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Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample RACE CONGENITAL ABNORMALITY TRAINING OR TEST SET CNS STATUS TESTICULAR INVOLVEMENT GENDER TISSUE TYPE BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) MLL SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE AMPLIFICATION SET AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER TRISOMY 4 AND 10
GSM299862 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female peripheral blood Negative Negative 1 90 Negative Positive 100 1 3953 175.0 Negative
GSM299863 Black or African American None training set No CNS disease Negative Male peripheral blood Negative Negative 1 90 Negative Negative 100 1 1976 142.0 Negative
GSM299864 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 2 70 Negative Negative 99 1 5250 220.7 Negative
GSM299865 White None test set No CNS disease Negative Male peripheral blood Negative Negative 2 95 Negative Negative 88 1 577 129.0 Negative
GSM299866 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 3 95 Negative Negative 95 1 4609 26.0 Negative
GSM299867 White None training set No CNS disease Negative Male bone marrow Negative Negative 3 80 Negative Negative 68 1 5289 14.7 Negative
GSM299868 Asian None training set No CNS disease Negative Male bone marrow Negative Negative 4 -1 Negative Negative 71 1 3987 68.6 Negative
GSM299869 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male bone marrow Negative Negative 4 90 Negative Negative 98 1 4856 21.4 Negative
GSM299870 White None test set No CNS disease Negative Male bone marrow Negative Negative 4 1 Negative Negative 99 1 4678 2.4 Negative
GSM29987 White Unknown training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male bone marrow Negative Negative 1 75 Negative Negative 68 1 796 21.0 Negative
GSM299872 White None training set No CNS disease Unknown Female peripheral blood Negative Negative 1 85 Negative Positive 100 1 4071 125.8 Negative
GSM299873 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 2 95 Negative Negative 99 1 5223 29.9 Negative
GSM299874 Hispanic or Latino Unknown training set No CNS disease Unknown Female peripheral blood Negative Negative 3 95 Negative Negative 99 1 5118 217.2 Negative
GSM299875 unknown None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male peripheral blood Negative Negative 3 90 Negative Negative 97 1 5219 180.0 Negative
GSM299876 White Downs training set No CNS disease Unknown Female bone marrow Negative Negative 4 95 Negative Negative 98 1 1429 118.0 Negative
GSM299877 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female peripheral blood Negative Negative 1 95 Negative Negative 97 1 3179 314.8 Negative
GSM299878 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 1 -1 Negative Negative 58 1 1450 5.2 Negative
GSM299879 White None training set No CNS disease Negative Male bone marrow Negative Negative 1 95 Negative Negative 91 1 5278 113.5 Negative
GSM299880 White None training set No CNS disease Negative Male bone marrow Negative Negative 2 85 Positive Negative 98 1 5330 5.8 Negative
GSM29988 Hispanic or Latino Unknown test set No CNS disease Unknown Female peripheral blood Negative Negative 4 90 Negative Negative 99 1 4861 592.6 Negative
GSM299882 White None training set No CNS disease Unknown Female peripheral blood Negative Negative 1 95 Negative Negative 80 1 428 248.0 Negative
GSM299883 White None training set No CNS disease Negative Male bone marrow Negative Negative 1 95 Negative Negative 97 1 4722 4.4 Negative
GSM299884 White Unknown test set No CNS disease Negative Male bone marrow Negative Negative 2 95 Negative Negative 99 1 3587 72.2 Negative
GSM299885 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female peripheral blood Negative Negative 2 90 Negative Positive 98 1 5431 133.0 Negative
GSM299886 Hispanic or Latino None training set No CNS disease Positive Male bone marrow Negative Negative 2 70 Negative Negative 98 1 3444 5.0 Negative
GSM299887 Other None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male peripheral blood Negative Negative 3 90 Negative Negative 99 1 862 194.0 Negative
GSM299888 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 3 90 Negative Negative 97 1 6674 3.8 Negative
