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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample TRAINING OR TEST SET CONGENITAL ABNORMALITY TESTICULAR INVOLVEMENT CNS STATUS MLL GENDER BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) TISSUE TYPE SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE AMPLIFICATION SET AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER RACE TRISOMY 4 AND 10
GSM299862 test set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Female Negative Negative 1 90 Negative peripheral blood 100 1 3953 175.0 White Negative
GSM299863 training set None Negative No CNS disease Negative Male Negative Negative 1 90 Negative peripheral blood 100 1 1976 142.0 Black or African American Negative
GSM299864 training set None Negative No CNS disease Negative Male Negative Negative 2 70 Negative peripheral blood 99 1 5250 220.7 Hispanic or Latino Negative
GSM299865 test set None Negative No CNS disease Negative Male Negative Negative 2 95 Negative peripheral blood 88 1 577 129.0 White Negative
GSM299866 training set None Negative No CNS disease Negative Male Negative Negative 3 95 Negative bone marrow 95 1 4609 26.0 Hispanic or Latino Negative
GSM299867 training set None Negative No CNS disease Negative Male Negative Negative 3 80 Negative bone marrow 68 1 5289 14.7 White Negative
GSM299868 training set None Negative No CNS disease Negative Male Negative Negative 4 -1 Negative bone marrow 71 1 3987 68.6 Asian Negative
GSM299869 test set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 4 90 Negative bone marrow 98 1 4856 21.4 White Negative
GSM299870 test set None Negative No CNS disease Negative Male Negative Negative 4 1 Negative bone marrow 99 1 4678 2.4 White Negative
GSM29987 training set Unknown Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 1 75 Negative bone marrow 68 1 796 21.0 White Negative
GSM299872 training set None Unknown No CNS disease Positive Female Negative Negative 1 85 Negative peripheral blood 100 1 4071 125.8 White Negative
GSM299873 training set Unknown Negative No CNS disease Negative Male Negative Negative 2 95 Negative bone marrow 99 1 5223 29.9 White Negative
GSM299874 training set Unknown Unknown No CNS disease Negative Female Negative Negative 3 95 Negative peripheral blood 99 1 5118 217.2 Hispanic or Latino Negative
GSM299875 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 3 90 Negative peripheral blood 97 1 5219 180.0 unknown Negative
GSM299876 training set Downs Unknown No CNS disease Negative Female Negative Negative 4 95 Negative bone marrow 98 1 1429 118.0 White Negative
GSM299877 test set Unknown Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 1 95 Negative peripheral blood 97 1 3179 314.8 White Negative
GSM299878 test set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 1 -1 Negative bone marrow 58 1 1450 5.2 White Negative
GSM299879 training set None Negative No CNS disease Negative Male Negative Negative 1 95 Negative bone marrow 91 1 5278 113.5 White Negative
GSM299880 training set None Negative No CNS disease Negative Male Negative Negative 2 85 Positive bone marrow 98 1 5330 5.8 White Negative
GSM29988 test set Unknown Unknown No CNS disease Negative Female Negative Negative 4 90 Negative peripheral blood 99 1 4861 592.6 Hispanic or Latino Negative
GSM299882 training set None Unknown No CNS disease Negative Female Negative Negative 1 95 Negative peripheral blood 80 1 428 248.0 White Negative
GSM299883 training set None Negative No CNS disease Negative Male Negative Negative 1 95 Negative bone marrow 97 1 4722 4.4 White Negative
GSM299884 test set Unknown Negative No CNS disease Negative Male Negative Negative 2 95 Negative bone marrow 99 1 3587 72.2 White Negative
GSM299885 test set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive Female Negative Negative 2 90 Negative peripheral blood 98 1 5431 133.0 White Negative
GSM299886 training set None Positive No CNS disease Negative Male Negative Negative 2 70 Negative bone marrow 98 1 3444 5.0 Hispanic or Latino Negative
GSM299887 test set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 3 90 Negative peripheral blood 99 1 862 194.0 Other Negative
GSM299888 training set None Negative No CNS disease Negative Male Negative Negative 3 90 Negative bone marrow 97 1 6674 3.8 Hispanic or Latino Negative
