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Home › Plugin Library › Plasmid DNA Production Service › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample TRAINING OR TEST SET CONGENITAL ABNORMALITY CNS STATUS TESTICULAR INVOLVEMENT BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE GENDER AMPLIFICATION SET E2A-PBX, T(1;19) BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE MLL TRISOMY 4 AND 10 TISSUE TYPE AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER RACE
GSM299862 test set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 90 Female 1 Negative Negative Negative 1 100 Positive Negative peripheral blood 3953 175.0 White
GSM299863 training set None No CNS disease Negative 90 Male 1 Negative Negative Negative 1 100 Negative Negative peripheral blood 1976 142.0 Black or African American
GSM299864 training set None No CNS disease Negative 70 Male 1 Negative Negative Negative 2 99 Negative Negative peripheral blood 5250 220.7 Hispanic or Latino
GSM299865 test set None No CNS disease Negative 95 Male 1 Negative Negative Negative 2 88 Negative Negative peripheral blood 577 129.0 White
GSM299866 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 3 95 Negative Negative bone marrow 4609 26.0 Hispanic or Latino
GSM299867 training set None No CNS disease Negative 80 Male 1 Negative Negative Negative 3 68 Negative Negative bone marrow 5289 14.7 White
GSM299868 training set None No CNS disease Negative -1 Male 1 Negative Negative Negative 4 71 Negative Negative bone marrow 3987 68.6 Asian
GSM299869 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 90 Male 1 Negative Negative Negative 4 98 Negative Negative bone marrow 4856 21.4 White
GSM299870 test set None No CNS disease Negative 1 Male 1 Negative Negative Negative 4 99 Negative Negative bone marrow 4678 2.4 White
GSM29987 training set Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 75 Male 1 Negative Negative Negative 1 68 Negative Negative bone marrow 796 21.0 White
GSM299872 training set None No CNS disease Unknown 85 Female 1 Negative Negative Negative 1 100 Positive Negative peripheral blood 4071 125.8 White
GSM299873 training set Unknown No CNS disease Negative 95 Male 1 Negative Negative Negative 2 99 Negative Negative bone marrow 5223 29.9 White
GSM299874 training set Unknown No CNS disease Unknown 95 Female 1 Negative Negative Negative 3 99 Negative Negative peripheral blood 5118 217.2 Hispanic or Latino
GSM299875 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 90 Male 1 Negative Negative Negative 3 97 Negative Negative peripheral blood 5219 180.0 unknown
GSM299876 training set Downs No CNS disease Unknown 95 Female 1 Negative Negative Negative 4 98 Negative Negative bone marrow 1429 118.0 White
GSM299877 test set Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 1 Negative Negative Negative 1 97 Negative Negative peripheral blood 3179 314.8 White
GSM299878 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown -1 Female 1 Negative Negative Negative 1 58 Negative Negative bone marrow 1450 5.2 White
GSM299879 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 1 91 Negative Negative bone marrow 5278 113.5 White
GSM299880 training set None No CNS disease Negative 85 Male 1 Positive Negative Negative 2 98 Negative Negative bone marrow 5330 5.8 White
GSM29988 test set Unknown No CNS disease Unknown 90 Female 1 Negative Negative Negative 4 99 Negative Negative peripheral blood 4861 592.6 Hispanic or Latino
GSM299882 training set None No CNS disease Unknown 95 Female 1 Negative Negative Negative 1 80 Negative Negative peripheral blood 428 248.0 White
GSM299883 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 1 97 Negative Negative bone marrow 4722 4.4 White
GSM299884 test set Unknown No CNS disease Negative 95 Male 1 Negative Negative Negative 2 99 Negative Negative bone marrow 3587 72.2 White
