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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample RACE TRAINING OR TEST SET TESTICULAR INVOLVEMENT BCR-ABL, T(9;22) MLL SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE CONGENITAL ABNORMALITY GENDER AMPLIFICATION SET E2A-PBX, T(1;19) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE CNS STATUS TRISOMY 4 AND 10 TISSUE TYPE AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER
GSM299862 White test set Unknown Negative Positive 100 None Female 1 Negative Negative 1 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 3953 175.0
GSM299863 Black or African American training set Negative Negative Negative 100 None Male 1 Negative Negative 1 90 No CNS disease Negative peripheral blood 1976 142.0
GSM299864 Hispanic or Latino training set Negative Negative Negative 99 None Male 1 Negative Negative 2 70 No CNS disease Negative peripheral blood 5250 220.7
GSM299865 White test set Negative Negative Negative 88 None Male 1 Negative Negative 2 95 No CNS disease Negative peripheral blood 577 129.0
GSM299866 Hispanic or Latino training set Negative Negative Negative 95 None Male 1 Negative Negative 3 95 No CNS disease Negative bone marrow 4609 26.0
GSM299867 White training set Negative Negative Negative 68 None Male 1 Negative Negative 3 80 No CNS disease Negative bone marrow 5289 14.7
GSM299868 Asian training set Negative Negative Negative 71 None Male 1 Negative Negative 4 -1 No CNS disease Negative bone marrow 3987 68.6
GSM299869 White test set Negative Negative Negative 98 None Male 1 Negative Negative 4 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 4856 21.4
GSM299870 White test set Negative Negative Negative 99 None Male 1 Negative Negative 4 1 No CNS disease Negative bone marrow 4678 2.4
GSM29987 White training set Negative Negative Negative 68 Unknown Male 1 Negative Negative 1 75 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 796 21.0
GSM299872 White training set Unknown Negative Positive 100 None Female 1 Negative Negative 1 85 No CNS disease Negative peripheral blood 4071 125.8
GSM299873 White training set Negative Negative Negative 99 Unknown Male 1 Negative Negative 2 95 No CNS disease Negative bone marrow 5223 29.9
GSM299874 Hispanic or Latino training set Unknown Negative Negative 99 Unknown Female 1 Negative Negative 3 95 No CNS disease Negative peripheral blood 5118 217.2
GSM299875 unknown training set Negative Negative Negative 97 None Male 1 Negative Negative 3 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 5219 180.0
GSM299876 White training set Unknown Negative Negative 98 Downs Female 1 Negative Negative 4 95 No CNS disease Negative bone marrow 1429 118.0
GSM299877 White test set Unknown Negative Negative 97 Unknown Female 1 Negative Negative 1 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 3179 314.8
GSM299878 White test set Unknown Negative Negative 58 None Female 1 Negative Negative 1 -1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 1450 5.2
GSM299879 White training set Negative Negative Negative 91 None Male 1 Negative Negative 1 95 No CNS disease Negative bone marrow 5278 113.5
GSM299880 White training set Negative Negative Negative 98 None Male 1 Positive Negative 2 85 No CNS disease Negative bone marrow 5330 5.8
GSM29988 Hispanic or Latino test set Unknown Negative Negative 99 Unknown Female 1 Negative Negative 4 90 No CNS disease Negative peripheral blood 4861 592.6
GSM299882 White training set Unknown Negative Negative 80 None Female 1 Negative Negative 1 95 No CNS disease Negative peripheral blood 428 248.0
GSM299883 White training set Negative Negative Negative 97 None Male 1 Negative Negative 1 95 No CNS disease Negative bone marrow 4722 4.4
GSM299884 White test set Negative Negative Negative 99 Unknown Male 1 Negative Negative 2 95 No CNS disease Negative bone marrow 3587 72.2
GSM299885 White test set Negative Negative Positive 98 None Female 1 Negative Negative 2 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative peripheral blood 5431 133.0
