{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"TBP-13Q-12_2": {"disease state": "normal", "strain": "TBP-13Q-12", "genotype": "TBP-13Q"}}, {"TBP-13Q-12_2": {"disease state": "normal", "strain": "TBP-13Q-12", "genotype": "TBP-13Q"}}, {"TBP-13Q-12_2": {"disease state": "normal", "strain": "TBP-13Q-12", "genotype": "TBP-13Q"}}, {"TBP-71Q-16_735": {"disease state": "SCA17", "strain": "TBP-71Q-16", "genotype": "TBP-71Q"}}, {"TBP-71Q-16_735": {"disease state": "SCA17", "strain": "TBP-71Q-16", "genotype": "TBP-71Q"}}, {"TBP-71Q-16_735": {"disease state": "SCA17", "strain": "TBP-71Q-16", "genotype": "TBP-71Q"}}, {"TBP-71Q-27_686": {"disease state": "SCA17", "strain": "TBP-71Q-27", "genotype": "TBP-71Q"}}, {"TBP-71Q-27_686": {"disease state": "SCA17", "strain": "TBP-71Q-27", "genotype": "TBP-71Q"}}, {"TBP-71Q-27_686": {"disease state": "SCA17", "strain": "TBP-71Q-27", "genotype": "TBP-71Q"}}], "id": 8048, "pop_total": 0, "platform": 6, "summary_wrapped": "[u'Transcription profiles were obtained for 2-month old mice containing an expanded or normal CAG trinucleotide repeat in the coding...", "pubmed_id": 17994014, "geo_gse_id": "E-MEXP-1313", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 9, "tags": ["disease", "huntington disease", "protein", "spinocerebellar ataxia"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-mouse-cerebellum-cells", "geo_id_plat": "E-MEXP-1313_A-AFFY-45", "name": "Transcription profiling of mouse cerebellum cells containing expanded or normal CAG trinucleotide repeats in the coding region for TATA-binding protein (TBP)", "created": "Nov.21, 2014", "summary": "[u'Transcription profiles were obtained for 2-month old mice containing an expanded or normal CAG trinucleotide repeat in the coding region for TATA-binding protein (TBP). Three different genotypes were used : TBP-13Q (normal), TBP-71Q (71 repeats), and TBP-105Q (105 repeats).  Two lines of TBP-71Q (lines 16 and 27) were used in these experiments. ', {u'br': None}, {u'br': None}, u' The 71Q and 105Q mice express a mutant version of the protein (TBP) and faithfully model the disease SCA17 (spinocerebellar ataxia-17, huntington disease-like 4, HDL4).  ', {u'br': None}, {u'br': None}, u' The constructs containing mixed CAG/CAA trinucleotide repeats (and encoding polyglutamine tracts) of variable length were made using a previously described method (Michalik A et al., Biotechniques, 2001). Briefly,  synthetic CAG/CAA oligonucleotides were subcloned into a cDNA construct of the normal mouse (13 CAG/CAA) TBP gene.  Because of the mixed nature of the repeat, its length is stable in mitotic and meiotic transmission.']", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1313", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1313/samples/"}