ArrayExpress Uploader05175normalnormalnormalnormalnormalnormalHutchinson-Gilford Progeria SyndromeHutchinson-Gilford Progeria SyndromeHutchinson-Gilford Progeria Syndromearrayexpress_sid4Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by...21738662E-MEXP-3097/profile/8773/arrayexpressuploader19genetic disordergenomehutchinson-gilford progeria syndromelamin anuclear laminaskinsyndromeDec.12, 2014FalseE-MEXP-3097_A-AFFY-44transcription-profiling-of-primary-fibroblasts-froTranscription profiling of primary fibroblasts from a family with autosomal recessive Hutchinson-Gilford Progeria SyndromeSep.22, 2014Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina. By studying a family with homozygous LMNA mutation (K542N), we showed that HGPS can also be caused by mutations affecting both isoforms, lamin A and C (J Med Genet 2004;41:609–614). With the aim to elucidate the molecular mechanisms underlying the pathogenesis of lamin A/C-related (hereditary) HGPS, we investigated primary cultured skin fibroblasts from affected homozygous K542N carriers (n=3), healthy heterozygotes (n=3), and controls (n=3) for differences in global gene expression using GeneChip Human Genome U133 Plus 2.0 arrays (Affymetrix UK Ltd.).http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-3097humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-3097/samples/