GSM299886 Hispanic or Latino training set Positive Negative Negative 98 None Male 1 Negative Negative 2 70 No CNS disease Negative bone marrow 3444 5.0
GSM299887 Other test set Negative Negative Negative 99 None Male 1 Negative Negative 3 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative peripheral blood 862 194.0
GSM299888 Hispanic or Latino training set Negative Negative Negative 97 None Male 1 Negative Negative 3 90 No CNS disease Negative bone marrow 6674 3.8
GSM299889 White training set Negative Negative Negative 70 None Male 1 Negative Negative 3 95 No CNS disease Negative bone marrow 6323 15.4
GSM299890 White training set Negative Negative Negative 98 Unknown Male 1 Negative Negative 4 90 No CNS disease Negative bone marrow 6219 16.5
GSM29989 White training set Negative Negative Negative 65 None Male 1 Negative Positive 4 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 2509 1.7
GSM299892 Hispanic or Latino training set Unknown Negative Negative 100 None Female 1 Positive Negative 4 95 No CNS disease Negative peripheral blood 1531 196.1
GSM299893 Hispanic or Latino test set Unknown Negative Negative 100 Unknown Male 1 Negative Negative 1 85 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 5516 202.4
GSM299894 White training set Negative Negative Negative 82 None Male 1 Negative Negative 1 90 No CNS disease Negative bone marrow 5513 2.5
GSM299895 White training set Negative Negative Negative 62 Unknown Male 1 Negative Negative 2 95 No CNS disease Negative bone marrow 5842 27.4
GSM299896 White training set Negative Negative Negative 98 Downs Male 1 Positive Negative 3 75 No CNS disease Negative peripheral blood 6496 9.1
GSM299897 White training set Negative Negative Positive 99 None Male 1 Negative Negative 3 95 No CNS disease Negative peripheral blood 6511 515.0
GSM299898 Hispanic or Latino training set Negative Negative Negative 97 None Male 1 Positive Negative 4 95 No CNS disease Negative bone marrow 1361 117.2
GSM299899 White training set Unknown Negative Negative 74 None Female 1 Negative Negative 1 95 No CNS disease Negative bone marrow 835 115.0
GSM299900 Hispanic or Latino training set Negative Negative Positive 99 None Male 1 Negative Negative 2 95 No CNS disease Negative peripheral blood 4774 246.4
GSM29990 White training set Unknown Negative Positive 95 None Female 1 Negative Negative 2 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 3311 489.0
GSM299902 White training set Negative Negative Negative 100 None Male 1 Negative Negative 3 80 No CNS disease Negative peripheral blood 6331 32.6
GSM299903 White training set Unknown Negative Positive 92 None Female 1 Negative Negative 3 95 No CNS disease Negative bone marrow 398 135.0
GSM299904 White test set Negative Negative Negative 96 None Male 1 Positive Negative 3 95 No CNS disease Negative bone marrow 5631 67.2
GSM299905 White test set Unknown Negative Negative 96 None Female 1 Negative Negative 1 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 944 12.1
GSM299906 White training set Negative Negative Negative 90 None Male 1 Positive Negative 1 90 No CNS disease Negative bone marrow 4940 8.0
GSM299907 White training set Negative Negative Negative 96 Downs Female 1 Negative Negative 2 95 No CNS disease Negative bone marrow 5721 88.9
GSM299908 White training set Negative Negative Negative 98 Unknown Male 1 Negative Negative 3 95 No CNS disease Negative peripheral blood 6114 80.9
GSM299909 White training set Negative Negative Negative 97 None Male 1 Negative Negative 4 95 No CNS disease Negative bone marrow 5086 36.2
GSM299910 White test set Negative Negative Negative 90 None Male 1 Negative Negative 4 95 No CNS disease Negative bone marrow 5359 80.8
GSM2999 White training set Negative Negative Negative 95 None Male 1 Negative Negative 2 90 No CNS disease Negative bone marrow 1167 156.0
GSM299912 White training set Negative Negative Negative 82 Unknown Female 1 Negative Negative 2 95 No CNS disease Negative peripheral blood 4090 289.3