GSM299885 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 90 Female 1 Negative Negative Negative 2 98 Positive Negative peripheral blood 5431 133.0 White
GSM299886 training set None No CNS disease Positive 70 Male 1 Negative Negative Negative 2 98 Negative Negative bone marrow 3444 5.0 Hispanic or Latino
GSM299887 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 90 Male 1 Negative Negative Negative 3 99 Negative Negative peripheral blood 862 194.0 Other
GSM299888 training set None No CNS disease Negative 90 Male 1 Negative Negative Negative 3 97 Negative Negative bone marrow 6674 3.8 Hispanic or Latino
GSM299889 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 3 70 Negative Negative bone marrow 6323 15.4 White
GSM299890 training set Unknown No CNS disease Negative 90 Male 1 Negative Negative Negative 4 98 Negative Negative bone marrow 6219 16.5 White
GSM29989 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 95 Male 1 Negative Negative Positive 4 65 Negative Negative bone marrow 2509 1.7 White
GSM299892 training set None No CNS disease Unknown 95 Female 1 Positive Negative Negative 4 100 Negative Negative peripheral blood 1531 196.1 Hispanic or Latino
GSM299893 test set Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 85 Male 1 Negative Negative Negative 1 100 Negative Negative peripheral blood 5516 202.4 Hispanic or Latino
GSM299894 training set None No CNS disease Negative 90 Male 1 Negative Negative Negative 1 82 Negative Negative bone marrow 5513 2.5 White
GSM299895 training set Unknown No CNS disease Negative 95 Male 1 Negative Negative Negative 2 62 Negative Negative bone marrow 5842 27.4 White
GSM299896 training set Downs No CNS disease Negative 75 Male 1 Positive Negative Negative 3 98 Negative Negative peripheral blood 6496 9.1 White
GSM299897 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 3 99 Positive Negative peripheral blood 6511 515.0 White
GSM299898 training set None No CNS disease Negative 95 Male 1 Positive Negative Negative 4 97 Negative Negative bone marrow 1361 117.2 Hispanic or Latino
GSM299899 training set None No CNS disease Unknown 95 Female 1 Negative Negative Negative 1 74 Negative Negative bone marrow 835 115.0 White
GSM299900 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 2 99 Positive Negative peripheral blood 4774 246.4 Hispanic or Latino
GSM29990 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 1 Negative Negative Negative 2 95 Positive Negative bone marrow 3311 489.0 White
GSM299902 training set None No CNS disease Negative 80 Male 1 Negative Negative Negative 3 100 Negative Negative peripheral blood 6331 32.6 White
GSM299903 training set None No CNS disease Unknown 95 Female 1 Negative Negative Negative 3 92 Positive Negative bone marrow 398 135.0 White
GSM299904 test set None No CNS disease Negative 95 Male 1 Positive Negative Negative 3 96 Negative Negative bone marrow 5631 67.2 White
GSM299905 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 95 Female 1 Negative Negative Negative 1 96 Negative Negative bone marrow 944 12.1 White
GSM299906 training set None No CNS disease Negative 90 Male 1 Positive Negative Negative 1 90 Negative Negative bone marrow 4940 8.0 White
GSM299907 training set Downs No CNS disease Negative 95 Female 1 Negative Negative Negative 2 96 Negative Negative bone marrow 5721 88.9 White
GSM299908 training set Unknown No CNS disease Negative 95 Male 1 Negative Negative Negative 3 98 Negative Negative peripheral blood 6114 80.9 White
GSM299909 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 4 97 Negative Negative bone marrow 5086 36.2 White
GSM299910 test set None No CNS disease Negative 95 Male 1 Negative Negative Negative 4 90 Negative Negative bone marrow 5359 80.8 White
GSM2999 training set None No CNS disease Negative 90 Male 1 Negative Negative Negative 2 95 Negative Negative bone marrow 1167 156.0 White
GSM299912 training set Unknown No CNS disease Negative 95 Female 1 Negative Negative Negative 2 82 Negative Negative peripheral blood 4090 289.3 White
