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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample RACE CONGENITAL ABNORMALITY TRAINING OR TEST SET CNS STATUS AMPLIFICATION SET GENDER MLL BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) TISSUE TYPE SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE TESTICULAR INVOLVEMENT AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER TRISOMY 4 AND 10
GSM299862 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 Female Positive Negative Negative 1 90 Negative peripheral blood 100 Unknown 3953 175.0 Negative
GSM299863 Black or African American None training set No CNS disease 1 Male Negative Negative Negative 1 90 Negative peripheral blood 100 Negative 1976 142.0 Negative
GSM299864 Hispanic or Latino None training set No CNS disease 1 Male Negative Negative Negative 2 70 Negative peripheral blood 99 Negative 5250 220.7 Negative
GSM299865 White None test set No CNS disease 1 Male Negative Negative Negative 2 95 Negative peripheral blood 88 Negative 577 129.0 Negative
GSM299866 Hispanic or Latino None training set No CNS disease 1 Male Negative Negative Negative 3 95 Negative bone marrow 95 Negative 4609 26.0 Negative
GSM299867 White None training set No CNS disease 1 Male Negative Negative Negative 3 80 Negative bone marrow 68 Negative 5289 14.7 Negative
GSM299868 Asian None training set No CNS disease 1 Male Negative Negative Negative 4 -1 Negative bone marrow 71 Negative 3987 68.6 Negative
GSM299869 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Male Negative Negative Negative 4 90 Negative bone marrow 98 Negative 4856 21.4 Negative
GSM299870 White None test set No CNS disease 1 Male Negative Negative Negative 4 1 Negative bone marrow 99 Negative 4678 2.4 Negative
GSM29987 White Unknown training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Male Negative Negative Negative 1 75 Negative bone marrow 68 Negative 796 21.0 Negative
GSM299872 White None training set No CNS disease 1 Female Positive Negative Negative 1 85 Negative peripheral blood 100 Unknown 4071 125.8 Negative
GSM299873 White Unknown training set No CNS disease 1 Male Negative Negative Negative 2 95 Negative bone marrow 99 Negative 5223 29.9 Negative
GSM299874 Hispanic or Latino Unknown training set No CNS disease 1 Female Negative Negative Negative 3 95 Negative peripheral blood 99 Unknown 5118 217.2 Negative
GSM299875 unknown None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 Male Negative Negative Negative 3 90 Negative peripheral blood 97 Negative 5219 180.0 Negative
GSM299876 White Downs training set No CNS disease 1 Female Negative Negative Negative 4 95 Negative bone marrow 98 Unknown 1429 118.0 Negative
GSM299877 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 Female Negative Negative Negative 1 95 Negative peripheral blood 97 Unknown 3179 314.8 Negative
GSM299878 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Female Negative Negative Negative 1 -1 Negative bone marrow 58 Unknown 1450 5.2 Negative
GSM299879 White None training set No CNS disease 1 Male Negative Negative Negative 1 95 Negative bone marrow 91 Negative 5278 113.5 Negative
GSM299880 White None training set No CNS disease 1 Male Negative Negative Negative 2 85 Positive bone marrow 98 Negative 5330 5.8 Negative
GSM29988 Hispanic or Latino Unknown test set No CNS disease 1 Female Negative Negative Negative 4 90 Negative peripheral blood 99 Unknown 4861 592.6 Negative
GSM299882 White None training set No CNS disease 1 Female Negative Negative Negative 1 95 Negative peripheral blood 80 Unknown 428 248.0 Negative
GSM299883 White None training set No CNS disease 1 Male Negative Negative Negative 1 95 Negative bone marrow 97 Negative 4722 4.4 Negative
GSM299884 White Unknown test set No CNS disease 1 Male Negative Negative Negative 2 95 Negative bone marrow 99 Negative 3587 72.2 Negative
