ArrayExpress Uploader08310E2F4 -/- germline knockoutkidneyE2F4 -/- germline knockoutkidneyE2F4 -/- germline knockoutliverE2F4 -/- germline knockoutliverE2F4 -/- germline knockouttestisE2F4 -/- germline knockouttestisE2F4 heterozygouskidneyE2F4 heterozygouskidneyE2F4 heterozygousliverE2F4 heterozygousliverE2F4 heterozygoustestisE2F4 heterozygoustestisarrayexpress_sid7We considered the possibility that removal of E2F4, as a key regulator of cellular quiescence, would cause systemic perturbations in the...17957245E-MEXP-1131/profile/8773/arrayexpressuploader212cellkidneyliverpointDec.12, 2014Falsetranscription-profiling-of-e2f4-double-knockout-miE-MEXP-1131_A-AFFY-23Transcription profiling of E2F4 double knockout mice and heterozygous littermatesNov.23, 2014We considered the possibility that removal of E2F4, as a key regulator of cellular quiescence, would cause systemic perturbations in the expression of E2F4 bound genes involved in cell cycle and proliferation. To test whether these pertubrations were reflected in the adult tissues' gene expression programs, we compared the gene expression profile of E2F4 double knockout mice to the gene expression found in identical tissues from E2F4 heterozygous littermates, that are phenotypically normal. We selected liver, testes, and kidney to profile by gene expression analysis, because two of these tissues are affected at some point during development when E2F4 is missing.http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1131mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1131/samples/