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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample RACE CONGENITAL ABNORMALITY TRAINING OR TEST SET CNS STATUS TESTICULAR INVOLVEMENT GENDER AMPLIFICATION SET E2A-PBX, T(1;19) BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE MLL SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE TISSUE TYPE AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER TRISOMY 4 AND 10
GSM299862 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 1 Negative Negative Negative 1 90 Positive 100 peripheral blood 3953 175.0 Negative
GSM299863 Black or African American None training set No CNS disease Negative Male 1 Negative Negative Negative 1 90 Negative 100 peripheral blood 1976 142.0 Negative
GSM299864 Hispanic or Latino None training set No CNS disease Negative Male 1 Negative Negative Negative 2 70 Negative 99 peripheral blood 5250 220.7 Negative
GSM299865 White None test set No CNS disease Negative Male 1 Negative Negative Negative 2 95 Negative 88 peripheral blood 577 129.0 Negative
GSM299866 Hispanic or Latino None training set No CNS disease Negative Male 1 Negative Negative Negative 3 95 Negative 95 bone marrow 4609 26.0 Negative
GSM299867 White None training set No CNS disease Negative Male 1 Negative Negative Negative 3 80 Negative 68 bone marrow 5289 14.7 Negative
GSM299868 Asian None training set No CNS disease Negative Male 1 Negative Negative Negative 4 -1 Negative 71 bone marrow 3987 68.6 Negative
GSM299869 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 1 Negative Negative Negative 4 90 Negative 98 bone marrow 4856 21.4 Negative
GSM299870 White None test set No CNS disease Negative Male 1 Negative Negative Negative 4 1 Negative 99 bone marrow 4678 2.4 Negative
GSM29987 White Unknown training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 1 Negative Negative Negative 1 75 Negative 68 bone marrow 796 21.0 Negative
GSM299872 White None training set No CNS disease Unknown Female 1 Negative Negative Negative 1 85 Positive 100 peripheral blood 4071 125.8 Negative
GSM299873 White Unknown training set No CNS disease Negative Male 1 Negative Negative Negative 2 95 Negative 99 bone marrow 5223 29.9 Negative
GSM299874 Hispanic or Latino Unknown training set No CNS disease Unknown Female 1 Negative Negative Negative 3 95 Negative 99 peripheral blood 5118 217.2 Negative
GSM299875 unknown None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 1 Negative Negative Negative 3 90 Negative 97 peripheral blood 5219 180.0 Negative
GSM299876 White Downs training set No CNS disease Unknown Female 1 Negative Negative Negative 4 95 Negative 98 bone marrow 1429 118.0 Negative
GSM299877 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 1 Negative Negative Negative 1 95 Negative 97 peripheral blood 3179 314.8 Negative
GSM299878 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 1 Negative Negative Negative 1 -1 Negative 58 bone marrow 1450 5.2 Negative
GSM299879 White None training set No CNS disease Negative Male 1 Negative Negative Negative 1 95 Negative 91 bone marrow 5278 113.5 Negative
GSM299880 White None training set No CNS disease Negative Male 1 Positive Negative Negative 2 85 Negative 98 bone marrow 5330 5.8 Negative
GSM29988 Hispanic or Latino Unknown test set No CNS disease Unknown Female 1 Negative Negative Negative 4 90 Negative 99 peripheral blood 4861 592.6 Negative
GSM299882 White None training set No CNS disease Unknown Female 1 Negative Negative Negative 1 95 Negative 80 peripheral blood 428 248.0 Negative
GSM299883 White None training set No CNS disease Negative Male 1 Negative Negative Negative 1 95 Negative 97 bone marrow 4722 4.4 Negative
GSM299884 White Unknown test set No CNS disease Negative Male 1 Negative Negative Negative 2 95 Negative 99 bone marrow 3587 72.2 Negative
