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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample RACE CONGENITAL ABNORMALITY TESTICULAR INVOLVEMENT CNS STATUS AMPLIFICATION SET SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE GENDER BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) MLL TRISOMY 4 AND 10 TISSUE TYPE AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER TRAINING OR TEST SET
GSM299862 White None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 100 Female Negative Negative 1 90 Negative Positive Negative peripheral blood 3953 175.0 test set
GSM299863 Black or African American None Negative No CNS disease 1 100 Male Negative Negative 1 90 Negative Negative Negative peripheral blood 1976 142.0 training set
GSM299864 Hispanic or Latino None Negative No CNS disease 1 99 Male Negative Negative 2 70 Negative Negative Negative peripheral blood 5250 220.7 training set
GSM299865 White None Negative No CNS disease 1 88 Male Negative Negative 2 95 Negative Negative Negative peripheral blood 577 129.0 test set
GSM299866 Hispanic or Latino None Negative No CNS disease 1 95 Male Negative Negative 3 95 Negative Negative Negative bone marrow 4609 26.0 training set
GSM299867 White None Negative No CNS disease 1 68 Male Negative Negative 3 80 Negative Negative Negative bone marrow 5289 14.7 training set
GSM299868 Asian None Negative No CNS disease 1 71 Male Negative Negative 4 -1 Negative Negative Negative bone marrow 3987 68.6 training set
GSM299869 White None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 98 Male Negative Negative 4 90 Negative Negative Negative bone marrow 4856 21.4 test set
GSM299870 White None Negative No CNS disease 1 99 Male Negative Negative 4 1 Negative Negative Negative bone marrow 4678 2.4 test set
GSM29987 White Unknown Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 68 Male Negative Negative 1 75 Negative Negative Negative bone marrow 796 21.0 training set
GSM299872 White None Unknown No CNS disease 1 100 Female Negative Negative 1 85 Negative Positive Negative peripheral blood 4071 125.8 training set
GSM299873 White Unknown Negative No CNS disease 1 99 Male Negative Negative 2 95 Negative Negative Negative bone marrow 5223 29.9 training set
GSM299874 Hispanic or Latino Unknown Unknown No CNS disease 1 99 Female Negative Negative 3 95 Negative Negative Negative peripheral blood 5118 217.2 training set
GSM299875 unknown None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 97 Male Negative Negative 3 90 Negative Negative Negative peripheral blood 5219 180.0 training set
GSM299876 White Downs Unknown No CNS disease 1 98 Female Negative Negative 4 95 Negative Negative Negative bone marrow 1429 118.0 training set
GSM299877 White Unknown Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 97 Female Negative Negative 1 95 Negative Negative Negative peripheral blood 3179 314.8 test set
GSM299878 White None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 58 Female Negative Negative 1 -1 Negative Negative Negative bone marrow 1450 5.2 test set
GSM299879 White None Negative No CNS disease 1 91 Male Negative Negative 1 95 Negative Negative Negative bone marrow 5278 113.5 training set
GSM299880 White None Negative No CNS disease 1 98 Male Negative Negative 2 85 Positive Negative Negative bone marrow 5330 5.8 training set
GSM29988 Hispanic or Latino Unknown Unknown No CNS disease 1 99 Female Negative Negative 4 90 Negative Negative Negative peripheral blood 4861 592.6 test set
GSM299882 White None Unknown No CNS disease 1 80 Female Negative Negative 1 95 Negative Negative Negative peripheral blood 428 248.0 training set
GSM299883 White None Negative No CNS disease 1 97 Male Negative Negative 1 95 Negative Negative Negative bone marrow 4722 4.4 training set
GSM299884 White Unknown Negative No CNS disease 1 99 Male Negative Negative 2 95 Negative Negative Negative bone marrow 3587 72.2 test set
GSM299885 White None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 98 Female Negative Negative 2 90 Negative Positive Negative peripheral blood 5431 133.0 test set