GSM299913 White test set Negative Negative Positive 90 None Male 1 Negative Negative 3 95 No CNS disease Negative peripheral blood 792 237.0
GSM299914 White training set Negative Negative Negative 99 None Male 1 Negative Negative 4 95 No CNS disease Negative bone marrow 6733 81.4
GSM299915 Asian training set Negative Negative Negative 98 Unknown Male 2 Negative Negative 5 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 2875 351.3
GSM299916 Hispanic or Latino training set Negative Negative Negative 99 Other Male 2 Negative Positive 5 80 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative peripheral blood 449 59.9
GSM299917 White training set Negative Negative Negative 100 Unknown Male 4 Negative Negative 6 95 No CNS disease Negative bone marrow 904 137.8
GSM299918 White test set Negative Negative Negative 98 None Male 2 Negative Negative 6 90 No CNS disease Negative bone marrow 1426 138.4
GSM299919 Hispanic or Latino training set Unknown Negative Negative 98 None Female 2 Negative Negative 6 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 4469 478.0
GSM299920 Hispanic or Latino training set Negative Negative Negative 88 None Male 2 Negative Negative 7 95 No CNS disease Negative bone marrow 6266 34.9
GSM29992 White training set Negative Negative Negative 100 None Male 2 Negative Negative 8 70 No CNS disease Negative bone marrow 6306 22.8
GSM299922 White training set Unknown Negative Negative 100 None Female 2 Negative Negative 8 90 No CNS disease Negative peripheral blood 727 109.5
GSM299923 Hispanic or Latino training set Negative Negative Negative 99 None Male 2 Negative Negative 5 95 No CNS disease Negative bone marrow 5867 21.1
GSM299924 Asian training set Unknown Negative Negative 95 None Female 2 Negative Negative 5 90 No CNS disease Negative bone marrow 6733 102.0
GSM299925 White training set Negative Negative Negative 98 None Male 4 Negative Negative 6 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 5495 96.2
GSM299926 unknown training set Negative Negative Negative 99 None Male 2 Negative Negative 6 95 No CNS disease Negative bone marrow 6063 2.3
GSM299927 Hispanic or Latino test set Unknown Negative Negative 87 None Female 2 Negative Negative 6 95 No CNS disease Negative bone marrow 5922 27.0
GSM299928 White training set Unknown Negative Negative 99 Downs Female 2 Negative Negative 7 90 No CNS disease Negative peripheral blood 6922 68.9
GSM299929 White training set Unknown Negative Negative 100 None Female 2 Negative Negative 8 95 No CNS disease Negative bone marrow 531 119.0
GSM299930 White test set Unknown Negative Negative 97 Unknown Female 2 Negative Negative 5 95 No CNS disease Negative bone marrow 4106 210.0
GSM29993 Hispanic or Latino training set Negative Negative Negative 91 None Male 2 Negative Negative 5 95 No CNS disease Negative bone marrow 2027 199.0
GSM299932 Asian training set Unknown Negative Negative 96 Unknown Female 2 Positive Negative 6 90 No CNS disease Negative peripheral blood 1191 175.5
GSM299933 Hispanic or Latino test set Unknown Negative Negative 94 None Female 6 Negative Negative 7 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 5310 92.7
GSM299934 White training set Negative Negative Negative 83 None Male 2 Negative Negative 7 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative peripheral blood 5163 270.0
GSM299935 White test set Unknown Negative Negative 66 None Female 2 Positive Negative 7 95 No CNS disease Negative bone marrow 977 115.1
GSM299936 White training set Negative Negative Negative 89 Unknown Male 2 Negative Negative 8 95 No CNS disease Negative bone marrow 4807 12.7
GSM299937 White training set Negative Negative Negative 99 None Male 2 Negative Negative 5 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 5564 112.0
GSM299938 White test set Negative Negative Negative 60 Unknown Male 2 Negative Negative 5 95 No CNS disease Negative bone marrow 4305 40.0
