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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample TRAINING OR TEST SET RACE TESTICULAR INVOLVEMENT MLL AMPLIFICATION SET CONGENITAL ABNORMALITY GENDER E2A-PBX, T(1;19) TEL-AML,T(12;21) HYBRIDIZATION SET SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE BCR-ABL, T(9;22) BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE TRISOMY 4 AND 10 TISSUE TYPE AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER CNS STATUS
GSM299862 test set White Unknown Positive 1 None Female Negative Negative 1 100 Negative 90 Negative peripheral blood 3953 175.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299863 training set Black or African American Negative Negative 1 None Male Negative Negative 1 100 Negative 90 Negative peripheral blood 1976 142.0 No CNS disease
GSM299864 training set Hispanic or Latino Negative Negative 1 None Male Negative Negative 2 99 Negative 70 Negative peripheral blood 5250 220.7 No CNS disease
GSM299865 test set White Negative Negative 1 None Male Negative Negative 2 88 Negative 95 Negative peripheral blood 577 129.0 No CNS disease
GSM299866 training set Hispanic or Latino Negative Negative 1 None Male Negative Negative 3 95 Negative 95 Negative bone marrow 4609 26.0 No CNS disease
GSM299867 training set White Negative Negative 1 None Male Negative Negative 3 68 Negative 80 Negative bone marrow 5289 14.7 No CNS disease
GSM299868 training set Asian Negative Negative 1 None Male Negative Negative 4 71 Negative -1 Negative bone marrow 3987 68.6 No CNS disease
GSM299869 test set White Negative Negative 1 None Male Negative Negative 4 98 Negative 90 Negative bone marrow 4856 21.4 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299870 test set White Negative Negative 1 None Male Negative Negative 4 99 Negative 1 Negative bone marrow 4678 2.4 No CNS disease
GSM29987 training set White Negative Negative 1 Unknown Male Negative Negative 1 68 Negative 75 Negative bone marrow 796 21.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299872 training set White Unknown Positive 1 None Female Negative Negative 1 100 Negative 85 Negative peripheral blood 4071 125.8 No CNS disease
GSM299873 training set White Negative Negative 1 Unknown Male Negative Negative 2 99 Negative 95 Negative bone marrow 5223 29.9 No CNS disease
GSM299874 training set Hispanic or Latino Unknown Negative 1 Unknown Female Negative Negative 3 99 Negative 95 Negative peripheral blood 5118 217.2 No CNS disease
GSM299875 training set unknown Negative Negative 1 None Male Negative Negative 3 97 Negative 90 Negative peripheral blood 5219 180.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299876 training set White Unknown Negative 1 Downs Female Negative Negative 4 98 Negative 95 Negative bone marrow 1429 118.0 No CNS disease
GSM299877 test set White Unknown Negative 1 Unknown Female Negative Negative 1 97 Negative 95 Negative peripheral blood 3179 314.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299878 test set White Unknown Negative 1 None Female Negative Negative 1 58 Negative -1 Negative bone marrow 1450 5.2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299879 training set White Negative Negative 1 None Male Negative Negative 1 91 Negative 95 Negative bone marrow 5278 113.5 No CNS disease
GSM299880 training set White Negative Negative 1 None Male Positive Negative 2 98 Negative 85 Negative bone marrow 5330 5.8 No CNS disease
GSM29988 test set Hispanic or Latino Unknown Negative 1 Unknown Female Negative Negative 4 99 Negative 90 Negative peripheral blood 4861 592.6 No CNS disease
GSM299882 training set White Unknown Negative 1 None Female Negative Negative 1 80 Negative 95 Negative peripheral blood 428 248.0 No CNS disease
GSM299883 training set White Negative Negative 1 None Male Negative Negative 1 97 Negative 95 Negative bone marrow 4722 4.4 No CNS disease
GSM299884 test set White Negative Negative 1 Unknown Male Negative Negative 2 99 Negative 95 Negative bone marrow 3587 72.2 No CNS disease
