{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 1380, "factors": [{"HUG133A_IFNA_C": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interferon alpha"}}, {"HUG133A_IFNA_C": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interferon alpha"}}, {"HUG133A_GMCSF_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "none"}}, {"HUG133A_IL4_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interleukin 4"}}, {"HUG133A_IFNA_C": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interferon alpha"}}, {"HUG133A_GMCSF_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "none"}}, {"HUG133A_IL4_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interleukin 4"}}, {"HUG133A_GMCSF_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "none"}}, {"HUG133A_IL4_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interleukin 4"}}, {"HUG133A_IFNA_C": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interferon alpha"}}, {"HUG133A_GMCSF_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "none"}}, {"HUG133A_IL4_A": {"COMPOUND1": "colony stimulating factor 2 (granulocyte-macrophage)", "COMPOUND2": "interleukin 4"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 3, "summary_wrapped": "[u'The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major...", "pubmed_id": 20009034, "geo_gse_id": "E-MEXP-2000", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 12, "tags": ["cell", "class", "dendritic", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-monocyte-derived", "geo_id_plat": "E-MEXP-2000_A-AFFY-33", "name": "Transcription profiling of human monocyte-derived dendritic cells to study uptake of apoptotic cells by dendritci cells and induction of T-cell immunity", "created": "Jun.19, 2014", "summary": "[u'The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major challenge in immunology.', {u'br': None}, u'DCs generated from monocytes in the presence of IFN-alpha (IFN-alpha-DCs) are competent in taking up ACs and inducing a strong T cell immunity. Capture of allogenetic apoptotic lymphocytes (APO-allo-PBLs) was associated with subcellular rearrangements of MHC class I/II molecules, subsequent cross-priming of auologous CD8+ T cells and CD4+ T cell activation. All these events were inhibited by the Scavenger Receptor (SR) LOX-1 protein, whose expression was up-regulated in IFN-alpha DCs. The results unravel a novel natural IFN-alpha-mediated pathway by which a defined SR molecule regulates AC uptake by DCs and subsequent induction of T cell immunity.']", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-2000", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-2000/samples/"}