GSM299889 training set None Negative No CNS disease Negative Male Negative Negative 3 95 Negative bone marrow 70 1 6323 15.4 White Negative
GSM299890 training set Unknown Negative No CNS disease Negative Male Negative Negative 4 90 Negative bone marrow 98 1 6219 16.5 White Negative
GSM29989 training set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Positive 4 95 Negative bone marrow 65 1 2509 1.7 White Negative
GSM299892 training set None Unknown No CNS disease Negative Female Negative Negative 4 95 Positive peripheral blood 100 1 1531 196.1 Hispanic or Latino Negative
GSM299893 test set Unknown Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 1 85 Negative peripheral blood 100 1 5516 202.4 Hispanic or Latino Negative
GSM299894 training set None Negative No CNS disease Negative Male Negative Negative 1 90 Negative bone marrow 82 1 5513 2.5 White Negative
GSM299895 training set Unknown Negative No CNS disease Negative Male Negative Negative 2 95 Negative bone marrow 62 1 5842 27.4 White Negative
GSM299896 training set Downs Negative No CNS disease Negative Male Negative Negative 3 75 Positive peripheral blood 98 1 6496 9.1 White Negative
GSM299897 training set None Negative No CNS disease Positive Male Negative Negative 3 95 Negative peripheral blood 99 1 6511 515.0 White Negative
GSM299898 training set None Negative No CNS disease Negative Male Negative Negative 4 95 Positive bone marrow 97 1 1361 117.2 Hispanic or Latino Negative
GSM299899 training set None Unknown No CNS disease Negative Female Negative Negative 1 95 Negative bone marrow 74 1 835 115.0 White Negative
GSM299900 training set None Negative No CNS disease Positive Male Negative Negative 2 95 Negative peripheral blood 99 1 4774 246.4 Hispanic or Latino Negative
GSM29990 training set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Female Negative Negative 2 95 Negative bone marrow 95 1 3311 489.0 White Negative
GSM299902 training set None Negative No CNS disease Negative Male Negative Negative 3 80 Negative peripheral blood 100 1 6331 32.6 White Negative
GSM299903 training set None Unknown No CNS disease Positive Female Negative Negative 3 95 Negative bone marrow 92 1 398 135.0 White Negative
GSM299904 test set None Negative No CNS disease Negative Male Negative Negative 3 95 Positive bone marrow 96 1 5631 67.2 White Negative
GSM299905 test set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 1 95 Negative bone marrow 96 1 944 12.1 White Negative
GSM299906 training set None Negative No CNS disease Negative Male Negative Negative 1 90 Positive bone marrow 90 1 4940 8.0 White Negative
GSM299907 training set Downs Negative No CNS disease Negative Female Negative Negative 2 95 Negative bone marrow 96 1 5721 88.9 White Negative
GSM299908 training set Unknown Negative No CNS disease Negative Male Negative Negative 3 95 Negative peripheral blood 98 1 6114 80.9 White Negative
GSM299909 training set None Negative No CNS disease Negative Male Negative Negative 4 95 Negative bone marrow 97 1 5086 36.2 White Negative
GSM299910 test set None Negative No CNS disease Negative Male Negative Negative 4 95 Negative bone marrow 90 1 5359 80.8 White Negative
GSM2999 training set None Negative No CNS disease Negative Male Negative Negative 2 90 Negative bone marrow 95 1 1167 156.0 White Negative
GSM299912 training set Unknown Negative No CNS disease Negative Female Negative Negative 2 95 Negative peripheral blood 82 1 4090 289.3 White Negative
GSM299913 test set None Negative No CNS disease Positive Male Negative Negative 3 95 Negative peripheral blood 90 1 792 237.0 White Negative
GSM299914 training set None Negative No CNS disease Negative Male Negative Negative 4 95 Negative bone marrow 99 1 6733 81.4 White Negative
GSM299915 training set Unknown Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 5 95 Negative bone marrow 98 2 2875 351.3 Asian Negative
GSM299916 training set Other Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Positive 5 80 Negative peripheral blood 99 2 449 59.9 Hispanic or Latino Negative
GSM299917 training set Unknown Negative No CNS disease Negative Male Negative Negative 6 95 Negative bone marrow 100 4 904 137.8 White Negative
GSM299918 test set None Negative No CNS disease Negative Male Negative Negative 6 90 Negative bone marrow 98 2 1426 138.4 White Negative
GSM299919 training set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 6 95 Negative peripheral blood 98 2 4469 478.0 Hispanic or Latino Negative