GSM299939 White training set Unknown Negative Negative 94 Unknown Female 6 Negative Negative 6 95 No CNS disease Negative bone marrow 4717 62.3
GSM299940 Hispanic or Latino test set Negative Negative Negative 99 None Male 4 Negative Negative 7 95 No CNS disease Negative bone marrow 4657 33.1
GSM29994 White training set Unknown Negative Negative 79 None Female 2 Negative Positive 7 90 No CNS disease Negative bone marrow 1429 192.0
GSM299942 Hispanic or Latino training set Negative Negative Negative 98 None Female 4 Negative Negative 8 65 No CNS disease Negative peripheral blood 6413 16.6
GSM299943 White training set Negative Negative Negative 92 None Female 2 Negative Negative 8 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative peripheral blood 2133 17.5
GSM299944 Hispanic or Latino test set Unknown Negative Positive 69 Unknown Female 2 Negative Negative 8 70 No CNS disease Negative peripheral blood 434 88.5
GSM299945 Asian training set Negative Negative Negative 87 Unknown Male 2 Negative Negative 5 90 No CNS disease Negative bone marrow 4935 24.5
GSM299946 White training set Negative Negative Negative 100 None Female 2 Negative Negative 5 85 No CNS disease Negative peripheral blood 6984 30.4
GSM299947 White test set Unknown Negative Negative 65 None Female 2 Negative Negative 5 90 No CNS disease Negative bone marrow 1068 190.0
GSM299948 Hispanic or Latino test set Negative Negative Negative 99 None Male 4 Negative Negative 6 95 No CNS disease Negative bone marrow 5877 66.9
GSM299949 White training set Negative Negative Positive 87 None Male 6 Negative Negative 7 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 5127 555.0
GSM299950 White training set Negative Negative Positive 95 None Male 4 Negative Negative 7 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 410 51.3
GSM29995 White training set Negative Negative Negative 97 Unknown Male 2 Negative Negative 7 95 No CNS disease Negative bone marrow 5408 1.2
GSM299952 Black or African American test set Negative Negative Negative 96 Unknown Male 2 Negative Negative 8 95 No CNS disease Negative bone marrow 2876 142.4
GSM299953 White training set Negative Negative Negative 87 Unknown Male 2 Negative Negative 8 95 No CNS disease Negative bone marrow 697 110.9
GSM299954 Hispanic or Latino test set Unknown Negative Negative 95 Downs Female 2 Negative Negative 5 90 No CNS disease Negative peripheral blood 2223 202.0
GSM299955 White test set Unknown Negative Positive 97 None Female 2 Negative Negative 5 95 No CNS disease Negative peripheral blood 7028 259.8
GSM299956 White training set Negative Negative Negative 26 None Male 2 Negative Negative 5 -1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown bone marrow 5177 166.5
GSM299957 Hispanic or Latino training set Unknown Negative Positive 91 None Female 2 Negative Negative 6 90 No CNS disease Negative peripheral blood 1038 114.0
GSM299958 Hispanic or Latino test set Unknown Negative Negative 100 Downs Female 2 Negative Negative 6 95 No CNS disease Negative peripheral blood 5008 321.2
GSM299959 Hispanic or Latino training set Unknown Negative Negative 71 None Female 2 Negative Negative 7 95 No CNS disease Negative bone marrow 5925 19.5
GSM299960 Hispanic or Latino training set Negative Negative Negative 93 None Male 2 Negative Negative 7 95 No CNS disease Negative peripheral blood 1258 145.0
GSM29996 Hispanic or Latino test set Unknown Negative Negative 85 None Female 2 Positive Negative 8 90 No CNS disease Negative bone marrow 1956 148.2
GSM299962 White training set Unknown Negative Positive 97 None Female 4 Negative Negative 6 90 No CNS disease Negative peripheral blood 4560 108.0
GSM299963 White training set Negative Negative Positive 84 None Male 2 Negative Negative 7 90 No CNS disease Negative peripheral blood 966 37.3
GSM299964 White test set Negative Negative Negative 100 None Male 2 Negative Unknown 7 95 No CNS disease Negative bone marrow 4585 12.0
