BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

Dataset: Children's Oncology Group Study 9906 for High-Risk Pediatric ALL

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised...

Registered by ArrayExpress Uploader
View Dataset

PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profiles of pre-treatment specimens from 207 patients from the COG P9906 study to identify signatures of children with high risk B-precursor acute lymphoblastic leukemia (ALL) and to determine whether the resulting clusters are associated with either specific clinical features or treatment response characteristics. Four unsupervised clustering methods were utilized to classify patients into similar groups. The different clustering algorithms showed significant overlap in cluster membership. Two clusters contained all cases with either t(1;19)(q23;p13) translocations or MLL rearrangements. The other six clusters were novel and had no recurring chromosomal abnormalities or distinctive clinical features. Members of two of these novel clusters had significant survival differences when compared to the overall 4-year relapse-free survival (RFS) of 61%. These included clusters of patients with either significantly better (94.7%) or worse (21.0%) RFS at 4 years. Children of Hispanic/Latino ethnicity were disproportionately present in the poor outcome cluster. The poor outcome cluster represents a novel biologically distinctive subset of B-precursor ALL that may occur at least as frequently as BCR/ABL. Further molecular characterization of this cluster may lead to the discovery of genomic abnormalities that can be targeted to improve the currently dismal outcome for children with this gene signature. The Sample data have also been used in another study: PAPER 2: "Gene expression classifiers for minimal residual disease and relapse free survival improve outcome prediction and risk classification in children with high risk acute lymphoblastic leukemia. A Children's Oncology Group study". ABSTRACT Background. Nearly 25% of children with B-precursor ALL present with "high-risk" disease (HR-ALL) that is resistant to current therapies. Gene expression profiling may yield molecular classifiers for outcome prediction that can be used to improve risk classification and therapeutic targeting. Methods. Expression profiles were obtained in pre-treatment leukemic samples from 207 uniformly treated children with HR-ALL. Relapse free survival (RFS) was 61% at 4 years and flow cytometric measures of minimal residual disease (MRD) at the end of induction (day 29) were predictive of outcome (P<0.001). Molecular classifiers predictive of RFS and MRD were developed using extensive cross-validation procedures. Results. A 38 gene molecular risk classifier predictive of RFS (MRC-RFS) distinguished two groups in HR-ALL with different relapse risks: low (4 yr RFS: 81%, n=109) vs. high (4 yr RFS: 50%, n=98) (P<0.0001). In multivariate analysis, the best predictor combined MRC-RFS and day 29 flow MRD data, classifying children into low (87% RFS), intermediate (62% RFS), or high risk (29% RFS) groups (P<0.0001). A 21 gene molecular classifier predictive of MRD could effectively substitute for day 29 flow MRD, yielding a combined classifier that similarly distinguished three risk groups at pre-treatment (low: 82% RFS; intermediate: 63% RFS; and high risk: 45% RFS) (P<0.0001). This combined molecular classifier was further validated on an independent cohort of 84 children with HR-ALL (P = 0.006). Conclusions. Molecular classifiers predictive of RFS and MRD can be used to distinguish distinct prognostic groups within HR-ALL, significantly improving risk classification schemes and the ability to prospectively identify children at diagnosis who will respond to or fail current treatment regimens. NOTE: Due to Children's Oncology Group (COG) restrictions, outcome and MRD data cannot be provided as part of the covariate data for this dataset at the present time. If you would like to arrange individual access to this data, please contact COG or the PI of this study, Dr. Cheryl Willman, at the University of New Mexico Cancer Center (cwillman@unm.edu) to arrange a collaboration. Unsupervised clustering and supervised risk classification analyses of 207 diagnostic samples and associated clinical covariate data. See the Summary for greater details. The data were analyzed using Microarray Suite version 5.0 (MAS 5.0) in the Affymetrix Gene Chip Operating Software Version 1.4. Probe masking was used (see 9906_TT207_Affymetrix_probe_mask.msk, linked below as a supplementary file). Otherwise all Affymetrix default parameter settings were used. Global scaling as the normalization method, with the default target intensity of 500, was used.

