{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 5179, "factors": [{"CB1": {"RNAi": "siRNA CBF-beta"}}, {"CB1": {"RNAi": "siRNA CBF-beta"}}, {"CB1": {"RNAi": "siRNA CBF-beta"}}, {"NS1": {"RNAi": "siRNA non-specific"}}, {"NS1": {"RNAi": "siRNA non-specific"}}, {"NS1": {"RNAi": "siRNA non-specific"}}, {"NS1": {"RNAi": "siRNA non-specific"}}, {"RX1": {"RNAi": "siRNA Runx2"}}, {"RX1": {"RNAi": "siRNA Runx2"}}, {"RX1": {"RNAi": "siRNA Runx2"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "[u'Cells of MDA-MB-231 breast cancer cell-line were transfected with siRNA against Runx2, CBF-beta or non-specific siRNA used as control....", "pubmed_id": 22032690, "geo_gse_id": "E-MEXP-3230", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 10, "tags": ["bone", "breast", "breast cancer", "cancer", "cell", "gland", "line", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-human-breast-9", "geo_id_plat": "E-MEXP-3230_A-AFFY-44", "name": "Transcription profiling by array of human breast cancer cell line MDA-MB-231 with siRNa against Runx2, CBF-beta or a non-specific siRNA", "created": "Sep.22, 2014", "summary": "[u'Cells of MDA-MB-231 breast cancer cell-line were transfected with siRNA against Runx2, CBF-beta or non-specific siRNA used as control. Runx2 is a member of the Runx transcription factor family and possesses a Runt domain capable of binding to the consensus DNA sequence ACC(A/G)CA. This domain also interacts with the co-activator protein core binding factor beta (CBF-beta), which enhances its binding to DNA. Runx2, primarily identified as a master regulator of bone development, but was also found expressed in the epithelium of the nascent mammary gland in mice. In contrast with its normal role in', {u'br': None}, {u'br': None}, u'breast, it has been shown that Runx2 is over-expressed in breast cancer cell lines.']", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-3230", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-3230/samples/"}