Dataset: Diverse human extracellular RNAs are widely detected in human plasma.

Extracellular RNA from the plasma of 40 individuals from the Framingham Heart Study were isolated using miRCURY RNA isolation kit...

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Extracellular RNA from the plasma of 40 individuals from the Framingham Heart Study were isolated using miRCURY RNA isolation kit Biofluids (Exiqon). Small RNA Library preparation was done with Ion Total RNA-Seq Kit v2 (Thermo Fisher Scientific) and the samples were sequenced with the Ion Proton. Next, using a targeted quantitative PCR with reverse transcription approach in 2,763 individuals, we characterized almost 500 of the most abundant extracellular transcripts including microRNAs, piRNAs and small nucleolar RNAs. The presence in plasma of many non-microRNA small-RNAs was confirmed in an independent cohort. We present comprehensive data to demonstrate the broad and consistent detection of diverse classes of circulating non-cellular small-RNAs from a large population.

Species:: human
Samples:: 39
PubMed:: 27112789
Updated:: Jul.30, 2018
Registered:: Jul.30, 2018

Factors:

Sample	trancriptome_genome-ratio	transcriptome_reads	related_dataset_id	fastq_identifier	exRNA_source	condition	cell_culture_source	species	biofluid_name	biosample_metadata_id	RNA_isolation_kit	profiling_assay	meets_ERCC_QC	reference_genome_reads	anatomical_location
11020	0.896134	542,550	EXR-JFREE1eZDUKB-AN	sample_FHS_1020_CVD_BC_12_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE11020-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	605,434	Entire cardiovascular system
11066	0.866619	269,652	EXR-JFREE1eZDUKB-AN	sample_FHS_1066_No_CVD_BC_11_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE11066-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	311,154	Entire cardiovascular system
11095	0.86556	333,771	EXR-JFREE1eZDUKB-AN	sample_FHS_1095_No_CVD_BC_13_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE11095-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	385,613	Entire cardiovascular system
11120	0.906389	166,607	EXR-JFREE1eZDUKB-AN	sample_FHS_1120_No_CVD_BC_01_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE11120-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	183,814	Entire cardiovascular system
11430	0.8688	731,229	EXR-JFREE1eZDUKB-AN	sample_FHS_1430_CVD_BC_10_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE11430-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	841,645	Entire cardiovascular system
11579	0.746617	183,753	EXR-JFREE1eZDUKB-AN	sample_FHS_1579_CVD_BC_10_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE11579-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	246,114	Entire cardiovascular system
11610	0.93647	1,007,685	EXR-JFREE1eZDUKB-AN	sample_FHS_1610_CVD_BC_04_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE11610-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	1,076,046	Entire cardiovascular system
10172	0.768581	276,109	EXR-JFREE1eZDUKB-AN	sample_FHS_172_CVD_BC_14_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE10172-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	359,245	Entire cardiovascular system
10216	0.945584	1,500,424	EXR-JFREE1eZDUKB-AN	sample_FHS_216_N0_CVD_BC_03_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE10216-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	1,586,770	Entire cardiovascular system
10021	0.83462	210,235	EXR-JFREE1eZDUKB-AN	sample_FHS_21_No_CVD_BC_01_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE10021-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	251,893	Entire cardiovascular system
12303	0.788773	211,627	EXR-JFREE1eZDUKB-AN	sample_FHS_2303_No_CVD_BC_07_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE12303-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	268,299	Entire cardiovascular system
12616	0.790398	130,701	EXR-JFREE1eZDUKB-AN	sample_FHS_2616_No_CVD_BC_05_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE12616-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	165,361	Entire cardiovascular system
12768	0.953922	1,249,385	EXR-JFREE1eZDUKB-AN	sample_FHS_2768_CVD_BC_02_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE12768-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	1,309,735	Entire cardiovascular system
12918	0.938385	1,095,028	EXR-JFREE1eZDUKB-AN	sample_FHS_2918_No_CVD_BC01_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE12918-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	1,166,928	Entire cardiovascular system
12938	0.716815	88,318	EXR-JFREE1eZDUKB-AN	sample_FHS_2938_CVD_BC_04_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE12938-BS	miRcury biofluids (Exiqon)	small RNA-Seq	NO	123,209	Entire cardiovascular system
13132	0.826711	177,265	EXR-JFREE1eZDUKB-AN	sample_FHS_3132_N0_CVD_BC_05_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE13132-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	214,422	Entire cardiovascular system