GSM299965 White training set Unknown Negative Negative 98 Unknown Female 2 Negative Negative 5 90 No CNS disease Negative bone marrow 4863 65.8
GSM299966 White training set Negative Negative Negative 100 None Male 2 Negative Negative 6 95 No CNS disease Negative peripheral blood 369 325.0
GSM299967 White test set Negative Negative Negative 20 None Male 2 Negative Negative 7 -1 No CNS disease Negative bone marrow 5853 2.3
GSM299968 White training set Negative Negative Negative 99 None Male 2 Negative Negative 8 80 No CNS disease Negative bone marrow 6335 13.3
GSM299969 American Indian or Alaska native test set Negative Negative Negative 97 None Male 2 Negative Negative 8 95 No CNS disease Negative peripheral blood 881 106.0
GSM299970 White training set Unknown Negative Negative 100 None Female 3 Negative Negative 9 95 No CNS disease Negative peripheral blood 2786 105.7
GSM29997 White training set Negative Negative Negative 94 None Male 3 Negative Negative 10 80 No CNS disease Negative peripheral blood 6306 16.7
GSM299972 White test set Negative Negative Negative 98 None Male 3 Negative Negative 10 90 No CNS disease Negative bone marrow 2519 112.0
GSM299973 Hispanic or Latino training set Negative Negative Negative 66 None Male 3 Negative Negative 11 95 No CNS disease Negative bone marrow 6142 18.5
GSM299974 Black or African American test set Negative Negative Negative 96 None Male 3 Negative Negative 11 80 No CNS disease Negative bone marrow 5343 30.2
GSM299975 White test set Negative Negative Positive 96 None Male 3 Negative Negative 11 90 No CNS disease Negative bone marrow 852 139.0
GSM299976 Hispanic or Latino training set Negative Negative Positive 94 None Male 3 Negative Negative 12 95 No CNS disease Negative bone marrow 462 17.3
GSM299977 Black or African American training set Unknown Negative Negative 75 Unknown Female 3 Positive Negative 12 90 No CNS disease Negative peripheral blood 5797 39.6
GSM299978 Hispanic or Latino training set Negative Negative Negative 97 None Male 3 Negative Negative 9 95 No CNS disease Negative peripheral blood 4253 236.4
GSM299979 Hispanic or Latino training set Unknown Negative Negative 99 None Female 3 Negative Negative 9 75 No CNS disease Negative peripheral blood 705 137.2
GSM299980 White training set Negative Negative Negative 99 Unknown Male 3 Negative Negative 10 70 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 7478 28.0
GSM29998 White training set Negative Negative Negative 100 Unknown Male 3 Negative Negative 10 90 No CNS disease Negative peripheral blood 2191 272.0
GSM299982 Hispanic or Latino training set Unknown Negative Negative 98 None Female 3 Negative Negative 11 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 1275 214.0
GSM299983 White test set Negative Negative Negative 96 None Male 3 Negative Negative 11 95 No CNS disease Negative bone marrow 5184 58.0
GSM299984 Other training set Negative Negative Negative 59 None Male 3 Negative Negative 11 -1 No CNS disease Negative bone marrow 5542 7.9
GSM299985 White test set Negative Negative Negative 64 None Male 3 Negative Negative 12 95 No CNS disease Negative bone marrow 5242 3.4
GSM299986 White training set Unknown Negative Negative 99 Unknown Female 3 Negative Negative 12 75 No CNS disease Negative peripheral blood 1313 69.4
GSM299987 White training set Unknown Negative Negative 94 None Female 3 Negative Negative 9 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 1751 238.0
GSM299988 White training set Unknown Negative Negative 98 None Female 3 Negative Negative 9 90 No CNS disease Negative bone marrow 4329 179.0
GSM299989 White training set Negative Negative Negative 86 None Male 3 Negative Negative 9 90 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive bone marrow 976 7.7
GSM299990 Hispanic or Latino test set Negative Negative Negative 91 None Female 3 Positive Negative 10 95 No CNS disease Negative bone marrow 5300 98.2
GSM29999 Hispanic or Latino training set Negative Negative Negative 81 None Male 3 Negative Negative 11 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 4307 44.9