Species:
human

Samples:
207

Source:
E-GEOD-11877

Updated:
Dec.12, 2014

Registered:
Sep.03, 2014


Factors: (via ArrayExpress)
Sample TRAINING OR TEST SET RACE TESTICULAR INVOLVEMENT BCR-ABL, T(9;22) AMPLIFICATION SET CONGENITAL ABNORMALITY GENDER TEL-AML,T(12;21) HYBRIDIZATION SET BLAST COUNT, % OF SAMPLE, -1=UNAVAILABLE E2A-PBX, T(1;19) TISSUE TYPE SAMPLE VIABILITY, % OF SAMPLE, -1=UNAVAILABLE MLL AGE IN DAYS AT DIAGNOSIS WBC, 1000/MICROLITER CNS STATUS TRISOMY 4 AND 10
GSM299862 test set White Unknown Negative 1 None Female Negative 1 90 Negative peripheral blood 100 Positive 3953 175.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299863 training set Black or African American Negative Negative 1 None Male Negative 1 90 Negative peripheral blood 100 Negative 1976 142.0 No CNS disease Negative
GSM299864 training set Hispanic or Latino Negative Negative 1 None Male Negative 2 70 Negative peripheral blood 99 Negative 5250 220.7 No CNS disease Negative
GSM299865 test set White Negative Negative 1 None Male Negative 2 95 Negative peripheral blood 88 Negative 577 129.0 No CNS disease Negative
GSM299866 training set Hispanic or Latino Negative Negative 1 None Male Negative 3 95 Negative bone marrow 95 Negative 4609 26.0 No CNS disease Negative
GSM299867 training set White Negative Negative 1 None Male Negative 3 80 Negative bone marrow 68 Negative 5289 14.7 No CNS disease Negative
GSM299868 training set Asian Negative Negative 1 None Male Negative 4 -1 Negative bone marrow 71 Negative 3987 68.6 No CNS disease Negative
GSM299869 test set White Negative Negative 1 None Male Negative 4 90 Negative bone marrow 98 Negative 4856 21.4 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299870 test set White Negative Negative 1 None Male Negative 4 1 Negative bone marrow 99 Negative 4678 2.4 No CNS disease Negative
GSM29987 training set White Negative Negative 1 Unknown Male Negative 1 75 Negative bone marrow 68 Negative 796 21.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299872 training set White Unknown Negative 1 None Female Negative 1 85 Negative peripheral blood 100 Positive 4071 125.8 No CNS disease Negative
GSM299873 training set White Negative Negative 1 Unknown Male Negative 2 95 Negative bone marrow 99 Negative 5223 29.9 No CNS disease Negative
GSM299874 training set Hispanic or Latino Unknown Negative 1 Unknown Female Negative 3 95 Negative peripheral blood 99 Negative 5118 217.2 No CNS disease Negative
GSM299875 training set unknown Negative Negative 1 None Male Negative 3 90 Negative peripheral blood 97 Negative 5219 180.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299876 training set White Unknown Negative 1 Downs Female Negative 4 95 Negative bone marrow 98 Negative 1429 118.0 No CNS disease Negative
GSM299877 test set White Unknown Negative 1 Unknown Female Negative 1 95 Negative peripheral blood 97 Negative 3179 314.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299878 test set White Unknown Negative 1 None Female Negative 1 -1 Negative bone marrow 58 Negative 1450 5.2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299879 training set White Negative Negative 1 None Male Negative 1 95 Negative bone marrow 91 Negative 5278 113.5 No CNS disease Negative
GSM299880 training set White Negative Negative 1 None Male Negative 2 85 Positive bone marrow 98 Negative 5330 5.8 No CNS disease Negative
GSM29988 test set Hispanic or Latino Unknown Negative 1 Unknown Female Negative 4 90 Negative peripheral blood 99 Negative 4861 592.6 No CNS disease Negative
GSM299882 training set White Unknown Negative 1 None Female Negative 1 95 Negative peripheral blood 80 Negative 428 248.0 No CNS disease Negative
GSM299883 training set White Negative Negative 1 None Male Negative 1 95 Negative bone marrow 97 Negative 4722 4.4 No CNS disease Negative
GSM299884 test set White Negative Negative 1 Unknown Male Negative 2 95 Negative bone marrow 99 Negative 3587 72.2 No CNS disease Negative
GSM299885 test set White Negative Negative 1 None Female Negative 2 90 Negative peripheral blood 98 Positive 5431 133.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299886 training set Hispanic or Latino Positive Negative 1 None Male Negative 2 70 Negative bone marrow 98 Negative 3444 5.0 No CNS disease Negative
GSM299887 test set Other Negative Negative 1 None Male Negative 3 90 Negative peripheral blood 99 Negative 862 194.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299888 training set Hispanic or Latino Negative Negative 1 None Male Negative 3 90 Negative bone marrow 97 Negative 6674 3.8 No CNS disease Negative