GSM299886 Hispanic or Latino None Positive No CNS disease 1 98 Male Negative Negative 2 70 Negative Negative Negative bone marrow 3444 5.0 training set
GSM299887 Other None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 99 Male Negative Negative 3 90 Negative Negative Negative peripheral blood 862 194.0 test set
GSM299888 Hispanic or Latino None Negative No CNS disease 1 97 Male Negative Negative 3 90 Negative Negative Negative bone marrow 6674 3.8 training set
GSM299889 White None Negative No CNS disease 1 70 Male Negative Negative 3 95 Negative Negative Negative bone marrow 6323 15.4 training set
GSM299890 White Unknown Negative No CNS disease 1 98 Male Negative Negative 4 90 Negative Negative Negative bone marrow 6219 16.5 training set
GSM29989 White None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 65 Male Negative Positive 4 95 Negative Negative Negative bone marrow 2509 1.7 training set
GSM299892 Hispanic or Latino None Unknown No CNS disease 1 100 Female Negative Negative 4 95 Positive Negative Negative peripheral blood 1531 196.1 training set
GSM299893 Hispanic or Latino Unknown Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 100 Male Negative Negative 1 85 Negative Negative Negative peripheral blood 5516 202.4 test set
GSM299894 White None Negative No CNS disease 1 82 Male Negative Negative 1 90 Negative Negative Negative bone marrow 5513 2.5 training set
GSM299895 White Unknown Negative No CNS disease 1 62 Male Negative Negative 2 95 Negative Negative Negative bone marrow 5842 27.4 training set
GSM299896 White Downs Negative No CNS disease 1 98 Male Negative Negative 3 75 Positive Negative Negative peripheral blood 6496 9.1 training set
GSM299897 White None Negative No CNS disease 1 99 Male Negative Negative 3 95 Negative Positive Negative peripheral blood 6511 515.0 training set
GSM299898 Hispanic or Latino None Negative No CNS disease 1 97 Male Negative Negative 4 95 Positive Negative Negative bone marrow 1361 117.2 training set
GSM299899 White None Unknown No CNS disease 1 74 Female Negative Negative 1 95 Negative Negative Negative bone marrow 835 115.0 training set
GSM299900 Hispanic or Latino None Negative No CNS disease 1 99 Male Negative Negative 2 95 Negative Positive Negative peripheral blood 4774 246.4 training set
GSM29990 White None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 95 Female Negative Negative 2 95 Negative Positive Negative bone marrow 3311 489.0 training set
GSM299902 White None Negative No CNS disease 1 100 Male Negative Negative 3 80 Negative Negative Negative peripheral blood 6331 32.6 training set
GSM299903 White None Unknown No CNS disease 1 92 Female Negative Negative 3 95 Negative Positive Negative bone marrow 398 135.0 training set
GSM299904 White None Negative No CNS disease 1 96 Male Negative Negative 3 95 Positive Negative Negative bone marrow 5631 67.2 test set
GSM299905 White None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 96 Female Negative Negative 1 95 Negative Negative Negative bone marrow 944 12.1 test set
GSM299906 White None Negative No CNS disease 1 90 Male Negative Negative 1 90 Positive Negative Negative bone marrow 4940 8.0 training set
GSM299907 White Downs Negative No CNS disease 1 96 Female Negative Negative 2 95 Negative Negative Negative bone marrow 5721 88.9 training set
GSM299908 White Unknown Negative No CNS disease 1 98 Male Negative Negative 3 95 Negative Negative Negative peripheral blood 6114 80.9 training set
GSM299909 White None Negative No CNS disease 1 97 Male Negative Negative 4 95 Negative Negative Negative bone marrow 5086 36.2 training set
GSM299910 White None Negative No CNS disease 1 90 Male Negative Negative 4 95 Negative Negative Negative bone marrow 5359 80.8 test set
GSM2999 White None Negative No CNS disease 1 95 Male Negative Negative 2 90 Negative Negative Negative bone marrow 1167 156.0 training set
GSM299912 White Unknown Negative No CNS disease 1 82 Female Negative Negative 2 95 Negative Negative Negative peripheral blood 4090 289.3 training set