GSM299889 White None training set No CNS disease Negative Male bone marrow Negative Negative 3 95 Negative Negative 70 1 6323 15.4 Negative
GSM299890 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 4 90 Negative Negative 98 1 6219 16.5 Negative
GSM29989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male bone marrow Negative Positive 4 95 Negative Negative 65 1 2509 1.7 Negative
GSM299892 Hispanic or Latino None training set No CNS disease Unknown Female peripheral blood Negative Negative 4 95 Positive Negative 100 1 1531 196.1 Negative
GSM299893 Hispanic or Latino Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Male peripheral blood Negative Negative 1 85 Negative Negative 100 1 5516 202.4 Negative
GSM299894 White None training set No CNS disease Negative Male bone marrow Negative Negative 1 90 Negative Negative 82 1 5513 2.5 Negative
GSM299895 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 2 95 Negative Negative 62 1 5842 27.4 Negative
GSM299896 White Downs training set No CNS disease Negative Male peripheral blood Negative Negative 3 75 Positive Negative 98 1 6496 9.1 Negative
GSM299897 White None training set No CNS disease Negative Male peripheral blood Negative Negative 3 95 Negative Positive 99 1 6511 515.0 Negative
GSM299898 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 4 95 Positive Negative 97 1 1361 117.2 Negative
GSM299899 White None training set No CNS disease Unknown Female bone marrow Negative Negative 1 95 Negative Negative 74 1 835 115.0 Negative
GSM299900 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 2 95 Negative Positive 99 1 4774 246.4 Negative
GSM29990 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female bone marrow Negative Negative 2 95 Negative Positive 95 1 3311 489.0 Negative
GSM299902 White None training set No CNS disease Negative Male peripheral blood Negative Negative 3 80 Negative Negative 100 1 6331 32.6 Negative
GSM299903 White None training set No CNS disease Unknown Female bone marrow Negative Negative 3 95 Negative Positive 92 1 398 135.0 Negative
GSM299904 White None test set No CNS disease Negative Male bone marrow Negative Negative 3 95 Positive Negative 96 1 5631 67.2 Negative
GSM299905 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 1 95 Negative Negative 96 1 944 12.1 Negative
GSM299906 White None training set No CNS disease Negative Male bone marrow Negative Negative 1 90 Positive Negative 90 1 4940 8.0 Negative
GSM299907 White Downs training set No CNS disease Negative Female bone marrow Negative Negative 2 95 Negative Negative 96 1 5721 88.9 Negative
GSM299908 White Unknown training set No CNS disease Negative Male peripheral blood Negative Negative 3 95 Negative Negative 98 1 6114 80.9 Negative
GSM299909 White None training set No CNS disease Negative Male bone marrow Negative Negative 4 95 Negative Negative 97 1 5086 36.2 Negative
GSM299910 White None test set No CNS disease Negative Male bone marrow Negative Negative 4 95 Negative Negative 90 1 5359 80.8 Negative
GSM2999 White None training set No CNS disease Negative Male bone marrow Negative Negative 2 90 Negative Negative 95 1 1167 156.0 Negative
GSM299912 White Unknown training set No CNS disease Negative Female peripheral blood Negative Negative 2 95 Negative Negative 82 1 4090 289.3 Negative
GSM299913 White None test set No CNS disease Negative Male peripheral blood Negative Negative 3 95 Negative Positive 90 1 792 237.0 Negative
GSM299914 White None training set No CNS disease Negative Male bone marrow Negative Negative 4 95 Negative Negative 99 1 6733 81.4 Negative
GSM299915 Asian Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 5 95 Negative Negative 98 2 2875 351.3 Negative
GSM299916 Hispanic or Latino Other training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male peripheral blood Negative Positive 5 80 Negative Negative 99 2 449 59.9 Negative
GSM299917 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 6 95 Negative Negative 100 4 904 137.8 Negative
GSM299918 White None test set No CNS disease Negative Male bone marrow Negative Negative 6 90 Negative Negative 98 2 1426 138.4 Negative
GSM299919 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female peripheral blood Negative Negative 6 95 Negative Negative 98 2 4469 478.0 Negative