GSM299889 training set White Negative Negative 1 None Male Negative 3 95 Negative bone marrow 70 Negative 6323 15.4 No CNS disease Negative
GSM299890 training set White Negative Negative 1 Unknown Male Negative 4 90 Negative bone marrow 98 Negative 6219 16.5 No CNS disease Negative
GSM29989 training set White Negative Negative 1 None Male Positive 4 95 Negative bone marrow 65 Negative 2509 1.7 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299892 training set Hispanic or Latino Unknown Negative 1 None Female Negative 4 95 Positive peripheral blood 100 Negative 1531 196.1 No CNS disease Negative
GSM299893 test set Hispanic or Latino Unknown Negative 1 Unknown Male Negative 1 85 Negative peripheral blood 100 Negative 5516 202.4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299894 training set White Negative Negative 1 None Male Negative 1 90 Negative bone marrow 82 Negative 5513 2.5 No CNS disease Negative
GSM299895 training set White Negative Negative 1 Unknown Male Negative 2 95 Negative bone marrow 62 Negative 5842 27.4 No CNS disease Negative
GSM299896 training set White Negative Negative 1 Downs Male Negative 3 75 Positive peripheral blood 98 Negative 6496 9.1 No CNS disease Negative
GSM299897 training set White Negative Negative 1 None Male Negative 3 95 Negative peripheral blood 99 Positive 6511 515.0 No CNS disease Negative
GSM299898 training set Hispanic or Latino Negative Negative 1 None Male Negative 4 95 Positive bone marrow 97 Negative 1361 117.2 No CNS disease Negative
GSM299899 training set White Unknown Negative 1 None Female Negative 1 95 Negative bone marrow 74 Negative 835 115.0 No CNS disease Negative
GSM299900 training set Hispanic or Latino Negative Negative 1 None Male Negative 2 95 Negative peripheral blood 99 Positive 4774 246.4 No CNS disease Negative
GSM29990 training set White Unknown Negative 1 None Female Negative 2 95 Negative bone marrow 95 Positive 3311 489.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299902 training set White Negative Negative 1 None Male Negative 3 80 Negative peripheral blood 100 Negative 6331 32.6 No CNS disease Negative
GSM299903 training set White Unknown Negative 1 None Female Negative 3 95 Negative bone marrow 92 Positive 398 135.0 No CNS disease Negative
GSM299904 test set White Negative Negative 1 None Male Negative 3 95 Positive bone marrow 96 Negative 5631 67.2 No CNS disease Negative
GSM299905 test set White Unknown Negative 1 None Female Negative 1 95 Negative bone marrow 96 Negative 944 12.1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299906 training set White Negative Negative 1 None Male Negative 1 90 Positive bone marrow 90 Negative 4940 8.0 No CNS disease Negative
GSM299907 training set White Negative Negative 1 Downs Female Negative 2 95 Negative bone marrow 96 Negative 5721 88.9 No CNS disease Negative
GSM299908 training set White Negative Negative 1 Unknown Male Negative 3 95 Negative peripheral blood 98 Negative 6114 80.9 No CNS disease Negative
GSM299909 training set White Negative Negative 1 None Male Negative 4 95 Negative bone marrow 97 Negative 5086 36.2 No CNS disease Negative
GSM299910 test set White Negative Negative 1 None Male Negative 4 95 Negative bone marrow 90 Negative 5359 80.8 No CNS disease Negative
GSM2999 training set White Negative Negative 1 None Male Negative 2 90 Negative bone marrow 95 Negative 1167 156.0 No CNS disease Negative
GSM299912 training set White Negative Negative 1 Unknown Female Negative 2 95 Negative peripheral blood 82 Negative 4090 289.3 No CNS disease Negative
GSM299913 test set White Negative Negative 1 None Male Negative 3 95 Negative peripheral blood 90 Positive 792 237.0 No CNS disease Negative
GSM299914 training set White Negative Negative 1 None Male Negative 4 95 Negative bone marrow 99 Negative 6733 81.4 No CNS disease Negative
GSM299915 training set Asian Negative Negative 2 Unknown Male Negative 5 95 Negative bone marrow 98 Negative 2875 351.3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299916 training set Hispanic or Latino Negative Negative 2 Other Male Positive 5 80 Negative peripheral blood 99 Negative 449 59.9 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299917 training set White Negative Negative 4 Unknown Male Negative 6 95 Negative bone marrow 100 Negative 904 137.8 No CNS disease Negative
GSM299918 test set White Negative Negative 2 None Male Negative 6 90 Negative bone marrow 98 Negative 1426 138.4 No CNS disease Negative
GSM299919 training set Hispanic or Latino Unknown Negative 2 None Female Negative 6 95 Negative peripheral blood 98 Negative 4469 478.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299920 training set Hispanic or Latino Negative Negative 2 None Male Negative 7 95 Negative bone marrow 88 Negative 6266 34.9 No CNS disease Negative