GSM299913 White None Negative No CNS disease 1 90 Male Negative Negative 3 95 Negative Positive Negative peripheral blood 792 237.0 test set
GSM299914 White None Negative No CNS disease 1 99 Male Negative Negative 4 95 Negative Negative Negative bone marrow 6733 81.4 training set
GSM299915 Asian Unknown Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 98 Male Negative Negative 5 95 Negative Negative Negative bone marrow 2875 351.3 training set
GSM299916 Hispanic or Latino Other Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 99 Male Negative Positive 5 80 Negative Negative Negative peripheral blood 449 59.9 training set
GSM299917 White Unknown Negative No CNS disease 4 100 Male Negative Negative 6 95 Negative Negative Negative bone marrow 904 137.8 training set
GSM299918 White None Negative No CNS disease 2 98 Male Negative Negative 6 90 Negative Negative Negative bone marrow 1426 138.4 test set
GSM299919 Hispanic or Latino None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 98 Female Negative Negative 6 95 Negative Negative Negative peripheral blood 4469 478.0 training set
GSM299920 Hispanic or Latino None Negative No CNS disease 2 88 Male Negative Negative 7 95 Negative Negative Negative bone marrow 6266 34.9 training set
GSM29992 White None Negative No CNS disease 2 100 Male Negative Negative 8 70 Negative Negative Negative bone marrow 6306 22.8 training set
GSM299922 White None Unknown No CNS disease 2 100 Female Negative Negative 8 90 Negative Negative Negative peripheral blood 727 109.5 training set
GSM299923 Hispanic or Latino None Negative No CNS disease 2 99 Male Negative Negative 5 95 Negative Negative Negative bone marrow 5867 21.1 training set
GSM299924 Asian None Unknown No CNS disease 2 95 Female Negative Negative 5 90 Negative Negative Negative bone marrow 6733 102.0 training set
GSM299925 White None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 98 Male Negative Negative 6 90 Negative Negative Negative peripheral blood 5495 96.2 training set
GSM299926 unknown None Negative No CNS disease 2 99 Male Negative Negative 6 95 Negative Negative Negative bone marrow 6063 2.3 training set
GSM299927 Hispanic or Latino None Unknown No CNS disease 2 87 Female Negative Negative 6 95 Negative Negative Negative bone marrow 5922 27.0 test set
GSM299928 White Downs Unknown No CNS disease 2 99 Female Negative Negative 7 90 Negative Negative Negative peripheral blood 6922 68.9 training set
GSM299929 White None Unknown No CNS disease 2 100 Female Negative Negative 8 95 Negative Negative Negative bone marrow 531 119.0 training set
GSM299930 White Unknown Unknown No CNS disease 2 97 Female Negative Negative 5 95 Negative Negative Negative bone marrow 4106 210.0 test set
GSM29993 Hispanic or Latino None Negative No CNS disease 2 91 Male Negative Negative 5 95 Negative Negative Negative bone marrow 2027 199.0 training set
GSM299932 Asian Unknown Unknown No CNS disease 2 96 Female Negative Negative 6 90 Positive Negative Negative peripheral blood 1191 175.5 training set
GSM299933 Hispanic or Latino None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 6 94 Female Negative Negative 7 95 Negative Negative Negative peripheral blood 5310 92.7 test set
GSM299934 White None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 83 Male Negative Negative 7 95 Negative Negative Negative peripheral blood 5163 270.0 training set
GSM299935 White None Unknown No CNS disease 2 66 Female Negative Negative 7 95 Positive Negative Negative bone marrow 977 115.1 test set
GSM299936 White Unknown Negative No CNS disease 2 89 Male Negative Negative 8 95 Negative Negative Negative bone marrow 4807 12.7 training set
GSM299937 White None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 99 Male Negative Negative 5 95 Negative Negative Negative peripheral blood 5564 112.0 training set
GSM299938 White Unknown Negative No CNS disease 2 60 Male Negative Negative 5 95 Negative Negative Negative bone marrow 4305 40.0 test set
