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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample TRAINING OR TEST SET RACE BCR-ABL, T(9;22) AMPLIFICATION SET CONGENITAL ABNORMALITY GENDER MLL E2A-PBX, T(1;19) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE CNS STATUS TISSUE TYPE SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE TESTICULAR INVOLVEMENT AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER TRISOMY 4 AND 10
GSM299862 test set White Negative 1 None Female Positive Negative Negative 1 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 100 Unknown 3953 175.0 Negative
GSM299863 training set Black or African American Negative 1 None Male Negative Negative Negative 1 90 No CNS disease peripheral blood 100 Negative 1976 142.0 Negative
GSM299864 training set Hispanic or Latino Negative 1 None Male Negative Negative Negative 2 70 No CNS disease peripheral blood 99 Negative 5250 220.7 Negative
GSM299865 test set White Negative 1 None Male Negative Negative Negative 2 95 No CNS disease peripheral blood 88 Negative 577 129.0 Negative
GSM299866 training set Hispanic or Latino Negative 1 None Male Negative Negative Negative 3 95 No CNS disease bone marrow 95 Negative 4609 26.0 Negative
GSM299867 training set White Negative 1 None Male Negative Negative Negative 3 80 No CNS disease bone marrow 68 Negative 5289 14.7 Negative
GSM299868 training set Asian Negative 1 None Male Negative Negative Negative 4 -1 No CNS disease bone marrow 71 Negative 3987 68.6 Negative
GSM299869 test set White Negative 1 None Male Negative Negative Negative 4 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 98 Negative 4856 21.4 Negative
GSM299870 test set White Negative 1 None Male Negative Negative Negative 4 1 No CNS disease bone marrow 99 Negative 4678 2.4 Negative
GSM29987 training set White Negative 1 Unknown Male Negative Negative Negative 1 75 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 68 Negative 796 21.0 Negative
GSM299872 training set White Negative 1 None Female Positive Negative Negative 1 85 No CNS disease peripheral blood 100 Unknown 4071 125.8 Negative
GSM299873 training set White Negative 1 Unknown Male Negative Negative Negative 2 95 No CNS disease bone marrow 99 Negative 5223 29.9 Negative
GSM299874 training set Hispanic or Latino Negative 1 Unknown Female Negative Negative Negative 3 95 No CNS disease peripheral blood 99 Unknown 5118 217.2 Negative
GSM299875 training set unknown Negative 1 None Male Negative Negative Negative 3 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 97 Negative 5219 180.0 Negative
GSM299876 training set White Negative 1 Downs Female Negative Negative Negative 4 95 No CNS disease bone marrow 98 Unknown 1429 118.0 Negative
GSM299877 test set White Negative 1 Unknown Female Negative Negative Negative 1 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 97 Unknown 3179 314.8 Negative
GSM299878 test set White Negative 1 None Female Negative Negative Negative 1 -1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 58 Unknown 1450 5.2 Negative
GSM299879 training set White Negative 1 None Male Negative Negative Negative 1 95 No CNS disease bone marrow 91 Negative 5278 113.5 Negative
GSM299880 training set White Negative 1 None Male Negative Positive Negative 2 85 No CNS disease bone marrow 98 Negative 5330 5.8 Negative
GSM29988 test set Hispanic or Latino Negative 1 Unknown Female Negative Negative Negative 4 90 No CNS disease peripheral blood 99 Unknown 4861 592.6 Negative
GSM299882 training set White Negative 1 None Female Negative Negative Negative 1 95 No CNS disease peripheral blood 80 Unknown 428 248.0 Negative
GSM299883 training set White Negative 1 None Male Negative Negative Negative 1 95 No CNS disease bone marrow 97 Negative 4722 4.4 Negative
GSM299884 test set White Negative 1 Unknown Male Negative Negative Negative 2 95 No CNS disease bone marrow 99 Negative 3587 72.2 Negative