GSM299992 White training set Unknown Negative Negative 98 None Female 3 Negative Negative 12 60 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 4324 35.7
GSM299993 White test set Unknown Negative Negative 97 Unknown Female 3 Positive Negative 9 95 No CNS disease Negative bone marrow 1033 118.1
GSM299994 Hispanic or Latino test set Negative Negative Negative 31 None Male 3 Negative Negative 9 -1 No CNS disease Negative bone marrow 6052 6.4
GSM299995 White training set Negative Unknown Negative 85 Unknown Male 3 Negative Unknown 10 95 No CNS disease Negative bone marrow 4157 77.6
GSM299996 Asian training set Unknown Negative Negative 64 None Male 3 Positive Negative 11 90 No CNS disease Negative bone marrow 5025 73.1
GSM299997 White training set Negative Negative Negative 99 None Male 3 Negative Negative 12 95 No CNS disease Negative bone marrow 6263 1.0
GSM299998 White training set Negative Negative Positive 96 None Male 3 Negative Negative 9 90 No CNS disease Negative bone marrow 5664 22.0
GSM299999 Other test set Negative Negative Negative 95 None Male 3 Negative Negative 9 95 No CNS disease Negative bone marrow 4776 1.3
GSM300000 White training set Unknown Negative Negative 99 None Female 3 Negative Negative 10 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 2192 209.6
GSM30000 Black or African American training set Negative Negative Negative 94 None Male 3 Negative Negative 11 95 No CNS disease Negative bone marrow 5954 15.5
GSM300002 White training set Negative Negative Negative 67 None Male 3 Negative Negative 11 95 No CNS disease Negative bone marrow 2038 193.0
GSM300003 White training set Unknown Negative Negative 96 None Female 3 Negative Negative 12 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive bone marrow 6032 59.2
GSM300004 White training set Positive Negative Negative 98 Unknown Male 3 Negative Negative 12 85 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 655 9.8
GSM300005 White training set Negative Negative Negative 94 None Male 3 Negative Negative 12 90 No CNS disease Negative bone marrow 4759 2.4
GSM300006 Hispanic or Latino test set Unknown Negative Negative 97 Unknown Female 3 Negative Negative 9 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 2769 3.0
GSM300007 American Indian or Alaska native training set Unknown Negative Negative 94 None Male 3 Negative Negative 9 40 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative peripheral blood 4972 6.3
GSM300008 Black or African American test set Negative Negative Negative 98 Unknown Male 3 Negative Negative 9 95 No CNS disease Negative bone marrow 4815 31.4
GSM300009 White test set Negative Negative Negative 98 None Male 3 Negative Negative 10 95 No CNS disease Negative peripheral blood 6315 245.0
GSM300010 White training set Negative Negative Negative 95 Downs Male 3 Negative Negative 10 95 No CNS disease Negative bone marrow 4276 24.4
GSM3000 White training set Negative Negative Negative 99 None Male 3 Negative Negative 10 95 No CNS disease Negative peripheral blood 5759 33.9
GSM300012 White test set Negative Negative Negative 44 None Male 3 Negative Negative 11 -1 No CNS disease Negative bone marrow 6487 7.6
GSM300013 Black or African American test set Negative Negative Negative 99 None Male 3 Positive Negative 11 95 No CNS disease Negative peripheral blood 1771 152.7
GSM300014 White training set Negative Negative Negative 89 None Male 3 Negative Negative 12 95 No CNS disease Negative bone marrow 515 124.0
GSM300015 White training set Unknown Negative Negative 96 None Female 3 Negative Negative 12 95 No CNS disease Negative bone marrow 6090 24.8
GSM300016 White training set Negative Negative Negative 99 Unknown Male 3 Negative Negative 9 95 No CNS disease Negative bone marrow 6633 1.9
GSM300017 Hispanic or Latino test set Negative Negative Negative 97 None Male 3 Negative Negative 9 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 5194 96.5
