Male	6.1	4.5h	79
GSM439807	Female	5.7	7h	88
GSM439808	Female	6.3	9.5h	94
GSM439809	Male	6.5	30h	63
GSM439810	Female	6.6	4h	46
GSM4398	Female	6	3h	75
GSM439812	Female	6.4	6h	68
GSM439813	Male	6.1	11.5h	83
GSM439814	Male	6.9	16h	60
GSM439815	Male	6.3	4.5h	79
GSM439816	Male	6.9	6h	38
GSM439817	Male	6.2	4h	79
GSM439818	Female	6.3	13h	71
GSM439819	Male	6.3	13h	91
GSM439820	Female	6.2	3.5h	97
GSM43982	Male	5.8	19.5h	82
GSM439822	Male	6.6	12h	25
GSM439823	Male	6.2	5h	82
GSM439824	Male	6.3	4h	44
GSM439825	Female	6.8	5h	88
GSM439826	Female	6.7	6h	67
GSM439827	Female	6.1	3.5h	67
GSM439828	Male	6.2	3h	77