GSM299885 test set White Negative 1 None Female Positive Negative Negative 2 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 98 Negative 5431 133.0 Negative
GSM299886 training set Hispanic or Latino Negative 1 None Male Negative Negative Negative 2 70 No CNS disease bone marrow 98 Positive 3444 5.0 Negative
GSM299887 test set Other Negative 1 None Male Negative Negative Negative 3 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 99 Negative 862 194.0 Negative
GSM299888 training set Hispanic or Latino Negative 1 None Male Negative Negative Negative 3 90 No CNS disease bone marrow 97 Negative 6674 3.8 Negative
GSM299889 training set White Negative 1 None Male Negative Negative Negative 3 95 No CNS disease bone marrow 70 Negative 6323 15.4 Negative
GSM299890 training set White Negative 1 Unknown Male Negative Negative Negative 4 90 No CNS disease bone marrow 98 Negative 6219 16.5 Negative
GSM29989 training set White Negative 1 None Male Negative Negative Positive 4 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 65 Negative 2509 1.7 Negative
GSM299892 training set Hispanic or Latino Negative 1 None Female Negative Positive Negative 4 95 No CNS disease peripheral blood 100 Unknown 1531 196.1 Negative
GSM299893 test set Hispanic or Latino Negative 1 Unknown Male Negative Negative Negative 1 85 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 100 Unknown 5516 202.4 Negative
GSM299894 training set White Negative 1 None Male Negative Negative Negative 1 90 No CNS disease bone marrow 82 Negative 5513 2.5 Negative
GSM299895 training set White Negative 1 Unknown Male Negative Negative Negative 2 95 No CNS disease bone marrow 62 Negative 5842 27.4 Negative
GSM299896 training set White Negative 1 Downs Male Negative Positive Negative 3 75 No CNS disease peripheral blood 98 Negative 6496 9.1 Negative
GSM299897 training set White Negative 1 None Male Positive Negative Negative 3 95 No CNS disease peripheral blood 99 Negative 6511 515.0 Negative
GSM299898 training set Hispanic or Latino Negative 1 None Male Negative Positive Negative 4 95 No CNS disease bone marrow 97 Negative 1361 117.2 Negative
GSM299899 training set White Negative 1 None Female Negative Negative Negative 1 95 No CNS disease bone marrow 74 Unknown 835 115.0 Negative
GSM299900 training set Hispanic or Latino Negative 1 None Male Positive Negative Negative 2 95 No CNS disease peripheral blood 99 Negative 4774 246.4 Negative
GSM29990 training set White Negative 1 None Female Positive Negative Negative 2 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 95 Unknown 3311 489.0 Negative
GSM299902 training set White Negative 1 None Male Negative Negative Negative 3 80 No CNS disease peripheral blood 100 Negative 6331 32.6 Negative
GSM299903 training set White Negative 1 None Female Positive Negative Negative 3 95 No CNS disease bone marrow 92 Unknown 398 135.0 Negative
GSM299904 test set White Negative 1 None Male Negative Positive Negative 3 95 No CNS disease bone marrow 96 Negative 5631 67.2 Negative
GSM299905 test set White Negative 1 None Female Negative Negative Negative 1 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 96 Unknown 944 12.1 Negative
GSM299906 training set White Negative 1 None Male Negative Positive Negative 1 90 No CNS disease bone marrow 90 Negative 4940 8.0 Negative
GSM299907 training set White Negative 1 Downs Female Negative Negative Negative 2 95 No CNS disease bone marrow 96 Negative 5721 88.9 Negative
GSM299908 training set White Negative 1 Unknown Male Negative Negative Negative 3 95 No CNS disease peripheral blood 98 Negative 6114 80.9 Negative
GSM299909 training set White Negative 1 None Male Negative Negative Negative 4 95 No CNS disease bone marrow 97 Negative 5086 36.2 Negative
GSM299910 test set White Negative 1 None Male Negative Negative Negative 4 95 No CNS disease bone marrow 90 Negative 5359 80.8 Negative
GSM2999 training set White Negative 1 None Male Negative Negative Negative 2 90 No CNS disease bone marrow 95 Negative 1167 156.0 Negative
