ArrayExpress Uploader05179siRNA CBF-betasiRNA CBF-betasiRNA CBF-betasiRNA non-specificsiRNA non-specificsiRNA non-specificsiRNA non-specificsiRNA Runx2siRNA Runx2siRNA Runx2arrayexpress_sid4[u'Cells of MDA-MB-231 breast cancer cell-line were transfected with siRNA against Runx2, CBF-beta or non-specific siRNA used as control....22032690E-MEXP-3230/profile/8773/arrayexpressuploader110bonebreastbreast cancercancercellglandlineproteinDec.12, 2014Falsetranscription-profiling-by-array-of-human-breast-9E-MEXP-3230_A-AFFY-44Transcription profiling by array of human breast cancer cell line MDA-MB-231 with siRNa against Runx2, CBF-beta or a non-specific siRNASep.22, 2014[u'Cells of MDA-MB-231 breast cancer cell-line were transfected with siRNA against Runx2, CBF-beta or non-specific siRNA used as control. Runx2 is a member of the Runx transcription factor family and possesses a Runt domain capable of binding to the consensus DNA sequence ACC(A/G)CA. This domain also interacts with the co-activator protein core binding factor beta (CBF-beta), which enhances its binding to DNA. Runx2, primarily identified as a master regulator of bone development, but was also found expressed in the epithelium of the nascent mammary gland in mice. In contrast with its normal role in', {u'br': None}, {u'br': None}, u'breast, it has been shown that Runx2 is over-expressed in breast cancer cell lines.']http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-3230humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-3230/samples/