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Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

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PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample RACE CONGENITAL ABNORMALITY TRAINING OR TEST SET CNS STATUS AMPLIFICATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE GENDER BCR-ABL, T(9;22) TEL-AML,T(12;21) HYBRIDIZATION SET SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) MLL TRISOMY 4 AND 10 TESTICULAR INVOLVEMENT AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER TISSUE TYPE
GSM299862 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 90 Female Negative Negative 1 100 Negative Positive Negative Unknown 3953 175.0 peripheral blood
GSM299863 Black or African American None training set No CNS disease 1 90 Male Negative Negative 1 100 Negative Negative Negative Negative 1976 142.0 peripheral blood
GSM299864 Hispanic or Latino None training set No CNS disease 1 70 Male Negative Negative 2 99 Negative Negative Negative Negative 5250 220.7 peripheral blood
GSM299865 White None test set No CNS disease 1 95 Male Negative Negative 2 88 Negative Negative Negative Negative 577 129.0 peripheral blood
GSM299866 Hispanic or Latino None training set No CNS disease 1 95 Male Negative Negative 3 95 Negative Negative Negative Negative 4609 26.0 bone marrow
GSM299867 White None training set No CNS disease 1 80 Male Negative Negative 3 68 Negative Negative Negative Negative 5289 14.7 bone marrow
GSM299868 Asian None training set No CNS disease 1 -1 Male Negative Negative 4 71 Negative Negative Negative Negative 3987 68.6 bone marrow
GSM299869 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 90 Male Negative Negative 4 98 Negative Negative Negative Negative 4856 21.4 bone marrow
GSM299870 White None test set No CNS disease 1 1 Male Negative Negative 4 99 Negative Negative Negative Negative 4678 2.4 bone marrow
GSM29987 White Unknown training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 75 Male Negative Negative 1 68 Negative Negative Negative Negative 796 21.0 bone marrow
GSM299872 White None training set No CNS disease 1 85 Female Negative Negative 1 100 Negative Positive Negative Unknown 4071 125.8 peripheral blood
GSM299873 White Unknown training set No CNS disease 1 95 Male Negative Negative 2 99 Negative Negative Negative Negative 5223 29.9 bone marrow
GSM299874 Hispanic or Latino Unknown training set No CNS disease 1 95 Female Negative Negative 3 99 Negative Negative Negative Unknown 5118 217.2 peripheral blood
GSM299875 unknown None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 90 Male Negative Negative 3 97 Negative Negative Negative Negative 5219 180.0 peripheral blood
GSM299876 White Downs training set No CNS disease 1 95 Female Negative Negative 4 98 Negative Negative Negative Unknown 1429 118.0 bone marrow
GSM299877 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 95 Female Negative Negative 1 97 Negative Negative Negative Unknown 3179 314.8 peripheral blood
GSM299878 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 -1 Female Negative Negative 1 58 Negative Negative Negative Unknown 1450 5.2 bone marrow
GSM299879 White None training set No CNS disease 1 95 Male Negative Negative 1 91 Negative Negative Negative Negative 5278 113.5 bone marrow
GSM299880 White None training set No CNS disease 1 85 Male Negative Negative 2 98 Positive Negative Negative Negative 5330 5.8 bone marrow
GSM29988 Hispanic or Latino Unknown test set No CNS disease 1 90 Female Negative Negative 4 99 Negative Negative Negative Unknown 4861 592.6 peripheral blood
GSM299882 White None training set No CNS disease 1 95 Female Negative Negative 1 80 Negative Negative Negative Unknown 428 248.0 peripheral blood
GSM299883 White None training set No CNS disease 1 95 Male Negative Negative 1 97 Negative Negative Negative Negative 4722 4.4 bone marrow
GSM299884 White Unknown test set No CNS disease 1 95 Male Negative Negative 2 99 Negative Negative Negative Negative 3587 72.2 bone marrow