GSM299885 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female 1 Negative Negative Negative 2 90 Positive 98 peripheral blood 5431 133.0 Negative
GSM299886 Hispanic or Latino None training set No CNS disease Positive Male 1 Negative Negative Negative 2 70 Negative 98 bone marrow 3444 5.0 Negative
GSM299887 Other None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 1 Negative Negative Negative 3 90 Negative 99 peripheral blood 862 194.0 Negative
GSM299888 Hispanic or Latino None training set No CNS disease Negative Male 1 Negative Negative Negative 3 90 Negative 97 bone marrow 6674 3.8 Negative
GSM299889 White None training set No CNS disease Negative Male 1 Negative Negative Negative 3 95 Negative 70 bone marrow 6323 15.4 Negative
GSM299890 White Unknown training set No CNS disease Negative Male 1 Negative Negative Negative 4 90 Negative 98 bone marrow 6219 16.5 Negative
GSM29989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 1 Negative Negative Positive 4 95 Negative 65 bone marrow 2509 1.7 Negative
GSM299892 Hispanic or Latino None training set No CNS disease Unknown Female 1 Positive Negative Negative 4 95 Negative 100 peripheral blood 1531 196.1 Negative
GSM299893 Hispanic or Latino Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Male 1 Negative Negative Negative 1 85 Negative 100 peripheral blood 5516 202.4 Negative
GSM299894 White None training set No CNS disease Negative Male 1 Negative Negative Negative 1 90 Negative 82 bone marrow 5513 2.5 Negative
GSM299895 White Unknown training set No CNS disease Negative Male 1 Negative Negative Negative 2 95 Negative 62 bone marrow 5842 27.4 Negative
GSM299896 White Downs training set No CNS disease Negative Male 1 Positive Negative Negative 3 75 Negative 98 peripheral blood 6496 9.1 Negative
GSM299897 White None training set No CNS disease Negative Male 1 Negative Negative Negative 3 95 Positive 99 peripheral blood 6511 515.0 Negative
GSM299898 Hispanic or Latino None training set No CNS disease Negative Male 1 Positive Negative Negative 4 95 Negative 97 bone marrow 1361 117.2 Negative
GSM299899 White None training set No CNS disease Unknown Female 1 Negative Negative Negative 1 95 Negative 74 bone marrow 835 115.0 Negative
GSM299900 Hispanic or Latino None training set No CNS disease Negative Male 1 Negative Negative Negative 2 95 Positive 99 peripheral blood 4774 246.4 Negative
GSM29990 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 1 Negative Negative Negative 2 95 Positive 95 bone marrow 3311 489.0 Negative
GSM299902 White None training set No CNS disease Negative Male 1 Negative Negative Negative 3 80 Negative 100 peripheral blood 6331 32.6 Negative
GSM299903 White None training set No CNS disease Unknown Female 1 Negative Negative Negative 3 95 Positive 92 bone marrow 398 135.0 Negative
GSM299904 White None test set No CNS disease Negative Male 1 Positive Negative Negative 3 95 Negative 96 bone marrow 5631 67.2 Negative
GSM299905 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 1 Negative Negative Negative 1 95 Negative 96 bone marrow 944 12.1 Negative
GSM299906 White None training set No CNS disease Negative Male 1 Positive Negative Negative 1 90 Negative 90 bone marrow 4940 8.0 Negative
GSM299907 White Downs training set No CNS disease Negative Female 1 Negative Negative Negative 2 95 Negative 96 bone marrow 5721 88.9 Negative
GSM299908 White Unknown training set No CNS disease Negative Male 1 Negative Negative Negative 3 95 Negative 98 peripheral blood 6114 80.9 Negative
GSM299909 White None training set No CNS disease Negative Male 1 Negative Negative Negative 4 95 Negative 97 bone marrow 5086 36.2 Negative
GSM299910 White None test set No CNS disease Negative Male 1 Negative Negative Negative 4 95 Negative 90 bone marrow 5359 80.8 Negative
GSM2999 White None training set No CNS disease Negative Male 1 Negative Negative Negative 2 90 Negative 95 bone marrow 1167 156.0 Negative