GSM299913 test set None No CNS disease Negative 95 Male 1 Negative Negative Negative 3 90 Positive Negative peripheral blood 792 237.0 White
GSM299914 training set None No CNS disease Negative 95 Male 1 Negative Negative Negative 4 99 Negative Negative bone marrow 6733 81.4 White
GSM299915 training set Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 95 Male 2 Negative Negative Negative 5 98 Negative Negative bone marrow 2875 351.3 Asian
GSM299916 training set Other > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 80 Male 2 Negative Negative Positive 5 99 Negative Negative peripheral blood 449 59.9 Hispanic or Latino
GSM299917 training set Unknown No CNS disease Negative 95 Male 4 Negative Negative Negative 6 100 Negative Negative bone marrow 904 137.8 White
GSM299918 test set None No CNS disease Negative 90 Male 2 Negative Negative Negative 6 98 Negative Negative bone marrow 1426 138.4 White
GSM299919 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 2 Negative Negative Negative 6 98 Negative Negative peripheral blood 4469 478.0 Hispanic or Latino
GSM299920 training set None No CNS disease Negative 95 Male 2 Negative Negative Negative 7 88 Negative Negative bone marrow 6266 34.9 Hispanic or Latino
GSM29992 training set None No CNS disease Negative 70 Male 2 Negative Negative Negative 8 100 Negative Negative bone marrow 6306 22.8 White
GSM299922 training set None No CNS disease Unknown 90 Female 2 Negative Negative Negative 8 100 Negative Negative peripheral blood 727 109.5 White
GSM299923 training set None No CNS disease Negative 95 Male 2 Negative Negative Negative 5 99 Negative Negative bone marrow 5867 21.1 Hispanic or Latino
GSM299924 training set None No CNS disease Unknown 90 Female 2 Negative Negative Negative 5 95 Negative Negative bone marrow 6733 102.0 Asian
GSM299925 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 90 Male 4 Negative Negative Negative 6 98 Negative Negative peripheral blood 5495 96.2 White
GSM299926 training set None No CNS disease Negative 95 Male 2 Negative Negative Negative 6 99 Negative Negative bone marrow 6063 2.3 unknown
GSM299927 test set None No CNS disease Unknown 95 Female 2 Negative Negative Negative 6 87 Negative Negative bone marrow 5922 27.0 Hispanic or Latino
GSM299928 training set Downs No CNS disease Unknown 90 Female 2 Negative Negative Negative 7 99 Negative Negative peripheral blood 6922 68.9 White
GSM299929 training set None No CNS disease Unknown 95 Female 2 Negative Negative Negative 8 100 Negative Negative bone marrow 531 119.0 White
GSM299930 test set Unknown No CNS disease Unknown 95 Female 2 Negative Negative Negative 5 97 Negative Negative bone marrow 4106 210.0 White
GSM29993 training set None No CNS disease Negative 95 Male 2 Negative Negative Negative 5 91 Negative Negative bone marrow 2027 199.0 Hispanic or Latino
GSM299932 training set Unknown No CNS disease Unknown 90 Female 2 Positive Negative Negative 6 96 Negative Negative peripheral blood 1191 175.5 Asian
GSM299933 test set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 6 Negative Negative Negative 7 94 Negative Negative peripheral blood 5310 92.7 Hispanic or Latino
GSM299934 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 95 Male 2 Negative Negative Negative 7 83 Negative Negative peripheral blood 5163 270.0 White
GSM299935 test set None No CNS disease Unknown 95 Female 2 Positive Negative Negative 7 66 Negative Negative bone marrow 977 115.1 White
GSM299936 training set Unknown No CNS disease Negative 95 Male 2 Negative Negative Negative 8 89 Negative Negative bone marrow 4807 12.7 White
GSM299937 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 95 Male 2 Negative Negative Negative 5 99 Negative Negative peripheral blood 5564 112.0 White
GSM299938 test set Unknown No CNS disease Negative 95 Male 2 Negative Negative Negative 5 60 Negative Negative bone marrow 4305 40.0 White