GSM299912 training set White Negative 1 Unknown Female Negative Negative Negative 2 95 No CNS disease peripheral blood 82 Negative 4090 289.3 Negative
GSM299913 test set White Negative 1 None Male Positive Negative Negative 3 95 No CNS disease peripheral blood 90 Negative 792 237.0 Negative
GSM299914 training set White Negative 1 None Male Negative Negative Negative 4 95 No CNS disease bone marrow 99 Negative 6733 81.4 Negative
GSM299915 training set Asian Negative 2 Unknown Male Negative Negative Negative 5 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 98 Negative 2875 351.3 Negative
GSM299916 training set Hispanic or Latino Negative 2 Other Male Negative Negative Positive 5 80 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 99 Negative 449 59.9 Negative
GSM299917 training set White Negative 4 Unknown Male Negative Negative Negative 6 95 No CNS disease bone marrow 100 Negative 904 137.8 Negative
GSM299918 test set White Negative 2 None Male Negative Negative Negative 6 90 No CNS disease bone marrow 98 Negative 1426 138.4 Negative
GSM299919 training set Hispanic or Latino Negative 2 None Female Negative Negative Negative 6 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 98 Unknown 4469 478.0 Negative
GSM299920 training set Hispanic or Latino Negative 2 None Male Negative Negative Negative 7 95 No CNS disease bone marrow 88 Negative 6266 34.9 Negative
GSM29992 training set White Negative 2 None Male Negative Negative Negative 8 70 No CNS disease bone marrow 100 Negative 6306 22.8 Negative
GSM299922 training set White Negative 2 None Female Negative Negative Negative 8 90 No CNS disease peripheral blood 100 Unknown 727 109.5 Negative
GSM299923 training set Hispanic or Latino Negative 2 None Male Negative Negative Negative 5 95 No CNS disease bone marrow 99 Negative 5867 21.1 Negative
GSM299924 training set Asian Negative 2 None Female Negative Negative Negative 5 90 No CNS disease bone marrow 95 Unknown 6733 102.0 Negative
GSM299925 training set White Negative 4 None Male Negative Negative Negative 6 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 98 Negative 5495 96.2 Negative
GSM299926 training set unknown Negative 2 None Male Negative Negative Negative 6 95 No CNS disease bone marrow 99 Negative 6063 2.3 Negative
GSM299927 test set Hispanic or Latino Negative 2 None Female Negative Negative Negative 6 95 No CNS disease bone marrow 87 Unknown 5922 27.0 Negative
GSM299928 training set White Negative 2 Downs Female Negative Negative Negative 7 90 No CNS disease peripheral blood 99 Unknown 6922 68.9 Negative
GSM299929 training set White Negative 2 None Female Negative Negative Negative 8 95 No CNS disease bone marrow 100 Unknown 531 119.0 Negative
GSM299930 test set White Negative 2 Unknown Female Negative Negative Negative 5 95 No CNS disease bone marrow 97 Unknown 4106 210.0 Negative
GSM29993 training set Hispanic or Latino Negative 2 None Male Negative Negative Negative 5 95 No CNS disease bone marrow 91 Negative 2027 199.0 Negative
GSM299932 training set Asian Negative 2 Unknown Female Negative Positive Negative 6 90 No CNS disease peripheral blood 96 Unknown 1191 175.5 Negative
GSM299933 test set Hispanic or Latino Negative 6 None Female Negative Negative Negative 7 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 94 Unknown 5310 92.7 Negative
GSM299934 training set White Negative 2 None Male Negative Negative Negative 7 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 83 Negative 5163 270.0 Negative
GSM299935 test set White Negative 2 None Female Negative Positive Negative 7 95 No CNS disease bone marrow 66 Unknown 977 115.1 Negative
GSM299936 training set White Negative 2 Unknown Male Negative Negative Negative 8 95 No CNS disease bone marrow 89 Negative 4807 12.7 Negative
GSM299937 training set White Negative 2 None Male Negative Negative Negative 5 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 99 Negative 5564 112.0 Negative
GSM299938 test set White Negative 2 Unknown Male Negative Negative Negative 5 95 No CNS disease bone marrow 60 Negative 4305 40.0 Negative