GSM29992 training set White Negative Negative 2 None Male Negative 8 70 Negative bone marrow 100 Negative 6306 22.8 No CNS disease Negative
GSM299922 training set White Unknown Negative 2 None Female Negative 8 90 Negative peripheral blood 100 Negative 727 109.5 No CNS disease Negative
GSM299923 training set Hispanic or Latino Negative Negative 2 None Male Negative 5 95 Negative bone marrow 99 Negative 5867 21.1 No CNS disease Negative
GSM299924 training set Asian Unknown Negative 2 None Female Negative 5 90 Negative bone marrow 95 Negative 6733 102.0 No CNS disease Negative
GSM299925 training set White Negative Negative 4 None Male Negative 6 90 Negative peripheral blood 98 Negative 5495 96.2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299926 training set unknown Negative Negative 2 None Male Negative 6 95 Negative bone marrow 99 Negative 6063 2.3 No CNS disease Negative
GSM299927 test set Hispanic or Latino Unknown Negative 2 None Female Negative 6 95 Negative bone marrow 87 Negative 5922 27.0 No CNS disease Negative
GSM299928 training set White Unknown Negative 2 Downs Female Negative 7 90 Negative peripheral blood 99 Negative 6922 68.9 No CNS disease Negative
GSM299929 training set White Unknown Negative 2 None Female Negative 8 95 Negative bone marrow 100 Negative 531 119.0 No CNS disease Negative
GSM299930 test set White Unknown Negative 2 Unknown Female Negative 5 95 Negative bone marrow 97 Negative 4106 210.0 No CNS disease Negative
GSM29993 training set Hispanic or Latino Negative Negative 2 None Male Negative 5 95 Negative bone marrow 91 Negative 2027 199.0 No CNS disease Negative
GSM299932 training set Asian Unknown Negative 2 Unknown Female Negative 6 90 Positive peripheral blood 96 Negative 1191 175.5 No CNS disease Negative
GSM299933 test set Hispanic or Latino Unknown Negative 6 None Female Negative 7 95 Negative peripheral blood 94 Negative 5310 92.7 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299934 training set White Negative Negative 2 None Male Negative 7 95 Negative peripheral blood 83 Negative 5163 270.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299935 test set White Unknown Negative 2 None Female Negative 7 95 Positive bone marrow 66 Negative 977 115.1 No CNS disease Negative
GSM299936 training set White Negative Negative 2 Unknown Male Negative 8 95 Negative bone marrow 89 Negative 4807 12.7 No CNS disease Negative
GSM299937 training set White Negative Negative 2 None Male Negative 5 95 Negative peripheral blood 99 Negative 5564 112.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299938 test set White Negative Negative 2 Unknown Male Negative 5 95 Negative bone marrow 60 Negative 4305 40.0 No CNS disease Negative
GSM299939 training set White Unknown Negative 6 Unknown Female Negative 6 95 Negative bone marrow 94 Negative 4717 62.3 No CNS disease Negative
GSM299940 test set Hispanic or Latino Negative Negative 4 None Male Negative 7 95 Negative bone marrow 99 Negative 4657 33.1 No CNS disease Negative
GSM29994 training set White Unknown Negative 2 None Female Positive 7 90 Negative bone marrow 79 Negative 1429 192.0 No CNS disease Negative
GSM299942 training set Hispanic or Latino Negative Negative 4 None Female Negative 8 65 Negative peripheral blood 98 Negative 6413 16.6 No CNS disease Negative
GSM299943 training set White Negative Negative 2 None Female Negative 8 95 Negative peripheral blood 92 Negative 2133 17.5 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299944 test set Hispanic or Latino Unknown Negative 2 Unknown Female Negative 8 70 Negative peripheral blood 69 Positive 434 88.5 No CNS disease Negative
GSM299945 training set Asian Negative Negative 2 Unknown Male Negative 5 90 Negative bone marrow 87 Negative 4935 24.5 No CNS disease Negative
GSM299946 training set White Negative Negative 2 None Female Negative 5 85 Negative peripheral blood 100 Negative 6984 30.4 No CNS disease Negative
GSM299947 test set White Unknown Negative 2 None Female Negative 5 90 Negative bone marrow 65 Negative 1068 190.0 No CNS disease Negative
GSM299948 test set Hispanic or Latino Negative Negative 4 None Male Negative 6 95 Negative bone marrow 99 Negative 5877 66.9 No CNS disease Negative
GSM299949 training set White Negative Negative 6 None Male Negative 7 95 Negative bone marrow 87 Positive 5127 555.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299950 training set White Negative Negative 4 None Male Negative 7 90 Negative bone marrow 95 Positive 410 51.3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM29995 training set White Negative Negative 2 Unknown Male Negative 7 95 Negative bone marrow 97 Negative 5408 1.2 No CNS disease Negative