GSM299920 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 7 95 Negative Negative 88 2 6266 34.9 Negative
GSM29992 White None training set No CNS disease Negative Male bone marrow Negative Negative 8 70 Negative Negative 100 2 6306 22.8 Negative
GSM299922 White None training set No CNS disease Unknown Female peripheral blood Negative Negative 8 90 Negative Negative 100 2 727 109.5 Negative
GSM299923 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 5 95 Negative Negative 99 2 5867 21.1 Negative
GSM299924 Asian None training set No CNS disease Unknown Female bone marrow Negative Negative 5 90 Negative Negative 95 2 6733 102.0 Negative
GSM299925 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male peripheral blood Negative Negative 6 90 Negative Negative 98 4 5495 96.2 Negative
GSM299926 unknown None training set No CNS disease Negative Male bone marrow Negative Negative 6 95 Negative Negative 99 2 6063 2.3 Negative
GSM299927 Hispanic or Latino None test set No CNS disease Unknown Female bone marrow Negative Negative 6 95 Negative Negative 87 2 5922 27.0 Negative
GSM299928 White Downs training set No CNS disease Unknown Female peripheral blood Negative Negative 7 90 Negative Negative 99 2 6922 68.9 Negative
GSM299929 White None training set No CNS disease Unknown Female bone marrow Negative Negative 8 95 Negative Negative 100 2 531 119.0 Negative
GSM299930 White Unknown test set No CNS disease Unknown Female bone marrow Negative Negative 5 95 Negative Negative 97 2 4106 210.0 Negative
GSM29993 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 5 95 Negative Negative 91 2 2027 199.0 Negative
GSM299932 Asian Unknown training set No CNS disease Unknown Female peripheral blood Negative Negative 6 90 Positive Negative 96 2 1191 175.5 Negative
GSM299933 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female peripheral blood Negative Negative 7 95 Negative Negative 94 6 5310 92.7 Negative
GSM299934 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male peripheral blood Negative Negative 7 95 Negative Negative 83 2 5163 270.0 Negative
GSM299935 White None test set No CNS disease Unknown Female bone marrow Negative Negative 7 95 Positive Negative 66 2 977 115.1 Negative
GSM299936 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 8 95 Negative Negative 89 2 4807 12.7 Negative
GSM299937 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male peripheral blood Negative Negative 5 95 Negative Negative 99 2 5564 112.0 Negative
GSM299938 White Unknown test set No CNS disease Negative Male bone marrow Negative Negative 5 95 Negative Negative 60 2 4305 40.0 Negative
GSM299939 White Unknown training set No CNS disease Unknown Female bone marrow Negative Negative 6 95 Negative Negative 94 6 4717 62.3 Negative
GSM299940 Hispanic or Latino None test set No CNS disease Negative Male bone marrow Negative Negative 7 95 Negative Negative 99 4 4657 33.1 Negative
GSM29994 White None training set No CNS disease Unknown Female bone marrow Negative Positive 7 90 Negative Negative 79 2 1429 192.0 Negative
GSM299942 Hispanic or Latino None training set No CNS disease Negative Female peripheral blood Negative Negative 8 65 Negative Negative 98 4 6413 16.6 Negative
GSM299943 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female peripheral blood Negative Negative 8 95 Negative Negative 92 2 2133 17.5 Negative
GSM299944 Hispanic or Latino Unknown test set No CNS disease Unknown Female peripheral blood Negative Negative 8 70 Negative Positive 69 2 434 88.5 Negative
GSM299945 Asian Unknown training set No CNS disease Negative Male bone marrow Negative Negative 5 90 Negative Negative 87 2 4935 24.5 Negative
GSM299946 White None training set No CNS disease Negative Female peripheral blood Negative Negative 5 85 Negative Negative 100 2 6984 30.4 Negative
GSM299947 White None test set No CNS disease Unknown Female bone marrow Negative Negative 5 90 Negative Negative 65 2 1068 190.0 Negative
GSM299948 Hispanic or Latino None test set No CNS disease Negative Male bone marrow Negative Negative 6 95 Negative Negative 99 4 5877 66.9 Negative
GSM299949 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 7 95 Negative Positive 87 6 5127 555.0 Negative