GSM299885 test set White Negative Positive 1 None Female Negative Negative 2 98 Negative 90 Negative peripheral blood 5431 133.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299886 training set Hispanic or Latino Positive Negative 1 None Male Negative Negative 2 98 Negative 70 Negative bone marrow 3444 5.0 No CNS disease
GSM299887 test set Other Negative Negative 1 None Male Negative Negative 3 99 Negative 90 Negative peripheral blood 862 194.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299888 training set Hispanic or Latino Negative Negative 1 None Male Negative Negative 3 97 Negative 90 Negative bone marrow 6674 3.8 No CNS disease
GSM299889 training set White Negative Negative 1 None Male Negative Negative 3 70 Negative 95 Negative bone marrow 6323 15.4 No CNS disease
GSM299890 training set White Negative Negative 1 Unknown Male Negative Negative 4 98 Negative 90 Negative bone marrow 6219 16.5 No CNS disease
GSM29989 training set White Negative Negative 1 None Male Negative Positive 4 65 Negative 95 Negative bone marrow 2509 1.7 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299892 training set Hispanic or Latino Unknown Negative 1 None Female Positive Negative 4 100 Negative 95 Negative peripheral blood 1531 196.1 No CNS disease
GSM299893 test set Hispanic or Latino Unknown Negative 1 Unknown Male Negative Negative 1 100 Negative 85 Negative peripheral blood 5516 202.4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299894 training set White Negative Negative 1 None Male Negative Negative 1 82 Negative 90 Negative bone marrow 5513 2.5 No CNS disease
GSM299895 training set White Negative Negative 1 Unknown Male Negative Negative 2 62 Negative 95 Negative bone marrow 5842 27.4 No CNS disease
GSM299896 training set White Negative Negative 1 Downs Male Positive Negative 3 98 Negative 75 Negative peripheral blood 6496 9.1 No CNS disease
GSM299897 training set White Negative Positive 1 None Male Negative Negative 3 99 Negative 95 Negative peripheral blood 6511 515.0 No CNS disease
GSM299898 training set Hispanic or Latino Negative Negative 1 None Male Positive Negative 4 97 Negative 95 Negative bone marrow 1361 117.2 No CNS disease
GSM299899 training set White Unknown Negative 1 None Female Negative Negative 1 74 Negative 95 Negative bone marrow 835 115.0 No CNS disease
GSM299900 training set Hispanic or Latino Negative Positive 1 None Male Negative Negative 2 99 Negative 95 Negative peripheral blood 4774 246.4 No CNS disease
GSM29990 training set White Unknown Positive 1 None Female Negative Negative 2 95 Negative 95 Negative bone marrow 3311 489.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299902 training set White Negative Negative 1 None Male Negative Negative 3 100 Negative 80 Negative peripheral blood 6331 32.6 No CNS disease
GSM299903 training set White Unknown Positive 1 None Female Negative Negative 3 92 Negative 95 Negative bone marrow 398 135.0 No CNS disease
GSM299904 test set White Negative Negative 1 None Male Positive Negative 3 96 Negative 95 Negative bone marrow 5631 67.2 No CNS disease
GSM299905 test set White Unknown Negative 1 None Female Negative Negative 1 96 Negative 95 Negative bone marrow 944 12.1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299906 training set White Negative Negative 1 None Male Positive Negative 1 90 Negative 90 Negative bone marrow 4940 8.0 No CNS disease
GSM299907 training set White Negative Negative 1 Downs Female Negative Negative 2 96 Negative 95 Negative bone marrow 5721 88.9 No CNS disease
GSM299908 training set White Negative Negative 1 Unknown Male Negative Negative 3 98 Negative 95 Negative peripheral blood 6114 80.9 No CNS disease
GSM299909 training set White Negative Negative 1 None Male Negative Negative 4 97 Negative 95 Negative bone marrow 5086 36.2 No CNS disease
GSM299910 test set White Negative Negative 1 None Male Negative Negative 4 90 Negative 95 Negative bone marrow 5359 80.8 No CNS disease
GSM2999 training set White Negative Negative 1 None Male Negative Negative 2 95 Negative 90 Negative bone marrow 1167 156.0 No CNS disease
