Dataset: Transcription profiling of mouse LPS-stimulated macrophages from wild-type and Zc3h12a-/- knockouts

Lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand, induces the expression of various genes including proinflammatory cytokines, and the expression is modified by the presence of Zc3h12a. We used microarrays to examine influence of Zc3h12a deficiency in LPS-inducible gene expression. Experiment Overall Design: Peritoneal macrophages from wild-type and Zc3h12a-/- mice were stimulated with LPS for 0, 1, 2 and 4 hours, followed by RNA extraction. Then hybridization on affymetrix microarrays was performed.

Species:

mouse

Samples:

8

Source:

E-GEOD-14891

Updated:

Dec.12, 2014

Registered:

Nov.11, 2014