ArrayExpress Uploaderarrayexpress_sidmouse802606The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice...19490417E-GEOD-9892/profile/8773/arrayexpressuploader012autoimmune hepatitishepatitisliverDec.12, 2014FalseE-GEOD-9892_A-AFFY-45gene-expression-profiling-in-acute-murine-autoimmuGene expression profiling in acute murine autoimmune hepatitisNov.21, 2014The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-β1-/- mice, to identify gene expression pathways dependent on IFN-γ as possible targets for rational therapy, and to test potential targets directly in vivo in mice. Keywords: Comparative analysis of gene expression in livers of WT, TGFB1 & IFN knockout mice DNA microarray analyses were applied to liver RNA from TGF-β1-/- mice, TGF-β1-/- /IFN-γ-/- mice, and TGF-β1+/+ littermate controls. 3 mice from each group were analyzed in this study.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-9892http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-9892/samples/