GSM299912 White Unknown training set No CNS disease Negative Female 1 Negative Negative Negative 2 95 Negative 82 peripheral blood 4090 289.3 Negative
GSM299913 White None test set No CNS disease Negative Male 1 Negative Negative Negative 3 95 Positive 90 peripheral blood 792 237.0 Negative
GSM299914 White None training set No CNS disease Negative Male 1 Negative Negative Negative 4 95 Negative 99 bone marrow 6733 81.4 Negative
GSM299915 Asian Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 2 Negative Negative Negative 5 95 Negative 98 bone marrow 2875 351.3 Negative
GSM299916 Hispanic or Latino Other training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 2 Negative Negative Positive 5 80 Negative 99 peripheral blood 449 59.9 Negative
GSM299917 White Unknown training set No CNS disease Negative Male 4 Negative Negative Negative 6 95 Negative 100 bone marrow 904 137.8 Negative
GSM299918 White None test set No CNS disease Negative Male 2 Negative Negative Negative 6 90 Negative 98 bone marrow 1426 138.4 Negative
GSM299919 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 2 Negative Negative Negative 6 95 Negative 98 peripheral blood 4469 478.0 Negative
GSM299920 Hispanic or Latino None training set No CNS disease Negative Male 2 Negative Negative Negative 7 95 Negative 88 bone marrow 6266 34.9 Negative
GSM29992 White None training set No CNS disease Negative Male 2 Negative Negative Negative 8 70 Negative 100 bone marrow 6306 22.8 Negative
GSM299922 White None training set No CNS disease Unknown Female 2 Negative Negative Negative 8 90 Negative 100 peripheral blood 727 109.5 Negative
GSM299923 Hispanic or Latino None training set No CNS disease Negative Male 2 Negative Negative Negative 5 95 Negative 99 bone marrow 5867 21.1 Negative
GSM299924 Asian None training set No CNS disease Unknown Female 2 Negative Negative Negative 5 90 Negative 95 bone marrow 6733 102.0 Negative
GSM299925 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 4 Negative Negative Negative 6 90 Negative 98 peripheral blood 5495 96.2 Negative
GSM299926 unknown None training set No CNS disease Negative Male 2 Negative Negative Negative 6 95 Negative 99 bone marrow 6063 2.3 Negative
GSM299927 Hispanic or Latino None test set No CNS disease Unknown Female 2 Negative Negative Negative 6 95 Negative 87 bone marrow 5922 27.0 Negative
GSM299928 White Downs training set No CNS disease Unknown Female 2 Negative Negative Negative 7 90 Negative 99 peripheral blood 6922 68.9 Negative
GSM299929 White None training set No CNS disease Unknown Female 2 Negative Negative Negative 8 95 Negative 100 bone marrow 531 119.0 Negative
GSM299930 White Unknown test set No CNS disease Unknown Female 2 Negative Negative Negative 5 95 Negative 97 bone marrow 4106 210.0 Negative
GSM29993 Hispanic or Latino None training set No CNS disease Negative Male 2 Negative Negative Negative 5 95 Negative 91 bone marrow 2027 199.0 Negative
GSM299932 Asian Unknown training set No CNS disease Unknown Female 2 Positive Negative Negative 6 90 Negative 96 peripheral blood 1191 175.5 Negative
GSM299933 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 6 Negative Negative Negative 7 95 Negative 94 peripheral blood 5310 92.7 Negative
GSM299934 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 2 Negative Negative Negative 7 95 Negative 83 peripheral blood 5163 270.0 Negative
GSM299935 White None test set No CNS disease Unknown Female 2 Positive Negative Negative 7 95 Negative 66 bone marrow 977 115.1 Negative
GSM299936 White Unknown training set No CNS disease Negative Male 2 Negative Negative Negative 8 95 Negative 89 bone marrow 4807 12.7 Negative
GSM299937 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 2 Negative Negative Negative 5 95 Negative 99 peripheral blood 5564 112.0 Negative
