ArrayExpress Uploaderarrayexpress_sidratBronchi23pMRTPParenchyma23pMRTPNasal Cavity Respiratory Epithelium23pMRTPBronchi83R4FParenchyma83R4FNasal Cavity Respiratory Epithelium83R4FBronchi153R4FParenchyma153R4FNasal Cavity Respiratory Epithelium153R4FBronchi Parenchyma Nasal Cavity Respiratory Epithelium Bronchi233R4FParenchyma233R4FNasal Cavity Respiratory Epithelium233R4FBronchi23pMRTPParenchyma23pMRTPNasal Cavity Respiratory Epithelium23pMRTPBronchi153R4FParenchyma153R4FNasal Cavity Respiratory Epithelium153R4FBronchi233R4FParenchyma233R4FNasal Cavity Respiratory Epithelium233R4FBronchi23pMRTPParenchyma23pMRTPNasal Cavity Respiratory Epithelium23pMRTPBronchi83R4FParenchyma83R4FNasal Cavity Respiratory Epithelium83R4FBronchi23pMRTPParenchyma23pMRTPNasal Cavity Respiratory Epithelium23pMRTPBronchi233R4FParenchyma233R4FNasal Cavity Respiratory Epithelium233R4FBronchi83R4FParenchyma83R4FNasal Cavity Respiratory Epithelium83R4FBronchi233R4FParenchyma233R4FNasal Cavity Respiratory Epithelium233R4FBronchi83R4FParenchyma83R4FNasal Cavity Respiratory Epithelium83R4FBronchi Parenchyma Nasal Cavity Respiratory Epithelium Bronchi153R4FParenchyma153R4FNasal Cavity Respiratory Epithelium153R4FBronchi83R4FParenchyma83R4FNasal Cavity Respiratory Epithelium83R4FBronchi23pMRTPParenchyma23pMRTPNasal Cavity Respiratory Epithelium23pMRTPBronchi Parenchyma Nasal Cavity Respiratory Epithelium Bronchi233R4FParenchyma233R4FNasal Cavity Respiratory Epithelium233R4FBronchi Parenchyma Nasal Cavity Respiratory Epithelium Bronchi153R4FParenchyma153R4FNasal Cavity Respiratory Epithelium153R4FBronchi153R4FParenchyma153R4FNasal Cavity Respiratory Epithelium153R4FBronchi Parenchyma Nasal Cavity Respiratory Epithelium 9560011We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to...E-MTAB-1842/profile/8773/arrayexpressuploader375cancercopddiseaselunglung cancerFeb.09, 2015FalseE-MTAB-1842_A-AFFY-4328d-rat-inhalation-study-with-prototypic-mrtp28d Rat Inhalation Study with Prototypic MRTPJan.12, 2015We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to a low, medium, or high concentration of mainstream (MS) cigarette smoke (CS) from the Reference cigarette 3R4F in addition to MS CS from a prototypic modified risk tobacco product (pMRTP) at the same nicotine concentration as the high 3R4F group, i.e., 23 ug nicotine/l. Following CS inhalation, rats mainly develop irritative stress-related adaptive changes in the upper airways and signs of inflammation in the lung, a common condition preceding smoking-related lung diseases such as COPD and lung cancer. In the current study, the feasibility of investigating disease-relevant molecular perturbations at the sites of histopathological changes towards a Systems systems Biologybiology-based risk assessment was tested, using state-of-the-art technologies for sample preparation, analysis, and interpretation of gene expression arrays in combination with the classical toxicology end points.http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1842http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1842/samples/