GSM300018 Hispanic or Latino training set Negative Negative Negative 96 None Male 3 Negative Negative 10 95 No CNS disease Negative bone marrow 6468 7.0
GSM300019 White test set Negative Negative Negative 92 None Male 3 Negative Negative 11 90 No CNS disease Negative bone marrow 6062 17.0
GSM300020 Other test set Unknown Negative Positive 95 Unknown Female 3 Negative Negative 11 90 No CNS disease Negative bone marrow 777 6.8
GSM30002 White test set Unknown Negative Negative 100 None Female 3 Positive Negative 12 85 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 5889 49.6
GSM300022 White test set Negative Negative Negative 95 None Male 3 Negative Negative 12 95 No CNS disease Negative peripheral blood 893 455.4
GSM300023 Hispanic or Latino training set Negative Negative Negative 98 None Male 3 Negative Negative 9 95 No CNS disease Negative bone marrow 4955 31.5
GSM300024 Hispanic or Latino training set Negative Negative Negative 99 None Male 3 Negative Negative 10 95 No CNS disease Negative peripheral blood 5081 307.0
GSM300025 Hispanic or Latino training set Unknown Negative Negative 98 Downs Female 3 Negative Negative 10 90 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 4665 95.2
GSM300026 Hispanic or Latino training set Negative Negative Negative 97 None Male 3 Negative Negative 11 95 No CNS disease Negative peripheral blood 988 958.8
GSM300027 White training set Negative Negative Negative 59 None Male 3 Positive Negative 12 -1 No CNS disease Negative bone marrow 5890 9.4
GSM300028 Black or African American test set Unknown Negative Negative 96 None Female 3 Negative Negative 12 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 6351 13.8
GSM300029 White test set Negative Negative Negative 86 Unknown Male 4 Negative Negative 13 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 1475 212.3
GSM300030 Hispanic or Latino training set Negative Negative Negative 99 Unknown Male 4 Negative Negative 13 90 No CNS disease Negative bone marrow 6036 8.8
GSM30003 White training set Unknown Negative Negative 96 None Female 1 Negative Negative 4 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 5217 135.8
GSM300032 Black or African American training set Negative Negative Negative 97 None Male 1 Negative Negative 4 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 523 82.9
GSM300033 White training set Unknown Negative Negative 99 Unknown Female 3 Positive Negative 11 95 No CNS disease Negative peripheral blood 1011 302.1
GSM300034 Native Hawaiian or other Pacific Islander test set Negative Negative Negative 98 None Male 3 Negative Negative 11 90 No CNS disease Negative bone marrow 6107 18.3
GSM300035 White training set Negative Negative Negative 95 None Male 4 Negative Negative 13 95 No CNS disease Negative peripheral blood 768 138.8
GSM300036 White training set Unknown Negative Negative 84 None Female 4 Positive Negative 13 90 No CNS disease Negative peripheral blood 5670 37.2
GSM300037 Hispanic or Latino training set Negative Negative Negative 99 None Male 6 Negative Negative 11 95 No CNS disease Negative peripheral blood 6666 114.6
GSM300038 Hispanic or Latino training set Unknown Negative Negative 96 None Female 4 Positive Negative 13 85 No CNS disease Negative bone marrow 3901 136.6
GSM300039 White training set Negative Negative Negative 51 None Female 7 Negative Negative 14 -1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative peripheral blood 728 138.4
GSM300040 White test set Unknown Negative Negative 79 None Female 7 Negative Negative 14 95 No CNS disease Negative bone marrow 1058 141.0
GSM30004 Hispanic or Latino test set Unknown Negative Negative 76 Unknown Female 7 Negative Negative 14 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive bone marrow 1323 30.6
GSM300042 Hispanic or Latino training set Negative Negative Negative 84 None Male 7 Negative Negative 14 95 No CNS disease Negative bone marrow 650 102.5
GSM300043 White test set Negative Negative Negative 99 None Male 8 Negative Negative 15 85 No CNS disease Negative bone marrow 5821 1.9