GSM299950 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 7 90 Negative Positive 95 4 410 51.3 Negative
GSM29995 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 7 95 Negative Negative 97 2 5408 1.2 Negative
GSM299952 Black or African American Unknown test set No CNS disease Negative Male bone marrow Negative Negative 8 95 Negative Negative 96 2 2876 142.4 Negative
GSM299953 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 8 95 Negative Negative 87 2 697 110.9 Negative
GSM299954 Hispanic or Latino Downs test set No CNS disease Unknown Female peripheral blood Negative Negative 5 90 Negative Negative 95 2 2223 202.0 Negative
GSM299955 White None test set No CNS disease Unknown Female peripheral blood Negative Negative 5 95 Negative Positive 97 2 7028 259.8 Negative
GSM299956 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 5 -1 Negative Negative 26 2 5177 166.5 Unknown
GSM299957 Hispanic or Latino None training set No CNS disease Unknown Female peripheral blood Negative Negative 6 90 Negative Positive 91 2 1038 114.0 Negative
GSM299958 Hispanic or Latino Downs test set No CNS disease Unknown Female peripheral blood Negative Negative 6 95 Negative Negative 100 2 5008 321.2 Negative
GSM299959 Hispanic or Latino None training set No CNS disease Unknown Female bone marrow Negative Negative 7 95 Negative Negative 71 2 5925 19.5 Negative
GSM299960 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 7 95 Negative Negative 93 2 1258 145.0 Negative
GSM29996 Hispanic or Latino None test set No CNS disease Unknown Female bone marrow Negative Negative 8 90 Positive Negative 85 2 1956 148.2 Negative
GSM299962 White None training set No CNS disease Unknown Female peripheral blood Negative Negative 6 90 Negative Positive 97 4 4560 108.0 Negative
GSM299963 White None training set No CNS disease Negative Male peripheral blood Negative Negative 7 90 Negative Positive 84 2 966 37.3 Negative
GSM299964 White None test set No CNS disease Negative Male bone marrow Negative Unknown 7 95 Negative Negative 100 2 4585 12.0 Negative
GSM299965 White Unknown training set No CNS disease Unknown Female bone marrow Negative Negative 5 90 Negative Negative 98 2 4863 65.8 Negative
GSM299966 White None training set No CNS disease Negative Male peripheral blood Negative Negative 6 95 Negative Negative 100 2 369 325.0 Negative
GSM299967 White None test set No CNS disease Negative Male bone marrow Negative Negative 7 -1 Negative Negative 20 2 5853 2.3 Negative
GSM299968 White None training set No CNS disease Negative Male bone marrow Negative Negative 8 80 Negative Negative 99 2 6335 13.3 Negative
GSM299969 American Indian or Alaska native None test set No CNS disease Negative Male peripheral blood Negative Negative 8 95 Negative Negative 97 2 881 106.0 Negative
GSM299970 White None training set No CNS disease Unknown Female peripheral blood Negative Negative 9 95 Negative Negative 100 3 2786 105.7 Negative
GSM29997 White None training set No CNS disease Negative Male peripheral blood Negative Negative 10 80 Negative Negative 94 3 6306 16.7 Negative
GSM299972 White None test set No CNS disease Negative Male bone marrow Negative Negative 10 90 Negative Negative 98 3 2519 112.0 Negative
GSM299973 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 11 95 Negative Negative 66 3 6142 18.5 Negative
GSM299974 Black or African American None test set No CNS disease Negative Male bone marrow Negative Negative 11 80 Negative Negative 96 3 5343 30.2 Negative
GSM299975 White None test set No CNS disease Negative Male bone marrow Negative Negative 11 90 Negative Positive 96 3 852 139.0 Negative
GSM299976 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 12 95 Negative Positive 94 3 462 17.3 Negative
GSM299977 Black or African American Unknown training set No CNS disease Unknown Female peripheral blood Negative Negative 12 90 Positive Negative 75 3 5797 39.6 Negative
GSM299978 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 9 95 Negative Negative 97 3 4253 236.4 Negative
GSM299979 Hispanic or Latino None training set No CNS disease Unknown Female peripheral blood Negative Negative 9 75 Negative Negative 99 3 705 137.2 Negative