GSM299939 training set White Negative 6 Unknown Female Negative Negative Negative 6 95 No CNS disease bone marrow 94 Unknown 4717 62.3 Negative
GSM299940 test set Hispanic or Latino Negative 4 None Male Negative Negative Negative 7 95 No CNS disease bone marrow 99 Negative 4657 33.1 Negative
GSM29994 training set White Negative 2 None Female Negative Negative Positive 7 90 No CNS disease bone marrow 79 Unknown 1429 192.0 Negative
GSM299942 training set Hispanic or Latino Negative 4 None Female Negative Negative Negative 8 65 No CNS disease peripheral blood 98 Negative 6413 16.6 Negative
GSM299943 training set White Negative 2 None Female Negative Negative Negative 8 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 92 Negative 2133 17.5 Negative
GSM299944 test set Hispanic or Latino Negative 2 Unknown Female Positive Negative Negative 8 70 No CNS disease peripheral blood 69 Unknown 434 88.5 Negative
GSM299945 training set Asian Negative 2 Unknown Male Negative Negative Negative 5 90 No CNS disease bone marrow 87 Negative 4935 24.5 Negative
GSM299946 training set White Negative 2 None Female Negative Negative Negative 5 85 No CNS disease peripheral blood 100 Negative 6984 30.4 Negative
GSM299947 test set White Negative 2 None Female Negative Negative Negative 5 90 No CNS disease bone marrow 65 Unknown 1068 190.0 Negative
GSM299948 test set Hispanic or Latino Negative 4 None Male Negative Negative Negative 6 95 No CNS disease bone marrow 99 Negative 5877 66.9 Negative
GSM299949 training set White Negative 6 None Male Positive Negative Negative 7 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 87 Negative 5127 555.0 Negative
GSM299950 training set White Negative 4 None Male Positive Negative Negative 7 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 95 Negative 410 51.3 Negative
GSM29995 training set White Negative 2 Unknown Male Negative Negative Negative 7 95 No CNS disease bone marrow 97 Negative 5408 1.2 Negative
GSM299952 test set Black or African American Negative 2 Unknown Male Negative Negative Negative 8 95 No CNS disease bone marrow 96 Negative 2876 142.4 Negative
GSM299953 training set White Negative 2 Unknown Male Negative Negative Negative 8 95 No CNS disease bone marrow 87 Negative 697 110.9 Negative
GSM299954 test set Hispanic or Latino Negative 2 Downs Female Negative Negative Negative 5 90 No CNS disease peripheral blood 95 Unknown 2223 202.0 Negative
GSM299955 test set White Negative 2 None Female Positive Negative Negative 5 95 No CNS disease peripheral blood 97 Unknown 7028 259.8 Negative
GSM299956 training set White Negative 2 None Male Negative Negative Negative 5 -1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 26 Negative 5177 166.5 Unknown
GSM299957 training set Hispanic or Latino Negative 2 None Female Positive Negative Negative 6 90 No CNS disease peripheral blood 91 Unknown 1038 114.0 Negative
GSM299958 test set Hispanic or Latino Negative 2 Downs Female Negative Negative Negative 6 95 No CNS disease peripheral blood 100 Unknown 5008 321.2 Negative
GSM299959 training set Hispanic or Latino Negative 2 None Female Negative Negative Negative 7 95 No CNS disease bone marrow 71 Unknown 5925 19.5 Negative
GSM299960 training set Hispanic or Latino Negative 2 None Male Negative Negative Negative 7 95 No CNS disease peripheral blood 93 Negative 1258 145.0 Negative
GSM29996 test set Hispanic or Latino Negative 2 None Female Negative Positive Negative 8 90 No CNS disease bone marrow 85 Unknown 1956 148.2 Negative
GSM299962 training set White Negative 4 None Female Positive Negative Negative 6 90 No CNS disease peripheral blood 97 Unknown 4560 108.0 Negative
GSM299963 training set White Negative 2 None Male Positive Negative Negative 7 90 No CNS disease peripheral blood 84 Negative 966 37.3 Negative
GSM299964 test set White Negative 2 None Male Negative Negative Unknown 7 95 No CNS disease bone marrow 100 Negative 4585 12.0 Negative