GSM299885 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 90 Female Negative Negative 2 98 Negative Positive Negative Negative 5431 133.0 peripheral blood
GSM299886 Hispanic or Latino None training set No CNS disease 1 70 Male Negative Negative 2 98 Negative Negative Negative Positive 3444 5.0 bone marrow
GSM299887 Other None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 90 Male Negative Negative 3 99 Negative Negative Negative Negative 862 194.0 peripheral blood
GSM299888 Hispanic or Latino None training set No CNS disease 1 90 Male Negative Negative 3 97 Negative Negative Negative Negative 6674 3.8 bone marrow
GSM299889 White None training set No CNS disease 1 95 Male Negative Negative 3 70 Negative Negative Negative Negative 6323 15.4 bone marrow
GSM299890 White Unknown training set No CNS disease 1 90 Male Negative Negative 4 98 Negative Negative Negative Negative 6219 16.5 bone marrow
GSM29989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 95 Male Negative Positive 4 65 Negative Negative Negative Negative 2509 1.7 bone marrow
GSM299892 Hispanic or Latino None training set No CNS disease 1 95 Female Negative Negative 4 100 Positive Negative Negative Unknown 1531 196.1 peripheral blood
GSM299893 Hispanic or Latino Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 85 Male Negative Negative 1 100 Negative Negative Negative Unknown 5516 202.4 peripheral blood
GSM299894 White None training set No CNS disease 1 90 Male Negative Negative 1 82 Negative Negative Negative Negative 5513 2.5 bone marrow
GSM299895 White Unknown training set No CNS disease 1 95 Male Negative Negative 2 62 Negative Negative Negative Negative 5842 27.4 bone marrow
GSM299896 White Downs training set No CNS disease 1 75 Male Negative Negative 3 98 Positive Negative Negative Negative 6496 9.1 peripheral blood
GSM299897 White None training set No CNS disease 1 95 Male Negative Negative 3 99 Negative Positive Negative Negative 6511 515.0 peripheral blood
GSM299898 Hispanic or Latino None training set No CNS disease 1 95 Male Negative Negative 4 97 Positive Negative Negative Negative 1361 117.2 bone marrow
GSM299899 White None training set No CNS disease 1 95 Female Negative Negative 1 74 Negative Negative Negative Unknown 835 115.0 bone marrow
GSM299900 Hispanic or Latino None training set No CNS disease 1 95 Male Negative Negative 2 99 Negative Positive Negative Negative 4774 246.4 peripheral blood
GSM29990 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 95 Female Negative Negative 2 95 Negative Positive Negative Unknown 3311 489.0 bone marrow
GSM299902 White None training set No CNS disease 1 80 Male Negative Negative 3 100 Negative Negative Negative Negative 6331 32.6 peripheral blood
GSM299903 White None training set No CNS disease 1 95 Female Negative Negative 3 92 Negative Positive Negative Unknown 398 135.0 bone marrow
GSM299904 White None test set No CNS disease 1 95 Male Negative Negative 3 96 Positive Negative Negative Negative 5631 67.2 bone marrow
GSM299905 White None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 95 Female Negative Negative 1 96 Negative Negative Negative Unknown 944 12.1 bone marrow
GSM299906 White None training set No CNS disease 1 90 Male Negative Negative 1 90 Positive Negative Negative Negative 4940 8.0 bone marrow
GSM299907 White Downs training set No CNS disease 1 95 Female Negative Negative 2 96 Negative Negative Negative Negative 5721 88.9 bone marrow
GSM299908 White Unknown training set No CNS disease 1 95 Male Negative Negative 3 98 Negative Negative Negative Negative 6114 80.9 peripheral blood
GSM299909 White None training set No CNS disease 1 95 Male Negative Negative 4 97 Negative Negative Negative Negative 5086 36.2 bone marrow
GSM299910 White None test set No CNS disease 1 95 Male Negative Negative 4 90 Negative Negative Negative Negative 5359 80.8 bone marrow