GSM299939 White Unknown Unknown No CNS disease 6 94 Female Negative Negative 6 95 Negative Negative Negative bone marrow 4717 62.3 training set
GSM299940 Hispanic or Latino None Negative No CNS disease 4 99 Male Negative Negative 7 95 Negative Negative Negative bone marrow 4657 33.1 test set
GSM29994 White None Unknown No CNS disease 2 79 Female Negative Positive 7 90 Negative Negative Negative bone marrow 1429 192.0 training set
GSM299942 Hispanic or Latino None Negative No CNS disease 4 98 Female Negative Negative 8 65 Negative Negative Negative peripheral blood 6413 16.6 training set
GSM299943 White None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 92 Female Negative Negative 8 95 Negative Negative Negative peripheral blood 2133 17.5 training set
GSM299944 Hispanic or Latino Unknown Unknown No CNS disease 2 69 Female Negative Negative 8 70 Negative Positive Negative peripheral blood 434 88.5 test set
GSM299945 Asian Unknown Negative No CNS disease 2 87 Male Negative Negative 5 90 Negative Negative Negative bone marrow 4935 24.5 training set
GSM299946 White None Negative No CNS disease 2 100 Female Negative Negative 5 85 Negative Negative Negative peripheral blood 6984 30.4 training set
GSM299947 White None Unknown No CNS disease 2 65 Female Negative Negative 5 90 Negative Negative Negative bone marrow 1068 190.0 test set
GSM299948 Hispanic or Latino None Negative No CNS disease 4 99 Male Negative Negative 6 95 Negative Negative Negative bone marrow 5877 66.9 test set
GSM299949 White None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 6 87 Male Negative Negative 7 95 Negative Positive Negative bone marrow 5127 555.0 training set
GSM299950 White None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 95 Male Negative Negative 7 90 Negative Positive Negative bone marrow 410 51.3 training set
GSM29995 White Unknown Negative No CNS disease 2 97 Male Negative Negative 7 95 Negative Negative Negative bone marrow 5408 1.2 training set
GSM299952 Black or African American Unknown Negative No CNS disease 2 96 Male Negative Negative 8 95 Negative Negative Negative bone marrow 2876 142.4 test set
GSM299953 White Unknown Negative No CNS disease 2 87 Male Negative Negative 8 95 Negative Negative Negative bone marrow 697 110.9 training set
GSM299954 Hispanic or Latino Downs Unknown No CNS disease 2 95 Female Negative Negative 5 90 Negative Negative Negative peripheral blood 2223 202.0 test set
GSM299955 White None Unknown No CNS disease 2 97 Female Negative Negative 5 95 Negative Positive Negative peripheral blood 7028 259.8 test set
GSM299956 White None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 26 Male Negative Negative 5 -1 Negative Negative Unknown bone marrow 5177 166.5 training set
GSM299957 Hispanic or Latino None Unknown No CNS disease 2 91 Female Negative Negative 6 90 Negative Positive Negative peripheral blood 1038 114.0 training set
GSM299958 Hispanic or Latino Downs Unknown No CNS disease 2 100 Female Negative Negative 6 95 Negative Negative Negative peripheral blood 5008 321.2 test set
GSM299959 Hispanic or Latino None Unknown No CNS disease 2 71 Female Negative Negative 7 95 Negative Negative Negative bone marrow 5925 19.5 training set
GSM299960 Hispanic or Latino None Negative No CNS disease 2 93 Male Negative Negative 7 95 Negative Negative Negative peripheral blood 1258 145.0 training set
GSM29996 Hispanic or Latino None Unknown No CNS disease 2 85 Female Negative Negative 8 90 Positive Negative Negative bone marrow 1956 148.2 test set
GSM299962 White None Unknown No CNS disease 4 97 Female Negative Negative 6 90 Negative Positive Negative peripheral blood 4560 108.0 training set
GSM299963 White None Negative No CNS disease 2 84 Male Negative Negative 7 90 Negative Positive Negative peripheral blood 966 37.3 training set
GSM299964 White None Negative No CNS disease 2 100 Male Negative Unknown 7 95 Negative Negative Negative bone marrow 4585 12.0 test set
