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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample TRAINING OR TEST SET AMPLIFICATION SET CNS STATUS TESTICULAR INVOLVEMENT SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE CONGENITAL ABNORMALITY GENDER BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) TISSUE TYPE TRISOMY 4 AND 10 MLL AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER RACE
GSM299862 test set 1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 100 None Female Negative Negative 1 90 Negative peripheral blood Negative Positive 3953 175.0 White
GSM299863 training set 1 No CNS disease Negative 100 None Male Negative Negative 1 90 Negative peripheral blood Negative Negative 1976 142.0 Black or African American
GSM299864 training set 1 No CNS disease Negative 99 None Male Negative Negative 2 70 Negative peripheral blood Negative Negative 5250 220.7 Hispanic or Latino
GSM299865 test set 1 No CNS disease Negative 88 None Male Negative Negative 2 95 Negative peripheral blood Negative Negative 577 129.0 White
GSM299866 training set 1 No CNS disease Negative 95 None Male Negative Negative 3 95 Negative bone marrow Negative Negative 4609 26.0 Hispanic or Latino
GSM299867 training set 1 No CNS disease Negative 68 None Male Negative Negative 3 80 Negative bone marrow Negative Negative 5289 14.7 White
GSM299868 training set 1 No CNS disease Negative 71 None Male Negative Negative 4 -1 Negative bone marrow Negative Negative 3987 68.6 Asian
GSM299869 test set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 98 None Male Negative Negative 4 90 Negative bone marrow Negative Negative 4856 21.4 White
GSM299870 test set 1 No CNS disease Negative 99 None Male Negative Negative 4 1 Negative bone marrow Negative Negative 4678 2.4 White
GSM29987 training set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 68 Unknown Male Negative Negative 1 75 Negative bone marrow Negative Negative 796 21.0 White
GSM299872 training set 1 No CNS disease Unknown 100 None Female Negative Negative 1 85 Negative peripheral blood Negative Positive 4071 125.8 White
GSM299873 training set 1 No CNS disease Negative 99 Unknown Male Negative Negative 2 95 Negative bone marrow Negative Negative 5223 29.9 White
GSM299874 training set 1 No CNS disease Unknown 99 Unknown Female Negative Negative 3 95 Negative peripheral blood Negative Negative 5118 217.2 Hispanic or Latino
GSM299875 training set 1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 97 None Male Negative Negative 3 90 Negative peripheral blood Negative Negative 5219 180.0 unknown
GSM299876 training set 1 No CNS disease Unknown 98 Downs Female Negative Negative 4 95 Negative bone marrow Negative Negative 1429 118.0 White
GSM299877 test set 1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 97 Unknown Female Negative Negative 1 95 Negative peripheral blood Negative Negative 3179 314.8 White
GSM299878 test set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 58 None Female Negative Negative 1 -1 Negative bone marrow Negative Negative 1450 5.2 White
GSM299879 training set 1 No CNS disease Negative 91 None Male Negative Negative 1 95 Negative bone marrow Negative Negative 5278 113.5 White
GSM299880 training set 1 No CNS disease Negative 98 None Male Negative Negative 2 85 Positive bone marrow Negative Negative 5330 5.8 White
GSM29988 test set 1 No CNS disease Unknown 99 Unknown Female Negative Negative 4 90 Negative peripheral blood Negative Negative 4861 592.6 Hispanic or Latino
GSM299882 training set 1 No CNS disease Unknown 80 None Female Negative Negative 1 95 Negative peripheral blood Negative Negative 428 248.0 White
GSM299883 training set 1 No CNS disease Negative 97 None Male Negative Negative 1 95 Negative bone marrow Negative Negative 4722 4.4 White
GSM299884 test set 1 No CNS disease Negative 99 Unknown Male Negative Negative 2 95 Negative bone marrow Negative Negative 3587 72.2 White
GSM299885 test set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 98 None Female Negative Negative 2 90 Negative peripheral blood Negative Positive 5431 133.0 White