GSM2999 White None training set No CNS disease 1 90 Male Negative Negative 2 95 Negative Negative Negative Negative 1167 156.0 bone marrow
GSM299912 White Unknown training set No CNS disease 1 95 Female Negative Negative 2 82 Negative Negative Negative Negative 4090 289.3 peripheral blood
GSM299913 White None test set No CNS disease 1 95 Male Negative Negative 3 90 Negative Positive Negative Negative 792 237.0 peripheral blood
GSM299914 White None training set No CNS disease 1 95 Male Negative Negative 4 99 Negative Negative Negative Negative 6733 81.4 bone marrow
GSM299915 Asian Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 95 Male Negative Negative 5 98 Negative Negative Negative Negative 2875 351.3 bone marrow
GSM299916 Hispanic or Latino Other training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 80 Male Negative Positive 5 99 Negative Negative Negative Negative 449 59.9 peripheral blood
GSM299917 White Unknown training set No CNS disease 4 95 Male Negative Negative 6 100 Negative Negative Negative Negative 904 137.8 bone marrow
GSM299918 White None test set No CNS disease 2 90 Male Negative Negative 6 98 Negative Negative Negative Negative 1426 138.4 bone marrow
GSM299919 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 95 Female Negative Negative 6 98 Negative Negative Negative Unknown 4469 478.0 peripheral blood
GSM299920 Hispanic or Latino None training set No CNS disease 2 95 Male Negative Negative 7 88 Negative Negative Negative Negative 6266 34.9 bone marrow
GSM29992 White None training set No CNS disease 2 70 Male Negative Negative 8 100 Negative Negative Negative Negative 6306 22.8 bone marrow
GSM299922 White None training set No CNS disease 2 90 Female Negative Negative 8 100 Negative Negative Negative Unknown 727 109.5 peripheral blood
GSM299923 Hispanic or Latino None training set No CNS disease 2 95 Male Negative Negative 5 99 Negative Negative Negative Negative 5867 21.1 bone marrow
GSM299924 Asian None training set No CNS disease 2 90 Female Negative Negative 5 95 Negative Negative Negative Unknown 6733 102.0 bone marrow
GSM299925 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 90 Male Negative Negative 6 98 Negative Negative Negative Negative 5495 96.2 peripheral blood
GSM299926 unknown None training set No CNS disease 2 95 Male Negative Negative 6 99 Negative Negative Negative Negative 6063 2.3 bone marrow
GSM299927 Hispanic or Latino None test set No CNS disease 2 95 Female Negative Negative 6 87 Negative Negative Negative Unknown 5922 27.0 bone marrow
GSM299928 White Downs training set No CNS disease 2 90 Female Negative Negative 7 99 Negative Negative Negative Unknown 6922 68.9 peripheral blood
GSM299929 White None training set No CNS disease 2 95 Female Negative Negative 8 100 Negative Negative Negative Unknown 531 119.0 bone marrow
GSM299930 White Unknown test set No CNS disease 2 95 Female Negative Negative 5 97 Negative Negative Negative Unknown 4106 210.0 bone marrow
GSM29993 Hispanic or Latino None training set No CNS disease 2 95 Male Negative Negative 5 91 Negative Negative Negative Negative 2027 199.0 bone marrow
GSM299932 Asian Unknown training set No CNS disease 2 90 Female Negative Negative 6 96 Positive Negative Negative Unknown 1191 175.5 peripheral blood
GSM299933 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 6 95 Female Negative Negative 7 94 Negative Negative Negative Unknown 5310 92.7 peripheral blood
GSM299934 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 95 Male Negative Negative 7 83 Negative Negative Negative Negative 5163 270.0 peripheral blood
GSM299935 White None test set No CNS disease 2 95 Female Negative Negative 7 66 Positive Negative Negative Unknown 977 115.1 bone marrow
GSM299936 White Unknown training set No CNS disease 2 95 Male Negative Negative 8 89 Negative Negative Negative Negative 4807 12.7 bone marrow
GSM299937 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 95 Male Negative Negative 5 99 Negative Negative Negative Negative 5564 112.0 peripheral blood
