Dataset: Gene expression profiling in acute murine autoimmune hepatitis
The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice...
The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-β1-/- mice, to identify gene expression pathways dependent on IFN-γ as possible targets for rational therapy, and to test potential targets directly in vivo in mice. Keywords: Comparative analysis of gene expression in livers of WT, TGFB1 & IFN knockout mice DNA microarray analyses were applied to liver RNA from TGF-β1-/- mice, TGF-β1-/- /IFN-γ-/- mice, and TGF-β1+/+ littermate controls. 3 mice from each group were analyzed in this study.
- Species:
- mouse
- Samples:
- 12
- Source:
- E-GEOD-9892
- PubMed:
- 19490417
- Updated:
- Dec.12, 2014
- Registered:
- Nov.21, 2014
| Sample |
|---|
| GSM249491 1 |
| GSM249493 1 |
| GSM249497 1 |
| GSM249498 1 |
| GSM249499 1 |
| GSM249500 1 |
| GSM249703 1 |
| GSM249712 1 |
| GSM249787 1 |
| GSM250003 1 |
| GSM250005 1 |
| GSM250008 1 |