GSM299938 White Unknown test set No CNS disease Negative Male 2 Negative Negative Negative 5 95 Negative 60 bone marrow 4305 40.0 Negative
GSM299939 White Unknown training set No CNS disease Unknown Female 6 Negative Negative Negative 6 95 Negative 94 bone marrow 4717 62.3 Negative
GSM299940 Hispanic or Latino None test set No CNS disease Negative Male 4 Negative Negative Negative 7 95 Negative 99 bone marrow 4657 33.1 Negative
GSM29994 White None training set No CNS disease Unknown Female 2 Negative Negative Positive 7 90 Negative 79 bone marrow 1429 192.0 Negative
GSM299942 Hispanic or Latino None training set No CNS disease Negative Female 4 Negative Negative Negative 8 65 Negative 98 peripheral blood 6413 16.6 Negative
GSM299943 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Female 2 Negative Negative Negative 8 95 Negative 92 peripheral blood 2133 17.5 Negative
GSM299944 Hispanic or Latino Unknown test set No CNS disease Unknown Female 2 Negative Negative Negative 8 70 Positive 69 peripheral blood 434 88.5 Negative
GSM299945 Asian Unknown training set No CNS disease Negative Male 2 Negative Negative Negative 5 90 Negative 87 bone marrow 4935 24.5 Negative
GSM299946 White None training set No CNS disease Negative Female 2 Negative Negative Negative 5 85 Negative 100 peripheral blood 6984 30.4 Negative
GSM299947 White None test set No CNS disease Unknown Female 2 Negative Negative Negative 5 90 Negative 65 bone marrow 1068 190.0 Negative
GSM299948 Hispanic or Latino None test set No CNS disease Negative Male 4 Negative Negative Negative 6 95 Negative 99 bone marrow 5877 66.9 Negative
GSM299949 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 6 Negative Negative Negative 7 95 Positive 87 bone marrow 5127 555.0 Negative
GSM299950 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 4 Negative Negative Negative 7 90 Positive 95 bone marrow 410 51.3 Negative
GSM29995 White Unknown training set No CNS disease Negative Male 2 Negative Negative Negative 7 95 Negative 97 bone marrow 5408 1.2 Negative
GSM299952 Black or African American Unknown test set No CNS disease Negative Male 2 Negative Negative Negative 8 95 Negative 96 bone marrow 2876 142.4 Negative
GSM299953 White Unknown training set No CNS disease Negative Male 2 Negative Negative Negative 8 95 Negative 87 bone marrow 697 110.9 Negative
GSM299954 Hispanic or Latino Downs test set No CNS disease Unknown Female 2 Negative Negative Negative 5 90 Negative 95 peripheral blood 2223 202.0 Negative
GSM299955 White None test set No CNS disease Unknown Female 2 Negative Negative Negative 5 95 Positive 97 peripheral blood 7028 259.8 Negative
GSM299956 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 2 Negative Negative Negative 5 -1 Negative 26 bone marrow 5177 166.5 Unknown
GSM299957 Hispanic or Latino None training set No CNS disease Unknown Female 2 Negative Negative Negative 6 90 Positive 91 peripheral blood 1038 114.0 Negative
GSM299958 Hispanic or Latino Downs test set No CNS disease Unknown Female 2 Negative Negative Negative 6 95 Negative 100 peripheral blood 5008 321.2 Negative
GSM299959 Hispanic or Latino None training set No CNS disease Unknown Female 2 Negative Negative Negative 7 95 Negative 71 bone marrow 5925 19.5 Negative
GSM299960 Hispanic or Latino None training set No CNS disease Negative Male 2 Negative Negative Negative 7 95 Negative 93 peripheral blood 1258 145.0 Negative
GSM29996 Hispanic or Latino None test set No CNS disease Unknown Female 2 Positive Negative Negative 8 90 Negative 85 bone marrow 1956 148.2 Negative
GSM299962 White None training set No CNS disease Unknown Female 4 Negative Negative Negative 6 90 Positive 97 peripheral blood 4560 108.0 Negative
GSM299963 White None training set No CNS disease Negative Male 2 Negative Negative Negative 7 90 Positive 84 peripheral blood 966 37.3 Negative
