Plugin: Phenologs

Mapping between genotype and phenotype is often non-obvious, complicating prediction of genes underlying specific phenotypes. This problem can be addressed through comparative analyses of phenotypes. We define orthologous phenotypes between organisms (phenologs) based upon overlapping sets of orthologous genes associated with each phenotype. Comparisons of >189,000 human, mouse, yeast, and worm gene-phenotype associations reveal many significant phenologs, including novel non-obvious human disease models. For example, phenologs suggest a yeast model for mammalian angiogenesis defects and an invertebrate model for vertebrate neural tube birth defects. Phenologs thus create a rich framework for comparing mutational phenotypes, identify adaptive reuse of gene systems, and suggest new disease genes.

Species:

human

URL Template:

http://www.phenologs.org//cgi-perl/pog.cgi/response?gene={{EntrezGene}}&refSpecies=1

Updated:

July 6, 2012

Registered:

July 6, 2012