GSM299886 training set 1 No CNS disease Positive 98 None Male Negative Negative 2 70 Negative bone marrow Negative Negative 3444 5.0 Hispanic or Latino
GSM299887 test set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 99 None Male Negative Negative 3 90 Negative peripheral blood Negative Negative 862 194.0 Other
GSM299888 training set 1 No CNS disease Negative 97 None Male Negative Negative 3 90 Negative bone marrow Negative Negative 6674 3.8 Hispanic or Latino
GSM299889 training set 1 No CNS disease Negative 70 None Male Negative Negative 3 95 Negative bone marrow Negative Negative 6323 15.4 White
GSM299890 training set 1 No CNS disease Negative 98 Unknown Male Negative Negative 4 90 Negative bone marrow Negative Negative 6219 16.5 White
GSM29989 training set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 65 None Male Negative Positive 4 95 Negative bone marrow Negative Negative 2509 1.7 White
GSM299892 training set 1 No CNS disease Unknown 100 None Female Negative Negative 4 95 Positive peripheral blood Negative Negative 1531 196.1 Hispanic or Latino
GSM299893 test set 1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 100 Unknown Male Negative Negative 1 85 Negative peripheral blood Negative Negative 5516 202.4 Hispanic or Latino
GSM299894 training set 1 No CNS disease Negative 82 None Male Negative Negative 1 90 Negative bone marrow Negative Negative 5513 2.5 White
GSM299895 training set 1 No CNS disease Negative 62 Unknown Male Negative Negative 2 95 Negative bone marrow Negative Negative 5842 27.4 White
GSM299896 training set 1 No CNS disease Negative 98 Downs Male Negative Negative 3 75 Positive peripheral blood Negative Negative 6496 9.1 White
GSM299897 training set 1 No CNS disease Negative 99 None Male Negative Negative 3 95 Negative peripheral blood Negative Positive 6511 515.0 White
GSM299898 training set 1 No CNS disease Negative 97 None Male Negative Negative 4 95 Positive bone marrow Negative Negative 1361 117.2 Hispanic or Latino
GSM299899 training set 1 No CNS disease Unknown 74 None Female Negative Negative 1 95 Negative bone marrow Negative Negative 835 115.0 White
GSM299900 training set 1 No CNS disease Negative 99 None Male Negative Negative 2 95 Negative peripheral blood Negative Positive 4774 246.4 Hispanic or Latino
GSM29990 training set 1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 None Female Negative Negative 2 95 Negative bone marrow Negative Positive 3311 489.0 White
GSM299902 training set 1 No CNS disease Negative 100 None Male Negative Negative 3 80 Negative peripheral blood Negative Negative 6331 32.6 White
GSM299903 training set 1 No CNS disease Unknown 92 None Female Negative Negative 3 95 Negative bone marrow Negative Positive 398 135.0 White
GSM299904 test set 1 No CNS disease Negative 96 None Male Negative Negative 3 95 Positive bone marrow Negative Negative 5631 67.2 White
GSM299905 test set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 96 None Female Negative Negative 1 95 Negative bone marrow Negative Negative 944 12.1 White
GSM299906 training set 1 No CNS disease Negative 90 None Male Negative Negative 1 90 Positive bone marrow Negative Negative 4940 8.0 White
GSM299907 training set 1 No CNS disease Negative 96 Downs Female Negative Negative 2 95 Negative bone marrow Negative Negative 5721 88.9 White
GSM299908 training set 1 No CNS disease Negative 98 Unknown Male Negative Negative 3 95 Negative peripheral blood Negative Negative 6114 80.9 White
GSM299909 training set 1 No CNS disease Negative 97 None Male Negative Negative 4 95 Negative bone marrow Negative Negative 5086 36.2 White
GSM299910 test set 1 No CNS disease Negative 90 None Male Negative Negative 4 95 Negative bone marrow Negative Negative 5359 80.8 White
GSM2999 training set 1 No CNS disease Negative 95 None Male Negative Negative 2 90 Negative bone marrow Negative Negative 1167 156.0 White