GSM299885 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Female Positive Negative Negative 2 90 Negative peripheral blood 98 Negative 5431 133.0 Negative
GSM299886 Hispanic or Latino None training set No CNS disease 1 Male Negative Negative Negative 2 70 Negative bone marrow 98 Positive 3444 5.0 Negative
GSM299887 Other None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Male Negative Negative Negative 3 90 Negative peripheral blood 99 Negative 862 194.0 Negative
GSM299888 Hispanic or Latino None training set No CNS disease 1 Male Negative Negative Negative 3 90 Negative bone marrow 97 Negative 6674 3.8 Negative
GSM299889 White None training set No CNS disease 1 Male Negative Negative Negative 3 95 Negative bone marrow 70 Negative 6323 15.4 Negative
GSM299890 White Unknown training set No CNS disease 1 Male Negative Negative Negative 4 90 Negative bone marrow 98 Negative 6219 16.5 Negative
GSM29989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Male Negative Negative Positive 4 95 Negative bone marrow 65 Negative 2509 1.7 Negative
GSM299892 Hispanic or Latino None training set No CNS disease 1 Female Negative Negative Negative 4 95 Positive peripheral blood 100 Unknown 1531 196.1 Negative
GSM299893 Hispanic or Latino Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 Male Negative Negative Negative 1 85 Negative peripheral blood 100 Unknown 5516 202.4 Negative
GSM299894 White None training set No CNS disease 1 Male Negative Negative Negative 1 90 Negative bone marrow 82 Negative 5513 2.5 Negative
GSM299895 White Unknown training set No CNS disease 1 Male Negative Negative Negative 2 95 Negative bone marrow 62 Negative 5842 27.4 Negative
GSM299896 White Downs training set No CNS disease 1 Male Negative Negative Negative 3 75 Positive peripheral blood 98 Negative 6496 9.1 Negative
GSM299897 White None training set No CNS disease 1 Male Positive Negative Negative 3 95 Negative peripheral blood 99 Negative 6511 515.0 Negative
GSM299898 Hispanic or Latino None training set No CNS disease 1 Male Negative Negative Negative 4 95 Positive bone marrow 97 Negative 1361 117.2 Negative
GSM299899 White None training set No CNS disease 1 Female Negative Negative Negative 1 95 Negative bone marrow 74 Unknown 835 115.0 Negative
GSM299900 Hispanic or Latino None training set No CNS disease 1 Male Positive Negative Negative 2 95 Negative peripheral blood 99 Negative 4774 246.4 Negative
GSM29990 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 Female Positive Negative Negative 2 95 Negative bone marrow 95 Unknown 3311 489.0 Negative
GSM299902 White None training set No CNS disease 1 Male Negative Negative Negative 3 80 Negative peripheral blood 100 Negative 6331 32.6 Negative
GSM299903 White None training set No CNS disease 1 Female Positive Negative Negative 3 95 Negative bone marrow 92 Unknown 398 135.0 Negative
GSM299904 White None test set No CNS disease 1 Male Negative Negative Negative 3 95 Positive bone marrow 96 Negative 5631 67.2 Negative
GSM299905 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Female Negative Negative Negative 1 95 Negative bone marrow 96 Unknown 944 12.1 Negative
GSM299906 White None training set No CNS disease 1 Male Negative Negative Negative 1 90 Positive bone marrow 90 Negative 4940 8.0 Negative
GSM299907 White Downs training set No CNS disease 1 Female Negative Negative Negative 2 95 Negative bone marrow 96 Negative 5721 88.9 Negative
GSM299908 White Unknown training set No CNS disease 1 Male Negative Negative Negative 3 95 Negative peripheral blood 98 Negative 6114 80.9 Negative
GSM299909 White None training set No CNS disease 1 Male Negative Negative Negative 4 95 Negative bone marrow 97 Negative 5086 36.2 Negative
GSM299910 White None test set No CNS disease 1 Male Negative Negative Negative 4 95 Negative bone marrow 90 Negative 5359 80.8 Negative
GSM2999 White None training set No CNS disease 1 Male Negative Negative Negative 2 90 Negative bone marrow 95 Negative 1167 156.0 Negative