GSM299939 training set Unknown No CNS disease Unknown 95 Female 6 Negative Negative Negative 6 94 Negative Negative bone marrow 4717 62.3 White
GSM299940 test set None No CNS disease Negative 95 Male 4 Negative Negative Negative 7 99 Negative Negative bone marrow 4657 33.1 Hispanic or Latino
GSM29994 training set None No CNS disease Unknown 90 Female 2 Negative Negative Positive 7 79 Negative Negative bone marrow 1429 192.0 White
GSM299942 training set None No CNS disease Negative 65 Female 4 Negative Negative Negative 8 98 Negative Negative peripheral blood 6413 16.6 Hispanic or Latino
GSM299943 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 95 Female 2 Negative Negative Negative 8 92 Negative Negative peripheral blood 2133 17.5 White
GSM299944 test set Unknown No CNS disease Unknown 70 Female 2 Negative Negative Negative 8 69 Positive Negative peripheral blood 434 88.5 Hispanic or Latino
GSM299945 training set Unknown No CNS disease Negative 90 Male 2 Negative Negative Negative 5 87 Negative Negative bone marrow 4935 24.5 Asian
GSM299946 training set None No CNS disease Negative 85 Female 2 Negative Negative Negative 5 100 Negative Negative peripheral blood 6984 30.4 White
GSM299947 test set None No CNS disease Unknown 90 Female 2 Negative Negative Negative 5 65 Negative Negative bone marrow 1068 190.0 White
GSM299948 test set None No CNS disease Negative 95 Male 4 Negative Negative Negative 6 99 Negative Negative bone marrow 5877 66.9 Hispanic or Latino
GSM299949 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 95 Male 6 Negative Negative Negative 7 87 Positive Negative bone marrow 5127 555.0 White
GSM299950 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 90 Male 4 Negative Negative Negative 7 95 Positive Negative bone marrow 410 51.3 White
GSM29995 training set Unknown No CNS disease Negative 95 Male 2 Negative Negative Negative 7 97 Negative Negative bone marrow 5408 1.2 White
GSM299952 test set Unknown No CNS disease Negative 95 Male 2 Negative Negative Negative 8 96 Negative Negative bone marrow 2876 142.4 Black or African American
GSM299953 training set Unknown No CNS disease Negative 95 Male 2 Negative Negative Negative 8 87 Negative Negative bone marrow 697 110.9 White
GSM299954 test set Downs No CNS disease Unknown 90 Female 2 Negative Negative Negative 5 95 Negative Negative peripheral blood 2223 202.0 Hispanic or Latino
GSM299955 test set None No CNS disease Unknown 95 Female 2 Negative Negative Negative 5 97 Positive Negative peripheral blood 7028 259.8 White
GSM299956 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative -1 Male 2 Negative Negative Negative 5 26 Negative Unknown bone marrow 5177 166.5 White
GSM299957 training set None No CNS disease Unknown 90 Female 2 Negative Negative Negative 6 91 Positive Negative peripheral blood 1038 114.0 Hispanic or Latino
GSM299958 test set Downs No CNS disease Unknown 95 Female 2 Negative Negative Negative 6 100 Negative Negative peripheral blood 5008 321.2 Hispanic or Latino
GSM299959 training set None No CNS disease Unknown 95 Female 2 Negative Negative Negative 7 71 Negative Negative bone marrow 5925 19.5 Hispanic or Latino
GSM299960 training set None No CNS disease Negative 95 Male 2 Negative Negative Negative 7 93 Negative Negative peripheral blood 1258 145.0 Hispanic or Latino
GSM29996 test set None No CNS disease Unknown 90 Female 2 Positive Negative Negative 8 85 Negative Negative bone marrow 1956 148.2 Hispanic or Latino
GSM299962 training set None No CNS disease Unknown 90 Female 4 Negative Negative Negative 6 97 Positive Negative peripheral blood 4560 108.0 White
GSM299963 training set None No CNS disease Negative 90 Male 2 Negative Negative Negative 7 84 Positive Negative peripheral blood 966 37.3 White
GSM299964 test set None No CNS disease Negative 95 Male 2 Negative Negative Unknown 7 100 Negative Negative bone marrow 4585 12.0 White
