{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM249491 1": {}}, {"GSM249493 1": {}}, {"GSM249497 1": {}}, {"GSM249498 1": {}}, {"GSM249499 1": {}}, {"GSM249500 1": {}}, {"GSM249703 1": {}}, {"GSM249712 1": {}}, {"GSM249787 1": {}}, {"GSM250003 1": {}}, {"GSM250005 1": {}}, {"GSM250008 1": {}}], "id": 8026, "pop_total": 0, "platform": 6, "summary_wrapped": "The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-\u03b3. BALB/c background TGF-\u03b21-/- mice...", "pubmed_id": 19490417, "geo_gse_id": "E-GEOD-9892", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 12, "tags": ["autoimmune hepatitis", "hepatitis", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-9892_A-AFFY-45", "slug": "gene-expression-profiling-in-acute-murine-autoimmu", "geo_gds_id": "", "name": "Gene expression profiling in acute murine autoimmune hepatitis", "created": "Nov.21, 2014", "summary": "The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-\u03b3. BALB/c background TGF-\u03b21-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-\u03b21-/- mice, to identify gene expression pathways dependent on IFN-\u03b3 as possible targets for rational therapy, and to test potential targets directly in vivo in mice. Keywords: Comparative analysis of gene expression in livers of WT, TGFB1 & IFN knockout mice DNA microarray analyses were applied to liver RNA from TGF-\u03b21-/- mice, TGF-\u03b21-/- /IFN-\u03b3-/- mice, and TGF-\u03b21+/+ littermate controls. 3 mice from each group were analyzed in this study.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-9892", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-9892/samples/"}