GSM299912 White Unknown training set No CNS disease 1 Female Negative Negative Negative 2 95 Negative peripheral blood 82 Negative 4090 289.3 Negative
GSM299913 White None test set No CNS disease 1 Male Positive Negative Negative 3 95 Negative peripheral blood 90 Negative 792 237.0 Negative
GSM299914 White None training set No CNS disease 1 Male Negative Negative Negative 4 95 Negative bone marrow 99 Negative 6733 81.4 Negative
GSM299915 Asian Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 Male Negative Negative Negative 5 95 Negative bone marrow 98 Negative 2875 351.3 Negative
GSM299916 Hispanic or Latino Other training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 Male Negative Negative Positive 5 80 Negative peripheral blood 99 Negative 449 59.9 Negative
GSM299917 White Unknown training set No CNS disease 4 Male Negative Negative Negative 6 95 Negative bone marrow 100 Negative 904 137.8 Negative
GSM299918 White None test set No CNS disease 2 Male Negative Negative Negative 6 90 Negative bone marrow 98 Negative 1426 138.4 Negative
GSM299919 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 Female Negative Negative Negative 6 95 Negative peripheral blood 98 Unknown 4469 478.0 Negative
GSM299920 Hispanic or Latino None training set No CNS disease 2 Male Negative Negative Negative 7 95 Negative bone marrow 88 Negative 6266 34.9 Negative
GSM29992 White None training set No CNS disease 2 Male Negative Negative Negative 8 70 Negative bone marrow 100 Negative 6306 22.8 Negative
GSM299922 White None training set No CNS disease 2 Female Negative Negative Negative 8 90 Negative peripheral blood 100 Unknown 727 109.5 Negative
GSM299923 Hispanic or Latino None training set No CNS disease 2 Male Negative Negative Negative 5 95 Negative bone marrow 99 Negative 5867 21.1 Negative
GSM299924 Asian None training set No CNS disease 2 Female Negative Negative Negative 5 90 Negative bone marrow 95 Unknown 6733 102.0 Negative
GSM299925 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 Male Negative Negative Negative 6 90 Negative peripheral blood 98 Negative 5495 96.2 Negative
GSM299926 unknown None training set No CNS disease 2 Male Negative Negative Negative 6 95 Negative bone marrow 99 Negative 6063 2.3 Negative
GSM299927 Hispanic or Latino None test set No CNS disease 2 Female Negative Negative Negative 6 95 Negative bone marrow 87 Unknown 5922 27.0 Negative
GSM299928 White Downs training set No CNS disease 2 Female Negative Negative Negative 7 90 Negative peripheral blood 99 Unknown 6922 68.9 Negative
GSM299929 White None training set No CNS disease 2 Female Negative Negative Negative 8 95 Negative bone marrow 100 Unknown 531 119.0 Negative
GSM299930 White Unknown test set No CNS disease 2 Female Negative Negative Negative 5 95 Negative bone marrow 97 Unknown 4106 210.0 Negative
GSM29993 Hispanic or Latino None training set No CNS disease 2 Male Negative Negative Negative 5 95 Negative bone marrow 91 Negative 2027 199.0 Negative
GSM299932 Asian Unknown training set No CNS disease 2 Female Negative Negative Negative 6 90 Positive peripheral blood 96 Unknown 1191 175.5 Negative
GSM299933 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 6 Female Negative Negative Negative 7 95 Negative peripheral blood 94 Unknown 5310 92.7 Negative
GSM299934 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 Male Negative Negative Negative 7 95 Negative peripheral blood 83 Negative 5163 270.0 Negative
GSM299935 White None test set No CNS disease 2 Female Negative Negative Negative 7 95 Positive bone marrow 66 Unknown 977 115.1 Negative
GSM299936 White Unknown training set No CNS disease 2 Male Negative Negative Negative 8 95 Negative bone marrow 89 Negative 4807 12.7 Negative
GSM299937 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 Male Negative Negative Negative 5 95 Negative peripheral blood 99 Negative 5564 112.0 Negative