GSM299912 training set White Negative Negative 1 Unknown Female Negative Negative 2 82 Negative 95 Negative peripheral blood 4090 289.3 No CNS disease
GSM299913 test set White Negative Positive 1 None Male Negative Negative 3 90 Negative 95 Negative peripheral blood 792 237.0 No CNS disease
GSM299914 training set White Negative Negative 1 None Male Negative Negative 4 99 Negative 95 Negative bone marrow 6733 81.4 No CNS disease
GSM299915 training set Asian Negative Negative 2 Unknown Male Negative Negative 5 98 Negative 95 Negative bone marrow 2875 351.3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299916 training set Hispanic or Latino Negative Negative 2 Other Male Negative Positive 5 99 Negative 80 Negative peripheral blood 449 59.9 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299917 training set White Negative Negative 4 Unknown Male Negative Negative 6 100 Negative 95 Negative bone marrow 904 137.8 No CNS disease
GSM299918 test set White Negative Negative 2 None Male Negative Negative 6 98 Negative 90 Negative bone marrow 1426 138.4 No CNS disease
GSM299919 training set Hispanic or Latino Unknown Negative 2 None Female Negative Negative 6 98 Negative 95 Negative peripheral blood 4469 478.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299920 training set Hispanic or Latino Negative Negative 2 None Male Negative Negative 7 88 Negative 95 Negative bone marrow 6266 34.9 No CNS disease
GSM29992 training set White Negative Negative 2 None Male Negative Negative 8 100 Negative 70 Negative bone marrow 6306 22.8 No CNS disease
GSM299922 training set White Unknown Negative 2 None Female Negative Negative 8 100 Negative 90 Negative peripheral blood 727 109.5 No CNS disease
GSM299923 training set Hispanic or Latino Negative Negative 2 None Male Negative Negative 5 99 Negative 95 Negative bone marrow 5867 21.1 No CNS disease
GSM299924 training set Asian Unknown Negative 2 None Female Negative Negative 5 95 Negative 90 Negative bone marrow 6733 102.0 No CNS disease
GSM299925 training set White Negative Negative 4 None Male Negative Negative 6 98 Negative 90 Negative peripheral blood 5495 96.2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299926 training set unknown Negative Negative 2 None Male Negative Negative 6 99 Negative 95 Negative bone marrow 6063 2.3 No CNS disease
GSM299927 test set Hispanic or Latino Unknown Negative 2 None Female Negative Negative 6 87 Negative 95 Negative bone marrow 5922 27.0 No CNS disease
GSM299928 training set White Unknown Negative 2 Downs Female Negative Negative 7 99 Negative 90 Negative peripheral blood 6922 68.9 No CNS disease
GSM299929 training set White Unknown Negative 2 None Female Negative Negative 8 100 Negative 95 Negative bone marrow 531 119.0 No CNS disease
GSM299930 test set White Unknown Negative 2 Unknown Female Negative Negative 5 97 Negative 95 Negative bone marrow 4106 210.0 No CNS disease
GSM29993 training set Hispanic or Latino Negative Negative 2 None Male Negative Negative 5 91 Negative 95 Negative bone marrow 2027 199.0 No CNS disease
GSM299932 training set Asian Unknown Negative 2 Unknown Female Positive Negative 6 96 Negative 90 Negative peripheral blood 1191 175.5 No CNS disease
GSM299933 test set Hispanic or Latino Unknown Negative 6 None Female Negative Negative 7 94 Negative 95 Negative peripheral blood 5310 92.7 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299934 training set White Negative Negative 2 None Male Negative Negative 7 83 Negative 95 Negative peripheral blood 5163 270.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299935 test set White Unknown Negative 2 None Female Positive Negative 7 66 Negative 95 Negative bone marrow 977 115.1 No CNS disease
GSM299936 training set White Negative Negative 2 Unknown Male Negative Negative 8 89 Negative 95 Negative bone marrow 4807 12.7 No CNS disease
GSM299937 training set White Negative Negative 2 None Male Negative Negative 5 99 Negative 95 Negative peripheral blood 5564 112.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299938 test set White Negative Negative 2 Unknown Male Negative Negative 5 60 Negative 95 Negative bone marrow 4305 40.0 No CNS disease
