ArrayExpress Uploaderarrayexpress_sidmouseTBP105QTBP105QTBP105QTBP13QTBP13QTBP13Qwild typewild typewild type804906[u'Transcription profiles were obtained for 2-month old mice. Three lines (WT, TBP-13Q12, and TBP105Q) were used in these experiments. ',...17994014E-MEXP-1314/profile/8773/arrayexpressuploader19diseasehuntington diseaseproteinspinocerebellar ataxiaDec.12, 2014Falsetranscription-profiling-of-cerebellum-cells-from-wE-MEXP-1314_A-AFFY-45Transcription profiling of cerebellum cells from wild type mice or mice overexpressing TATA-binding protein (TBP) or a mutant version of TBPNov.21, 2014[u'Transcription profiles were obtained for 2-month old mice. Three lines (WT, TBP-13Q12, and TBP105Q) were used in these experiments. ', {u'br': None}, {u'br': None}, u' Wild-type and 13Q mice are normal. The 13Q mice overexpress the normal protein on the RNA but not protein level and do not show a phenotype. The 105Q mice express a mutant version of the protein TBP and faithfully model the disease SCA17 (spinocerebellar ataxia-17, huntington disease-like 4, HDL4). ', {u'br': None}, {u'br': None}, u' The constructs containing mixed CAG/CAA trinucleotide repeats (and encoding polyglutamine tracts) of variable length were made using a previously described method (Michalik A et al., Biotechniques, 2001). Briefly, synthetic CAG/CAA oligonucleotides were subcloned into a cDNA construct of the normal mouse (13 CAG/CAA) TBP gene. Because of the mixed nature of the repeat, its length is stable in mitotic and meiotic transmission.']http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1314http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1314/samples/