GSM299965 White Unknown Unknown No CNS disease 2 98 Female Negative Negative 5 90 Negative Negative Negative bone marrow 4863 65.8 training set
GSM299966 White None Negative No CNS disease 2 100 Male Negative Negative 6 95 Negative Negative Negative peripheral blood 369 325.0 training set
GSM299967 White None Negative No CNS disease 2 20 Male Negative Negative 7 -1 Negative Negative Negative bone marrow 5853 2.3 test set
GSM299968 White None Negative No CNS disease 2 99 Male Negative Negative 8 80 Negative Negative Negative bone marrow 6335 13.3 training set
GSM299969 American Indian or Alaska native None Negative No CNS disease 2 97 Male Negative Negative 8 95 Negative Negative Negative peripheral blood 881 106.0 test set
GSM299970 White None Unknown No CNS disease 3 100 Female Negative Negative 9 95 Negative Negative Negative peripheral blood 2786 105.7 training set
GSM29997 White None Negative No CNS disease 3 94 Male Negative Negative 10 80 Negative Negative Negative peripheral blood 6306 16.7 training set
GSM299972 White None Negative No CNS disease 3 98 Male Negative Negative 10 90 Negative Negative Negative bone marrow 2519 112.0 test set
GSM299973 Hispanic or Latino None Negative No CNS disease 3 66 Male Negative Negative 11 95 Negative Negative Negative bone marrow 6142 18.5 training set
GSM299974 Black or African American None Negative No CNS disease 3 96 Male Negative Negative 11 80 Negative Negative Negative bone marrow 5343 30.2 test set
GSM299975 White None Negative No CNS disease 3 96 Male Negative Negative 11 90 Negative Positive Negative bone marrow 852 139.0 test set
GSM299976 Hispanic or Latino None Negative No CNS disease 3 94 Male Negative Negative 12 95 Negative Positive Negative bone marrow 462 17.3 training set
GSM299977 Black or African American Unknown Unknown No CNS disease 3 75 Female Negative Negative 12 90 Positive Negative Negative peripheral blood 5797 39.6 training set
GSM299978 Hispanic or Latino None Negative No CNS disease 3 97 Male Negative Negative 9 95 Negative Negative Negative peripheral blood 4253 236.4 training set
GSM299979 Hispanic or Latino None Unknown No CNS disease 3 99 Female Negative Negative 9 75 Negative Negative Negative peripheral blood 705 137.2 training set
GSM299980 White Unknown Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 99 Male Negative Negative 10 70 Negative Negative Negative peripheral blood 7478 28.0 training set
GSM29998 White Unknown Negative No CNS disease 3 100 Male Negative Negative 10 90 Negative Negative Negative peripheral blood 2191 272.0 training set
GSM299982 Hispanic or Latino None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 98 Female Negative Negative 11 90 Negative Negative Negative bone marrow 1275 214.0 training set
GSM299983 White None Negative No CNS disease 3 96 Male Negative Negative 11 95 Negative Negative Negative bone marrow 5184 58.0 test set
GSM299984 Other None Negative No CNS disease 3 59 Male Negative Negative 11 -1 Negative Negative Negative bone marrow 5542 7.9 training set
GSM299985 White None Negative No CNS disease 3 64 Male Negative Negative 12 95 Negative Negative Negative bone marrow 5242 3.4 test set
GSM299986 White Unknown Unknown No CNS disease 3 99 Female Negative Negative 12 75 Negative Negative Negative peripheral blood 1313 69.4 training set
GSM299987 White None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 94 Female Negative Negative 9 95 Negative Negative Negative bone marrow 1751 238.0 training set
GSM299988 White None Unknown No CNS disease 3 98 Female Negative Negative 9 90 Negative Negative Negative bone marrow 4329 179.0 training set
GSM299989 White None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 86 Male Negative Negative 9 90 Negative Negative Positive bone marrow 976 7.7 training set
GSM299990 Hispanic or Latino None Negative No CNS disease 3 91 Female Negative Negative 10 95 Positive Negative Negative bone marrow 5300 98.2 test set
GSM29999 Hispanic or Latino None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 81 Male Negative Negative 11 90 Negative Negative Negative bone marrow 4307 44.9 training set