GSM299965 training set Unknown No CNS disease Unknown 90 Female 2 Negative Negative Negative 5 98 Negative Negative bone marrow 4863 65.8 White
GSM299966 training set None No CNS disease Negative 95 Male 2 Negative Negative Negative 6 100 Negative Negative peripheral blood 369 325.0 White
GSM299967 test set None No CNS disease Negative -1 Male 2 Negative Negative Negative 7 20 Negative Negative bone marrow 5853 2.3 White
GSM299968 training set None No CNS disease Negative 80 Male 2 Negative Negative Negative 8 99 Negative Negative bone marrow 6335 13.3 White
GSM299969 test set None No CNS disease Negative 95 Male 2 Negative Negative Negative 8 97 Negative Negative peripheral blood 881 106.0 American Indian or Alaska native
GSM299970 training set None No CNS disease Unknown 95 Female 3 Negative Negative Negative 9 100 Negative Negative peripheral blood 2786 105.7 White
GSM29997 training set None No CNS disease Negative 80 Male 3 Negative Negative Negative 10 94 Negative Negative peripheral blood 6306 16.7 White
GSM299972 test set None No CNS disease Negative 90 Male 3 Negative Negative Negative 10 98 Negative Negative bone marrow 2519 112.0 White
GSM299973 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 11 66 Negative Negative bone marrow 6142 18.5 Hispanic or Latino
GSM299974 test set None No CNS disease Negative 80 Male 3 Negative Negative Negative 11 96 Negative Negative bone marrow 5343 30.2 Black or African American
GSM299975 test set None No CNS disease Negative 90 Male 3 Negative Negative Negative 11 96 Positive Negative bone marrow 852 139.0 White
GSM299976 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 12 94 Positive Negative bone marrow 462 17.3 Hispanic or Latino
GSM299977 training set Unknown No CNS disease Unknown 90 Female 3 Positive Negative Negative 12 75 Negative Negative peripheral blood 5797 39.6 Black or African American
GSM299978 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 9 97 Negative Negative peripheral blood 4253 236.4 Hispanic or Latino
GSM299979 training set None No CNS disease Unknown 75 Female 3 Negative Negative Negative 9 99 Negative Negative peripheral blood 705 137.2 Hispanic or Latino
GSM299980 training set Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 70 Male 3 Negative Negative Negative 10 99 Negative Negative peripheral blood 7478 28.0 White
GSM29998 training set Unknown No CNS disease Negative 90 Male 3 Negative Negative Negative 10 100 Negative Negative peripheral blood 2191 272.0 White
GSM299982 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 90 Female 3 Negative Negative Negative 11 98 Negative Negative bone marrow 1275 214.0 Hispanic or Latino
GSM299983 test set None No CNS disease Negative 95 Male 3 Negative Negative Negative 11 96 Negative Negative bone marrow 5184 58.0 White
GSM299984 training set None No CNS disease Negative -1 Male 3 Negative Negative Negative 11 59 Negative Negative bone marrow 5542 7.9 Other
GSM299985 test set None No CNS disease Negative 95 Male 3 Negative Negative Negative 12 64 Negative Negative bone marrow 5242 3.4 White
GSM299986 training set Unknown No CNS disease Unknown 75 Female 3 Negative Negative Negative 12 99 Negative Negative peripheral blood 1313 69.4 White
GSM299987 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 95 Female 3 Negative Negative Negative 9 94 Negative Negative bone marrow 1751 238.0 White
GSM299988 training set None No CNS disease Unknown 90 Female 3 Negative Negative Negative 9 98 Negative Negative bone marrow 4329 179.0 White
GSM299989 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 90 Male 3 Negative Negative Negative 9 86 Negative Positive bone marrow 976 7.7 White
GSM299990 test set None No CNS disease Negative 95 Female 3 Positive Negative Negative 10 91 Negative Negative bone marrow 5300 98.2 Hispanic or Latino
GSM29999 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 90 Male 3 Negative Negative Negative 11 81 Negative Negative bone marrow 4307 44.9 Hispanic or Latino