GSM299938 White Unknown test set No CNS disease 2 Male Negative Negative Negative 5 95 Negative bone marrow 60 Negative 4305 40.0 Negative
GSM299939 White Unknown training set No CNS disease 6 Female Negative Negative Negative 6 95 Negative bone marrow 94 Unknown 4717 62.3 Negative
GSM299940 Hispanic or Latino None test set No CNS disease 4 Male Negative Negative Negative 7 95 Negative bone marrow 99 Negative 4657 33.1 Negative
GSM29994 White None training set No CNS disease 2 Female Negative Negative Positive 7 90 Negative bone marrow 79 Unknown 1429 192.0 Negative
GSM299942 Hispanic or Latino None training set No CNS disease 4 Female Negative Negative Negative 8 65 Negative peripheral blood 98 Negative 6413 16.6 Negative
GSM299943 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 Female Negative Negative Negative 8 95 Negative peripheral blood 92 Negative 2133 17.5 Negative
GSM299944 Hispanic or Latino Unknown test set No CNS disease 2 Female Positive Negative Negative 8 70 Negative peripheral blood 69 Unknown 434 88.5 Negative
GSM299945 Asian Unknown training set No CNS disease 2 Male Negative Negative Negative 5 90 Negative bone marrow 87 Negative 4935 24.5 Negative
GSM299946 White None training set No CNS disease 2 Female Negative Negative Negative 5 85 Negative peripheral blood 100 Negative 6984 30.4 Negative
GSM299947 White None test set No CNS disease 2 Female Negative Negative Negative 5 90 Negative bone marrow 65 Unknown 1068 190.0 Negative
GSM299948 Hispanic or Latino None test set No CNS disease 4 Male Negative Negative Negative 6 95 Negative bone marrow 99 Negative 5877 66.9 Negative
GSM299949 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 6 Male Positive Negative Negative 7 95 Negative bone marrow 87 Negative 5127 555.0 Negative
GSM299950 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 Male Positive Negative Negative 7 90 Negative bone marrow 95 Negative 410 51.3 Negative
GSM29995 White Unknown training set No CNS disease 2 Male Negative Negative Negative 7 95 Negative bone marrow 97 Negative 5408 1.2 Negative
GSM299952 Black or African American Unknown test set No CNS disease 2 Male Negative Negative Negative 8 95 Negative bone marrow 96 Negative 2876 142.4 Negative
GSM299953 White Unknown training set No CNS disease 2 Male Negative Negative Negative 8 95 Negative bone marrow 87 Negative 697 110.9 Negative
GSM299954 Hispanic or Latino Downs test set No CNS disease 2 Female Negative Negative Negative 5 90 Negative peripheral blood 95 Unknown 2223 202.0 Negative
GSM299955 White None test set No CNS disease 2 Female Positive Negative Negative 5 95 Negative peripheral blood 97 Unknown 7028 259.8 Negative
GSM299956 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 Male Negative Negative Negative 5 -1 Negative bone marrow 26 Negative 5177 166.5 Unknown
GSM299957 Hispanic or Latino None training set No CNS disease 2 Female Positive Negative Negative 6 90 Negative peripheral blood 91 Unknown 1038 114.0 Negative
GSM299958 Hispanic or Latino Downs test set No CNS disease 2 Female Negative Negative Negative 6 95 Negative peripheral blood 100 Unknown 5008 321.2 Negative
GSM299959 Hispanic or Latino None training set No CNS disease 2 Female Negative Negative Negative 7 95 Negative bone marrow 71 Unknown 5925 19.5 Negative
GSM299960 Hispanic or Latino None training set No CNS disease 2 Male Negative Negative Negative 7 95 Negative peripheral blood 93 Negative 1258 145.0 Negative
GSM29996 Hispanic or Latino None test set No CNS disease 2 Female Negative Negative Negative 8 90 Positive bone marrow 85 Unknown 1956 148.2 Negative
GSM299962 White None training set No CNS disease 4 Female Positive Negative Negative 6 90 Negative peripheral blood 97 Unknown 4560 108.0 Negative
GSM299963 White None training set No CNS disease 2 Male Positive Negative Negative 7 90 Negative peripheral blood 84 Negative 966 37.3 Negative
GSM299964 White None test set No CNS disease 2 Male Negative Negative Unknown 7 95 Negative bone marrow 100 Negative 4585 12.0 Negative