GSM299938 White Unknown test set No CNS disease 2 95 Male Negative Negative 5 60 Negative Negative Negative Negative 4305 40.0 bone marrow
GSM299939 White Unknown training set No CNS disease 6 95 Female Negative Negative 6 94 Negative Negative Negative Unknown 4717 62.3 bone marrow
GSM299940 Hispanic or Latino None test set No CNS disease 4 95 Male Negative Negative 7 99 Negative Negative Negative Negative 4657 33.1 bone marrow
GSM29994 White None training set No CNS disease 2 90 Female Negative Positive 7 79 Negative Negative Negative Unknown 1429 192.0 bone marrow
GSM299942 Hispanic or Latino None training set No CNS disease 4 65 Female Negative Negative 8 98 Negative Negative Negative Negative 6413 16.6 peripheral blood
GSM299943 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 2 95 Female Negative Negative 8 92 Negative Negative Negative Negative 2133 17.5 peripheral blood
GSM299944 Hispanic or Latino Unknown test set No CNS disease 2 70 Female Negative Negative 8 69 Negative Positive Negative Unknown 434 88.5 peripheral blood
GSM299945 Asian Unknown training set No CNS disease 2 90 Male Negative Negative 5 87 Negative Negative Negative Negative 4935 24.5 bone marrow
GSM299946 White None training set No CNS disease 2 85 Female Negative Negative 5 100 Negative Negative Negative Negative 6984 30.4 peripheral blood
GSM299947 White None test set No CNS disease 2 90 Female Negative Negative 5 65 Negative Negative Negative Unknown 1068 190.0 bone marrow
GSM299948 Hispanic or Latino None test set No CNS disease 4 95 Male Negative Negative 6 99 Negative Negative Negative Negative 5877 66.9 bone marrow
GSM299949 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 6 95 Male Negative Negative 7 87 Negative Positive Negative Negative 5127 555.0 bone marrow
GSM299950 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 90 Male Negative Negative 7 95 Negative Positive Negative Negative 410 51.3 bone marrow
GSM29995 White Unknown training set No CNS disease 2 95 Male Negative Negative 7 97 Negative Negative Negative Negative 5408 1.2 bone marrow
GSM299952 Black or African American Unknown test set No CNS disease 2 95 Male Negative Negative 8 96 Negative Negative Negative Negative 2876 142.4 bone marrow
GSM299953 White Unknown training set No CNS disease 2 95 Male Negative Negative 8 87 Negative Negative Negative Negative 697 110.9 bone marrow
GSM299954 Hispanic or Latino Downs test set No CNS disease 2 90 Female Negative Negative 5 95 Negative Negative Negative Unknown 2223 202.0 peripheral blood
GSM299955 White None test set No CNS disease 2 95 Female Negative Negative 5 97 Negative Positive Negative Unknown 7028 259.8 peripheral blood
GSM299956 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 2 -1 Male Negative Negative 5 26 Negative Negative Unknown Negative 5177 166.5 bone marrow
GSM299957 Hispanic or Latino None training set No CNS disease 2 90 Female Negative Negative 6 91 Negative Positive Negative Unknown 1038 114.0 peripheral blood
GSM299958 Hispanic or Latino Downs test set No CNS disease 2 95 Female Negative Negative 6 100 Negative Negative Negative Unknown 5008 321.2 peripheral blood
GSM299959 Hispanic or Latino None training set No CNS disease 2 95 Female Negative Negative 7 71 Negative Negative Negative Unknown 5925 19.5 bone marrow
GSM299960 Hispanic or Latino None training set No CNS disease 2 95 Male Negative Negative 7 93 Negative Negative Negative Negative 1258 145.0 peripheral blood
GSM29996 Hispanic or Latino None test set No CNS disease 2 90 Female Negative Negative 8 85 Positive Negative Negative Unknown 1956 148.2 bone marrow
GSM299962 White None training set No CNS disease 4 90 Female Negative Negative 6 97 Negative Positive Negative Unknown 4560 108.0 peripheral blood
GSM299963 White None training set No CNS disease 2 90 Male Negative Negative 7 84 Negative Positive Negative Negative 966 37.3 peripheral blood
GSM299964 White None test set No CNS disease 2 95 Male Negative Unknown 7 100 Negative Negative Negative Negative 4585 12.0 bone marrow