GSM299992 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 60 Female 3 Negative Negative Negative 12 98 Negative Negative peripheral blood 4324 35.7 White
GSM299993 test set Unknown No CNS disease Unknown 95 Female 3 Positive Negative Negative 9 97 Negative Negative bone marrow 1033 118.1 White
GSM299994 test set None No CNS disease Negative -1 Male 3 Negative Negative Negative 9 31 Negative Negative bone marrow 6052 6.4 Hispanic or Latino
GSM299995 training set Unknown No CNS disease Negative 95 Male 3 Negative Unknown Unknown 10 85 Negative Negative bone marrow 4157 77.6 White
GSM299996 training set None No CNS disease Unknown 90 Male 3 Positive Negative Negative 11 64 Negative Negative bone marrow 5025 73.1 Asian
GSM299997 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 12 99 Negative Negative bone marrow 6263 1.0 White
GSM299998 training set None No CNS disease Negative 90 Male 3 Negative Negative Negative 9 96 Positive Negative bone marrow 5664 22.0 White
GSM299999 test set None No CNS disease Negative 95 Male 3 Negative Negative Negative 9 95 Negative Negative bone marrow 4776 1.3 Other
GSM300000 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 3 Negative Negative Negative 10 99 Negative Negative peripheral blood 2192 209.6 White
GSM30000 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 11 94 Negative Negative bone marrow 5954 15.5 Black or African American
GSM300002 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 11 67 Negative Negative bone marrow 2038 193.0 White
GSM300003 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 95 Female 3 Negative Negative Negative 12 96 Negative Positive bone marrow 6032 59.2 White
GSM300004 training set Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive 85 Male 3 Negative Negative Negative 12 98 Negative Negative peripheral blood 655 9.8 White
GSM300005 training set None No CNS disease Negative 90 Male 3 Negative Negative Negative 12 94 Negative Negative bone marrow 4759 2.4 White
GSM300006 test set Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 95 Female 3 Negative Negative Negative 9 97 Negative Negative bone marrow 2769 3.0 Hispanic or Latino
GSM300007 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 40 Male 3 Negative Negative Negative 9 94 Negative Negative peripheral blood 4972 6.3 American Indian or Alaska native
GSM300008 test set Unknown No CNS disease Negative 95 Male 3 Negative Negative Negative 9 98 Negative Negative bone marrow 4815 31.4 Black or African American
GSM300009 test set None No CNS disease Negative 95 Male 3 Negative Negative Negative 10 98 Negative Negative peripheral blood 6315 245.0 White
GSM300010 training set Downs No CNS disease Negative 95 Male 3 Negative Negative Negative 10 95 Negative Negative bone marrow 4276 24.4 White
GSM3000 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 10 99 Negative Negative peripheral blood 5759 33.9 White
GSM300012 test set None No CNS disease Negative -1 Male 3 Negative Negative Negative 11 44 Negative Negative bone marrow 6487 7.6 White
GSM300013 test set None No CNS disease Negative 95 Male 3 Positive Negative Negative 11 99 Negative Negative peripheral blood 1771 152.7 Black or African American
GSM300014 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 12 89 Negative Negative bone marrow 515 124.0 White
GSM300015 training set None No CNS disease Unknown 95 Female 3 Negative Negative Negative 12 96 Negative Negative bone marrow 6090 24.8 White
GSM300016 training set Unknown No CNS disease Negative 95 Male 3 Negative Negative Negative 9 99 Negative Negative bone marrow 6633 1.9 White
GSM300017 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 95 Male 3 Negative Negative Negative 9 97 Negative Negative bone marrow 5194 96.5 Hispanic or Latino
GSM300018 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 10 96 Negative Negative bone marrow 6468 7.0 Hispanic or Latino
