Dataset: Comparison of post-mortem tissue from brain BA10 region between schizophrenic and control patients.

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function....

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Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some environmental influences on aetiology. To gain further insight into disease mechanism, we used microarray technology to determine the expression of over 30 000 mRNA transcripts in post-mortem tissue from a brain region associated with the pathophysiology of the disease (Brodmann area 10: anterior prefrontal cortex) in 28 schizophrenic and 23 control patients. Post-mortem derived BA10 tissue from 28 schizophrenic and 23 control patients were compared. Age, gender, post-mortem delay and pH of brain lysates data were also captured.

Species:: human
Samples:: 51
Source:: E-GEOD-17612
PubMed:: 19255580
Updated:: Dec.12, 2014
Registered:: Sep.12, 2014

Factors: (via ArrayExpress)

Sample	GENDER	AGE	POST-MORTEM DELAY	PH
GSM439778	Male	74	4.5h	6
GSM439779	Male	72	12h	6.8
GSM439780	Female	89	5h	6.5
GSM43978	Female	85	3.5h	5.9
GSM439782	Male	61	16.5h	6.2
GSM439783	Female	54	4h	6.5
GSM439784	Male	41	8h	6.3
GSM439785	Male	71	6.5h	6
GSM439786	Male	77	3h	6.1
GSM439787	Female	90	12.5h	5.7
GSM439788	not specified	91	4.5h	6.3
GSM439789	Male	54	12h	6.6
GSM439790	Female	65	3h	6.1
GSM43979	Male	75	9h	6.3
GSM439792	Female	78	8h	6.7
GSM439793	Male	90	6.75h	6.2
GSM439794	Male	56	16.5h	6.4
GSM439795	Female	81	22h	not specified
GSM439796	Male	82	11h	6
GSM439797	Male	91	9.5h	6.3
GSM439798	Male	82	11h	6.4
GSM439799	Male	58	15h	6.5
GSM439800	Female	28	11h	6.3
GSM43980	Male	87	3.5h	6
GSM439802	Female	87	14.5h	6.5
GSM439803	Male	72	20h	6.6
GSM439804	Male	25	17h	6.9
GSM439805	Female	82	8.5h	5.9
GSM439806	Male	79	4.5h	6.1
GSM439807	Female	88	7h	5.7
GSM439808	Female	94	9.5h	6.3
GSM439809	Male	63	30h	6.5
GSM439810	Female	46	4h	6.6
GSM4398	Female	75	3h	6
GSM439812	Female	68	6h	6.4
GSM439813	Male	83	11.5h	6.1
GSM439814	Male	60	16h	6.9
GSM439815	Male	79	4.5h	6.3
GSM439816	Male	38	6h	6.9
GSM439817	Male	79	4h	6.2
GSM439818	Female	71	13h	6.3
GSM439819	Male	91	13h	6.3
GSM439820	Female	97	3.5h	6.2
GSM43982	Male	82	19.5h	5.8
GSM439822	Male	25	12h	6.6
GSM439823	Male	82	5h	6.2
GSM439824	Male	44	4h	6.3
GSM439825	Female	88	5h	6.8
GSM439826	Female	67	6h	6.7
GSM439827	Female	67	3.5h	6.1
GSM439828	Male	77	3h	6.2