GSM299952 test set Black or African American Negative Negative 2 Unknown Male Negative 8 95 Negative bone marrow 96 Negative 2876 142.4 No CNS disease Negative
GSM299953 training set White Negative Negative 2 Unknown Male Negative 8 95 Negative bone marrow 87 Negative 697 110.9 No CNS disease Negative
GSM299954 test set Hispanic or Latino Unknown Negative 2 Downs Female Negative 5 90 Negative peripheral blood 95 Negative 2223 202.0 No CNS disease Negative
GSM299955 test set White Unknown Negative 2 None Female Negative 5 95 Negative peripheral blood 97 Positive 7028 259.8 No CNS disease Negative
GSM299956 training set White Negative Negative 2 None Male Negative 5 -1 Negative bone marrow 26 Negative 5177 166.5 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Unknown
GSM299957 training set Hispanic or Latino Unknown Negative 2 None Female Negative 6 90 Negative peripheral blood 91 Positive 1038 114.0 No CNS disease Negative
GSM299958 test set Hispanic or Latino Unknown Negative 2 Downs Female Negative 6 95 Negative peripheral blood 100 Negative 5008 321.2 No CNS disease Negative
GSM299959 training set Hispanic or Latino Unknown Negative 2 None Female Negative 7 95 Negative bone marrow 71 Negative 5925 19.5 No CNS disease Negative
GSM299960 training set Hispanic or Latino Negative Negative 2 None Male Negative 7 95 Negative peripheral blood 93 Negative 1258 145.0 No CNS disease Negative
GSM29996 test set Hispanic or Latino Unknown Negative 2 None Female Negative 8 90 Positive bone marrow 85 Negative 1956 148.2 No CNS disease Negative
GSM299962 training set White Unknown Negative 4 None Female Negative 6 90 Negative peripheral blood 97 Positive 4560 108.0 No CNS disease Negative
GSM299963 training set White Negative Negative 2 None Male Negative 7 90 Negative peripheral blood 84 Positive 966 37.3 No CNS disease Negative
GSM299964 test set White Negative Negative 2 None Male Unknown 7 95 Negative bone marrow 100 Negative 4585 12.0 No CNS disease Negative
GSM299965 training set White Unknown Negative 2 Unknown Female Negative 5 90 Negative bone marrow 98 Negative 4863 65.8 No CNS disease Negative
GSM299966 training set White Negative Negative 2 None Male Negative 6 95 Negative peripheral blood 100 Negative 369 325.0 No CNS disease Negative
GSM299967 test set White Negative Negative 2 None Male Negative 7 -1 Negative bone marrow 20 Negative 5853 2.3 No CNS disease Negative
GSM299968 training set White Negative Negative 2 None Male Negative 8 80 Negative bone marrow 99 Negative 6335 13.3 No CNS disease Negative
GSM299969 test set American Indian or Alaska native Negative Negative 2 None Male Negative 8 95 Negative peripheral blood 97 Negative 881 106.0 No CNS disease Negative
GSM299970 training set White Unknown Negative 3 None Female Negative 9 95 Negative peripheral blood 100 Negative 2786 105.7 No CNS disease Negative
GSM29997 training set White Negative Negative 3 None Male Negative 10 80 Negative peripheral blood 94 Negative 6306 16.7 No CNS disease Negative
GSM299972 test set White Negative Negative 3 None Male Negative 10 90 Negative bone marrow 98 Negative 2519 112.0 No CNS disease Negative
GSM299973 training set Hispanic or Latino Negative Negative 3 None Male Negative 11 95 Negative bone marrow 66 Negative 6142 18.5 No CNS disease Negative
GSM299974 test set Black or African American Negative Negative 3 None Male Negative 11 80 Negative bone marrow 96 Negative 5343 30.2 No CNS disease Negative
GSM299975 test set White Negative Negative 3 None Male Negative 11 90 Negative bone marrow 96 Positive 852 139.0 No CNS disease Negative
GSM299976 training set Hispanic or Latino Negative Negative 3 None Male Negative 12 95 Negative bone marrow 94 Positive 462 17.3 No CNS disease Negative
GSM299977 training set Black or African American Unknown Negative 3 Unknown Female Negative 12 90 Positive peripheral blood 75 Negative 5797 39.6 No CNS disease Negative
GSM299978 training set Hispanic or Latino Negative Negative 3 None Male Negative 9 95 Negative peripheral blood 97 Negative 4253 236.4 No CNS disease Negative
GSM299979 training set Hispanic or Latino Unknown Negative 3 None Female Negative 9 75 Negative peripheral blood 99 Negative 705 137.2 No CNS disease Negative
GSM299980 training set White Negative Negative 3 Unknown Male Negative 10 70 Negative peripheral blood 99 Negative 7478 28.0 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM29998 training set White Negative Negative 3 Unknown Male Negative 10 90 Negative peripheral blood 100 Negative 2191 272.0 No CNS disease Negative