GSM299912 training set 1 No CNS disease Negative 82 Unknown Female Negative Negative 2 95 Negative peripheral blood Negative Negative 4090 289.3 White
GSM299913 test set 1 No CNS disease Negative 90 None Male Negative Negative 3 95 Negative peripheral blood Negative Positive 792 237.0 White
GSM299914 training set 1 No CNS disease Negative 99 None Male Negative Negative 4 95 Negative bone marrow Negative Negative 6733 81.4 White
GSM299915 training set 2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 98 Unknown Male Negative Negative 5 95 Negative bone marrow Negative Negative 2875 351.3 Asian
GSM299916 training set 2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 99 Other Male Negative Positive 5 80 Negative peripheral blood Negative Negative 449 59.9 Hispanic or Latino
GSM299917 training set 4 No CNS disease Negative 100 Unknown Male Negative Negative 6 95 Negative bone marrow Negative Negative 904 137.8 White
GSM299918 test set 2 No CNS disease Negative 98 None Male Negative Negative 6 90 Negative bone marrow Negative Negative 1426 138.4 White
GSM299919 training set 2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 98 None Female Negative Negative 6 95 Negative peripheral blood Negative Negative 4469 478.0 Hispanic or Latino
GSM299920 training set 2 No CNS disease Negative 88 None Male Negative Negative 7 95 Negative bone marrow Negative Negative 6266 34.9 Hispanic or Latino
GSM29992 training set 2 No CNS disease Negative 100 None Male Negative Negative 8 70 Negative bone marrow Negative Negative 6306 22.8 White
GSM299922 training set 2 No CNS disease Unknown 100 None Female Negative Negative 8 90 Negative peripheral blood Negative Negative 727 109.5 White
GSM299923 training set 2 No CNS disease Negative 99 None Male Negative Negative 5 95 Negative bone marrow Negative Negative 5867 21.1 Hispanic or Latino
GSM299924 training set 2 No CNS disease Unknown 95 None Female Negative Negative 5 90 Negative bone marrow Negative Negative 6733 102.0 Asian
GSM299925 training set 4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 98 None Male Negative Negative 6 90 Negative peripheral blood Negative Negative 5495 96.2 White
GSM299926 training set 2 No CNS disease Negative 99 None Male Negative Negative 6 95 Negative bone marrow Negative Negative 6063 2.3 unknown
GSM299927 test set 2 No CNS disease Unknown 87 None Female Negative Negative 6 95 Negative bone marrow Negative Negative 5922 27.0 Hispanic or Latino
GSM299928 training set 2 No CNS disease Unknown 99 Downs Female Negative Negative 7 90 Negative peripheral blood Negative Negative 6922 68.9 White
GSM299929 training set 2 No CNS disease Unknown 100 None Female Negative Negative 8 95 Negative bone marrow Negative Negative 531 119.0 White
GSM299930 test set 2 No CNS disease Unknown 97 Unknown Female Negative Negative 5 95 Negative bone marrow Negative Negative 4106 210.0 White
GSM29993 training set 2 No CNS disease Negative 91 None Male Negative Negative 5 95 Negative bone marrow Negative Negative 2027 199.0 Hispanic or Latino
GSM299932 training set 2 No CNS disease Unknown 96 Unknown Female Negative Negative 6 90 Positive peripheral blood Negative Negative 1191 175.5 Asian
GSM299933 test set 6 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 94 None Female Negative Negative 7 95 Negative peripheral blood Negative Negative 5310 92.7 Hispanic or Latino
GSM299934 training set 2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 83 None Male Negative Negative 7 95 Negative peripheral blood Negative Negative 5163 270.0 White
GSM299935 test set 2 No CNS disease Unknown 66 None Female Negative Negative 7 95 Positive bone marrow Negative Negative 977 115.1 White
GSM299936 training set 2 No CNS disease Negative 89 Unknown Male Negative Negative 8 95 Negative bone marrow Negative Negative 4807 12.7 White
GSM299937 training set 2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 99 None Male Negative Negative 5 95 Negative peripheral blood Negative Negative 5564 112.0 White
GSM299938 test set 2 No CNS disease Negative 60 Unknown Male Negative Negative 5 95 Negative bone marrow Negative Negative 4305 40.0 White