GSM299965 White Unknown training set No CNS disease 2 Female Negative Negative Negative 5 90 Negative bone marrow 98 Unknown 4863 65.8 Negative
GSM299966 White None training set No CNS disease 2 Male Negative Negative Negative 6 95 Negative peripheral blood 100 Negative 369 325.0 Negative
GSM299967 White None test set No CNS disease 2 Male Negative Negative Negative 7 -1 Negative bone marrow 20 Negative 5853 2.3 Negative
GSM299968 White None training set No CNS disease 2 Male Negative Negative Negative 8 80 Negative bone marrow 99 Negative 6335 13.3 Negative
GSM299969 American Indian or Alaska native None test set No CNS disease 2 Male Negative Negative Negative 8 95 Negative peripheral blood 97 Negative 881 106.0 Negative
GSM299970 White None training set No CNS disease 3 Female Negative Negative Negative 9 95 Negative peripheral blood 100 Unknown 2786 105.7 Negative
GSM29997 White None training set No CNS disease 3 Male Negative Negative Negative 10 80 Negative peripheral blood 94 Negative 6306 16.7 Negative
GSM299972 White None test set No CNS disease 3 Male Negative Negative Negative 10 90 Negative bone marrow 98 Negative 2519 112.0 Negative
GSM299973 Hispanic or Latino None training set No CNS disease 3 Male Negative Negative Negative 11 95 Negative bone marrow 66 Negative 6142 18.5 Negative
GSM299974 Black or African American None test set No CNS disease 3 Male Negative Negative Negative 11 80 Negative bone marrow 96 Negative 5343 30.2 Negative
GSM299975 White None test set No CNS disease 3 Male Positive Negative Negative 11 90 Negative bone marrow 96 Negative 852 139.0 Negative
GSM299976 Hispanic or Latino None training set No CNS disease 3 Male Positive Negative Negative 12 95 Negative bone marrow 94 Negative 462 17.3 Negative
GSM299977 Black or African American Unknown training set No CNS disease 3 Female Negative Negative Negative 12 90 Positive peripheral blood 75 Unknown 5797 39.6 Negative
GSM299978 Hispanic or Latino None training set No CNS disease 3 Male Negative Negative Negative 9 95 Negative peripheral blood 97 Negative 4253 236.4 Negative
GSM299979 Hispanic or Latino None training set No CNS disease 3 Female Negative Negative Negative 9 75 Negative peripheral blood 99 Unknown 705 137.2 Negative
GSM299980 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Male Negative Negative Negative 10 70 Negative peripheral blood 99 Negative 7478 28.0 Negative
GSM29998 White Unknown training set No CNS disease 3 Male Negative Negative Negative 10 90 Negative peripheral blood 100 Negative 2191 272.0 Negative
GSM299982 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Female Negative Negative Negative 11 90 Negative bone marrow 98 Unknown 1275 214.0 Negative
GSM299983 White None test set No CNS disease 3 Male Negative Negative Negative 11 95 Negative bone marrow 96 Negative 5184 58.0 Negative
GSM299984 Other None training set No CNS disease 3 Male Negative Negative Negative 11 -1 Negative bone marrow 59 Negative 5542 7.9 Negative
GSM299985 White None test set No CNS disease 3 Male Negative Negative Negative 12 95 Negative bone marrow 64 Negative 5242 3.4 Negative
GSM299986 White Unknown training set No CNS disease 3 Female Negative Negative Negative 12 75 Negative peripheral blood 99 Unknown 1313 69.4 Negative
GSM299987 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Female Negative Negative Negative 9 95 Negative bone marrow 94 Unknown 1751 238.0 Negative
GSM299988 White None training set No CNS disease 3 Female Negative Negative Negative 9 90 Negative bone marrow 98 Unknown 4329 179.0 Negative
GSM299989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Male Negative Negative Negative 9 90 Negative bone marrow 86 Negative 976 7.7 Positive
GSM299990 Hispanic or Latino None test set No CNS disease 3 Female Negative Negative Negative 10 95 Positive bone marrow 91 Negative 5300 98.2 Negative