GSM299965 training set White Negative 2 Unknown Female Negative Negative Negative 5 90 No CNS disease bone marrow 98 Unknown 4863 65.8 Negative
GSM299966 training set White Negative 2 None Male Negative Negative Negative 6 95 No CNS disease peripheral blood 100 Negative 369 325.0 Negative
GSM299967 test set White Negative 2 None Male Negative Negative Negative 7 -1 No CNS disease bone marrow 20 Negative 5853 2.3 Negative
GSM299968 training set White Negative 2 None Male Negative Negative Negative 8 80 No CNS disease bone marrow 99 Negative 6335 13.3 Negative
GSM299969 test set American Indian or Alaska native Negative 2 None Male Negative Negative Negative 8 95 No CNS disease peripheral blood 97 Negative 881 106.0 Negative
GSM299970 training set White Negative 3 None Female Negative Negative Negative 9 95 No CNS disease peripheral blood 100 Unknown 2786 105.7 Negative
GSM29997 training set White Negative 3 None Male Negative Negative Negative 10 80 No CNS disease peripheral blood 94 Negative 6306 16.7 Negative
GSM299972 test set White Negative 3 None Male Negative Negative Negative 10 90 No CNS disease bone marrow 98 Negative 2519 112.0 Negative
GSM299973 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 11 95 No CNS disease bone marrow 66 Negative 6142 18.5 Negative
GSM299974 test set Black or African American Negative 3 None Male Negative Negative Negative 11 80 No CNS disease bone marrow 96 Negative 5343 30.2 Negative
GSM299975 test set White Negative 3 None Male Positive Negative Negative 11 90 No CNS disease bone marrow 96 Negative 852 139.0 Negative
GSM299976 training set Hispanic or Latino Negative 3 None Male Positive Negative Negative 12 95 No CNS disease bone marrow 94 Negative 462 17.3 Negative
GSM299977 training set Black or African American Negative 3 Unknown Female Negative Positive Negative 12 90 No CNS disease peripheral blood 75 Unknown 5797 39.6 Negative
GSM299978 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 9 95 No CNS disease peripheral blood 97 Negative 4253 236.4 Negative
GSM299979 training set Hispanic or Latino Negative 3 None Female Negative Negative Negative 9 75 No CNS disease peripheral blood 99 Unknown 705 137.2 Negative
GSM299980 training set White Negative 3 Unknown Male Negative Negative Negative 10 70 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 99 Negative 7478 28.0 Negative
GSM29998 training set White Negative 3 Unknown Male Negative Negative Negative 10 90 No CNS disease peripheral blood 100 Negative 2191 272.0 Negative
GSM299982 training set Hispanic or Latino Negative 3 None Female Negative Negative Negative 11 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 98 Unknown 1275 214.0 Negative
GSM299983 test set White Negative 3 None Male Negative Negative Negative 11 95 No CNS disease bone marrow 96 Negative 5184 58.0 Negative
GSM299984 training set Other Negative 3 None Male Negative Negative Negative 11 -1 No CNS disease bone marrow 59 Negative 5542 7.9 Negative
GSM299985 test set White Negative 3 None Male Negative Negative Negative 12 95 No CNS disease bone marrow 64 Negative 5242 3.4 Negative
GSM299986 training set White Negative 3 Unknown Female Negative Negative Negative 12 75 No CNS disease peripheral blood 99 Unknown 1313 69.4 Negative
GSM299987 training set White Negative 3 None Female Negative Negative Negative 9 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 94 Unknown 1751 238.0 Negative
GSM299988 training set White Negative 3 None Female Negative Negative Negative 9 90 No CNS disease bone marrow 98 Unknown 4329 179.0 Negative
GSM299989 training set White Negative 3 None Male Negative Negative Negative 9 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 86 Negative 976 7.7 Positive
GSM299990 test set Hispanic or Latino Negative 3 None Female Negative Positive Negative 10 95 No CNS disease bone marrow 91 Negative 5300 98.2 Negative
GSM29999 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 11 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 81 Negative 4307 44.9 Negative