GSM299980 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male peripheral blood Negative Negative 10 70 Negative Negative 99 3 7478 28.0 Negative
GSM29998 White Unknown training set No CNS disease Negative Male peripheral blood Negative Negative 10 90 Negative Negative 100 3 2191 272.0 Negative
GSM299982 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 11 90 Negative Negative 98 3 1275 214.0 Negative
GSM299983 White None test set No CNS disease Negative Male bone marrow Negative Negative 11 95 Negative Negative 96 3 5184 58.0 Negative
GSM299984 Other None training set No CNS disease Negative Male bone marrow Negative Negative 11 -1 Negative Negative 59 3 5542 7.9 Negative
GSM299985 White None test set No CNS disease Negative Male bone marrow Negative Negative 12 95 Negative Negative 64 3 5242 3.4 Negative
GSM299986 White Unknown training set No CNS disease Unknown Female peripheral blood Negative Negative 12 75 Negative Negative 99 3 1313 69.4 Negative
GSM299987 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 9 95 Negative Negative 94 3 1751 238.0 Negative
GSM299988 White None training set No CNS disease Unknown Female bone marrow Negative Negative 9 90 Negative Negative 98 3 4329 179.0 Negative
GSM299989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male bone marrow Negative Negative 9 90 Negative Negative 86 3 976 7.7 Positive
GSM299990 Hispanic or Latino None test set No CNS disease Negative Female bone marrow Negative Negative 10 95 Positive Negative 91 3 5300 98.2 Negative
GSM29999 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 11 90 Negative Negative 81 3 4307 44.9 Negative
GSM299992 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female peripheral blood Negative Negative 12 60 Negative Negative 98 3 4324 35.7 Negative
GSM299993 White Unknown test set No CNS disease Unknown Female bone marrow Negative Negative 9 95 Positive Negative 97 3 1033 118.1 Negative
GSM299994 Hispanic or Latino None test set No CNS disease Negative Male bone marrow Negative Negative 9 -1 Negative Negative 31 3 6052 6.4 Negative
GSM299995 White Unknown training set No CNS disease Negative Male bone marrow Unknown Unknown 10 95 Negative Negative 85 3 4157 77.6 Negative
GSM299996 Asian None training set No CNS disease Unknown Male bone marrow Negative Negative 11 90 Positive Negative 64 3 5025 73.1 Negative
GSM299997 White None training set No CNS disease Negative Male bone marrow Negative Negative 12 95 Negative Negative 99 3 6263 1.0 Negative
GSM299998 White None training set No CNS disease Negative Male bone marrow Negative Negative 9 90 Negative Positive 96 3 5664 22.0 Negative
GSM299999 Other None test set No CNS disease Negative Male bone marrow Negative Negative 9 95 Negative Negative 95 3 4776 1.3 Negative
GSM300000 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female peripheral blood Negative Negative 10 95 Negative Negative 99 3 2192 209.6 Negative
GSM30000 Black or African American None training set No CNS disease Negative Male bone marrow Negative Negative 11 95 Negative Negative 94 3 5954 15.5 Negative
GSM300002 White None training set No CNS disease Negative Male bone marrow Negative Negative 11 95 Negative Negative 67 3 2038 193.0 Negative
GSM300003 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 12 95 Negative Negative 96 3 6032 59.2 Positive
GSM300004 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Male peripheral blood Negative Negative 12 85 Negative Negative 98 3 655 9.8 Negative
GSM300005 White None training set No CNS disease Negative Male bone marrow Negative Negative 12 90 Negative Negative 94 3 4759 2.4 Negative
GSM300006 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 9 95 Negative Negative 97 3 2769 3.0 Negative
GSM300007 American Indian or Alaska native None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Male peripheral blood Negative Negative 9 40 Negative Negative 94 3 4972 6.3 Negative
GSM300008 Black or African American Unknown test set No CNS disease Negative Male bone marrow Negative Negative 9 95 Negative Negative 98 3 4815 31.4 Negative
GSM300009 White None test set No CNS disease Negative Male peripheral blood Negative Negative 10 95 Negative Negative 98 3 6315 245.0 Negative