GSM299920 training set None Negative No CNS disease Negative Male Negative Negative 7 95 Negative bone marrow 88 2 6266 34.9 Hispanic or Latino Negative
GSM29992 training set None Negative No CNS disease Negative Male Negative Negative 8 70 Negative bone marrow 100 2 6306 22.8 White Negative
GSM299922 training set None Unknown No CNS disease Negative Female Negative Negative 8 90 Negative peripheral blood 100 2 727 109.5 White Negative
GSM299923 training set None Negative No CNS disease Negative Male Negative Negative 5 95 Negative bone marrow 99 2 5867 21.1 Hispanic or Latino Negative
GSM299924 training set None Unknown No CNS disease Negative Female Negative Negative 5 90 Negative bone marrow 95 2 6733 102.0 Asian Negative
GSM299925 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 6 90 Negative peripheral blood 98 4 5495 96.2 White Negative
GSM299926 training set None Negative No CNS disease Negative Male Negative Negative 6 95 Negative bone marrow 99 2 6063 2.3 unknown Negative
GSM299927 test set None Unknown No CNS disease Negative Female Negative Negative 6 95 Negative bone marrow 87 2 5922 27.0 Hispanic or Latino Negative
GSM299928 training set Downs Unknown No CNS disease Negative Female Negative Negative 7 90 Negative peripheral blood 99 2 6922 68.9 White Negative
GSM299929 training set None Unknown No CNS disease Negative Female Negative Negative 8 95 Negative bone marrow 100 2 531 119.0 White Negative
GSM299930 test set Unknown Unknown No CNS disease Negative Female Negative Negative 5 95 Negative bone marrow 97 2 4106 210.0 White Negative
GSM29993 training set None Negative No CNS disease Negative Male Negative Negative 5 95 Negative bone marrow 91 2 2027 199.0 Hispanic or Latino Negative
GSM299932 training set Unknown Unknown No CNS disease Negative Female Negative Negative 6 90 Positive peripheral blood 96 2 1191 175.5 Asian Negative
GSM299933 test set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 7 95 Negative peripheral blood 94 6 5310 92.7 Hispanic or Latino Negative
GSM299934 training set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 7 95 Negative peripheral blood 83 2 5163 270.0 White Negative
GSM299935 test set None Unknown No CNS disease Negative Female Negative Negative 7 95 Positive bone marrow 66 2 977 115.1 White Negative
GSM299936 training set Unknown Negative No CNS disease Negative Male Negative Negative 8 95 Negative bone marrow 89 2 4807 12.7 White Negative
GSM299937 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 5 95 Negative peripheral blood 99 2 5564 112.0 White Negative
GSM299938 test set Unknown Negative No CNS disease Negative Male Negative Negative 5 95 Negative bone marrow 60 2 4305 40.0 White Negative
GSM299939 training set Unknown Unknown No CNS disease Negative Female Negative Negative 6 95 Negative bone marrow 94 6 4717 62.3 White Negative
GSM299940 test set None Negative No CNS disease Negative Male Negative Negative 7 95 Negative bone marrow 99 4 4657 33.1 Hispanic or Latino Negative
GSM29994 training set None Unknown No CNS disease Negative Female Negative Positive 7 90 Negative bone marrow 79 2 1429 192.0 White Negative
GSM299942 training set None Negative No CNS disease Negative Female Negative Negative 8 65 Negative peripheral blood 98 4 6413 16.6 Hispanic or Latino Negative
GSM299943 training set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 8 95 Negative peripheral blood 92 2 2133 17.5 White Negative
GSM299944 test set Unknown Unknown No CNS disease Positive Female Negative Negative 8 70 Negative peripheral blood 69 2 434 88.5 Hispanic or Latino Negative
GSM299945 training set Unknown Negative No CNS disease Negative Male Negative Negative 5 90 Negative bone marrow 87 2 4935 24.5 Asian Negative
GSM299946 training set None Negative No CNS disease Negative Female Negative Negative 5 85 Negative peripheral blood 100 2 6984 30.4 White Negative
GSM299947 test set None Unknown No CNS disease Negative Female Negative Negative 5 90 Negative bone marrow 65 2 1068 190.0 White Negative
GSM299948 test set None Negative No CNS disease Negative Male Negative Negative 6 95 Negative bone marrow 99 4 5877 66.9 Hispanic or Latino Negative
GSM299949 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Male Negative Negative 7 95 Negative bone marrow 87 6 5127 555.0 White Negative