GSM29999 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Male Negative Negative Negative 11 90 Negative bone marrow 81 Negative 4307 44.9 Negative
GSM299992 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Female Negative Negative Negative 12 60 Negative peripheral blood 98 Unknown 4324 35.7 Negative
GSM299993 White Unknown test set No CNS disease 3 Female Negative Negative Negative 9 95 Positive bone marrow 97 Unknown 1033 118.1 Negative
GSM299994 Hispanic or Latino None test set No CNS disease 3 Male Negative Negative Negative 9 -1 Negative bone marrow 31 Negative 6052 6.4 Negative
GSM299995 White Unknown training set No CNS disease 3 Male Negative Unknown Unknown 10 95 Negative bone marrow 85 Negative 4157 77.6 Negative
GSM299996 Asian None training set No CNS disease 3 Male Negative Negative Negative 11 90 Positive bone marrow 64 Unknown 5025 73.1 Negative
GSM299997 White None training set No CNS disease 3 Male Negative Negative Negative 12 95 Negative bone marrow 99 Negative 6263 1.0 Negative
GSM299998 White None training set No CNS disease 3 Male Positive Negative Negative 9 90 Negative bone marrow 96 Negative 5664 22.0 Negative
GSM299999 Other None test set No CNS disease 3 Male Negative Negative Negative 9 95 Negative bone marrow 95 Negative 4776 1.3 Negative
GSM300000 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Female Negative Negative Negative 10 95 Negative peripheral blood 99 Unknown 2192 209.6 Negative
GSM30000 Black or African American None training set No CNS disease 3 Male Negative Negative Negative 11 95 Negative bone marrow 94 Negative 5954 15.5 Negative
GSM300002 White None training set No CNS disease 3 Male Negative Negative Negative 11 95 Negative bone marrow 67 Negative 2038 193.0 Negative
GSM300003 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Female Negative Negative Negative 12 95 Negative bone marrow 96 Unknown 6032 59.2 Positive
GSM300004 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Male Negative Negative Negative 12 85 Negative peripheral blood 98 Positive 655 9.8 Negative
GSM300005 White None training set No CNS disease 3 Male Negative Negative Negative 12 90 Negative bone marrow 94 Negative 4759 2.4 Negative
GSM300006 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Female Negative Negative Negative 9 95 Negative bone marrow 97 Unknown 2769 3.0 Negative
GSM300007 American Indian or Alaska native None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Male Negative Negative Negative 9 40 Negative peripheral blood 94 Unknown 4972 6.3 Negative
GSM300008 Black or African American Unknown test set No CNS disease 3 Male Negative Negative Negative 9 95 Negative bone marrow 98 Negative 4815 31.4 Negative
GSM300009 White None test set No CNS disease 3 Male Negative Negative Negative 10 95 Negative peripheral blood 98 Negative 6315 245.0 Negative
GSM300010 White Downs training set No CNS disease 3 Male Negative Negative Negative 10 95 Negative bone marrow 95 Negative 4276 24.4 Negative
GSM3000 White None training set No CNS disease 3 Male Negative Negative Negative 10 95 Negative peripheral blood 99 Negative 5759 33.9 Negative
GSM300012 White None test set No CNS disease 3 Male Negative Negative Negative 11 -1 Negative bone marrow 44 Negative 6487 7.6 Negative
GSM300013 Black or African American None test set No CNS disease 3 Male Negative Negative Negative 11 95 Positive peripheral blood 99 Negative 1771 152.7 Negative
GSM300014 White None training set No CNS disease 3 Male Negative Negative Negative 12 95 Negative bone marrow 89 Negative 515 124.0 Negative
GSM300015 White None training set No CNS disease 3 Female Negative Negative Negative 12 95 Negative bone marrow 96 Unknown 6090 24.8 Negative
GSM300016 White Unknown training set No CNS disease 3 Male Negative Negative Negative 9 95 Negative bone marrow 99 Negative 6633 1.9 Negative
GSM300017 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 Male Negative Negative Negative 9 95 Negative bone marrow 97 Negative 5194 96.5 Negative