GSM299992 White None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 98 Female Negative Negative 12 60 Negative Negative Negative peripheral blood 4324 35.7 training set
GSM299993 White Unknown Unknown No CNS disease 3 97 Female Negative Negative 9 95 Positive Negative Negative bone marrow 1033 118.1 test set
GSM299994 Hispanic or Latino None Negative No CNS disease 3 31 Male Negative Negative 9 -1 Negative Negative Negative bone marrow 6052 6.4 test set
GSM299995 White Unknown Negative No CNS disease 3 85 Male Unknown Unknown 10 95 Negative Negative Negative bone marrow 4157 77.6 training set
GSM299996 Asian None Unknown No CNS disease 3 64 Male Negative Negative 11 90 Positive Negative Negative bone marrow 5025 73.1 training set
GSM299997 White None Negative No CNS disease 3 99 Male Negative Negative 12 95 Negative Negative Negative bone marrow 6263 1.0 training set
GSM299998 White None Negative No CNS disease 3 96 Male Negative Negative 9 90 Negative Positive Negative bone marrow 5664 22.0 training set
GSM299999 Other None Negative No CNS disease 3 95 Male Negative Negative 9 95 Negative Negative Negative bone marrow 4776 1.3 test set
GSM300000 White None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 99 Female Negative Negative 10 95 Negative Negative Negative peripheral blood 2192 209.6 training set
GSM30000 Black or African American None Negative No CNS disease 3 94 Male Negative Negative 11 95 Negative Negative Negative bone marrow 5954 15.5 training set
GSM300002 White None Negative No CNS disease 3 67 Male Negative Negative 11 95 Negative Negative Negative bone marrow 2038 193.0 training set
GSM300003 White None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 96 Female Negative Negative 12 95 Negative Negative Positive bone marrow 6032 59.2 training set
GSM300004 White Unknown Positive < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 98 Male Negative Negative 12 85 Negative Negative Negative peripheral blood 655 9.8 training set
GSM300005 White None Negative No CNS disease 3 94 Male Negative Negative 12 90 Negative Negative Negative bone marrow 4759 2.4 training set
GSM300006 Hispanic or Latino Unknown Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 97 Female Negative Negative 9 95 Negative Negative Negative bone marrow 2769 3.0 test set
GSM300007 American Indian or Alaska native None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 94 Male Negative Negative 9 40 Negative Negative Negative peripheral blood 4972 6.3 training set
GSM300008 Black or African American Unknown Negative No CNS disease 3 98 Male Negative Negative 9 95 Negative Negative Negative bone marrow 4815 31.4 test set
GSM300009 White None Negative No CNS disease 3 98 Male Negative Negative 10 95 Negative Negative Negative peripheral blood 6315 245.0 test set
GSM300010 White Downs Negative No CNS disease 3 95 Male Negative Negative 10 95 Negative Negative Negative bone marrow 4276 24.4 training set
GSM3000 White None Negative No CNS disease 3 99 Male Negative Negative 10 95 Negative Negative Negative peripheral blood 5759 33.9 training set
GSM300012 White None Negative No CNS disease 3 44 Male Negative Negative 11 -1 Negative Negative Negative bone marrow 6487 7.6 test set
GSM300013 Black or African American None Negative No CNS disease 3 99 Male Negative Negative 11 95 Positive Negative Negative peripheral blood 1771 152.7 test set
GSM300014 White None Negative No CNS disease 3 89 Male Negative Negative 12 95 Negative Negative Negative bone marrow 515 124.0 training set
GSM300015 White None Unknown No CNS disease 3 96 Female Negative Negative 12 95 Negative Negative Negative bone marrow 6090 24.8 training set
GSM300016 White Unknown Negative No CNS disease 3 99 Male Negative Negative 9 95 Negative Negative Negative bone marrow 6633 1.9 training set
GSM300017 Hispanic or Latino None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 97 Male Negative Negative 9 95 Negative Negative Negative bone marrow 5194 96.5 test set