GSM299982 training set Hispanic or Latino Unknown Negative 3 None Female Negative 11 90 Negative bone marrow 98 Negative 1275 214.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299983 test set White Negative Negative 3 None Male Negative 11 95 Negative bone marrow 96 Negative 5184 58.0 No CNS disease Negative
GSM299984 training set Other Negative Negative 3 None Male Negative 11 -1 Negative bone marrow 59 Negative 5542 7.9 No CNS disease Negative
GSM299985 test set White Negative Negative 3 None Male Negative 12 95 Negative bone marrow 64 Negative 5242 3.4 No CNS disease Negative
GSM299986 training set White Unknown Negative 3 Unknown Female Negative 12 75 Negative peripheral blood 99 Negative 1313 69.4 No CNS disease Negative
GSM299987 training set White Unknown Negative 3 None Female Negative 9 95 Negative bone marrow 94 Negative 1751 238.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM299988 training set White Unknown Negative 3 None Female Negative 9 90 Negative bone marrow 98 Negative 4329 179.0 No CNS disease Negative
GSM299989 training set White Negative Negative 3 None Male Negative 9 90 Negative bone marrow 86 Negative 976 7.7 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive
GSM299990 test set Hispanic or Latino Negative Negative 3 None Female Negative 10 95 Positive bone marrow 91 Negative 5300 98.2 No CNS disease Negative
GSM29999 training set Hispanic or Latino Negative Negative 3 None Male Negative 11 90 Negative bone marrow 81 Negative 4307 44.9 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299992 training set White Unknown Negative 3 None Female Negative 12 60 Negative peripheral blood 98 Negative 4324 35.7 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM299993 test set White Unknown Negative 3 Unknown Female Negative 9 95 Positive bone marrow 97 Negative 1033 118.1 No CNS disease Negative
GSM299994 test set Hispanic or Latino Negative Negative 3 None Male Negative 9 -1 Negative bone marrow 31 Negative 6052 6.4 No CNS disease Negative
GSM299995 training set White Negative Unknown 3 Unknown Male Unknown 10 95 Negative bone marrow 85 Negative 4157 77.6 No CNS disease Negative
GSM299996 training set Asian Unknown Negative 3 None Male Negative 11 90 Positive bone marrow 64 Negative 5025 73.1 No CNS disease Negative
GSM299997 training set White Negative Negative 3 None Male Negative 12 95 Negative bone marrow 99 Negative 6263 1.0 No CNS disease Negative
GSM299998 training set White Negative Negative 3 None Male Negative 9 90 Negative bone marrow 96 Positive 5664 22.0 No CNS disease Negative
GSM299999 test set Other Negative Negative 3 None Male Negative 9 95 Negative bone marrow 95 Negative 4776 1.3 No CNS disease Negative
GSM300000 training set White Unknown Negative 3 None Female Negative 10 95 Negative peripheral blood 99 Negative 2192 209.6 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM30000 training set Black or African American Negative Negative 3 None Male Negative 11 95 Negative bone marrow 94 Negative 5954 15.5 No CNS disease Negative
GSM300002 training set White Negative Negative 3 None Male Negative 11 95 Negative bone marrow 67 Negative 2038 193.0 No CNS disease Negative
GSM300003 training set White Unknown Negative 3 None Female Negative 12 95 Negative bone marrow 96 Negative 6032 59.2 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive
GSM300004 training set White Positive Negative 3 Unknown Male Negative 12 85 Negative peripheral blood 98 Negative 655 9.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300005 training set White Negative Negative 3 None Male Negative 12 90 Negative bone marrow 94 Negative 4759 2.4 No CNS disease Negative
GSM300006 test set Hispanic or Latino Unknown Negative 3 Unknown Female Negative 9 95 Negative bone marrow 97 Negative 2769 3.0 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM300007 training set American Indian or Alaska native Unknown Negative 3 None Male Negative 9 40 Negative peripheral blood 94 Negative 4972 6.3 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM300008 test set Black or African American Negative Negative 3 Unknown Male Negative 9 95 Negative bone marrow 98 Negative 4815 31.4 No CNS disease Negative
GSM300009 test set White Negative Negative 3 None Male Negative 10 95 Negative peripheral blood 98 Negative 6315 245.0 No CNS disease Negative
GSM300010 training set White Negative Negative 3 Downs Male Negative 10 95 Negative bone marrow 95 Negative 4276 24.4 No CNS disease Negative