GSM300018 Hispanic or Latino None training set No CNS disease 3 Male Negative Negative Negative 10 95 Negative bone marrow 96 Negative 6468 7.0 Negative
GSM300019 White None test set No CNS disease 3 Male Negative Negative Negative 11 90 Negative bone marrow 92 Negative 6062 17.0 Negative
GSM300020 Other Unknown test set No CNS disease 3 Female Positive Negative Negative 11 90 Negative bone marrow 95 Unknown 777 6.8 Negative
GSM30002 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Female Negative Negative Negative 12 85 Positive bone marrow 100 Unknown 5889 49.6 Negative
GSM300022 White None test set No CNS disease 3 Male Negative Negative Negative 12 95 Negative peripheral blood 95 Negative 893 455.4 Negative
GSM300023 Hispanic or Latino None training set No CNS disease 3 Male Negative Negative Negative 9 95 Negative bone marrow 98 Negative 4955 31.5 Negative
GSM300024 Hispanic or Latino None training set No CNS disease 3 Male Negative Negative Negative 10 95 Negative peripheral blood 99 Negative 5081 307.0 Negative
GSM300025 Hispanic or Latino Downs training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Female Negative Negative Negative 10 90 Negative bone marrow 98 Unknown 4665 95.2 Negative
GSM300026 Hispanic or Latino None training set No CNS disease 3 Male Negative Negative Negative 11 95 Negative peripheral blood 97 Negative 988 958.8 Negative
GSM300027 White None training set No CNS disease 3 Male Negative Negative Negative 12 -1 Positive bone marrow 59 Negative 5890 9.4 Negative
GSM300028 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 Female Negative Negative Negative 12 95 Negative bone marrow 96 Unknown 6351 13.8 Negative
GSM300029 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 Male Negative Negative Negative 13 95 Negative bone marrow 86 Negative 1475 212.3 Negative
GSM300030 Hispanic or Latino Unknown training set No CNS disease 4 Male Negative Negative Negative 13 90 Negative bone marrow 99 Negative 6036 8.8 Negative
GSM30003 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 Female Negative Negative Negative 4 95 Negative bone marrow 96 Unknown 5217 135.8 Negative
GSM300032 Black or African American None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 Male Negative Negative Negative 4 95 Negative bone marrow 97 Negative 523 82.9 Negative
GSM300033 White Unknown training set No CNS disease 3 Female Negative Negative Negative 11 95 Positive peripheral blood 99 Unknown 1011 302.1 Negative
GSM300034 Native Hawaiian or other Pacific Islander None test set No CNS disease 3 Male Negative Negative Negative 11 90 Negative bone marrow 98 Negative 6107 18.3 Negative
GSM300035 White None training set No CNS disease 4 Male Negative Negative Negative 13 95 Negative peripheral blood 95 Negative 768 138.8 Negative
GSM300036 White None training set No CNS disease 4 Female Negative Negative Negative 13 90 Positive peripheral blood 84 Unknown 5670 37.2 Negative
GSM300037 Hispanic or Latino None training set No CNS disease 6 Male Negative Negative Negative 11 95 Negative peripheral blood 99 Negative 6666 114.6 Negative
GSM300038 Hispanic or Latino None training set No CNS disease 4 Female Negative Negative Negative 13 85 Positive bone marrow 96 Unknown 3901 136.6 Negative
GSM300039 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 7 Female Negative Negative Negative 14 -1 Negative peripheral blood 51 Negative 728 138.4 Negative
GSM300040 White None test set No CNS disease 7 Female Negative Negative Negative 14 95 Negative bone marrow 79 Unknown 1058 141.0 Negative
GSM30004 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 7 Female Negative Negative Negative 14 95 Negative bone marrow 76 Unknown 1323 30.6 Positive
GSM300042 Hispanic or Latino None training set No CNS disease 7 Male Negative Negative Negative 14 95 Negative bone marrow 84 Negative 650 102.5 Negative