GSM299965 White Unknown training set No CNS disease 2 90 Female Negative Negative 5 98 Negative Negative Negative Unknown 4863 65.8 bone marrow
GSM299966 White None training set No CNS disease 2 95 Male Negative Negative 6 100 Negative Negative Negative Negative 369 325.0 peripheral blood
GSM299967 White None test set No CNS disease 2 -1 Male Negative Negative 7 20 Negative Negative Negative Negative 5853 2.3 bone marrow
GSM299968 White None training set No CNS disease 2 80 Male Negative Negative 8 99 Negative Negative Negative Negative 6335 13.3 bone marrow
GSM299969 American Indian or Alaska native None test set No CNS disease 2 95 Male Negative Negative 8 97 Negative Negative Negative Negative 881 106.0 peripheral blood
GSM299970 White None training set No CNS disease 3 95 Female Negative Negative 9 100 Negative Negative Negative Unknown 2786 105.7 peripheral blood
GSM29997 White None training set No CNS disease 3 80 Male Negative Negative 10 94 Negative Negative Negative Negative 6306 16.7 peripheral blood
GSM299972 White None test set No CNS disease 3 90 Male Negative Negative 10 98 Negative Negative Negative Negative 2519 112.0 bone marrow
GSM299973 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 11 66 Negative Negative Negative Negative 6142 18.5 bone marrow
GSM299974 Black or African American None test set No CNS disease 3 80 Male Negative Negative 11 96 Negative Negative Negative Negative 5343 30.2 bone marrow
GSM299975 White None test set No CNS disease 3 90 Male Negative Negative 11 96 Negative Positive Negative Negative 852 139.0 bone marrow
GSM299976 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 12 94 Negative Positive Negative Negative 462 17.3 bone marrow
GSM299977 Black or African American Unknown training set No CNS disease 3 90 Female Negative Negative 12 75 Positive Negative Negative Unknown 5797 39.6 peripheral blood
GSM299978 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 9 97 Negative Negative Negative Negative 4253 236.4 peripheral blood
GSM299979 Hispanic or Latino None training set No CNS disease 3 75 Female Negative Negative 9 99 Negative Negative Negative Unknown 705 137.2 peripheral blood
GSM299980 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 70 Male Negative Negative 10 99 Negative Negative Negative Negative 7478 28.0 peripheral blood
GSM29998 White Unknown training set No CNS disease 3 90 Male Negative Negative 10 100 Negative Negative Negative Negative 2191 272.0 peripheral blood
GSM299982 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 90 Female Negative Negative 11 98 Negative Negative Negative Unknown 1275 214.0 bone marrow
GSM299983 White None test set No CNS disease 3 95 Male Negative Negative 11 96 Negative Negative Negative Negative 5184 58.0 bone marrow
GSM299984 Other None training set No CNS disease 3 -1 Male Negative Negative 11 59 Negative Negative Negative Negative 5542 7.9 bone marrow
GSM299985 White None test set No CNS disease 3 95 Male Negative Negative 12 64 Negative Negative Negative Negative 5242 3.4 bone marrow
GSM299986 White Unknown training set No CNS disease 3 75 Female Negative Negative 12 99 Negative Negative Negative Unknown 1313 69.4 peripheral blood
GSM299987 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 95 Female Negative Negative 9 94 Negative Negative Negative Unknown 1751 238.0 bone marrow
GSM299988 White None training set No CNS disease 3 90 Female Negative Negative 9 98 Negative Negative Negative Unknown 4329 179.0 bone marrow
GSM299989 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 90 Male Negative Negative 9 86 Negative Negative Positive Negative 976 7.7 bone marrow
GSM299990 Hispanic or Latino None test set No CNS disease 3 95 Female Negative Negative 10 91 Positive Negative Negative Negative 5300 98.2 bone marrow
GSM29999 Hispanic or Latino None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 90 Male Negative Negative 11 81 Negative Negative Negative Negative 4307 44.9 bone marrow