GSM299964 White None test set No CNS disease Negative Male 2 Negative Negative Unknown 7 95 Negative 100 bone marrow 4585 12.0 Negative
GSM299965 White Unknown training set No CNS disease Unknown Female 2 Negative Negative Negative 5 90 Negative 98 bone marrow 4863 65.8 Negative
GSM299966 White None training set No CNS disease Negative Male 2 Negative Negative Negative 6 95 Negative 100 peripheral blood 369 325.0 Negative
GSM299967 White None test set No CNS disease Negative Male 2 Negative Negative Negative 7 -1 Negative 20 bone marrow 5853 2.3 Negative
GSM299968 White None training set No CNS disease Negative Male 2 Negative Negative Negative 8 80 Negative 99 bone marrow 6335 13.3 Negative
GSM299969 American Indian or Alaska native None test set No CNS disease Negative Male 2 Negative Negative Negative 8 95 Negative 97 peripheral blood 881 106.0 Negative
GSM299970 White None training set No CNS disease Unknown Female 3 Negative Negative Negative 9 95 Negative 100 peripheral blood 2786 105.7 Negative
GSM29997 White None training set No CNS disease Negative Male 3 Negative Negative Negative 10 80 Negative 94 peripheral blood 6306 16.7 Negative
GSM299972 White None test set No CNS disease Negative Male 3 Negative Negative Negative 10 90 Negative 98 bone marrow 2519 112.0 Negative
GSM299973 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 11 95 Negative 66 bone marrow 6142 18.5 Negative
GSM299974 Black or African American None test set No CNS disease Negative Male 3 Negative Negative Negative 11 80 Negative 96 bone marrow 5343 30.2 Negative
GSM299975 White None test set No CNS disease Negative Male 3 Negative Negative Negative 11 90 Positive 96 bone marrow 852 139.0 Negative
GSM299976 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 12 95 Positive 94 bone marrow 462 17.3 Negative
GSM299977 Black or African American Unknown training set No CNS disease Unknown Female 3 Positive Negative Negative 12 90 Negative 75 peripheral blood 5797 39.6 Negative
GSM299978 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 9 95 Negative 97 peripheral blood 4253 236.4 Negative
GSM299979 Hispanic or Latino None training set No CNS disease Unknown Female 3 Negative Negative Negative 9 75 Negative 99 peripheral blood 705 137.2 Negative
GSM299980 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 3 Negative Negative Negative 10 70 Negative 99 peripheral blood 7478 28.0 Negative
GSM29998 White Unknown training set No CNS disease Negative Male 3 Negative Negative Negative 10 90 Negative 100 peripheral blood 2191 272.0 Negative
GSM299982 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 3 Negative Negative Negative 11 90 Negative 98 bone marrow 1275 214.0 Negative
GSM299983 White None test set No CNS disease Negative Male 3 Negative Negative Negative 11 95 Negative 96 bone marrow 5184 58.0 Negative
GSM299984 Other None training set No CNS disease Negative Male 3 Negative Negative Negative 11 -1 Negative 59 bone marrow 5542 7.9 Negative
GSM299985 White None test set No CNS disease Negative Male 3 Negative Negative Negative 12 95 Negative 64 bone marrow 5242 3.4 Negative
GSM299986 White Unknown training set No CNS disease Unknown Female 3 Negative Negative Negative 12 75 Negative 99 peripheral blood 1313 69.4 Negative
GSM299987 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 3 Negative Negative Negative 9 95 Negative 94 bone marrow 1751 238.0 Negative
GSM299988 White None training set No CNS disease Unknown Female 3 Negative Negative Negative 9 90 Negative 98 bone marrow 4329 179.0 Negative
GSM299989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 3 Negative Negative Negative 9 90 Negative 86 bone marrow 976 7.7 Positive
GSM299990 Hispanic or Latino None test set No CNS disease Negative Female 3 Positive Negative Negative 10 95 Negative 91 bone marrow 5300 98.2 Negative
