Dataset: Transcription profiling of livers of adult UPF2 null mice in response to partial hepatectomy

Deletion of the NMD component UPF2 in adult liver and response to partial hepatectomy. Lethally irradiated Upf2flox/flox and Upf2flox/flox; Mx1Cre animals were transplanted with WT BM at 10-12 weeks of age. 5-6 following transplantion the bone marrow transplanted (BMT) animals were injected 3 times with poly-IC (Days 0, 2, 4), which facilitates Cre-mediated deletion in BMT Upf2flox/flox; Mx1Cre (hitherto UPF2 null) but not in BMT Upf2flox/flox control (hitherto WT) mice. A day 14 mice were subjected to partial hepatectomy (0 hours) and sacrificed after 36 hours (36 hours)..

Species:

mouse

Samples:

13

Source:

E-MEXP-2249

PubMed:

20657840

Updated:

Dec.12, 2014

Registered:

Nov.21, 2014