ArrayExpress Uploader08067Ercc1 knock outErcc1 knock outErcc1 knock outErcc1 knock outErcc1 knock outErcc1 knock outwild typewild typewild typewild typewild typewild typearrayexpress_sid6The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a...18704162/profile/8773/arrayexpressuploader112helixliverprogeriaDec.12, 2014FalseE-MEXP-1503_A-AFFY-45transcription-profiling-by-array-of-liver-from-michttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1503Transcription profiling by array of liver from mice mutant for Ercc1Nov.21, 2014The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To investigate whether a disturbance in growth and metabolism could explain the pronounced accelerated organismal deterioration seen in Ercc1 delta mice, we evaluated the liver transcriptome of 16-week-old wt and mutant mice (n=6). At this age, the Ercc1-delta mice have not yet become cachectic.E-MEXP-1503mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1503/samples/