GSM29999 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 3 Negative Negative Negative 11 90 Negative 81 bone marrow 4307 44.9 Negative
GSM299992 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 3 Negative Negative Negative 12 60 Negative 98 peripheral blood 4324 35.7 Negative
GSM299993 White Unknown test set No CNS disease Unknown Female 3 Positive Negative Negative 9 95 Negative 97 bone marrow 1033 118.1 Negative
GSM299994 Hispanic or Latino None test set No CNS disease Negative Male 3 Negative Negative Negative 9 -1 Negative 31 bone marrow 6052 6.4 Negative
GSM299995 White Unknown training set No CNS disease Negative Male 3 Negative Unknown Unknown 10 95 Negative 85 bone marrow 4157 77.6 Negative
GSM299996 Asian None training set No CNS disease Unknown Male 3 Positive Negative Negative 11 90 Negative 64 bone marrow 5025 73.1 Negative
GSM299997 White None training set No CNS disease Negative Male 3 Negative Negative Negative 12 95 Negative 99 bone marrow 6263 1.0 Negative
GSM299998 White None training set No CNS disease Negative Male 3 Negative Negative Negative 9 90 Positive 96 bone marrow 5664 22.0 Negative
GSM299999 Other None test set No CNS disease Negative Male 3 Negative Negative Negative 9 95 Negative 95 bone marrow 4776 1.3 Negative
GSM300000 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 3 Negative Negative Negative 10 95 Negative 99 peripheral blood 2192 209.6 Negative
GSM30000 Black or African American None training set No CNS disease Negative Male 3 Negative Negative Negative 11 95 Negative 94 bone marrow 5954 15.5 Negative
GSM300002 White None training set No CNS disease Negative Male 3 Negative Negative Negative 11 95 Negative 67 bone marrow 2038 193.0 Negative
GSM300003 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 3 Negative Negative Negative 12 95 Negative 96 bone marrow 6032 59.2 Positive
GSM300004 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Male 3 Negative Negative Negative 12 85 Negative 98 peripheral blood 655 9.8 Negative
GSM300005 White None training set No CNS disease Negative Male 3 Negative Negative Negative 12 90 Negative 94 bone marrow 4759 2.4 Negative
GSM300006 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 3 Negative Negative Negative 9 95 Negative 97 bone marrow 2769 3.0 Negative
GSM300007 American Indian or Alaska native None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Male 3 Negative Negative Negative 9 40 Negative 94 peripheral blood 4972 6.3 Negative
GSM300008 Black or African American Unknown test set No CNS disease Negative Male 3 Negative Negative Negative 9 95 Negative 98 bone marrow 4815 31.4 Negative
GSM300009 White None test set No CNS disease Negative Male 3 Negative Negative Negative 10 95 Negative 98 peripheral blood 6315 245.0 Negative
GSM300010 White Downs training set No CNS disease Negative Male 3 Negative Negative Negative 10 95 Negative 95 bone marrow 4276 24.4 Negative
GSM3000 White None training set No CNS disease Negative Male 3 Negative Negative Negative 10 95 Negative 99 peripheral blood 5759 33.9 Negative
GSM300012 White None test set No CNS disease Negative Male 3 Negative Negative Negative 11 -1 Negative 44 bone marrow 6487 7.6 Negative
GSM300013 Black or African American None test set No CNS disease Negative Male 3 Positive Negative Negative 11 95 Negative 99 peripheral blood 1771 152.7 Negative
GSM300014 White None training set No CNS disease Negative Male 3 Negative Negative Negative 12 95 Negative 89 bone marrow 515 124.0 Negative
GSM300015 White None training set No CNS disease Unknown Female 3 Negative Negative Negative 12 95 Negative 96 bone marrow 6090 24.8 Negative
GSM300016 White Unknown training set No CNS disease Negative Male 3 Negative Negative Negative 9 95 Negative 99 bone marrow 6633 1.9 Negative
