{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 8067, "factors": [{"Ercc1-D1": {"genotype": "Ercc1 knock out"}}, {"Ercc1-D1": {"genotype": "Ercc1 knock out"}}, {"Ercc1-D1": {"genotype": "Ercc1 knock out"}}, {"Ercc1-D1": {"genotype": "Ercc1 knock out"}}, {"Ercc1-D1": {"genotype": "Ercc1 knock out"}}, {"Ercc1-D1": {"genotype": "Ercc1 knock out"}}, {"wt1": {"genotype": "wild type"}}, {"wt1": {"genotype": "wild type"}}, {"wt1": {"genotype": "wild type"}}, {"wt1": {"genotype": "wild type"}}, {"wt1": {"genotype": "wild type"}}, {"wt1": {"genotype": "wild type"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a...", "pubmed_id": 18704162, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["helix", "liver", "progeria"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-MEXP-1503_A-AFFY-45", "slug": "transcription-profiling-by-array-of-liver-from-mic", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1503", "geo_gds_id": "", "name": "Transcription profiling by array of liver from mice mutant for Ercc1", "created": "Nov.21, 2014", "summary": "The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as \"Ercc1-delta\") leading to extreme sensitivity to DNA crosslinks and progeria.To investigate whether a disturbance in growth and metabolism could explain the pronounced accelerated organismal deterioration seen in Ercc1 delta mice, we evaluated the liver transcriptome of 16-week-old wt and mutant mice (n=6). At this age, the Ercc1-delta mice have not yet become cachectic.", "geo_gse_id": "E-MEXP-1503", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1503/samples/"}