GSM300010 White Downs training set No CNS disease Negative Male bone marrow Negative Negative 10 95 Negative Negative 95 3 4276 24.4 Negative
GSM3000 White None training set No CNS disease Negative Male peripheral blood Negative Negative 10 95 Negative Negative 99 3 5759 33.9 Negative
GSM300012 White None test set No CNS disease Negative Male bone marrow Negative Negative 11 -1 Negative Negative 44 3 6487 7.6 Negative
GSM300013 Black or African American None test set No CNS disease Negative Male peripheral blood Negative Negative 11 95 Positive Negative 99 3 1771 152.7 Negative
GSM300014 White None training set No CNS disease Negative Male bone marrow Negative Negative 12 95 Negative Negative 89 3 515 124.0 Negative
GSM300015 White None training set No CNS disease Unknown Female bone marrow Negative Negative 12 95 Negative Negative 96 3 6090 24.8 Negative
GSM300016 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 9 95 Negative Negative 99 3 6633 1.9 Negative
GSM300017 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male bone marrow Negative Negative 9 95 Negative Negative 97 3 5194 96.5 Negative
GSM300018 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 10 95 Negative Negative 96 3 6468 7.0 Negative
GSM300019 White None test set No CNS disease Negative Male bone marrow Negative Negative 11 90 Negative Negative 92 3 6062 17.0 Negative
GSM300020 Other Unknown test set No CNS disease Unknown Female bone marrow Negative Negative 11 90 Negative Positive 95 3 777 6.8 Negative
GSM30002 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female bone marrow Negative Negative 12 85 Positive Negative 100 3 5889 49.6 Negative
GSM300022 White None test set No CNS disease Negative Male peripheral blood Negative Negative 12 95 Negative Negative 95 3 893 455.4 Negative
GSM300023 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 9 95 Negative Negative 98 3 4955 31.5 Negative
GSM300024 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 10 95 Negative Negative 99 3 5081 307.0 Negative
GSM300025 Hispanic or Latino Downs training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female bone marrow Negative Negative 10 90 Negative Negative 98 3 4665 95.2 Negative
GSM300026 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 11 95 Negative Negative 97 3 988 958.8 Negative
GSM300027 White None training set No CNS disease Negative Male bone marrow Negative Negative 12 -1 Positive Negative 59 3 5890 9.4 Negative
GSM300028 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female bone marrow Negative Negative 12 95 Negative Negative 96 3 6351 13.8 Negative
GSM300029 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 13 95 Negative Negative 86 4 1475 212.3 Negative
GSM300030 Hispanic or Latino Unknown training set No CNS disease Negative Male bone marrow Negative Negative 13 90 Negative Negative 99 4 6036 8.8 Negative
GSM30003 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female bone marrow Negative Negative 4 95 Negative Negative 96 1 5217 135.8 Negative
GSM300032 Black or African American None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male bone marrow Negative Negative 4 95 Negative Negative 97 1 523 82.9 Negative
GSM300033 White Unknown training set No CNS disease Unknown Female peripheral blood Negative Negative 11 95 Positive Negative 99 3 1011 302.1 Negative
GSM300034 Native Hawaiian or other Pacific Islander None test set No CNS disease Negative Male bone marrow Negative Negative 11 90 Negative Negative 98 3 6107 18.3 Negative
GSM300035 White None training set No CNS disease Negative Male peripheral blood Negative Negative 13 95 Negative Negative 95 4 768 138.8 Negative
GSM300036 White None training set No CNS disease Unknown Female peripheral blood Negative Negative 13 90 Positive Negative 84 4 5670 37.2 Negative
GSM300037 Hispanic or Latino None training set No CNS disease Negative Male peripheral blood Negative Negative 11 95 Negative Negative 99 6 6666 114.6 Negative
GSM300038 Hispanic or Latino None training set No CNS disease Unknown Female bone marrow Negative Negative 13 85 Positive Negative 96 4 3901 136.6 Negative
GSM300039 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female peripheral blood Negative Negative 14 -1 Negative Negative 51 7 728 138.4 Negative