GSM299939 training set 6 No CNS disease Unknown 94 Unknown Female Negative Negative 6 95 Negative bone marrow Negative Negative 4717 62.3 White
GSM299940 test set 4 No CNS disease Negative 99 None Male Negative Negative 7 95 Negative bone marrow Negative Negative 4657 33.1 Hispanic or Latino
GSM29994 training set 2 No CNS disease Unknown 79 None Female Negative Positive 7 90 Negative bone marrow Negative Negative 1429 192.0 White
GSM299942 training set 4 No CNS disease Negative 98 None Female Negative Negative 8 65 Negative peripheral blood Negative Negative 6413 16.6 Hispanic or Latino
GSM299943 training set 2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 92 None Female Negative Negative 8 95 Negative peripheral blood Negative Negative 2133 17.5 White
GSM299944 test set 2 No CNS disease Unknown 69 Unknown Female Negative Negative 8 70 Negative peripheral blood Negative Positive 434 88.5 Hispanic or Latino
GSM299945 training set 2 No CNS disease Negative 87 Unknown Male Negative Negative 5 90 Negative bone marrow Negative Negative 4935 24.5 Asian
GSM299946 training set 2 No CNS disease Negative 100 None Female Negative Negative 5 85 Negative peripheral blood Negative Negative 6984 30.4 White
GSM299947 test set 2 No CNS disease Unknown 65 None Female Negative Negative 5 90 Negative bone marrow Negative Negative 1068 190.0 White
GSM299948 test set 4 No CNS disease Negative 99 None Male Negative Negative 6 95 Negative bone marrow Negative Negative 5877 66.9 Hispanic or Latino
GSM299949 training set 6 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 87 None Male Negative Negative 7 95 Negative bone marrow Negative Positive 5127 555.0 White
GSM299950 training set 4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 95 None Male Negative Negative 7 90 Negative bone marrow Negative Positive 410 51.3 White
GSM29995 training set 2 No CNS disease Negative 97 Unknown Male Negative Negative 7 95 Negative bone marrow Negative Negative 5408 1.2 White
GSM299952 test set 2 No CNS disease Negative 96 Unknown Male Negative Negative 8 95 Negative bone marrow Negative Negative 2876 142.4 Black or African American
GSM299953 training set 2 No CNS disease Negative 87 Unknown Male Negative Negative 8 95 Negative bone marrow Negative Negative 697 110.9 White
GSM299954 test set 2 No CNS disease Unknown 95 Downs Female Negative Negative 5 90 Negative peripheral blood Negative Negative 2223 202.0 Hispanic or Latino
GSM299955 test set 2 No CNS disease Unknown 97 None Female Negative Negative 5 95 Negative peripheral blood Negative Positive 7028 259.8 White
GSM299956 training set 2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 26 None Male Negative Negative 5 -1 Negative bone marrow Unknown Negative 5177 166.5 White
GSM299957 training set 2 No CNS disease Unknown 91 None Female Negative Negative 6 90 Negative peripheral blood Negative Positive 1038 114.0 Hispanic or Latino
GSM299958 test set 2 No CNS disease Unknown 100 Downs Female Negative Negative 6 95 Negative peripheral blood Negative Negative 5008 321.2 Hispanic or Latino
GSM299959 training set 2 No CNS disease Unknown 71 None Female Negative Negative 7 95 Negative bone marrow Negative Negative 5925 19.5 Hispanic or Latino
GSM299960 training set 2 No CNS disease Negative 93 None Male Negative Negative 7 95 Negative peripheral blood Negative Negative 1258 145.0 Hispanic or Latino
GSM29996 test set 2 No CNS disease Unknown 85 None Female Negative Negative 8 90 Positive bone marrow Negative Negative 1956 148.2 Hispanic or Latino
GSM299962 training set 4 No CNS disease Unknown 97 None Female Negative Negative 6 90 Negative peripheral blood Negative Positive 4560 108.0 White
GSM299963 training set 2 No CNS disease Negative 84 None Male Negative Negative 7 90 Negative peripheral blood Negative Positive 966 37.3 White
GSM299964 test set 2 No CNS disease Negative 100 None Male Negative Unknown 7 95 Negative bone marrow Negative Negative 4585 12.0 White
