Dataset: Transcription profiling of mouse naive and tolerant macrophages treated with MDP- and Pam3CSK4

Most of the genes were self-tolerized by Pam3CSK4 and MDP but there was no or minimal cross-tolerization. The transcriptome induced via Nod2 stimulation is greatly expanded in TLR2-tolerant macrophages. Experiment Overall Design: Genes induced by Pam3CSK4 or MDP were selected based on a three-fold increase over expression levels in unstimulated macrophages. Tolerized genes are defined as genes downregulated more than 2-fold in tolerant macrophages stimulated with Pam3CSK4 or MDP.

Species:

mouse

Samples:

7

Source:

E-GEOD-10182

Updated:

Dec.12, 2014

Registered:

Nov.10, 2014