GSM299992 training set White Negative 3 None Female Negative Negative Negative 12 60 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 98 Unknown 4324 35.7 Negative
GSM299993 test set White Negative 3 Unknown Female Negative Positive Negative 9 95 No CNS disease bone marrow 97 Unknown 1033 118.1 Negative
GSM299994 test set Hispanic or Latino Negative 3 None Male Negative Negative Negative 9 -1 No CNS disease bone marrow 31 Negative 6052 6.4 Negative
GSM299995 training set White Unknown 3 Unknown Male Negative Negative Unknown 10 95 No CNS disease bone marrow 85 Negative 4157 77.6 Negative
GSM299996 training set Asian Negative 3 None Male Negative Positive Negative 11 90 No CNS disease bone marrow 64 Unknown 5025 73.1 Negative
GSM299997 training set White Negative 3 None Male Negative Negative Negative 12 95 No CNS disease bone marrow 99 Negative 6263 1.0 Negative
GSM299998 training set White Negative 3 None Male Positive Negative Negative 9 90 No CNS disease bone marrow 96 Negative 5664 22.0 Negative
GSM299999 test set Other Negative 3 None Male Negative Negative Negative 9 95 No CNS disease bone marrow 95 Negative 4776 1.3 Negative
GSM300000 training set White Negative 3 None Female Negative Negative Negative 10 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 99 Unknown 2192 209.6 Negative
GSM30000 training set Black or African American Negative 3 None Male Negative Negative Negative 11 95 No CNS disease bone marrow 94 Negative 5954 15.5 Negative
GSM300002 training set White Negative 3 None Male Negative Negative Negative 11 95 No CNS disease bone marrow 67 Negative 2038 193.0 Negative
GSM300003 training set White Negative 3 None Female Negative Negative Negative 12 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 96 Unknown 6032 59.2 Positive
GSM300004 training set White Negative 3 Unknown Male Negative Negative Negative 12 85 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 98 Positive 655 9.8 Negative
GSM300005 training set White Negative 3 None Male Negative Negative Negative 12 90 No CNS disease bone marrow 94 Negative 4759 2.4 Negative
GSM300006 test set Hispanic or Latino Negative 3 Unknown Female Negative Negative Negative 9 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 97 Unknown 2769 3.0 Negative
GSM300007 training set American Indian or Alaska native Negative 3 None Male Negative Negative Negative 9 40 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 94 Unknown 4972 6.3 Negative
GSM300008 test set Black or African American Negative 3 Unknown Male Negative Negative Negative 9 95 No CNS disease bone marrow 98 Negative 4815 31.4 Negative
GSM300009 test set White Negative 3 None Male Negative Negative Negative 10 95 No CNS disease peripheral blood 98 Negative 6315 245.0 Negative
GSM300010 training set White Negative 3 Downs Male Negative Negative Negative 10 95 No CNS disease bone marrow 95 Negative 4276 24.4 Negative
GSM3000 training set White Negative 3 None Male Negative Negative Negative 10 95 No CNS disease peripheral blood 99 Negative 5759 33.9 Negative
GSM300012 test set White Negative 3 None Male Negative Negative Negative 11 -1 No CNS disease bone marrow 44 Negative 6487 7.6 Negative
GSM300013 test set Black or African American Negative 3 None Male Negative Positive Negative 11 95 No CNS disease peripheral blood 99 Negative 1771 152.7 Negative
GSM300014 training set White Negative 3 None Male Negative Negative Negative 12 95 No CNS disease bone marrow 89 Negative 515 124.0 Negative
GSM300015 training set White Negative 3 None Female Negative Negative Negative 12 95 No CNS disease bone marrow 96 Unknown 6090 24.8 Negative
GSM300016 training set White Negative 3 Unknown Male Negative Negative Negative 9 95 No CNS disease bone marrow 99 Negative 6633 1.9 Negative
GSM300017 test set Hispanic or Latino Negative 3 None Male Negative Negative Negative 9 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 97 Negative 5194 96.5 Negative