GSM299939 training set White Unknown Negative 6 Unknown Female Negative Negative 6 94 Negative 95 Negative bone marrow 4717 62.3 No CNS disease
GSM299940 test set Hispanic or Latino Negative Negative 4 None Male Negative Negative 7 99 Negative 95 Negative bone marrow 4657 33.1 No CNS disease
GSM29994 training set White Unknown Negative 2 None Female Negative Positive 7 79 Negative 90 Negative bone marrow 1429 192.0 No CNS disease
GSM299942 training set Hispanic or Latino Negative Negative 4 None Female Negative Negative 8 98 Negative 65 Negative peripheral blood 6413 16.6 No CNS disease
GSM299943 training set White Negative Negative 2 None Female Negative Negative 8 92 Negative 95 Negative peripheral blood 2133 17.5 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299944 test set Hispanic or Latino Unknown Positive 2 Unknown Female Negative Negative 8 69 Negative 70 Negative peripheral blood 434 88.5 No CNS disease
GSM299945 training set Asian Negative Negative 2 Unknown Male Negative Negative 5 87 Negative 90 Negative bone marrow 4935 24.5 No CNS disease
GSM299946 training set White Negative Negative 2 None Female Negative Negative 5 100 Negative 85 Negative peripheral blood 6984 30.4 No CNS disease
GSM299947 test set White Unknown Negative 2 None Female Negative Negative 5 65 Negative 90 Negative bone marrow 1068 190.0 No CNS disease
GSM299948 test set Hispanic or Latino Negative Negative 4 None Male Negative Negative 6 99 Negative 95 Negative bone marrow 5877 66.9 No CNS disease
GSM299949 training set White Negative Positive 6 None Male Negative Negative 7 87 Negative 95 Negative bone marrow 5127 555.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299950 training set White Negative Positive 4 None Male Negative Negative 7 95 Negative 90 Negative bone marrow 410 51.3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM29995 training set White Negative Negative 2 Unknown Male Negative Negative 7 97 Negative 95 Negative bone marrow 5408 1.2 No CNS disease
GSM299952 test set Black or African American Negative Negative 2 Unknown Male Negative Negative 8 96 Negative 95 Negative bone marrow 2876 142.4 No CNS disease
GSM299953 training set White Negative Negative 2 Unknown Male Negative Negative 8 87 Negative 95 Negative bone marrow 697 110.9 No CNS disease
GSM299954 test set Hispanic or Latino Unknown Negative 2 Downs Female Negative Negative 5 95 Negative 90 Negative peripheral blood 2223 202.0 No CNS disease
GSM299955 test set White Unknown Positive 2 None Female Negative Negative 5 97 Negative 95 Negative peripheral blood 7028 259.8 No CNS disease
GSM299956 training set White Negative Negative 2 None Male Negative Negative 5 26 Negative -1 Unknown bone marrow 5177 166.5 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299957 training set Hispanic or Latino Unknown Positive 2 None Female Negative Negative 6 91 Negative 90 Negative peripheral blood 1038 114.0 No CNS disease
GSM299958 test set Hispanic or Latino Unknown Negative 2 Downs Female Negative Negative 6 100 Negative 95 Negative peripheral blood 5008 321.2 No CNS disease
GSM299959 training set Hispanic or Latino Unknown Negative 2 None Female Negative Negative 7 71 Negative 95 Negative bone marrow 5925 19.5 No CNS disease
GSM299960 training set Hispanic or Latino Negative Negative 2 None Male Negative Negative 7 93 Negative 95 Negative peripheral blood 1258 145.0 No CNS disease
GSM29996 test set Hispanic or Latino Unknown Negative 2 None Female Positive Negative 8 85 Negative 90 Negative bone marrow 1956 148.2 No CNS disease
GSM299962 training set White Unknown Positive 4 None Female Negative Negative 6 97 Negative 90 Negative peripheral blood 4560 108.0 No CNS disease
GSM299963 training set White Negative Positive 2 None Male Negative Negative 7 84 Negative 90 Negative peripheral blood 966 37.3 No CNS disease
GSM299964 test set White Negative Negative 2 None Male Negative Unknown 7 100 Negative 95 Negative bone marrow 4585 12.0 No CNS disease