GSM3000 training set White Negative Negative 3 None Male Negative 10 95 Negative peripheral blood 99 Negative 5759 33.9 No CNS disease Negative
GSM300012 test set White Negative Negative 3 None Male Negative 11 -1 Negative bone marrow 44 Negative 6487 7.6 No CNS disease Negative
GSM300013 test set Black or African American Negative Negative 3 None Male Negative 11 95 Positive peripheral blood 99 Negative 1771 152.7 No CNS disease Negative
GSM300014 training set White Negative Negative 3 None Male Negative 12 95 Negative bone marrow 89 Negative 515 124.0 No CNS disease Negative
GSM300015 training set White Unknown Negative 3 None Female Negative 12 95 Negative bone marrow 96 Negative 6090 24.8 No CNS disease Negative
GSM300016 training set White Negative Negative 3 Unknown Male Negative 9 95 Negative bone marrow 99 Negative 6633 1.9 No CNS disease Negative
GSM300017 test set Hispanic or Latino Negative Negative 3 None Male Negative 9 95 Negative bone marrow 97 Negative 5194 96.5 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM300018 training set Hispanic or Latino Negative Negative 3 None Male Negative 10 95 Negative bone marrow 96 Negative 6468 7.0 No CNS disease Negative
GSM300019 test set White Negative Negative 3 None Male Negative 11 90 Negative bone marrow 92 Negative 6062 17.0 No CNS disease Negative
GSM300020 test set Other Unknown Negative 3 Unknown Female Negative 11 90 Negative bone marrow 95 Positive 777 6.8 No CNS disease Negative
GSM30002 test set White Unknown Negative 3 None Female Negative 12 85 Positive bone marrow 100 Negative 5889 49.6 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300022 test set White Negative Negative 3 None Male Negative 12 95 Negative peripheral blood 95 Negative 893 455.4 No CNS disease Negative
GSM300023 training set Hispanic or Latino Negative Negative 3 None Male Negative 9 95 Negative bone marrow 98 Negative 4955 31.5 No CNS disease Negative
GSM300024 training set Hispanic or Latino Negative Negative 3 None Male Negative 10 95 Negative peripheral blood 99 Negative 5081 307.0 No CNS disease Negative
GSM300025 training set Hispanic or Latino Unknown Negative 3 Downs Female Negative 10 90 Negative bone marrow 98 Negative 4665 95.2 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300026 training set Hispanic or Latino Negative Negative 3 None Male Negative 11 95 Negative peripheral blood 97 Negative 988 958.8 No CNS disease Negative
GSM300027 training set White Negative Negative 3 None Male Negative 12 -1 Positive bone marrow 59 Negative 5890 9.4 No CNS disease Negative
GSM300028 test set Black or African American Unknown Negative 3 None Female Negative 12 95 Negative bone marrow 96 Negative 6351 13.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300029 test set White Negative Negative 4 Unknown Male Negative 13 95 Negative bone marrow 86 Negative 1475 212.3 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300030 training set Hispanic or Latino Negative Negative 4 Unknown Male Negative 13 90 Negative bone marrow 99 Negative 6036 8.8 No CNS disease Negative
GSM30003 training set White Unknown Negative 1 None Female Negative 4 95 Negative bone marrow 96 Negative 5217 135.8 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300032 training set Black or African American Negative Negative 1 None Male Negative 4 95 Negative bone marrow 97 Negative 523 82.9 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM300033 training set White Unknown Negative 3 Unknown Female Negative 11 95 Positive peripheral blood 99 Negative 1011 302.1 No CNS disease Negative
GSM300034 test set Native Hawaiian or other Pacific Islander Negative Negative 3 None Male Negative 11 90 Negative bone marrow 98 Negative 6107 18.3 No CNS disease Negative
GSM300035 training set White Negative Negative 4 None Male Negative 13 95 Negative peripheral blood 95 Negative 768 138.8 No CNS disease Negative
GSM300036 training set White Unknown Negative 4 None Female Negative 13 90 Positive peripheral blood 84 Negative 5670 37.2 No CNS disease Negative
GSM300037 training set Hispanic or Latino Negative Negative 6 None Male Negative 11 95 Negative peripheral blood 99 Negative 6666 114.6 No CNS disease Negative
GSM300038 training set Hispanic or Latino Unknown Negative 4 None Female Negative 13 85 Positive bone marrow 96 Negative 3901 136.6 No CNS disease Negative
GSM300039 training set White Negative Negative 7 None Female Negative 14 -1 Negative peripheral blood 51 Negative 728 138.4 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300040 test set White Unknown Negative 7 None Female Negative 14 95 Negative bone marrow 79 Negative 1058 141.0 No CNS disease Negative