GSM300044 White training set Negative Negative Negative 100 Unknown Male 8 Negative Negative 15 40 No CNS disease Negative peripheral blood 6202 2.3
GSM300045 American Indian or Alaska native training set Negative Negative Negative 98 None Female 8 Negative Negative 15 90 No CNS disease Negative bone marrow 6119 2.3
GSM300046 White training set Positive Negative Negative 99 None Male 8 Negative Negative 15 60 No CNS disease Negative peripheral blood 4571 6.9
GSM300047 Hispanic or Latino training set Negative Negative Negative 93 None Male 8 Negative Negative 15 60 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive peripheral blood 1896 4.1
GSM300048 White training set Negative Negative Negative 97 None Female 8 Negative Negative 15 75 No CNS disease Negative bone marrow 7461 3.8
GSM300049 White test set Negative Negative Negative 96 None Male 8 Negative Negative 15 65 No CNS disease Negative bone marrow 6634 11.1
GSM300050 White training set Negative Negative Negative 83 None Male 8 Negative Negative 15 80 No CNS disease Negative peripheral blood 5097 6.3
GSM30005 Hispanic or Latino test set Negative Negative Negative 96 None Male 8 Negative Negative 15 95 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative bone marrow 5532 5.5
GSM300052 Black or African American test set Positive Negative Negative 47 None Male 8 Negative Negative 15 -1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive peripheral blood 1914 45.1
GSM300053 White training set Negative Negative Negative 72 None Male 8 Positive Negative 15 90 No CNS disease Negative peripheral blood 4434 42.1
GSM300054 Asian test set Negative Negative Negative 93 None Male 8 Positive Negative 15 50 No CNS disease Negative peripheral blood 4782 4.4
GSM300055 White test set Negative Negative Negative 84 None Male 8 Negative Negative 15 90 No CNS disease Negative bone marrow 5232 1.1
GSM300056 Black or African American test set Negative Negative Negative 83 None Male 8 Positive Negative 15 80 No CNS disease Negative peripheral blood 6500 17.8
GSM300057 White training set Unknown Negative Positive 50 None Male 9 Negative Negative 16 -1 No CNS disease Negative bone marrow 585 7.5
GSM300058 Black or African American test set Negative Negative Negative 98 None Male 9 Negative Negative 16 95 No CNS disease Negative bone marrow 6539 2.6
GSM300059 White test set Negative Negative Negative 100 None Female 9 Negative Negative 16 85 No CNS disease Negative bone marrow 5991 5.2
GSM300060 White training set Negative Negative Negative 93 None Male 9 Negative Negative 16 70 No CNS disease Negative peripheral blood 6479 31.9
GSM30006 Black or African American training set Negative Negative Negative 98 None Male 9 Negative Negative 16 90 No CNS disease Negative bone marrow 5183 23.0
GSM300062 White training set Negative Negative Negative 46 None Male 9 Negative Negative 16 -1 No CNS disease Negative peripheral blood 713 110.3
GSM300063 White test set Unknown Negative Positive 82 None Male 9 Negative Negative 16 90 No CNS disease Negative bone marrow 1704 85.1
GSM300064 White test set Negative Negative Negative 99 Unknown Male 9 Negative Negative 16 95 No CNS disease Negative bone marrow 5594 2.8
GSM300065 White training set Negative Negative Negative 88 Unknown Male 9 Negative Negative 16 95 No CNS disease Negative bone marrow 5857 13.3
GSM300066 Hispanic or Latino test set Unknown Negative Negative 81 None Female 9 Positive Negative 16 95 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative bone marrow 4017 3.5
GSM300067 White training set Negative Negative Negative 85 Unknown Male 9 Negative Negative 16 95 No CNS disease Negative bone marrow 4918 5.5
GSM300068 Hispanic or Latino training set Negative Negative Negative 66 Unknown Male 10 Negative Negative 18 90 No CNS disease Negative bone marrow 5349 147.6

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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