GSM300019 test set None No CNS disease Negative 90 Male 3 Negative Negative Negative 11 92 Negative Negative bone marrow 6062 17.0 White
GSM300020 test set Unknown No CNS disease Unknown 90 Female 3 Negative Negative Negative 11 95 Positive Negative bone marrow 777 6.8 Other
GSM30002 test set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 85 Female 3 Positive Negative Negative 12 100 Negative Negative bone marrow 5889 49.6 White
GSM300022 test set None No CNS disease Negative 95 Male 3 Negative Negative Negative 12 95 Negative Negative peripheral blood 893 455.4 White
GSM300023 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 9 98 Negative Negative bone marrow 4955 31.5 Hispanic or Latino
GSM300024 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 10 99 Negative Negative peripheral blood 5081 307.0 Hispanic or Latino
GSM300025 training set Downs < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 90 Female 3 Negative Negative Negative 10 98 Negative Negative bone marrow 4665 95.2 Hispanic or Latino
GSM300026 training set None No CNS disease Negative 95 Male 3 Negative Negative Negative 11 97 Negative Negative peripheral blood 988 958.8 Hispanic or Latino
GSM300027 training set None No CNS disease Negative -1 Male 3 Positive Negative Negative 12 59 Negative Negative bone marrow 5890 9.4 White
GSM300028 test set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 3 Negative Negative Negative 12 96 Negative Negative bone marrow 6351 13.8 Black or African American
GSM300029 test set Unknown < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 95 Male 4 Negative Negative Negative 13 86 Negative Negative bone marrow 1475 212.3 White
GSM300030 training set Unknown No CNS disease Negative 90 Male 4 Negative Negative Negative 13 99 Negative Negative bone marrow 6036 8.8 Hispanic or Latino
GSM30003 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown 95 Female 1 Negative Negative Negative 4 96 Negative Negative bone marrow 5217 135.8 White
GSM300032 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 95 Male 1 Negative Negative Negative 4 97 Negative Negative bone marrow 523 82.9 Black or African American
GSM300033 training set Unknown No CNS disease Unknown 95 Female 3 Positive Negative Negative 11 99 Negative Negative peripheral blood 1011 302.1 White
GSM300034 test set None No CNS disease Negative 90 Male 3 Negative Negative Negative 11 98 Negative Negative bone marrow 6107 18.3 Native Hawaiian or other Pacific Islander
GSM300035 training set None No CNS disease Negative 95 Male 4 Negative Negative Negative 13 95 Negative Negative peripheral blood 768 138.8 White
GSM300036 training set None No CNS disease Unknown 90 Female 4 Positive Negative Negative 13 84 Negative Negative peripheral blood 5670 37.2 White
GSM300037 training set None No CNS disease Negative 95 Male 6 Negative Negative Negative 11 99 Negative Negative peripheral blood 6666 114.6 Hispanic or Latino
GSM300038 training set None No CNS disease Unknown 85 Female 4 Positive Negative Negative 13 96 Negative Negative bone marrow 3901 136.6 Hispanic or Latino
GSM300039 training set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative -1 Female 7 Negative Negative Negative 14 51 Negative Negative peripheral blood 728 138.4 White
GSM300040 test set None No CNS disease Unknown 95 Female 7 Negative Negative Negative 14 79 Negative Negative bone marrow 1058 141.0 White
GSM30004 test set Unknown > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 95 Female 7 Negative Negative Negative 14 76 Negative Positive bone marrow 1323 30.6 Hispanic or Latino
GSM300042 training set None No CNS disease Negative 95 Male 7 Negative Negative Negative 14 84 Negative Negative bone marrow 650 102.5 Hispanic or Latino
GSM300043 test set None No CNS disease Negative 85 Male 8 Negative Negative Negative 15 99 Negative Negative bone marrow 5821 1.9 White