GSM299992 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 60 Female Negative Negative 12 98 Negative Negative Negative Unknown 4324 35.7 peripheral blood
GSM299993 White Unknown test set No CNS disease 3 95 Female Negative Negative 9 97 Positive Negative Negative Unknown 1033 118.1 bone marrow
GSM299994 Hispanic or Latino None test set No CNS disease 3 -1 Male Negative Negative 9 31 Negative Negative Negative Negative 6052 6.4 bone marrow
GSM299995 White Unknown training set No CNS disease 3 95 Male Unknown Unknown 10 85 Negative Negative Negative Negative 4157 77.6 bone marrow
GSM299996 Asian None training set No CNS disease 3 90 Male Negative Negative 11 64 Positive Negative Negative Unknown 5025 73.1 bone marrow
GSM299997 White None training set No CNS disease 3 95 Male Negative Negative 12 99 Negative Negative Negative Negative 6263 1.0 bone marrow
GSM299998 White None training set No CNS disease 3 90 Male Negative Negative 9 96 Negative Positive Negative Negative 5664 22.0 bone marrow
GSM299999 Other None test set No CNS disease 3 95 Male Negative Negative 9 95 Negative Negative Negative Negative 4776 1.3 bone marrow
GSM300000 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 95 Female Negative Negative 10 99 Negative Negative Negative Unknown 2192 209.6 peripheral blood
GSM30000 Black or African American None training set No CNS disease 3 95 Male Negative Negative 11 94 Negative Negative Negative Negative 5954 15.5 bone marrow
GSM300002 White None training set No CNS disease 3 95 Male Negative Negative 11 67 Negative Negative Negative Negative 2038 193.0 bone marrow
GSM300003 White None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 95 Female Negative Negative 12 96 Negative Negative Positive Unknown 6032 59.2 bone marrow
GSM300004 White Unknown training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 85 Male Negative Negative 12 98 Negative Negative Negative Positive 655 9.8 peripheral blood
GSM300005 White None training set No CNS disease 3 90 Male Negative Negative 12 94 Negative Negative Negative Negative 4759 2.4 bone marrow
GSM300006 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 95 Female Negative Negative 9 97 Negative Negative Negative Unknown 2769 3.0 bone marrow
GSM300007 American Indian or Alaska native None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 40 Male Negative Negative 9 94 Negative Negative Negative Unknown 4972 6.3 peripheral blood
GSM300008 Black or African American Unknown test set No CNS disease 3 95 Male Negative Negative 9 98 Negative Negative Negative Negative 4815 31.4 bone marrow
GSM300009 White None test set No CNS disease 3 95 Male Negative Negative 10 98 Negative Negative Negative Negative 6315 245.0 peripheral blood
GSM300010 White Downs training set No CNS disease 3 95 Male Negative Negative 10 95 Negative Negative Negative Negative 4276 24.4 bone marrow
GSM3000 White None training set No CNS disease 3 95 Male Negative Negative 10 99 Negative Negative Negative Negative 5759 33.9 peripheral blood
GSM300012 White None test set No CNS disease 3 -1 Male Negative Negative 11 44 Negative Negative Negative Negative 6487 7.6 bone marrow
GSM300013 Black or African American None test set No CNS disease 3 95 Male Negative Negative 11 99 Positive Negative Negative Negative 1771 152.7 peripheral blood
GSM300014 White None training set No CNS disease 3 95 Male Negative Negative 12 89 Negative Negative Negative Negative 515 124.0 bone marrow
GSM300015 White None training set No CNS disease 3 95 Female Negative Negative 12 96 Negative Negative Negative Unknown 6090 24.8 bone marrow
GSM300016 White Unknown training set No CNS disease 3 95 Male Negative Negative 9 99 Negative Negative Negative Negative 6633 1.9 bone marrow
GSM300017 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 3 95 Male Negative Negative 9 97 Negative Negative Negative Negative 5194 96.5 bone marrow