GSM300018 Hispanic or Latino None Negative No CNS disease 3 96 Male Negative Negative 10 95 Negative Negative Negative bone marrow 6468 7.0 training set
GSM300019 White None Negative No CNS disease 3 92 Male Negative Negative 11 90 Negative Negative Negative bone marrow 6062 17.0 test set
GSM300020 Other Unknown Unknown No CNS disease 3 95 Female Negative Negative 11 90 Negative Positive Negative bone marrow 777 6.8 test set
GSM30002 White None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 100 Female Negative Negative 12 85 Positive Negative Negative bone marrow 5889 49.6 test set
GSM300022 White None Negative No CNS disease 3 95 Male Negative Negative 12 95 Negative Negative Negative peripheral blood 893 455.4 test set
GSM300023 Hispanic or Latino None Negative No CNS disease 3 98 Male Negative Negative 9 95 Negative Negative Negative bone marrow 4955 31.5 training set
GSM300024 Hispanic or Latino None Negative No CNS disease 3 99 Male Negative Negative 10 95 Negative Negative Negative peripheral blood 5081 307.0 training set
GSM300025 Hispanic or Latino Downs Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 98 Female Negative Negative 10 90 Negative Negative Negative bone marrow 4665 95.2 training set
GSM300026 Hispanic or Latino None Negative No CNS disease 3 97 Male Negative Negative 11 95 Negative Negative Negative peripheral blood 988 958.8 training set
GSM300027 White None Negative No CNS disease 3 59 Male Negative Negative 12 -1 Positive Negative Negative bone marrow 5890 9.4 training set
GSM300028 Black or African American None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 96 Female Negative Negative 12 95 Negative Negative Negative bone marrow 6351 13.8 test set
GSM300029 White Unknown Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 86 Male Negative Negative 13 95 Negative Negative Negative bone marrow 1475 212.3 test set
GSM300030 Hispanic or Latino Unknown Negative No CNS disease 4 99 Male Negative Negative 13 90 Negative Negative Negative bone marrow 6036 8.8 training set
GSM30003 White None Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 96 Female Negative Negative 4 95 Negative Negative Negative bone marrow 5217 135.8 training set
GSM300032 Black or African American None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 97 Male Negative Negative 4 95 Negative Negative Negative bone marrow 523 82.9 training set
GSM300033 White Unknown Unknown No CNS disease 3 99 Female Negative Negative 11 95 Positive Negative Negative peripheral blood 1011 302.1 training set
GSM300034 Native Hawaiian or other Pacific Islander None Negative No CNS disease 3 98 Male Negative Negative 11 90 Negative Negative Negative bone marrow 6107 18.3 test set
GSM300035 White None Negative No CNS disease 4 95 Male Negative Negative 13 95 Negative Negative Negative peripheral blood 768 138.8 training set
GSM300036 White None Unknown No CNS disease 4 84 Female Negative Negative 13 90 Positive Negative Negative peripheral blood 5670 37.2 training set
GSM300037 Hispanic or Latino None Negative No CNS disease 6 99 Male Negative Negative 11 95 Negative Negative Negative peripheral blood 6666 114.6 training set
GSM300038 Hispanic or Latino None Unknown No CNS disease 4 96 Female Negative Negative 13 85 Positive Negative Negative bone marrow 3901 136.6 training set
GSM300039 White None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 7 51 Female Negative Negative 14 -1 Negative Negative Negative peripheral blood 728 138.4 training set
GSM300040 White None Unknown No CNS disease 7 79 Female Negative Negative 14 95 Negative Negative Negative bone marrow 1058 141.0 test set
GSM30004 Hispanic or Latino Unknown Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 7 76 Female Negative Negative 14 95 Negative Negative Positive bone marrow 1323 30.6 test set
GSM300042 Hispanic or Latino None Negative No CNS disease 7 84 Male Negative Negative 14 95 Negative Negative Negative bone marrow 650 102.5 training set