GSM300018 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 10 95 No CNS disease bone marrow 96 Negative 6468 7.0 Negative
GSM300019 test set White Negative 3 None Male Negative Negative Negative 11 90 No CNS disease bone marrow 92 Negative 6062 17.0 Negative
GSM300020 test set Other Negative 3 Unknown Female Positive Negative Negative 11 90 No CNS disease bone marrow 95 Unknown 777 6.8 Negative
GSM30002 test set White Negative 3 None Female Negative Positive Negative 12 85 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 100 Unknown 5889 49.6 Negative
GSM300022 test set White Negative 3 None Male Negative Negative Negative 12 95 No CNS disease peripheral blood 95 Negative 893 455.4 Negative
GSM300023 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 9 95 No CNS disease bone marrow 98 Negative 4955 31.5 Negative
GSM300024 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 10 95 No CNS disease peripheral blood 99 Negative 5081 307.0 Negative
GSM300025 training set Hispanic or Latino Negative 3 Downs Female Negative Negative Negative 10 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 98 Unknown 4665 95.2 Negative
GSM300026 training set Hispanic or Latino Negative 3 None Male Negative Negative Negative 11 95 No CNS disease peripheral blood 97 Negative 988 958.8 Negative
GSM300027 training set White Negative 3 None Male Negative Positive Negative 12 -1 No CNS disease bone marrow 59 Negative 5890 9.4 Negative
GSM300028 test set Black or African American Negative 3 None Female Negative Negative Negative 12 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 96 Unknown 6351 13.8 Negative
GSM300029 test set White Negative 4 Unknown Male Negative Negative Negative 13 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 86 Negative 1475 212.3 Negative
GSM300030 training set Hispanic or Latino Negative 4 Unknown Male Negative Negative Negative 13 90 No CNS disease bone marrow 99 Negative 6036 8.8 Negative
GSM30003 training set White Negative 1 None Female Negative Negative Negative 4 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 96 Unknown 5217 135.8 Negative
GSM300032 training set Black or African American Negative 1 None Male Negative Negative Negative 4 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 97 Negative 523 82.9 Negative
GSM300033 training set White Negative 3 Unknown Female Negative Positive Negative 11 95 No CNS disease peripheral blood 99 Unknown 1011 302.1 Negative
GSM300034 test set Native Hawaiian or other Pacific Islander Negative 3 None Male Negative Negative Negative 11 90 No CNS disease bone marrow 98 Negative 6107 18.3 Negative
GSM300035 training set White Negative 4 None Male Negative Negative Negative 13 95 No CNS disease peripheral blood 95 Negative 768 138.8 Negative
GSM300036 training set White Negative 4 None Female Negative Positive Negative 13 90 No CNS disease peripheral blood 84 Unknown 5670 37.2 Negative
GSM300037 training set Hispanic or Latino Negative 6 None Male Negative Negative Negative 11 95 No CNS disease peripheral blood 99 Negative 6666 114.6 Negative
GSM300038 training set Hispanic or Latino Negative 4 None Female Negative Positive Negative 13 85 No CNS disease bone marrow 96 Unknown 3901 136.6 Negative
GSM300039 training set White Negative 7 None Female Negative Negative Negative 14 -1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 51 Negative 728 138.4 Negative
GSM300040 test set White Negative 7 None Female Negative Negative Negative 14 95 No CNS disease bone marrow 79 Unknown 1058 141.0 Negative
GSM30004 test set Hispanic or Latino Negative 7 Unknown Female Negative Negative Negative 14 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 76 Unknown 1323 30.6 Positive
GSM300042 training set Hispanic or Latino Negative 7 None Male Negative Negative Negative 14 95 No CNS disease bone marrow 84 Negative 650 102.5 Negative
GSM300043 test set White Negative 8 None Male Negative Negative Negative 15 85 No CNS disease bone marrow 99 Negative 5821 1.9 Negative