GSM299950 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Male Negative Negative 7 90 Negative bone marrow 95 4 410 51.3 White Negative
GSM29995 training set Unknown Negative No CNS disease Negative Male Negative Negative 7 95 Negative bone marrow 97 2 5408 1.2 White Negative
GSM299952 test set Unknown Negative No CNS disease Negative Male Negative Negative 8 95 Negative bone marrow 96 2 2876 142.4 Black or African American Negative
GSM299953 training set Unknown Negative No CNS disease Negative Male Negative Negative 8 95 Negative bone marrow 87 2 697 110.9 White Negative
GSM299954 test set Downs Unknown No CNS disease Negative Female Negative Negative 5 90 Negative peripheral blood 95 2 2223 202.0 Hispanic or Latino Negative
GSM299955 test set None Unknown No CNS disease Positive Female Negative Negative 5 95 Negative peripheral blood 97 2 7028 259.8 White Negative
GSM299956 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 5 -1 Negative bone marrow 26 2 5177 166.5 White Unknown
GSM299957 training set None Unknown No CNS disease Positive Female Negative Negative 6 90 Negative peripheral blood 91 2 1038 114.0 Hispanic or Latino Negative
GSM299958 test set Downs Unknown No CNS disease Negative Female Negative Negative 6 95 Negative peripheral blood 100 2 5008 321.2 Hispanic or Latino Negative
GSM299959 training set None Unknown No CNS disease Negative Female Negative Negative 7 95 Negative bone marrow 71 2 5925 19.5 Hispanic or Latino Negative
GSM299960 training set None Negative No CNS disease Negative Male Negative Negative 7 95 Negative peripheral blood 93 2 1258 145.0 Hispanic or Latino Negative
GSM29996 test set None Unknown No CNS disease Negative Female Negative Negative 8 90 Positive bone marrow 85 2 1956 148.2 Hispanic or Latino Negative
GSM299962 training set None Unknown No CNS disease Positive Female Negative Negative 6 90 Negative peripheral blood 97 4 4560 108.0 White Negative
GSM299963 training set None Negative No CNS disease Positive Male Negative Negative 7 90 Negative peripheral blood 84 2 966 37.3 White Negative
GSM299964 test set None Negative No CNS disease Negative Male Negative Unknown 7 95 Negative bone marrow 100 2 4585 12.0 White Negative
GSM299965 training set Unknown Unknown No CNS disease Negative Female Negative Negative 5 90 Negative bone marrow 98 2 4863 65.8 White Negative
GSM299966 training set None Negative No CNS disease Negative Male Negative Negative 6 95 Negative peripheral blood 100 2 369 325.0 White Negative
GSM299967 test set None Negative No CNS disease Negative Male Negative Negative 7 -1 Negative bone marrow 20 2 5853 2.3 White Negative
GSM299968 training set None Negative No CNS disease Negative Male Negative Negative 8 80 Negative bone marrow 99 2 6335 13.3 White Negative
GSM299969 test set None Negative No CNS disease Negative Male Negative Negative 8 95 Negative peripheral blood 97 2 881 106.0 American Indian or Alaska native Negative
GSM299970 training set None Unknown No CNS disease Negative Female Negative Negative 9 95 Negative peripheral blood 100 3 2786 105.7 White Negative
GSM29997 training set None Negative No CNS disease Negative Male Negative Negative 10 80 Negative peripheral blood 94 3 6306 16.7 White Negative
GSM299972 test set None Negative No CNS disease Negative Male Negative Negative 10 90 Negative bone marrow 98 3 2519 112.0 White Negative
GSM299973 training set None Negative No CNS disease Negative Male Negative Negative 11 95 Negative bone marrow 66 3 6142 18.5 Hispanic or Latino Negative
GSM299974 test set None Negative No CNS disease Negative Male Negative Negative 11 80 Negative bone marrow 96 3 5343 30.2 Black or African American Negative
GSM299975 test set None Negative No CNS disease Positive Male Negative Negative 11 90 Negative bone marrow 96 3 852 139.0 White Negative
GSM299976 training set None Negative No CNS disease Positive Male Negative Negative 12 95 Negative bone marrow 94 3 462 17.3 Hispanic or Latino Negative
GSM299977 training set Unknown Unknown No CNS disease Negative Female Negative Negative 12 90 Positive peripheral blood 75 3 5797 39.6 Black or African American Negative
GSM299978 training set None Negative No CNS disease Negative Male Negative Negative 9 95 Negative peripheral blood 97 3 4253 236.4 Hispanic or Latino Negative
GSM299979 training set None Unknown No CNS disease Negative Female Negative Negative 9 75 Negative peripheral blood 99 3 705 137.2 Hispanic or Latino Negative