GSM299965 training set 2 No CNS disease Unknown 98 Unknown Female Negative Negative 5 90 Negative bone marrow Negative Negative 4863 65.8 White
GSM299966 training set 2 No CNS disease Negative 100 None Male Negative Negative 6 95 Negative peripheral blood Negative Negative 369 325.0 White
GSM299967 test set 2 No CNS disease Negative 20 None Male Negative Negative 7 -1 Negative bone marrow Negative Negative 5853 2.3 White
GSM299968 training set 2 No CNS disease Negative 99 None Male Negative Negative 8 80 Negative bone marrow Negative Negative 6335 13.3 White
GSM299969 test set 2 No CNS disease Negative 97 None Male Negative Negative 8 95 Negative peripheral blood Negative Negative 881 106.0 American Indian or Alaska native
GSM299970 training set 3 No CNS disease Unknown 100 None Female Negative Negative 9 95 Negative peripheral blood Negative Negative 2786 105.7 White
GSM29997 training set 3 No CNS disease Negative 94 None Male Negative Negative 10 80 Negative peripheral blood Negative Negative 6306 16.7 White
GSM299972 test set 3 No CNS disease Negative 98 None Male Negative Negative 10 90 Negative bone marrow Negative Negative 2519 112.0 White
GSM299973 training set 3 No CNS disease Negative 66 None Male Negative Negative 11 95 Negative bone marrow Negative Negative 6142 18.5 Hispanic or Latino
GSM299974 test set 3 No CNS disease Negative 96 None Male Negative Negative 11 80 Negative bone marrow Negative Negative 5343 30.2 Black or African American
GSM299975 test set 3 No CNS disease Negative 96 None Male Negative Negative 11 90 Negative bone marrow Negative Positive 852 139.0 White
GSM299976 training set 3 No CNS disease Negative 94 None Male Negative Negative 12 95 Negative bone marrow Negative Positive 462 17.3 Hispanic or Latino
GSM299977 training set 3 No CNS disease Unknown 75 Unknown Female Negative Negative 12 90 Positive peripheral blood Negative Negative 5797 39.6 Black or African American
GSM299978 training set 3 No CNS disease Negative 97 None Male Negative Negative 9 95 Negative peripheral blood Negative Negative 4253 236.4 Hispanic or Latino
GSM299979 training set 3 No CNS disease Unknown 99 None Female Negative Negative 9 75 Negative peripheral blood Negative Negative 705 137.2 Hispanic or Latino
GSM299980 training set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 99 Unknown Male Negative Negative 10 70 Negative peripheral blood Negative Negative 7478 28.0 White
GSM29998 training set 3 No CNS disease Negative 100 Unknown Male Negative Negative 10 90 Negative peripheral blood Negative Negative 2191 272.0 White
GSM299982 training set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 98 None Female Negative Negative 11 90 Negative bone marrow Negative Negative 1275 214.0 Hispanic or Latino
GSM299983 test set 3 No CNS disease Negative 96 None Male Negative Negative 11 95 Negative bone marrow Negative Negative 5184 58.0 White
GSM299984 training set 3 No CNS disease Negative 59 None Male Negative Negative 11 -1 Negative bone marrow Negative Negative 5542 7.9 Other
GSM299985 test set 3 No CNS disease Negative 64 None Male Negative Negative 12 95 Negative bone marrow Negative Negative 5242 3.4 White
GSM299986 training set 3 No CNS disease Unknown 99 Unknown Female Negative Negative 12 75 Negative peripheral blood Negative Negative 1313 69.4 White
GSM299987 training set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 94 None Female Negative Negative 9 95 Negative bone marrow Negative Negative 1751 238.0 White
GSM299988 training set 3 No CNS disease Unknown 98 None Female Negative Negative 9 90 Negative bone marrow Negative Negative 4329 179.0 White
GSM299989 training set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 86 None Male Negative Negative 9 90 Negative bone marrow Positive Negative 976 7.7 White
GSM299990 test set 3 No CNS disease Negative 91 None Female Negative Negative 10 95 Positive bone marrow Negative Negative 5300 98.2 Hispanic or Latino
GSM29999 training set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 81 None Male Negative Negative 11 90 Negative bone marrow Negative Negative 4307 44.9 Hispanic or Latino