GSM300018 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 10 96 Negative Negative Negative Negative 6468 7.0 bone marrow
GSM300019 White None test set No CNS disease 3 90 Male Negative Negative 11 92 Negative Negative Negative Negative 6062 17.0 bone marrow
GSM300020 Other Unknown test set No CNS disease 3 90 Female Negative Negative 11 95 Negative Positive Negative Unknown 777 6.8 bone marrow
GSM30002 White None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 85 Female Negative Negative 12 100 Positive Negative Negative Unknown 5889 49.6 bone marrow
GSM300022 White None test set No CNS disease 3 95 Male Negative Negative 12 95 Negative Negative Negative Negative 893 455.4 peripheral blood
GSM300023 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 9 98 Negative Negative Negative Negative 4955 31.5 bone marrow
GSM300024 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 10 99 Negative Negative Negative Negative 5081 307.0 peripheral blood
GSM300025 Hispanic or Latino Downs training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 90 Female Negative Negative 10 98 Negative Negative Negative Unknown 4665 95.2 bone marrow
GSM300026 Hispanic or Latino None training set No CNS disease 3 95 Male Negative Negative 11 97 Negative Negative Negative Negative 988 958.8 peripheral blood
GSM300027 White None training set No CNS disease 3 -1 Male Negative Negative 12 59 Positive Negative Negative Negative 5890 9.4 bone marrow
GSM300028 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 3 95 Female Negative Negative 12 96 Negative Negative Negative Unknown 6351 13.8 bone marrow
GSM300029 White Unknown test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 4 95 Male Negative Negative 13 86 Negative Negative Negative Negative 1475 212.3 bone marrow
GSM300030 Hispanic or Latino Unknown training set No CNS disease 4 90 Male Negative Negative 13 99 Negative Negative Negative Negative 6036 8.8 bone marrow
GSM30003 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 1 95 Female Negative Negative 4 96 Negative Negative Negative Unknown 5217 135.8 bone marrow
GSM300032 Black or African American None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 1 95 Male Negative Negative 4 97 Negative Negative Negative Negative 523 82.9 bone marrow
GSM300033 White Unknown training set No CNS disease 3 95 Female Negative Negative 11 99 Positive Negative Negative Unknown 1011 302.1 peripheral blood
GSM300034 Native Hawaiian or other Pacific Islander None test set No CNS disease 3 90 Male Negative Negative 11 98 Negative Negative Negative Negative 6107 18.3 bone marrow
GSM300035 White None training set No CNS disease 4 95 Male Negative Negative 13 95 Negative Negative Negative Negative 768 138.8 peripheral blood
GSM300036 White None training set No CNS disease 4 90 Female Negative Negative 13 84 Positive Negative Negative Unknown 5670 37.2 peripheral blood
GSM300037 Hispanic or Latino None training set No CNS disease 6 95 Male Negative Negative 11 99 Negative Negative Negative Negative 6666 114.6 peripheral blood
GSM300038 Hispanic or Latino None training set No CNS disease 4 85 Female Negative Negative 13 96 Positive Negative Negative Unknown 3901 136.6 bone marrow
GSM300039 White None training set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 7 -1 Female Negative Negative 14 51 Negative Negative Negative Negative 728 138.4 peripheral blood
GSM300040 White None test set No CNS disease 7 95 Female Negative Negative 14 79 Negative Negative Negative Unknown 1058 141.0 bone marrow
GSM30004 Hispanic or Latino Unknown test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 7 95 Female Negative Negative 14 76 Negative Negative Positive Unknown 1323 30.6 bone marrow
GSM300042 Hispanic or Latino None training set No CNS disease 7 95 Male Negative Negative 14 84 Negative Negative Negative Negative 650 102.5 bone marrow
GSM300043 White None test set No CNS disease 8 85 Male Negative Negative 15 99 Negative Negative Negative Negative 5821 1.9 bone marrow