GSM300043 White None test set No CNS disease 8 Male Negative Negative Negative 15 85 Negative bone marrow 99 Negative 5821 1.9 Negative
GSM300044 White Unknown training set No CNS disease 8 Male Negative Negative Negative 15 40 Negative peripheral blood 100 Negative 6202 2.3 Negative
GSM300045 American Indian or Alaska native None training set No CNS disease 8 Female Negative Negative Negative 15 90 Negative bone marrow 98 Negative 6119 2.3 Negative
GSM300046 White None training set No CNS disease 8 Male Negative Negative Negative 15 60 Negative peripheral blood 99 Positive 4571 6.9 Negative
GSM300047 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 8 Male Negative Negative Negative 15 60 Negative peripheral blood 93 Negative 1896 4.1 Positive
GSM300048 White None training set No CNS disease 8 Female Negative Negative Negative 15 75 Negative bone marrow 97 Negative 7461 3.8 Negative
GSM300049 White None test set No CNS disease 8 Male Negative Negative Negative 15 65 Negative bone marrow 96 Negative 6634 11.1 Negative
GSM300050 White None training set No CNS disease 8 Male Negative Negative Negative 15 80 Negative peripheral blood 83 Negative 5097 6.3 Negative
GSM30005 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 8 Male Negative Negative Negative 15 95 Negative bone marrow 96 Negative 5532 5.5 Negative
GSM300052 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 8 Male Negative Negative Negative 15 -1 Negative peripheral blood 47 Positive 1914 45.1 Positive
GSM300053 White None training set No CNS disease 8 Male Negative Negative Negative 15 90 Positive peripheral blood 72 Negative 4434 42.1 Negative
GSM300054 Asian None test set No CNS disease 8 Male Negative Negative Negative 15 50 Positive peripheral blood 93 Negative 4782 4.4 Negative
GSM300055 White None test set No CNS disease 8 Male Negative Negative Negative 15 90 Negative bone marrow 84 Negative 5232 1.1 Negative
GSM300056 Black or African American None test set No CNS disease 8 Male Negative Negative Negative 15 80 Positive peripheral blood 83 Negative 6500 17.8 Negative
GSM300057 White None training set No CNS disease 9 Male Positive Negative Negative 16 -1 Negative bone marrow 50 Unknown 585 7.5 Negative
GSM300058 Black or African American None test set No CNS disease 9 Male Negative Negative Negative 16 95 Negative bone marrow 98 Negative 6539 2.6 Negative
GSM300059 White None test set No CNS disease 9 Female Negative Negative Negative 16 85 Negative bone marrow 100 Negative 5991 5.2 Negative
GSM300060 White None training set No CNS disease 9 Male Negative Negative Negative 16 70 Negative peripheral blood 93 Negative 6479 31.9 Negative
GSM30006 Black or African American None training set No CNS disease 9 Male Negative Negative Negative 16 90 Negative bone marrow 98 Negative 5183 23.0 Negative
GSM300062 White None training set No CNS disease 9 Male Negative Negative Negative 16 -1 Negative peripheral blood 46 Negative 713 110.3 Negative
GSM300063 White None test set No CNS disease 9 Male Positive Negative Negative 16 90 Negative bone marrow 82 Unknown 1704 85.1 Negative
GSM300064 White Unknown test set No CNS disease 9 Male Negative Negative Negative 16 95 Negative bone marrow 99 Negative 5594 2.8 Negative
GSM300065 White Unknown training set No CNS disease 9 Male Negative Negative Negative 16 95 Negative bone marrow 88 Negative 5857 13.3 Negative
GSM300066 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 9 Female Negative Negative Negative 16 95 Positive bone marrow 81 Unknown 4017 3.5 Negative
GSM300067 White Unknown training set No CNS disease 9 Male Negative Negative Negative 16 95 Negative bone marrow 85 Negative 4918 5.5 Negative
GSM300068 Hispanic or Latino Unknown training set No CNS disease 10 Male Negative Negative Negative 18 90 Negative bone marrow 66 Negative 5349 147.6 Negative

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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