GSM299992 training set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 98 None Female Negative Negative 12 60 Negative peripheral blood Negative Negative 4324 35.7 White
GSM299993 test set 3 No CNS disease Unknown 97 Unknown Female Negative Negative 9 95 Positive bone marrow Negative Negative 1033 118.1 White
GSM299994 test set 3 No CNS disease Negative 31 None Male Negative Negative 9 -1 Negative bone marrow Negative Negative 6052 6.4 Hispanic or Latino
GSM299995 training set 3 No CNS disease Negative 85 Unknown Male Unknown Unknown 10 95 Negative bone marrow Negative Negative 4157 77.6 White
GSM299996 training set 3 No CNS disease Unknown 64 None Male Negative Negative 11 90 Positive bone marrow Negative Negative 5025 73.1 Asian
GSM299997 training set 3 No CNS disease Negative 99 None Male Negative Negative 12 95 Negative bone marrow Negative Negative 6263 1.0 White
GSM299998 training set 3 No CNS disease Negative 96 None Male Negative Negative 9 90 Negative bone marrow Negative Positive 5664 22.0 White
GSM299999 test set 3 No CNS disease Negative 95 None Male Negative Negative 9 95 Negative bone marrow Negative Negative 4776 1.3 Other
GSM300000 training set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 99 None Female Negative Negative 10 95 Negative peripheral blood Negative Negative 2192 209.6 White
GSM30000 training set 3 No CNS disease Negative 94 None Male Negative Negative 11 95 Negative bone marrow Negative Negative 5954 15.5 Black or African American
GSM300002 training set 3 No CNS disease Negative 67 None Male Negative Negative 11 95 Negative bone marrow Negative Negative 2038 193.0 White
GSM300003 training set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 96 None Female Negative Negative 12 95 Negative bone marrow Positive Negative 6032 59.2 White
GSM300004 training set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive 98 Unknown Male Negative Negative 12 85 Negative peripheral blood Negative Negative 655 9.8 White
GSM300005 training set 3 No CNS disease Negative 94 None Male Negative Negative 12 90 Negative bone marrow Negative Negative 4759 2.4 White
GSM300006 test set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 97 Unknown Female Negative Negative 9 95 Negative bone marrow Negative Negative 2769 3.0 Hispanic or Latino
GSM300007 training set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 94 None Male Negative Negative 9 40 Negative peripheral blood Negative Negative 4972 6.3 American Indian or Alaska native
GSM300008 test set 3 No CNS disease Negative 98 Unknown Male Negative Negative 9 95 Negative bone marrow Negative Negative 4815 31.4 Black or African American
GSM300009 test set 3 No CNS disease Negative 98 None Male Negative Negative 10 95 Negative peripheral blood Negative Negative 6315 245.0 White
GSM300010 training set 3 No CNS disease Negative 95 Downs Male Negative Negative 10 95 Negative bone marrow Negative Negative 4276 24.4 White
GSM3000 training set 3 No CNS disease Negative 99 None Male Negative Negative 10 95 Negative peripheral blood Negative Negative 5759 33.9 White
GSM300012 test set 3 No CNS disease Negative 44 None Male Negative Negative 11 -1 Negative bone marrow Negative Negative 6487 7.6 White
GSM300013 test set 3 No CNS disease Negative 99 None Male Negative Negative 11 95 Positive peripheral blood Negative Negative 1771 152.7 Black or African American
GSM300014 training set 3 No CNS disease Negative 89 None Male Negative Negative 12 95 Negative bone marrow Negative Negative 515 124.0 White
GSM300015 training set 3 No CNS disease Unknown 96 None Female Negative Negative 12 95 Negative bone marrow Negative Negative 6090 24.8 White
GSM300016 training set 3 No CNS disease Negative 99 Unknown Male Negative Negative 9 95 Negative bone marrow Negative Negative 6633 1.9 White
GSM300017 test set 3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 97 None Male Negative Negative 9 95 Negative bone marrow Negative Negative 5194 96.5 Hispanic or Latino