GSM299980 training set Unknown Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 10 70 Negative peripheral blood 99 3 7478 28.0 White Negative
GSM29998 training set Unknown Negative No CNS disease Negative Male Negative Negative 10 90 Negative peripheral blood 100 3 2191 272.0 White Negative
GSM299982 training set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 11 90 Negative bone marrow 98 3 1275 214.0 Hispanic or Latino Negative
GSM299983 test set None Negative No CNS disease Negative Male Negative Negative 11 95 Negative bone marrow 96 3 5184 58.0 White Negative
GSM299984 training set None Negative No CNS disease Negative Male Negative Negative 11 -1 Negative bone marrow 59 3 5542 7.9 Other Negative
GSM299985 test set None Negative No CNS disease Negative Male Negative Negative 12 95 Negative bone marrow 64 3 5242 3.4 White Negative
GSM299986 training set Unknown Unknown No CNS disease Negative Female Negative Negative 12 75 Negative peripheral blood 99 3 1313 69.4 White Negative
GSM299987 training set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 9 95 Negative bone marrow 94 3 1751 238.0 White Negative
GSM299988 training set None Unknown No CNS disease Negative Female Negative Negative 9 90 Negative bone marrow 98 3 4329 179.0 White Negative
GSM299989 training set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 9 90 Negative bone marrow 86 3 976 7.7 White Positive
GSM299990 test set None Negative No CNS disease Negative Female Negative Negative 10 95 Positive bone marrow 91 3 5300 98.2 Hispanic or Latino Negative
GSM29999 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 11 90 Negative bone marrow 81 3 4307 44.9 Hispanic or Latino Negative
GSM299992 training set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 12 60 Negative peripheral blood 98 3 4324 35.7 White Negative
GSM299993 test set Unknown Unknown No CNS disease Negative Female Negative Negative 9 95 Positive bone marrow 97 3 1033 118.1 White Negative
GSM299994 test set None Negative No CNS disease Negative Male Negative Negative 9 -1 Negative bone marrow 31 3 6052 6.4 Hispanic or Latino Negative
GSM299995 training set Unknown Negative No CNS disease Negative Male Unknown Unknown 10 95 Negative bone marrow 85 3 4157 77.6 White Negative
GSM299996 training set None Unknown No CNS disease Negative Male Negative Negative 11 90 Positive bone marrow 64 3 5025 73.1 Asian Negative
GSM299997 training set None Negative No CNS disease Negative Male Negative Negative 12 95 Negative bone marrow 99 3 6263 1.0 White Negative
GSM299998 training set None Negative No CNS disease Positive Male Negative Negative 9 90 Negative bone marrow 96 3 5664 22.0 White Negative
GSM299999 test set None Negative No CNS disease Negative Male Negative Negative 9 95 Negative bone marrow 95 3 4776 1.3 Other Negative
GSM300000 training set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 10 95 Negative peripheral blood 99 3 2192 209.6 White Negative
GSM30000 training set None Negative No CNS disease Negative Male Negative Negative 11 95 Negative bone marrow 94 3 5954 15.5 Black or African American Negative
GSM300002 training set None Negative No CNS disease Negative Male Negative Negative 11 95 Negative bone marrow 67 3 2038 193.0 White Negative
GSM300003 training set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 12 95 Negative bone marrow 96 3 6032 59.2 White Positive
GSM300004 training set Unknown Positive < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 12 85 Negative peripheral blood 98 3 655 9.8 White Negative
GSM300005 training set None Negative No CNS disease Negative Male Negative Negative 12 90 Negative bone marrow 94 3 4759 2.4 White Negative
GSM300006 test set Unknown Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 9 95 Negative bone marrow 97 3 2769 3.0 Hispanic or Latino Negative
GSM300007 training set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 9 40 Negative peripheral blood 94 3 4972 6.3 American Indian or Alaska native Negative
GSM300008 test set Unknown Negative No CNS disease Negative Male Negative Negative 9 95 Negative bone marrow 98 3 4815 31.4 Black or African American Negative
GSM300009 test set None Negative No CNS disease Negative Male Negative Negative 10 95 Negative peripheral blood 98 3 6315 245.0 White Negative
GSM300010 training set Downs Negative No CNS disease Negative Male Negative Negative 10 95 Negative bone marrow 95 3 4276 24.4 White Negative