13170	0.751055	76,519	EXR-JFREE1eZDUKB-AN	sample_FHS_3170_No_CVD_BC_07_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE13170-BS	miRcury biofluids (Exiqon)	small RNA-Seq	NO	101,882	Entire cardiovascular system
10320	0.946026	812,926	EXR-JFREE1eZDUKB-AN	sample_FHS_320_No_CVD_BC_07_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE10320-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	859,306	Entire cardiovascular system
13392	0.838254	243,884	EXR-JFREE1eZDUKB-AN	sample_FHS_3392_CVD_BC_02_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE13392-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	290,943	Entire cardiovascular system
13464	0.713995	59,670	EXR-JFREE1eZDUKB-AN	sample_FHS_3464_No_CVD_BC_03_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE13464-BS	miRcury biofluids (Exiqon)	small RNA-Seq	NO	83,572	Entire cardiovascular system
13713	0.822151	148,945	EXR-JFREE1eZDUKB-AN	sample_FHS_3713_CVD_BC_06_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE13713-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	181,165	Entire cardiovascular system
14043	0.834504	177,837	EXR-JFREE1eZDUKB-AN	sample_FHS_4043_CVD_BC_04_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE14043-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	213,105	Entire cardiovascular system
14820	0.80196	175,885	EXR-JFREE1eZDUKB-AN	sample_FHS_4820_No_CVD_BC_13_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE14820-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	219,319	Entire cardiovascular system
14912	0.701753	46,449	EXR-JFREE1eZDUKB-AN	sample_FHS_4912_CVD_BC_02_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE14912-BS	miRcury biofluids (Exiqon)	small RNA-Seq	NO	66,190	Entire cardiovascular system
10500	0.689864	90,586	EXR-JFREE1eZDUKB-AN	sample_FHS_500_No_CVD_BC_09_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE10500-BS	miRcury biofluids (Exiqon)	small RNA-Seq	NO	131,310	Entire cardiovascular system
15237	0.822248	151,001	EXR-JFREE1eZDUKB-AN	sample_FHS_5237_CVD_BC_06_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE15237-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	183,644	Entire cardiovascular system
10543	0.757923	91,811	EXR-JFREE1eZDUKB-AN	sample_FHS_543_CVD_BC_16_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE10543-BS	miRcury biofluids (Exiqon)	small RNA-Seq	NO	121,135	Entire cardiovascular system
10590	0.842146	150,126	EXR-JFREE1eZDUKB-AN	sample_FHS_590_N0_CVD_BC_15_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE10590-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	178,266	Entire cardiovascular system
16077	0.953763	1,378,861	EXR-JFREE1eZDUKB-AN	sample_FHS_6077_No_CVD_BC_09_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE16077-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	1,445,706	Entire cardiovascular system
16136	0.825893	156,354	EXR-JFREE1eZDUKB-AN	sample_FHS_6136_CVD_BC_08_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE16136-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	189,315	Entire cardiovascular system
16355	0.908901	727,498	EXR-JFREE1eZDUKB-AN	sample_FHS_6355_CVD_BC_08_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE16355-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	800,415	Entire cardiovascular system
16684	0.825828	294,681	EXR-JFREE1eZDUKB-AN	sample_FHS_6684_CVD_BC_16_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE16684-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	356,831	Entire cardiovascular system
16758	0.766947	185,579	EXR-JFREE1eZDUKB-AN	sample_FHS_6758_CVD_BC_14_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE16758-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	241,971	Entire cardiovascular system
10676	0.943756	1,031,504	EXR-JFREE1eZDUKB-AN	sample_FHS_676_CVD_BC_06_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE10676-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	1,092,977	Entire cardiovascular system
16926	0.868186	178,532	EXR-JFREE1eZDUKB-AN	sample_FHS_6926_No_CVD_BC_03_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE16926-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	205,638	Entire cardiovascular system
17138	0.804494	295,317	EXR-JFREE1eZDUKB-AN	sample_FHS_7138_CVD_BC_12_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE17138-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	367,084	Entire cardiovascular system
17226	0.765965	466,364	EXR-JFREE1eZDUKB-AN	sample_FHS_7226_No_CVD_BC_15_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE17226-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	608,858	Entire cardiovascular system
10728	0.770573	128,725	EXR-JFREE1eZDUKB-AN	sample_FHS_728_CVD_BC_08_fastq	total cell-free biofluid RNA	Cardiovascular Disorder	Not Applicable	Human	Plasma	EXR-JFREE10728-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	167,051	Entire cardiovascular system
17326	0.750356	139,705	EXR-JFREE1eZDUKB-AN	sample_FHS_7326_No_CVD_BC_11_fastq	total cell-free biofluid RNA	Healthy Control	Not Applicable	Human	Plasma	EXR-JFREE17326-BS	miRcury biofluids (Exiqon)	small RNA-Seq	YES	186,185	Entire cardiovascular system