GSM300018 training set 3 No CNS disease Negative 96 None Male Negative Negative 10 95 Negative bone marrow Negative Negative 6468 7.0 Hispanic or Latino
GSM300019 test set 3 No CNS disease Negative 92 None Male Negative Negative 11 90 Negative bone marrow Negative Negative 6062 17.0 White
GSM300020 test set 3 No CNS disease Unknown 95 Unknown Female Negative Negative 11 90 Negative bone marrow Negative Positive 777 6.8 Other
GSM30002 test set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 100 None Female Negative Negative 12 85 Positive bone marrow Negative Negative 5889 49.6 White
GSM300022 test set 3 No CNS disease Negative 95 None Male Negative Negative 12 95 Negative peripheral blood Negative Negative 893 455.4 White
GSM300023 training set 3 No CNS disease Negative 98 None Male Negative Negative 9 95 Negative bone marrow Negative Negative 4955 31.5 Hispanic or Latino
GSM300024 training set 3 No CNS disease Negative 99 None Male Negative Negative 10 95 Negative peripheral blood Negative Negative 5081 307.0 Hispanic or Latino
GSM300025 training set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 98 Downs Female Negative Negative 10 90 Negative bone marrow Negative Negative 4665 95.2 Hispanic or Latino
GSM300026 training set 3 No CNS disease Negative 97 None Male Negative Negative 11 95 Negative peripheral blood Negative Negative 988 958.8 Hispanic or Latino
GSM300027 training set 3 No CNS disease Negative 59 None Male Negative Negative 12 -1 Positive bone marrow Negative Negative 5890 9.4 White
GSM300028 test set 3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 96 None Female Negative Negative 12 95 Negative bone marrow Negative Negative 6351 13.8 Black or African American
GSM300029 test set 4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 86 Unknown Male Negative Negative 13 95 Negative bone marrow Negative Negative 1475 212.3 White
GSM300030 training set 4 No CNS disease Negative 99 Unknown Male Negative Negative 13 90 Negative bone marrow Negative Negative 6036 8.8 Hispanic or Latino
GSM30003 training set 1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 96 None Female Negative Negative 4 95 Negative bone marrow Negative Negative 5217 135.8 White
GSM300032 training set 1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 97 None Male Negative Negative 4 95 Negative bone marrow Negative Negative 523 82.9 Black or African American
GSM300033 training set 3 No CNS disease Unknown 99 Unknown Female Negative Negative 11 95 Positive peripheral blood Negative Negative 1011 302.1 White
GSM300034 test set 3 No CNS disease Negative 98 None Male Negative Negative 11 90 Negative bone marrow Negative Negative 6107 18.3 Native Hawaiian or other Pacific Islander
GSM300035 training set 4 No CNS disease Negative 95 None Male Negative Negative 13 95 Negative peripheral blood Negative Negative 768 138.8 White
GSM300036 training set 4 No CNS disease Unknown 84 None Female Negative Negative 13 90 Positive peripheral blood Negative Negative 5670 37.2 White
GSM300037 training set 6 No CNS disease Negative 99 None Male Negative Negative 11 95 Negative peripheral blood Negative Negative 6666 114.6 Hispanic or Latino
GSM300038 training set 4 No CNS disease Unknown 96 None Female Negative Negative 13 85 Positive bone marrow Negative Negative 3901 136.6 Hispanic or Latino
GSM300039 training set 7 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 51 None Female Negative Negative 14 -1 Negative peripheral blood Negative Negative 728 138.4 White
GSM300040 test set 7 No CNS disease Unknown 79 None Female Negative Negative 14 95 Negative bone marrow Negative Negative 1058 141.0 White
GSM30004 test set 7 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 76 Unknown Female Negative Negative 14 95 Negative bone marrow Positive Negative 1323 30.6 Hispanic or Latino
GSM300042 training set 7 No CNS disease Negative 84 None Male Negative Negative 14 95 Negative bone marrow Negative Negative 650 102.5 Hispanic or Latino
