ArrayExpress Uploader01380colony stimulating factor 2 (granulocyte-macrophage)interferon alphacolony stimulating factor 2 (granulocyte-macrophage)interferon alphacolony stimulating factor 2 (granulocyte-macrophage)nonecolony stimulating factor 2 (granulocyte-macrophage)interleukin 4colony stimulating factor 2 (granulocyte-macrophage)interferon alphacolony stimulating factor 2 (granulocyte-macrophage)nonecolony stimulating factor 2 (granulocyte-macrophage)interleukin 4colony stimulating factor 2 (granulocyte-macrophage)nonecolony stimulating factor 2 (granulocyte-macrophage)interleukin 4colony stimulating factor 2 (granulocyte-macrophage)interferon alphacolony stimulating factor 2 (granulocyte-macrophage)nonecolony stimulating factor 2 (granulocyte-macrophage)interleukin 4arrayexpress_sid3[u'The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major...20009034E-MEXP-2000/profile/8773/arrayexpressuploader212cellclassdendriticproteinDec.12, 2014Falsetranscription-profiling-of-human-monocyte-derivedE-MEXP-2000_A-AFFY-33Transcription profiling of human monocyte-derived dendritic cells to study uptake of apoptotic cells by dendritci cells and induction of T-cell immunityJun.19, 2014[u'The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major challenge in immunology.', {u'br': None}, u'DCs generated from monocytes in the presence of IFN-alpha (IFN-alpha-DCs) are competent in taking up ACs and inducing a strong T cell immunity. Capture of allogenetic apoptotic lymphocytes (APO-allo-PBLs) was associated with subcellular rearrangements of MHC class I/II molecules, subsequent cross-priming of auologous CD8+ T cells and CD4+ T cell activation. All these events were inhibited by the Scavenger Receptor (SR) LOX-1 protein, whose expression was up-regulated in IFN-alpha DCs. The results unravel a novel natural IFN-alpha-mediated pathway by which a defined SR molecule regulates AC uptake by DCs and subsequent induction of T cell immunity.']http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-2000humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-2000/samples/