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"SmokeConcentration": "23", "Treatment": "3R4F"}}, {"910078": {"Tissue": "Bronchi", "SmokeConcentration": "  ", "Treatment": "  "}}, {"910078": {"Tissue": "Parenchyma", "SmokeConcentration": "  ", "Treatment": "  "}}, {"910078": {"Tissue": "Nasal Cavity Respiratory Epithelium", "SmokeConcentration": "  ", "Treatment": "  "}}, {"910077": {"Tissue": "Bronchi", "SmokeConcentration": "15", "Treatment": "3R4F"}}, {"910077": {"Tissue": "Parenchyma", "SmokeConcentration": "15", "Treatment": "3R4F"}}, {"910077": {"Tissue": "Nasal Cavity Respiratory Epithelium", "SmokeConcentration": "15", "Treatment": "3R4F"}}, {"910077": {"Tissue": "Bronchi", "SmokeConcentration": "15", "Treatment": "3R4F"}}, {"910077": {"Tissue": "Parenchyma", "SmokeConcentration": "15", "Treatment": "3R4F"}}, {"910077": {"Tissue": "Nasal Cavity Respiratory Epithelium", "SmokeConcentration": "15", "Treatment": "3R4F"}}, {"910078": {"Tissue": "Bronchi", "SmokeConcentration": "  ", "Treatment": "  "}}, {"910078": {"Tissue": "Parenchyma", "SmokeConcentration": "  ", "Treatment": "  "}}, {"910078": {"Tissue": "Nasal Cavity Respiratory Epithelium", "SmokeConcentration": "  ", "Treatment": "  "}}], "id": 9560, "ownerprofile_id": "arrayexpress_sid", "platform": 11, "summary_wrapped": "We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to...", "geo_gse_id": "E-MTAB-1842", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 75, "tags": ["cancer", "copd", "disease", "lung", "lung cancer"], "lastmodified": "Feb.09, 2015", "is_default": false, "geo_gds_id": "", "slug": "28d-rat-inhalation-study-with-prototypic-mrtp", "geo_id_plat": "E-MTAB-1842_A-AFFY-43", "name": "28d Rat Inhalation Study with Prototypic MRTP", "created": "Jan.12, 2015", "summary": "We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to a low, medium, or high concentration of mainstream (MS) cigarette smoke (CS) from the Reference cigarette 3R4F in addition to MS CS from a prototypic modified risk tobacco product (pMRTP) at the same nicotine concentration as the high 3R4F group, i.e., 23 ug nicotine/l. Following CS inhalation, rats mainly develop irritative stress-related adaptive changes in the upper airways and signs of inflammation in the lung, a common condition preceding smoking-related lung diseases such as COPD and lung cancer. In the current study, the feasibility of investigating disease-relevant molecular perturbations at the sites of histopathological changes towards a Systems systems Biologybiology-based risk assessment was tested, using state-of-the-art technologies for sample preparation, analysis, and interpretation of gene expression arrays in combination with the classical toxicology end points.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1842", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1842/samples/"}