GSM30004 test set Hispanic or Latino Unknown Negative 7 Unknown Female Negative 14 95 Negative bone marrow 76 Negative 1323 30.6 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive
GSM300042 training set Hispanic or Latino Negative Negative 7 None Male Negative 14 95 Negative bone marrow 84 Negative 650 102.5 No CNS disease Negative
GSM300043 test set White Negative Negative 8 None Male Negative 15 85 Negative bone marrow 99 Negative 5821 1.9 No CNS disease Negative
GSM300044 training set White Negative Negative 8 Unknown Male Negative 15 40 Negative peripheral blood 100 Negative 6202 2.3 No CNS disease Negative
GSM300045 training set American Indian or Alaska native Negative Negative 8 None Female Negative 15 90 Negative bone marrow 98 Negative 6119 2.3 No CNS disease Negative
GSM300046 training set White Positive Negative 8 None Male Negative 15 60 Negative peripheral blood 99 Negative 4571 6.9 No CNS disease Negative
GSM300047 training set Hispanic or Latino Negative Negative 8 None Male Negative 15 60 Negative peripheral blood 93 Negative 1896 4.1 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Positive
GSM300048 training set White Negative Negative 8 None Female Negative 15 75 Negative bone marrow 97 Negative 7461 3.8 No CNS disease Negative
GSM300049 test set White Negative Negative 8 None Male Negative 15 65 Negative bone marrow 96 Negative 6634 11.1 No CNS disease Negative
GSM300050 training set White Negative Negative 8 None Male Negative 15 80 Negative peripheral blood 83 Negative 5097 6.3 No CNS disease Negative
GSM30005 test set Hispanic or Latino Negative Negative 8 None Male Negative 15 95 Negative bone marrow 96 Negative 5532 5.5 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Negative
GSM300052 test set Black or African American Positive Negative 8 None Male Negative 15 -1 Negative peripheral blood 47 Negative 1914 45.1 < 5 CSF (cerebrospinal fluid) WBC/ul with blasts on cytospin Positive
GSM300053 training set White Negative Negative 8 None Male Negative 15 90 Positive peripheral blood 72 Negative 4434 42.1 No CNS disease Negative
GSM300054 test set Asian Negative Negative 8 None Male Negative 15 50 Positive peripheral blood 93 Negative 4782 4.4 No CNS disease Negative
GSM300055 test set White Negative Negative 8 None Male Negative 15 90 Negative bone marrow 84 Negative 5232 1.1 No CNS disease Negative
GSM300056 test set Black or African American Negative Negative 8 None Male Negative 15 80 Positive peripheral blood 83 Negative 6500 17.8 No CNS disease Negative
GSM300057 training set White Unknown Negative 9 None Male Negative 16 -1 Negative bone marrow 50 Positive 585 7.5 No CNS disease Negative
GSM300058 test set Black or African American Negative Negative 9 None Male Negative 16 95 Negative bone marrow 98 Negative 6539 2.6 No CNS disease Negative
GSM300059 test set White Negative Negative 9 None Female Negative 16 85 Negative bone marrow 100 Negative 5991 5.2 No CNS disease Negative
GSM300060 training set White Negative Negative 9 None Male Negative 16 70 Negative peripheral blood 93 Negative 6479 31.9 No CNS disease Negative
GSM30006 training set Black or African American Negative Negative 9 None Male Negative 16 90 Negative bone marrow 98 Negative 5183 23.0 No CNS disease Negative
GSM300062 training set White Negative Negative 9 None Male Negative 16 -1 Negative peripheral blood 46 Negative 713 110.3 No CNS disease Negative
GSM300063 test set White Unknown Negative 9 None Male Negative 16 90 Negative bone marrow 82 Positive 1704 85.1 No CNS disease Negative
GSM300064 test set White Negative Negative 9 Unknown Male Negative 16 95 Negative bone marrow 99 Negative 5594 2.8 No CNS disease Negative
GSM300065 training set White Negative Negative 9 Unknown Male Negative 16 95 Negative bone marrow 88 Negative 5857 13.3 No CNS disease Negative
GSM300066 test set Hispanic or Latino Unknown Negative 9 None Female Negative 16 95 Positive bone marrow 81 Negative 4017 3.5 > 5 CSF WBC/ul with blasts on cytospin and/or eye involvement, cranial nerve involvement, parenchymal brain involvement Negative
GSM300067 training set White Negative Negative 9 Unknown Male Negative 16 95 Negative bone marrow 85 Negative 4918 5.5 No CNS disease Negative
GSM300068 training set Hispanic or Latino Negative Negative 10 Unknown Male Negative 18 90 Negative bone marrow 66 Negative 5349 147.6 No CNS disease Negative

Tags

  • acute lymphoblastic leukemia
  • cancer
  • disease
  • intermediate
  • leukemia
  • lymphoblastic leukemia

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2026 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use