GSM299965 training set White Unknown Negative 2 Unknown Female Negative Negative 5 98 Negative 90 Negative bone marrow 4863 65.8 No CNS disease
GSM299966 training set White Negative Negative 2 None Male Negative Negative 6 100 Negative 95 Negative peripheral blood 369 325.0 No CNS disease
GSM299967 test set White Negative Negative 2 None Male Negative Negative 7 20 Negative -1 Negative bone marrow 5853 2.3 No CNS disease
GSM299968 training set White Negative Negative 2 None Male Negative Negative 8 99 Negative 80 Negative bone marrow 6335 13.3 No CNS disease
GSM299969 test set American Indian or Alaska native Negative Negative 2 None Male Negative Negative 8 97 Negative 95 Negative peripheral blood 881 106.0 No CNS disease
GSM299970 training set White Unknown Negative 3 None Female Negative Negative 9 100 Negative 95 Negative peripheral blood 2786 105.7 No CNS disease
GSM29997 training set White Negative Negative 3 None Male Negative Negative 10 94 Negative 80 Negative peripheral blood 6306 16.7 No CNS disease
GSM299972 test set White Negative Negative 3 None Male Negative Negative 10 98 Negative 90 Negative bone marrow 2519 112.0 No CNS disease
GSM299973 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 11 66 Negative 95 Negative bone marrow 6142 18.5 No CNS disease
GSM299974 test set Black or African American Negative Negative 3 None Male Negative Negative 11 96 Negative 80 Negative bone marrow 5343 30.2 No CNS disease
GSM299975 test set White Negative Positive 3 None Male Negative Negative 11 96 Negative 90 Negative bone marrow 852 139.0 No CNS disease
GSM299976 training set Hispanic or Latino Negative Positive 3 None Male Negative Negative 12 94 Negative 95 Negative bone marrow 462 17.3 No CNS disease
GSM299977 training set Black or African American Unknown Negative 3 Unknown Female Positive Negative 12 75 Negative 90 Negative peripheral blood 5797 39.6 No CNS disease
GSM299978 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 9 97 Negative 95 Negative peripheral blood 4253 236.4 No CNS disease
GSM299979 training set Hispanic or Latino Unknown Negative 3 None Female Negative Negative 9 99 Negative 75 Negative peripheral blood 705 137.2 No CNS disease
GSM299980 training set White Negative Negative 3 Unknown Male Negative Negative 10 99 Negative 70 Negative peripheral blood 7478 28.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM29998 training set White Negative Negative 3 Unknown Male Negative Negative 10 100 Negative 90 Negative peripheral blood 2191 272.0 No CNS disease
GSM299982 training set Hispanic or Latino Unknown Negative 3 None Female Negative Negative 11 98 Negative 90 Negative bone marrow 1275 214.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299983 test set White Negative Negative 3 None Male Negative Negative 11 96 Negative 95 Negative bone marrow 5184 58.0 No CNS disease
GSM299984 training set Other Negative Negative 3 None Male Negative Negative 11 59 Negative -1 Negative bone marrow 5542 7.9 No CNS disease
GSM299985 test set White Negative Negative 3 None Male Negative Negative 12 64 Negative 95 Negative bone marrow 5242 3.4 No CNS disease
GSM299986 training set White Unknown Negative 3 Unknown Female Negative Negative 12 99 Negative 75 Negative peripheral blood 1313 69.4 No CNS disease
GSM299987 training set White Unknown Negative 3 None Female Negative Negative 9 94 Negative 95 Negative bone marrow 1751 238.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299988 training set White Unknown Negative 3 None Female Negative Negative 9 98 Negative 90 Negative bone marrow 4329 179.0 No CNS disease
GSM299989 training set White Negative Negative 3 None Male Negative Negative 9 86 Negative 90 Positive bone marrow 976 7.7 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM299990 test set Hispanic or Latino Negative Negative 3 None Female Positive Negative 10 91 Negative 95 Negative bone marrow 5300 98.2 No CNS disease