GSM300043 White None Negative No CNS disease 8 99 Male Negative Negative 15 85 Negative Negative Negative bone marrow 5821 1.9 test set
GSM300044 White Unknown Negative No CNS disease 8 100 Male Negative Negative 15 40 Negative Negative Negative peripheral blood 6202 2.3 training set
GSM300045 American Indian or Alaska native None Negative No CNS disease 8 98 Female Negative Negative 15 90 Negative Negative Negative bone marrow 6119 2.3 training set
GSM300046 White None Positive No CNS disease 8 99 Male Negative Negative 15 60 Negative Negative Negative peripheral blood 4571 6.9 training set
GSM300047 Hispanic or Latino None Negative > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 8 93 Male Negative Negative 15 60 Negative Negative Positive peripheral blood 1896 4.1 training set
GSM300048 White None Negative No CNS disease 8 97 Female Negative Negative 15 75 Negative Negative Negative bone marrow 7461 3.8 training set
GSM300049 White None Negative No CNS disease 8 96 Male Negative Negative 15 65 Negative Negative Negative bone marrow 6634 11.1 test set
GSM300050 White None Negative No CNS disease 8 83 Male Negative Negative 15 80 Negative Negative Negative peripheral blood 5097 6.3 training set
GSM30005 Hispanic or Latino None Negative < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 8 96 Male Negative Negative 15 95 Negative Negative Negative bone marrow 5532 5.5 test set
GSM300052 Black or African American None Positive < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 8 47 Male Negative Negative 15 -1 Negative Negative Positive peripheral blood 1914 45.1 test set
GSM300053 White None Negative No CNS disease 8 72 Male Negative Negative 15 90 Positive Negative Negative peripheral blood 4434 42.1 training set
GSM300054 Asian None Negative No CNS disease 8 93 Male Negative Negative 15 50 Positive Negative Negative peripheral blood 4782 4.4 test set
GSM300055 White None Negative No CNS disease 8 84 Male Negative Negative 15 90 Negative Negative Negative bone marrow 5232 1.1 test set
GSM300056 Black or African American None Negative No CNS disease 8 83 Male Negative Negative 15 80 Positive Negative Negative peripheral blood 6500 17.8 test set
GSM300057 White None Unknown No CNS disease 9 50 Male Negative Negative 16 -1 Negative Positive Negative bone marrow 585 7.5 training set
GSM300058 Black or African American None Negative No CNS disease 9 98 Male Negative Negative 16 95 Negative Negative Negative bone marrow 6539 2.6 test set
GSM300059 White None Negative No CNS disease 9 100 Female Negative Negative 16 85 Negative Negative Negative bone marrow 5991 5.2 test set
GSM300060 White None Negative No CNS disease 9 93 Male Negative Negative 16 70 Negative Negative Negative peripheral blood 6479 31.9 training set
GSM30006 Black or African American None Negative No CNS disease 9 98 Male Negative Negative 16 90 Negative Negative Negative bone marrow 5183 23.0 training set
GSM300062 White None Negative No CNS disease 9 46 Male Negative Negative 16 -1 Negative Negative Negative peripheral blood 713 110.3 training set
GSM300063 White None Unknown No CNS disease 9 82 Male Negative Negative 16 90 Negative Positive Negative bone marrow 1704 85.1 test set
GSM300064 White Unknown Negative No CNS disease 9 99 Male Negative Negative 16 95 Negative Negative Negative bone marrow 5594 2.8 test set
GSM300065 White Unknown Negative No CNS disease 9 88 Male Negative Negative 16 95 Negative Negative Negative bone marrow 5857 13.3 training set
GSM300066 Hispanic or Latino None Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 9 81 Female Negative Negative 16 95 Positive Negative Negative bone marrow 4017 3.5 test set
GSM300067 White Unknown Negative No CNS disease 9 85 Male Negative Negative 16 95 Negative Negative Negative bone marrow 4918 5.5 training set
GSM300068 Hispanic or Latino Unknown Negative No CNS disease 10 66 Male Negative Negative 18 90 Negative Negative Negative bone marrow 5349 147.6 training set

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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