GSM300044 training set Unknown No CNS disease Negative 40 Male 8 Negative Negative Negative 15 100 Negative Negative peripheral blood 6202 2.3 White
GSM300045 training set None No CNS disease Negative 90 Female 8 Negative Negative Negative 15 98 Negative Negative bone marrow 6119 2.3 American Indian or Alaska native
GSM300046 training set None No CNS disease Positive 60 Male 8 Negative Negative Negative 15 99 Negative Negative peripheral blood 4571 6.9 White
GSM300047 training set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative 60 Male 8 Negative Negative Negative 15 93 Negative Positive peripheral blood 1896 4.1 Hispanic or Latino
GSM300048 training set None No CNS disease Negative 75 Female 8 Negative Negative Negative 15 97 Negative Negative bone marrow 7461 3.8 White
GSM300049 test set None No CNS disease Negative 65 Male 8 Negative Negative Negative 15 96 Negative Negative bone marrow 6634 11.1 White
GSM300050 training set None No CNS disease Negative 80 Male 8 Negative Negative Negative 15 83 Negative Negative peripheral blood 5097 6.3 White
GSM30005 test set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative 95 Male 8 Negative Negative Negative 15 96 Negative Negative bone marrow 5532 5.5 Hispanic or Latino
GSM300052 test set None < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive -1 Male 8 Negative Negative Negative 15 47 Negative Positive peripheral blood 1914 45.1 Black or African American
GSM300053 training set None No CNS disease Negative 90 Male 8 Positive Negative Negative 15 72 Negative Negative peripheral blood 4434 42.1 White
GSM300054 test set None No CNS disease Negative 50 Male 8 Positive Negative Negative 15 93 Negative Negative peripheral blood 4782 4.4 Asian
GSM300055 test set None No CNS disease Negative 90 Male 8 Negative Negative Negative 15 84 Negative Negative bone marrow 5232 1.1 White
GSM300056 test set None No CNS disease Negative 80 Male 8 Positive Negative Negative 15 83 Negative Negative peripheral blood 6500 17.8 Black or African American
GSM300057 training set None No CNS disease Unknown -1 Male 9 Negative Negative Negative 16 50 Positive Negative bone marrow 585 7.5 White
GSM300058 test set None No CNS disease Negative 95 Male 9 Negative Negative Negative 16 98 Negative Negative bone marrow 6539 2.6 Black or African American
GSM300059 test set None No CNS disease Negative 85 Female 9 Negative Negative Negative 16 100 Negative Negative bone marrow 5991 5.2 White
GSM300060 training set None No CNS disease Negative 70 Male 9 Negative Negative Negative 16 93 Negative Negative peripheral blood 6479 31.9 White
GSM30006 training set None No CNS disease Negative 90 Male 9 Negative Negative Negative 16 98 Negative Negative bone marrow 5183 23.0 Black or African American
GSM300062 training set None No CNS disease Negative -1 Male 9 Negative Negative Negative 16 46 Negative Negative peripheral blood 713 110.3 White
GSM300063 test set None No CNS disease Unknown 90 Male 9 Negative Negative Negative 16 82 Positive Negative bone marrow 1704 85.1 White
GSM300064 test set Unknown No CNS disease Negative 95 Male 9 Negative Negative Negative 16 99 Negative Negative bone marrow 5594 2.8 White
GSM300065 training set Unknown No CNS disease Negative 95 Male 9 Negative Negative Negative 16 88 Negative Negative bone marrow 5857 13.3 White
GSM300066 test set None > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown 95 Female 9 Positive Negative Negative 16 81 Negative Negative bone marrow 4017 3.5 Hispanic or Latino
GSM300067 training set Unknown No CNS disease Negative 95 Male 9 Negative Negative Negative 16 85 Negative Negative bone marrow 4918 5.5 White
GSM300068 training set Unknown No CNS disease Negative 90 Male 10 Negative Negative Negative 18 66 Negative Negative bone marrow 5349 147.6 Hispanic or Latino

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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