GSM29999 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 11 81 Negative 90 Negative bone marrow 4307 44.9 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299992 training set White Unknown Negative 3 None Female Negative Negative 12 98 Negative 60 Negative peripheral blood 4324 35.7 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM299993 test set White Unknown Negative 3 Unknown Female Positive Negative 9 97 Negative 95 Negative bone marrow 1033 118.1 No CNS disease
GSM299994 test set Hispanic or Latino Negative Negative 3 None Male Negative Negative 9 31 Negative -1 Negative bone marrow 6052 6.4 No CNS disease
GSM299995 training set White Negative Negative 3 Unknown Male Negative Unknown 10 85 Unknown 95 Negative bone marrow 4157 77.6 No CNS disease
GSM299996 training set Asian Unknown Negative 3 None Male Positive Negative 11 64 Negative 90 Negative bone marrow 5025 73.1 No CNS disease
GSM299997 training set White Negative Negative 3 None Male Negative Negative 12 99 Negative 95 Negative bone marrow 6263 1.0 No CNS disease
GSM299998 training set White Negative Positive 3 None Male Negative Negative 9 96 Negative 90 Negative bone marrow 5664 22.0 No CNS disease
GSM299999 test set Other Negative Negative 3 None Male Negative Negative 9 95 Negative 95 Negative bone marrow 4776 1.3 No CNS disease
GSM300000 training set White Unknown Negative 3 None Female Negative Negative 10 99 Negative 95 Negative peripheral blood 2192 209.6 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM30000 training set Black or African American Negative Negative 3 None Male Negative Negative 11 94 Negative 95 Negative bone marrow 5954 15.5 No CNS disease
GSM300002 training set White Negative Negative 3 None Male Negative Negative 11 67 Negative 95 Negative bone marrow 2038 193.0 No CNS disease
GSM300003 training set White Unknown Negative 3 None Female Negative Negative 12 96 Negative 95 Positive bone marrow 6032 59.2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300004 training set White Positive Negative 3 Unknown Male Negative Negative 12 98 Negative 85 Negative peripheral blood 655 9.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300005 training set White Negative Negative 3 None Male Negative Negative 12 94 Negative 90 Negative bone marrow 4759 2.4 No CNS disease
GSM300006 test set Hispanic or Latino Unknown Negative 3 Unknown Female Negative Negative 9 97 Negative 95 Negative bone marrow 2769 3.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300007 training set American Indian or Alaska native Unknown Negative 3 None Male Negative Negative 9 94 Negative 40 Negative peripheral blood 4972 6.3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300008 test set Black or African American Negative Negative 3 Unknown Male Negative Negative 9 98 Negative 95 Negative bone marrow 4815 31.4 No CNS disease
GSM300009 test set White Negative Negative 3 None Male Negative Negative 10 98 Negative 95 Negative peripheral blood 6315 245.0 No CNS disease
GSM300010 training set White Negative Negative 3 Downs Male Negative Negative 10 95 Negative 95 Negative bone marrow 4276 24.4 No CNS disease
GSM3000 training set White Negative Negative 3 None Male Negative Negative 10 99 Negative 95 Negative peripheral blood 5759 33.9 No CNS disease
GSM300012 test set White Negative Negative 3 None Male Negative Negative 11 44 Negative -1 Negative bone marrow 6487 7.6 No CNS disease
GSM300013 test set Black or African American Negative Negative 3 None Male Positive Negative 11 99 Negative 95 Negative peripheral blood 1771 152.7 No CNS disease
GSM300014 training set White Negative Negative 3 None Male Negative Negative 12 89 Negative 95 Negative bone marrow 515 124.0 No CNS disease
GSM300015 training set White Unknown Negative 3 None Female Negative Negative 12 96 Negative 95 Negative bone marrow 6090 24.8 No CNS disease
GSM300016 training set White Negative Negative 3 Unknown Male Negative Negative 9 99 Negative 95 Negative bone marrow 6633 1.9 No CNS disease