GSM300040 White None test set No CNS disease Unknown Female bone marrow Negative Negative 14 95 Negative Negative 79 7 1058 141.0 Negative
GSM30004 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 14 95 Negative Negative 76 7 1323 30.6 Positive
GSM300042 Hispanic or Latino None training set No CNS disease Negative Male bone marrow Negative Negative 14 95 Negative Negative 84 7 650 102.5 Negative
GSM300043 White None test set No CNS disease Negative Male bone marrow Negative Negative 15 85 Negative Negative 99 8 5821 1.9 Negative
GSM300044 White Unknown training set No CNS disease Negative Male peripheral blood Negative Negative 15 40 Negative Negative 100 8 6202 2.3 Negative
GSM300045 American Indian or Alaska native None training set No CNS disease Negative Female bone marrow Negative Negative 15 90 Negative Negative 98 8 6119 2.3 Negative
GSM300046 White None training set No CNS disease Positive Male peripheral blood Negative Negative 15 60 Negative Negative 99 8 4571 6.9 Negative
GSM300047 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male peripheral blood Negative Negative 15 60 Negative Negative 93 8 1896 4.1 Positive
GSM300048 White None training set No CNS disease Negative Female bone marrow Negative Negative 15 75 Negative Negative 97 8 7461 3.8 Negative
GSM300049 White None test set No CNS disease Negative Male bone marrow Negative Negative 15 65 Negative Negative 96 8 6634 11.1 Negative
GSM300050 White None training set No CNS disease Negative Male peripheral blood Negative Negative 15 80 Negative Negative 83 8 5097 6.3 Negative
GSM30005 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male bone marrow Negative Negative 15 95 Negative Negative 96 8 5532 5.5 Negative
GSM300052 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Male peripheral blood Negative Negative 15 -1 Negative Negative 47 8 1914 45.1 Positive
GSM300053 White None training set No CNS disease Negative Male peripheral blood Negative Negative 15 90 Positive Negative 72 8 4434 42.1 Negative
GSM300054 Asian None test set No CNS disease Negative Male peripheral blood Negative Negative 15 50 Positive Negative 93 8 4782 4.4 Negative
GSM300055 White None test set No CNS disease Negative Male bone marrow Negative Negative 15 90 Negative Negative 84 8 5232 1.1 Negative
GSM300056 Black or African American None test set No CNS disease Negative Male peripheral blood Negative Negative 15 80 Positive Negative 83 8 6500 17.8 Negative
GSM300057 White None training set No CNS disease Unknown Male bone marrow Negative Negative 16 -1 Negative Positive 50 9 585 7.5 Negative
GSM300058 Black or African American None test set No CNS disease Negative Male bone marrow Negative Negative 16 95 Negative Negative 98 9 6539 2.6 Negative
GSM300059 White None test set No CNS disease Negative Female bone marrow Negative Negative 16 85 Negative Negative 100 9 5991 5.2 Negative
GSM300060 White None training set No CNS disease Negative Male peripheral blood Negative Negative 16 70 Negative Negative 93 9 6479 31.9 Negative
GSM30006 Black or African American None training set No CNS disease Negative Male bone marrow Negative Negative 16 90 Negative Negative 98 9 5183 23.0 Negative
GSM300062 White None training set No CNS disease Negative Male peripheral blood Negative Negative 16 -1 Negative Negative 46 9 713 110.3 Negative
GSM300063 White None test set No CNS disease Unknown Male bone marrow Negative Negative 16 90 Negative Positive 82 9 1704 85.1 Negative
GSM300064 White Unknown test set No CNS disease Negative Male bone marrow Negative Negative 16 95 Negative Negative 99 9 5594 2.8 Negative
GSM300065 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 16 95 Negative Negative 88 9 5857 13.3 Negative
GSM300066 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female bone marrow Negative Negative 16 95 Positive Negative 81 9 4017 3.5 Negative
GSM300067 White Unknown training set No CNS disease Negative Male bone marrow Negative Negative 16 95 Negative Negative 85 9 4918 5.5 Negative
GSM300068 Hispanic or Latino Unknown training set No CNS disease Negative Male bone marrow Negative Negative 18 90 Negative Negative 66 10 5349 147.6 Negative

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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