GSM300017 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 3 Negative Negative Negative 9 95 Negative 97 bone marrow 5194 96.5 Negative
GSM300018 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 10 95 Negative 96 bone marrow 6468 7.0 Negative
GSM300019 White None test set No CNS disease Negative Male 3 Negative Negative Negative 11 90 Negative 92 bone marrow 6062 17.0 Negative
GSM300020 Other Unknown test set No CNS disease Unknown Female 3 Negative Negative Negative 11 90 Positive 95 bone marrow 777 6.8 Negative
GSM30002 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 3 Positive Negative Negative 12 85 Negative 100 bone marrow 5889 49.6 Negative
GSM300022 White None test set No CNS disease Negative Male 3 Negative Negative Negative 12 95 Negative 95 peripheral blood 893 455.4 Negative
GSM300023 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 9 95 Negative 98 bone marrow 4955 31.5 Negative
GSM300024 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 10 95 Negative 99 peripheral blood 5081 307.0 Negative
GSM300025 Hispanic or Latino Downs training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 3 Negative Negative Negative 10 90 Negative 98 bone marrow 4665 95.2 Negative
GSM300026 Hispanic or Latino None training set No CNS disease Negative Male 3 Negative Negative Negative 11 95 Negative 97 peripheral blood 988 958.8 Negative
GSM300027 White None training set No CNS disease Negative Male 3 Positive Negative Negative 12 -1 Negative 59 bone marrow 5890 9.4 Negative
GSM300028 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 3 Negative Negative Negative 12 95 Negative 96 bone marrow 6351 13.8 Negative
GSM300029 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 4 Negative Negative Negative 13 95 Negative 86 bone marrow 1475 212.3 Negative
GSM300030 Hispanic or Latino Unknown training set No CNS disease Negative Male 4 Negative Negative Negative 13 90 Negative 99 bone marrow 6036 8.8 Negative
GSM30003 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown Female 1 Negative Negative Negative 4 95 Negative 96 bone marrow 5217 135.8 Negative
GSM300032 Black or African American None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 1 Negative Negative Negative 4 95 Negative 97 bone marrow 523 82.9 Negative
GSM300033 White Unknown training set No CNS disease Unknown Female 3 Positive Negative Negative 11 95 Negative 99 peripheral blood 1011 302.1 Negative
GSM300034 Native Hawaiian or other Pacific Islander None test set No CNS disease Negative Male 3 Negative Negative Negative 11 90 Negative 98 bone marrow 6107 18.3 Negative
GSM300035 White None training set No CNS disease Negative Male 4 Negative Negative Negative 13 95 Negative 95 peripheral blood 768 138.8 Negative
GSM300036 White None training set No CNS disease Unknown Female 4 Positive Negative Negative 13 90 Negative 84 peripheral blood 5670 37.2 Negative
GSM300037 Hispanic or Latino None training set No CNS disease Negative Male 6 Negative Negative Negative 11 95 Negative 99 peripheral blood 6666 114.6 Negative
GSM300038 Hispanic or Latino None training set No CNS disease Unknown Female 4 Positive Negative Negative 13 85 Negative 96 bone marrow 3901 136.6 Negative
GSM300039 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Female 7 Negative Negative Negative 14 -1 Negative 51 peripheral blood 728 138.4 Negative
GSM300040 White None test set No CNS disease Unknown Female 7 Negative Negative Negative 14 95 Negative 79 bone marrow 1058 141.0 Negative
GSM30004 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 7 Negative Negative Negative 14 95 Negative 76 bone marrow 1323 30.6 Positive
GSM300042 Hispanic or Latino None training set No CNS disease Negative Male 7 Negative Negative Negative 14 95 Negative 84 bone marrow 650 102.5 Negative
GSM300043 White None test set No CNS disease Negative Male 8 Negative Negative Negative 15 85 Negative 99 bone marrow 5821 1.9 Negative