GSM300017 test set Hispanic or Latino Negative Negative 3 None Male Negative Negative 9 97 Negative 95 Negative bone marrow 5194 96.5 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300018 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 10 96 Negative 95 Negative bone marrow 6468 7.0 No CNS disease
GSM300019 test set White Negative Negative 3 None Male Negative Negative 11 92 Negative 90 Negative bone marrow 6062 17.0 No CNS disease
GSM300020 test set Other Unknown Positive 3 Unknown Female Negative Negative 11 95 Negative 90 Negative bone marrow 777 6.8 No CNS disease
GSM30002 test set White Unknown Negative 3 None Female Positive Negative 12 100 Negative 85 Negative bone marrow 5889 49.6 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300022 test set White Negative Negative 3 None Male Negative Negative 12 95 Negative 95 Negative peripheral blood 893 455.4 No CNS disease
GSM300023 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 9 98 Negative 95 Negative bone marrow 4955 31.5 No CNS disease
GSM300024 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 10 99 Negative 95 Negative peripheral blood 5081 307.0 No CNS disease
GSM300025 training set Hispanic or Latino Unknown Negative 3 Downs Female Negative Negative 10 98 Negative 90 Negative bone marrow 4665 95.2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300026 training set Hispanic or Latino Negative Negative 3 None Male Negative Negative 11 97 Negative 95 Negative peripheral blood 988 958.8 No CNS disease
GSM300027 training set White Negative Negative 3 None Male Positive Negative 12 59 Negative -1 Negative bone marrow 5890 9.4 No CNS disease
GSM300028 test set Black or African American Unknown Negative 3 None Female Negative Negative 12 96 Negative 95 Negative bone marrow 6351 13.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300029 test set White Negative Negative 4 Unknown Male Negative Negative 13 86 Negative 95 Negative bone marrow 1475 212.3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300030 training set Hispanic or Latino Negative Negative 4 Unknown Male Negative Negative 13 99 Negative 90 Negative bone marrow 6036 8.8 No CNS disease
GSM30003 training set White Unknown Negative 1 None Female Negative Negative 4 96 Negative 95 Negative bone marrow 5217 135.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300032 training set Black or African American Negative Negative 1 None Male Negative Negative 4 97 Negative 95 Negative bone marrow 523 82.9 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300033 training set White Unknown Negative 3 Unknown Female Positive Negative 11 99 Negative 95 Negative peripheral blood 1011 302.1 No CNS disease
GSM300034 test set Native Hawaiian or other Pacific Islander Negative Negative 3 None Male Negative Negative 11 98 Negative 90 Negative bone marrow 6107 18.3 No CNS disease
GSM300035 training set White Negative Negative 4 None Male Negative Negative 13 95 Negative 95 Negative peripheral blood 768 138.8 No CNS disease
GSM300036 training set White Unknown Negative 4 None Female Positive Negative 13 84 Negative 90 Negative peripheral blood 5670 37.2 No CNS disease
GSM300037 training set Hispanic or Latino Negative Negative 6 None Male Negative Negative 11 99 Negative 95 Negative peripheral blood 6666 114.6 No CNS disease
GSM300038 training set Hispanic or Latino Unknown Negative 4 None Female Positive Negative 13 96 Negative 85 Negative bone marrow 3901 136.6 No CNS disease
GSM300039 training set White Negative Negative 7 None Female Negative Negative 14 51 Negative -1 Negative peripheral blood 728 138.4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300040 test set White Unknown Negative 7 None Female Negative Negative 14 79 Negative 95 Negative bone marrow 1058 141.0 No CNS disease
GSM30004 test set Hispanic or Latino Unknown Negative 7 Unknown Female Negative Negative 14 76 Negative 95 Positive bone marrow 1323 30.6 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300042 training set Hispanic or Latino Negative Negative 7 None Male Negative Negative 14 84 Negative 95 Negative bone marrow 650 102.5 No CNS disease