GSM3000 training set None Negative No CNS disease Negative Male Negative Negative 10 95 Negative peripheral blood 99 3 5759 33.9 White Negative
GSM300012 test set None Negative No CNS disease Negative Male Negative Negative 11 -1 Negative bone marrow 44 3 6487 7.6 White Negative
GSM300013 test set None Negative No CNS disease Negative Male Negative Negative 11 95 Positive peripheral blood 99 3 1771 152.7 Black or African American Negative
GSM300014 training set None Negative No CNS disease Negative Male Negative Negative 12 95 Negative bone marrow 89 3 515 124.0 White Negative
GSM300015 training set None Unknown No CNS disease Negative Female Negative Negative 12 95 Negative bone marrow 96 3 6090 24.8 White Negative
GSM300016 training set Unknown Negative No CNS disease Negative Male Negative Negative 9 95 Negative bone marrow 99 3 6633 1.9 White Negative
GSM300017 test set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 9 95 Negative bone marrow 97 3 5194 96.5 Hispanic or Latino Negative
GSM300018 training set None Negative No CNS disease Negative Male Negative Negative 10 95 Negative bone marrow 96 3 6468 7.0 Hispanic or Latino Negative
GSM300019 test set None Negative No CNS disease Negative Male Negative Negative 11 90 Negative bone marrow 92 3 6062 17.0 White Negative
GSM300020 test set Unknown Unknown No CNS disease Positive Female Negative Negative 11 90 Negative bone marrow 95 3 777 6.8 Other Negative
GSM30002 test set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 12 85 Positive bone marrow 100 3 5889 49.6 White Negative
GSM300022 test set None Negative No CNS disease Negative Male Negative Negative 12 95 Negative peripheral blood 95 3 893 455.4 White Negative
GSM300023 training set None Negative No CNS disease Negative Male Negative Negative 9 95 Negative bone marrow 98 3 4955 31.5 Hispanic or Latino Negative
GSM300024 training set None Negative No CNS disease Negative Male Negative Negative 10 95 Negative peripheral blood 99 3 5081 307.0 Hispanic or Latino Negative
GSM300025 training set Downs Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 10 90 Negative bone marrow 98 3 4665 95.2 Hispanic or Latino Negative
GSM300026 training set None Negative No CNS disease Negative Male Negative Negative 11 95 Negative peripheral blood 97 3 988 958.8 Hispanic or Latino Negative
GSM300027 training set None Negative No CNS disease Negative Male Negative Negative 12 -1 Positive bone marrow 59 3 5890 9.4 White Negative
GSM300028 test set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 12 95 Negative bone marrow 96 3 6351 13.8 Black or African American Negative
GSM300029 test set Unknown Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 13 95 Negative bone marrow 86 4 1475 212.3 White Negative
GSM300030 training set Unknown Negative No CNS disease Negative Male Negative Negative 13 90 Negative bone marrow 99 4 6036 8.8 Hispanic or Latino Negative
GSM30003 training set None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 4 95 Negative bone marrow 96 1 5217 135.8 White Negative
GSM300032 training set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 4 95 Negative bone marrow 97 1 523 82.9 Black or African American Negative
GSM300033 training set Unknown Unknown No CNS disease Negative Female Negative Negative 11 95 Positive peripheral blood 99 3 1011 302.1 White Negative
GSM300034 test set None Negative No CNS disease Negative Male Negative Negative 11 90 Negative bone marrow 98 3 6107 18.3 Native Hawaiian or other Pacific Islander Negative
GSM300035 training set None Negative No CNS disease Negative Male Negative Negative 13 95 Negative peripheral blood 95 4 768 138.8 White Negative
GSM300036 training set None Unknown No CNS disease Negative Female Negative Negative 13 90 Positive peripheral blood 84 4 5670 37.2 White Negative
GSM300037 training set None Negative No CNS disease Negative Male Negative Negative 11 95 Negative peripheral blood 99 6 6666 114.6 Hispanic or Latino Negative
GSM300038 training set None Unknown No CNS disease Negative Female Negative Negative 13 85 Positive bone marrow 96 4 3901 136.6 Hispanic or Latino Negative
GSM300039 training set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female Negative Negative 14 -1 Negative peripheral blood 51 7 728 138.4 White Negative