GSM300043 test set 8 No CNS disease Negative 99 None Male Negative Negative 15 85 Negative bone marrow Negative Negative 5821 1.9 White
GSM300044 training set 8 No CNS disease Negative 100 Unknown Male Negative Negative 15 40 Negative peripheral blood Negative Negative 6202 2.3 White
GSM300045 training set 8 No CNS disease Negative 98 None Female Negative Negative 15 90 Negative bone marrow Negative Negative 6119 2.3 American Indian or Alaska native
GSM300046 training set 8 No CNS disease Positive 99 None Male Negative Negative 15 60 Negative peripheral blood Negative Negative 4571 6.9 White
GSM300047 training set 8 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 93 None Male Negative Negative 15 60 Negative peripheral blood Positive Negative 1896 4.1 Hispanic or Latino
GSM300048 training set 8 No CNS disease Negative 97 None Female Negative Negative 15 75 Negative bone marrow Negative Negative 7461 3.8 White
GSM300049 test set 8 No CNS disease Negative 96 None Male Negative Negative 15 65 Negative bone marrow Negative Negative 6634 11.1 White
GSM300050 training set 8 No CNS disease Negative 83 None Male Negative Negative 15 80 Negative peripheral blood Negative Negative 5097 6.3 White
GSM30005 test set 8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 96 None Male Negative Negative 15 95 Negative bone marrow Negative Negative 5532 5.5 Hispanic or Latino
GSM300052 test set 8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive 47 None Male Negative Negative 15 -1 Negative peripheral blood Positive Negative 1914 45.1 Black or African American
GSM300053 training set 8 No CNS disease Negative 72 None Male Negative Negative 15 90 Positive peripheral blood Negative Negative 4434 42.1 White
GSM300054 test set 8 No CNS disease Negative 93 None Male Negative Negative 15 50 Positive peripheral blood Negative Negative 4782 4.4 Asian
GSM300055 test set 8 No CNS disease Negative 84 None Male Negative Negative 15 90 Negative bone marrow Negative Negative 5232 1.1 White
GSM300056 test set 8 No CNS disease Negative 83 None Male Negative Negative 15 80 Positive peripheral blood Negative Negative 6500 17.8 Black or African American
GSM300057 training set 9 No CNS disease Unknown 50 None Male Negative Negative 16 -1 Negative bone marrow Negative Positive 585 7.5 White
GSM300058 test set 9 No CNS disease Negative 98 None Male Negative Negative 16 95 Negative bone marrow Negative Negative 6539 2.6 Black or African American
GSM300059 test set 9 No CNS disease Negative 100 None Female Negative Negative 16 85 Negative bone marrow Negative Negative 5991 5.2 White
GSM300060 training set 9 No CNS disease Negative 93 None Male Negative Negative 16 70 Negative peripheral blood Negative Negative 6479 31.9 White
GSM30006 training set 9 No CNS disease Negative 98 None Male Negative Negative 16 90 Negative bone marrow Negative Negative 5183 23.0 Black or African American
GSM300062 training set 9 No CNS disease Negative 46 None Male Negative Negative 16 -1 Negative peripheral blood Negative Negative 713 110.3 White
GSM300063 test set 9 No CNS disease Unknown 82 None Male Negative Negative 16 90 Negative bone marrow Negative Positive 1704 85.1 White
GSM300064 test set 9 No CNS disease Negative 99 Unknown Male Negative Negative 16 95 Negative bone marrow Negative Negative 5594 2.8 White
GSM300065 training set 9 No CNS disease Negative 88 Unknown Male Negative Negative 16 95 Negative bone marrow Negative Negative 5857 13.3 White
GSM300066 test set 9 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 81 None Female Negative Negative 16 95 Positive bone marrow Negative Negative 4017 3.5 Hispanic or Latino
GSM300067 training set 9 No CNS disease Negative 85 Unknown Male Negative Negative 16 95 Negative bone marrow Negative Negative 4918 5.5 White
GSM300068 training set 10 No CNS disease Negative 66 Unknown Male Negative Negative 18 90 Negative bone marrow Negative Negative 5349 147.6 Hispanic or Latino

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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