GSM300043 test set White Negative Negative 8 None Male Negative Negative 15 99 Negative 85 Negative bone marrow 5821 1.9 No CNS disease
GSM300044 training set White Negative Negative 8 Unknown Male Negative Negative 15 100 Negative 40 Negative peripheral blood 6202 2.3 No CNS disease
GSM300045 training set American Indian or Alaska native Negative Negative 8 None Female Negative Negative 15 98 Negative 90 Negative bone marrow 6119 2.3 No CNS disease
GSM300046 training set White Positive Negative 8 None Male Negative Negative 15 99 Negative 60 Negative peripheral blood 4571 6.9 No CNS disease
GSM300047 training set Hispanic or Latino Negative Negative 8 None Male Negative Negative 15 93 Negative 60 Positive peripheral blood 1896 4.1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300048 training set White Negative Negative 8 None Female Negative Negative 15 97 Negative 75 Negative bone marrow 7461 3.8 No CNS disease
GSM300049 test set White Negative Negative 8 None Male Negative Negative 15 96 Negative 65 Negative bone marrow 6634 11.1 No CNS disease
GSM300050 training set White Negative Negative 8 None Male Negative Negative 15 83 Negative 80 Negative peripheral blood 5097 6.3 No CNS disease
GSM30005 test set Hispanic or Latino Negative Negative 8 None Male Negative Negative 15 96 Negative 95 Negative bone marrow 5532 5.5 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300052 test set Black or African American Positive Negative 8 None Male Negative Negative 15 47 Negative -1 Positive peripheral blood 1914 45.1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin
GSM300053 training set White Negative Negative 8 None Male Positive Negative 15 72 Negative 90 Negative peripheral blood 4434 42.1 No CNS disease
GSM300054 test set Asian Negative Negative 8 None Male Positive Negative 15 93 Negative 50 Negative peripheral blood 4782 4.4 No CNS disease
GSM300055 test set White Negative Negative 8 None Male Negative Negative 15 84 Negative 90 Negative bone marrow 5232 1.1 No CNS disease
GSM300056 test set Black or African American Negative Negative 8 None Male Positive Negative 15 83 Negative 80 Negative peripheral blood 6500 17.8 No CNS disease
GSM300057 training set White Unknown Positive 9 None Male Negative Negative 16 50 Negative -1 Negative bone marrow 585 7.5 No CNS disease
GSM300058 test set Black or African American Negative Negative 9 None Male Negative Negative 16 98 Negative 95 Negative bone marrow 6539 2.6 No CNS disease
GSM300059 test set White Negative Negative 9 None Female Negative Negative 16 100 Negative 85 Negative bone marrow 5991 5.2 No CNS disease
GSM300060 training set White Negative Negative 9 None Male Negative Negative 16 93 Negative 70 Negative peripheral blood 6479 31.9 No CNS disease
GSM30006 training set Black or African American Negative Negative 9 None Male Negative Negative 16 98 Negative 90 Negative bone marrow 5183 23.0 No CNS disease
GSM300062 training set White Negative Negative 9 None Male Negative Negative 16 46 Negative -1 Negative peripheral blood 713 110.3 No CNS disease
GSM300063 test set White Unknown Positive 9 None Male Negative Negative 16 82 Negative 90 Negative bone marrow 1704 85.1 No CNS disease
GSM300064 test set White Negative Negative 9 Unknown Male Negative Negative 16 99 Negative 95 Negative bone marrow 5594 2.8 No CNS disease
GSM300065 training set White Negative Negative 9 Unknown Male Negative Negative 16 88 Negative 95 Negative bone marrow 5857 13.3 No CNS disease
GSM300066 test set Hispanic or Latino Unknown Negative 9 None Female Positive Negative 16 81 Negative 95 Negative bone marrow 4017 3.5 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement
GSM300067 training set White Negative Negative 9 Unknown Male Negative Negative 16 85 Negative 95 Negative bone marrow 4918 5.5 No CNS disease
GSM300068 training set Hispanic or Latino Negative Negative 10 Unknown Male Negative Negative 18 66 Negative 90 Negative bone marrow 5349 147.6 No CNS disease

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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