GSM300044 training set White Negative 8 Unknown Male Negative Negative Negative 15 40 No CNS disease peripheral blood 100 Negative 6202 2.3 Negative
GSM300045 training set American Indian or Alaska native Negative 8 None Female Negative Negative Negative 15 90 No CNS disease bone marrow 98 Negative 6119 2.3 Negative
GSM300046 training set White Negative 8 None Male Negative Negative Negative 15 60 No CNS disease peripheral blood 99 Positive 4571 6.9 Negative
GSM300047 training set Hispanic or Latino Negative 8 None Male Negative Negative Negative 15 60 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement peripheral blood 93 Negative 1896 4.1 Positive
GSM300048 training set White Negative 8 None Female Negative Negative Negative 15 75 No CNS disease bone marrow 97 Negative 7461 3.8 Negative
GSM300049 test set White Negative 8 None Male Negative Negative Negative 15 65 No CNS disease bone marrow 96 Negative 6634 11.1 Negative
GSM300050 training set White Negative 8 None Male Negative Negative Negative 15 80 No CNS disease peripheral blood 83 Negative 5097 6.3 Negative
GSM30005 test set Hispanic or Latino Negative 8 None Male Negative Negative Negative 15 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin bone marrow 96 Negative 5532 5.5 Negative
GSM300052 test set Black or African American Negative 8 None Male Negative Negative Negative 15 -1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin peripheral blood 47 Positive 1914 45.1 Positive
GSM300053 training set White Negative 8 None Male Negative Positive Negative 15 90 No CNS disease peripheral blood 72 Negative 4434 42.1 Negative
GSM300054 test set Asian Negative 8 None Male Negative Positive Negative 15 50 No CNS disease peripheral blood 93 Negative 4782 4.4 Negative
GSM300055 test set White Negative 8 None Male Negative Negative Negative 15 90 No CNS disease bone marrow 84 Negative 5232 1.1 Negative
GSM300056 test set Black or African American Negative 8 None Male Negative Positive Negative 15 80 No CNS disease peripheral blood 83 Negative 6500 17.8 Negative
GSM300057 training set White Negative 9 None Male Positive Negative Negative 16 -1 No CNS disease bone marrow 50 Unknown 585 7.5 Negative
GSM300058 test set Black or African American Negative 9 None Male Negative Negative Negative 16 95 No CNS disease bone marrow 98 Negative 6539 2.6 Negative
GSM300059 test set White Negative 9 None Female Negative Negative Negative 16 85 No CNS disease bone marrow 100 Negative 5991 5.2 Negative
GSM300060 training set White Negative 9 None Male Negative Negative Negative 16 70 No CNS disease peripheral blood 93 Negative 6479 31.9 Negative
GSM30006 training set Black or African American Negative 9 None Male Negative Negative Negative 16 90 No CNS disease bone marrow 98 Negative 5183 23.0 Negative
GSM300062 training set White Negative 9 None Male Negative Negative Negative 16 -1 No CNS disease peripheral blood 46 Negative 713 110.3 Negative
GSM300063 test set White Negative 9 None Male Positive Negative Negative 16 90 No CNS disease bone marrow 82 Unknown 1704 85.1 Negative
GSM300064 test set White Negative 9 Unknown Male Negative Negative Negative 16 95 No CNS disease bone marrow 99 Negative 5594 2.8 Negative
GSM300065 training set White Negative 9 Unknown Male Negative Negative Negative 16 95 No CNS disease bone marrow 88 Negative 5857 13.3 Negative
GSM300066 test set Hispanic or Latino Negative 9 None Female Negative Positive Negative 16 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement bone marrow 81 Unknown 4017 3.5 Negative
GSM300067 training set White Negative 9 Unknown Male Negative Negative Negative 16 95 No CNS disease bone marrow 85 Negative 4918 5.5 Negative
GSM300068 training set Hispanic or Latino Negative 10 Unknown Male Negative Negative Negative 18 90 No CNS disease bone marrow 66 Negative 5349 147.6 Negative

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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