GSM300040 test set None Unknown No CNS disease Negative Female Negative Negative 14 95 Negative bone marrow 79 7 1058 141.0 White Negative
GSM30004 test set Unknown Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 14 95 Negative bone marrow 76 7 1323 30.6 Hispanic or Latino Positive
GSM300042 training set None Negative No CNS disease Negative Male Negative Negative 14 95 Negative bone marrow 84 7 650 102.5 Hispanic or Latino Negative
GSM300043 test set None Negative No CNS disease Negative Male Negative Negative 15 85 Negative bone marrow 99 8 5821 1.9 White Negative
GSM300044 training set Unknown Negative No CNS disease Negative Male Negative Negative 15 40 Negative peripheral blood 100 8 6202 2.3 White Negative
GSM300045 training set None Negative No CNS disease Negative Female Negative Negative 15 90 Negative bone marrow 98 8 6119 2.3 American Indian or Alaska native Negative
GSM300046 training set None Positive No CNS disease Negative Male Negative Negative 15 60 Negative peripheral blood 99 8 4571 6.9 White Negative
GSM300047 training set None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male Negative Negative 15 60 Negative peripheral blood 93 8 1896 4.1 Hispanic or Latino Positive
GSM300048 training set None Negative No CNS disease Negative Female Negative Negative 15 75 Negative bone marrow 97 8 7461 3.8 White Negative
GSM300049 test set None Negative No CNS disease Negative Male Negative Negative 15 65 Negative bone marrow 96 8 6634 11.1 White Negative
GSM300050 training set None Negative No CNS disease Negative Male Negative Negative 15 80 Negative peripheral blood 83 8 5097 6.3 White Negative
GSM30005 test set None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 15 95 Negative bone marrow 96 8 5532 5.5 Hispanic or Latino Negative
GSM300052 test set None Positive < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male Negative Negative 15 -1 Negative peripheral blood 47 8 1914 45.1 Black or African American Positive
GSM300053 training set None Negative No CNS disease Negative Male Negative Negative 15 90 Positive peripheral blood 72 8 4434 42.1 White Negative
GSM300054 test set None Negative No CNS disease Negative Male Negative Negative 15 50 Positive peripheral blood 93 8 4782 4.4 Asian Negative
GSM300055 test set None Negative No CNS disease Negative Male Negative Negative 15 90 Negative bone marrow 84 8 5232 1.1 White Negative
GSM300056 test set None Negative No CNS disease Negative Male Negative Negative 15 80 Positive peripheral blood 83 8 6500 17.8 Black or African American Negative
GSM300057 training set None Unknown No CNS disease Positive Male Negative Negative 16 -1 Negative bone marrow 50 9 585 7.5 White Negative
GSM300058 test set None Negative No CNS disease Negative Male Negative Negative 16 95 Negative bone marrow 98 9 6539 2.6 Black or African American Negative
GSM300059 test set None Negative No CNS disease Negative Female Negative Negative 16 85 Negative bone marrow 100 9 5991 5.2 White Negative
GSM300060 training set None Negative No CNS disease Negative Male Negative Negative 16 70 Negative peripheral blood 93 9 6479 31.9 White Negative
GSM30006 training set None Negative No CNS disease Negative Male Negative Negative 16 90 Negative bone marrow 98 9 5183 23.0 Black or African American Negative
GSM300062 training set None Negative No CNS disease Negative Male Negative Negative 16 -1 Negative peripheral blood 46 9 713 110.3 White Negative
GSM300063 test set None Unknown No CNS disease Positive Male Negative Negative 16 90 Negative bone marrow 82 9 1704 85.1 White Negative
GSM300064 test set Unknown Negative No CNS disease Negative Male Negative Negative 16 95 Negative bone marrow 99 9 5594 2.8 White Negative
GSM300065 training set Unknown Negative No CNS disease Negative Male Negative Negative 16 95 Negative bone marrow 88 9 5857 13.3 White Negative
GSM300066 test set None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female Negative Negative 16 95 Positive bone marrow 81 9 4017 3.5 Hispanic or Latino Negative
GSM300067 training set Unknown Negative No CNS disease Negative Male Negative Negative 16 95 Negative bone marrow 85 9 4918 5.5 White Negative
GSM300068 training set Unknown Negative No CNS disease Negative Male Negative Negative 18 90 Negative bone marrow 66 10 5349 147.6 Hispanic or Latino Negative

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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