GSM300044 White Unknown training set No CNS disease 8 40 Male Negative Negative 15 100 Negative Negative Negative Negative 6202 2.3 peripheral blood
GSM300045 American Indian or Alaska native None training set No CNS disease 8 90 Female Negative Negative 15 98 Negative Negative Negative Negative 6119 2.3 bone marrow
GSM300046 White None training set No CNS disease 8 60 Male Negative Negative 15 99 Negative Negative Negative Positive 4571 6.9 peripheral blood
GSM300047 Hispanic or Latino None training set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 8 60 Male Negative Negative 15 93 Negative Negative Positive Negative 1896 4.1 peripheral blood
GSM300048 White None training set No CNS disease 8 75 Female Negative Negative 15 97 Negative Negative Negative Negative 7461 3.8 bone marrow
GSM300049 White None test set No CNS disease 8 65 Male Negative Negative 15 96 Negative Negative Negative Negative 6634 11.1 bone marrow
GSM300050 White None training set No CNS disease 8 80 Male Negative Negative 15 83 Negative Negative Negative Negative 5097 6.3 peripheral blood
GSM30005 Hispanic or Latino None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 8 95 Male Negative Negative 15 96 Negative Negative Negative Negative 5532 5.5 bone marrow
GSM300052 Black or African American None test set < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin 8 -1 Male Negative Negative 15 47 Negative Negative Positive Positive 1914 45.1 peripheral blood
GSM300053 White None training set No CNS disease 8 90 Male Negative Negative 15 72 Positive Negative Negative Negative 4434 42.1 peripheral blood
GSM300054 Asian None test set No CNS disease 8 50 Male Negative Negative 15 93 Positive Negative Negative Negative 4782 4.4 peripheral blood
GSM300055 White None test set No CNS disease 8 90 Male Negative Negative 15 84 Negative Negative Negative Negative 5232 1.1 bone marrow
GSM300056 Black or African American None test set No CNS disease 8 80 Male Negative Negative 15 83 Positive Negative Negative Negative 6500 17.8 peripheral blood
GSM300057 White None training set No CNS disease 9 -1 Male Negative Negative 16 50 Negative Positive Negative Unknown 585 7.5 bone marrow
GSM300058 Black or African American None test set No CNS disease 9 95 Male Negative Negative 16 98 Negative Negative Negative Negative 6539 2.6 bone marrow
GSM300059 White None test set No CNS disease 9 85 Female Negative Negative 16 100 Negative Negative Negative Negative 5991 5.2 bone marrow
GSM300060 White None training set No CNS disease 9 70 Male Negative Negative 16 93 Negative Negative Negative Negative 6479 31.9 peripheral blood
GSM30006 Black or African American None training set No CNS disease 9 90 Male Negative Negative 16 98 Negative Negative Negative Negative 5183 23.0 bone marrow
GSM300062 White None training set No CNS disease 9 -1 Male Negative Negative 16 46 Negative Negative Negative Negative 713 110.3 peripheral blood
GSM300063 White None test set No CNS disease 9 90 Male Negative Negative 16 82 Negative Positive Negative Unknown 1704 85.1 bone marrow
GSM300064 White Unknown test set No CNS disease 9 95 Male Negative Negative 16 99 Negative Negative Negative Negative 5594 2.8 bone marrow
GSM300065 White Unknown training set No CNS disease 9 95 Male Negative Negative 16 88 Negative Negative Negative Negative 5857 13.3 bone marrow
GSM300066 Hispanic or Latino None test set > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement 9 95 Female Negative Negative 16 81 Positive Negative Negative Unknown 4017 3.5 bone marrow
GSM300067 White Unknown training set No CNS disease 9 95 Male Negative Negative 16 85 Negative Negative Negative Negative 4918 5.5 bone marrow
GSM300068 Hispanic or Latino Unknown training set No CNS disease 10 90 Male Negative Negative 18 66 Negative Negative Negative Negative 5349 147.6 bone marrow

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

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