GSM300044 White Unknown training set No CNS disease Negative Male 8 Negative Negative Negative 15 40 Negative 100 peripheral blood 6202 2.3 Negative
GSM300045 American Indian or Alaska native None training set No CNS disease Negative Female 8 Negative Negative Negative 15 90 Negative 98 bone marrow 6119 2.3 Negative
GSM300046 White None training set No CNS disease Positive Male 8 Negative Negative Negative 15 60 Negative 99 peripheral blood 4571 6.9 Negative
GSM300047 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative Male 8 Negative Negative Negative 15 60 Negative 93 peripheral blood 1896 4.1 Positive
GSM300048 White None training set No CNS disease Negative Female 8 Negative Negative Negative 15 75 Negative 97 bone marrow 7461 3.8 Negative
GSM300049 White None test set No CNS disease Negative Male 8 Negative Negative Negative 15 65 Negative 96 bone marrow 6634 11.1 Negative
GSM300050 White None training set No CNS disease Negative Male 8 Negative Negative Negative 15 80 Negative 83 peripheral blood 5097 6.3 Negative
GSM30005 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative Male 8 Negative Negative Negative 15 95 Negative 96 bone marrow 5532 5.5 Negative
GSM300052 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive Male 8 Negative Negative Negative 15 -1 Negative 47 peripheral blood 1914 45.1 Positive
GSM300053 White None training set No CNS disease Negative Male 8 Positive Negative Negative 15 90 Negative 72 peripheral blood 4434 42.1 Negative
GSM300054 Asian None test set No CNS disease Negative Male 8 Positive Negative Negative 15 50 Negative 93 peripheral blood 4782 4.4 Negative
GSM300055 White None test set No CNS disease Negative Male 8 Negative Negative Negative 15 90 Negative 84 bone marrow 5232 1.1 Negative
GSM300056 Black or African American None test set No CNS disease Negative Male 8 Positive Negative Negative 15 80 Negative 83 peripheral blood 6500 17.8 Negative
GSM300057 White None training set No CNS disease Unknown Male 9 Negative Negative Negative 16 -1 Positive 50 bone marrow 585 7.5 Negative
GSM300058 Black or African American None test set No CNS disease Negative Male 9 Negative Negative Negative 16 95 Negative 98 bone marrow 6539 2.6 Negative
GSM300059 White None test set No CNS disease Negative Female 9 Negative Negative Negative 16 85 Negative 100 bone marrow 5991 5.2 Negative
GSM300060 White None training set No CNS disease Negative Male 9 Negative Negative Negative 16 70 Negative 93 peripheral blood 6479 31.9 Negative
GSM30006 Black or African American None training set No CNS disease Negative Male 9 Negative Negative Negative 16 90 Negative 98 bone marrow 5183 23.0 Negative
GSM300062 White None training set No CNS disease Negative Male 9 Negative Negative Negative 16 -1 Negative 46 peripheral blood 713 110.3 Negative
GSM300063 White None test set No CNS disease Unknown Male 9 Negative Negative Negative 16 90 Positive 82 bone marrow 1704 85.1 Negative
GSM300064 White Unknown test set No CNS disease Negative Male 9 Negative Negative Negative 16 95 Negative 99 bone marrow 5594 2.8 Negative
GSM300065 White Unknown training set No CNS disease Negative Male 9 Negative Negative Negative 16 95 Negative 88 bone marrow 5857 13.3 Negative
GSM300066 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Unknown Female 9 Positive Negative Negative 16 95 Negative 81 bone marrow 4017 3.5 Negative
GSM300067 White Unknown training set No CNS disease Negative Male 9 Negative Negative Negative 16 95 Negative 85 bone marrow 4918 5.5 Negative
GSM300068 Hispanic or Latino Unknown training set No CNS disease Negative Male 10 Negative Negative Negative 18 90 Negative 66 bone marrow 5349 147.6 Negative

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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