{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 5048, "factors": [{"GSM242881 1": {}}, {"GSM242882 1": {}}, {"GSM242883 1": {}}, {"GSM242884 1": {}}, {"GSM242885 1": {}}, {"GSM242886 1": {}}, {"GSM242887 1": {}}, {"GSM242888 1": {}}, {"GSM242889 1": {}}, {"GSM242890 1": {}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited...", "pubmed_id": 20652976, "geo_gse_id": "E-GEOD-9600", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 10, "tags": ["cancer", "carcinoma", "cell", "head", "head and neck squamous cell carcinoma", "insulin", "neck", "squamous", "squamous cell", "squamous cell carcinoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "insulin-like-growth-factor-1-receptor-inhibitor-am", "geo_id_plat": "E-GEOD-9600_A-AFFY-44", "name": "Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma", "created": "Sep.22, 2014", "summary": "Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; cetuximab, a monoclonal antibody (mAb) against Epidermal Growth Factor Receptor (EGFR), and AMG 479, a mAb against Insulin-like Growth Factor-1 Receptor (IGF-1R). In tumor tissue of this patient we observed gene expression modulation by cetuximab and AMG 479 suggesting crosstalk between the EGFR and IGF-1R pathways that may have sensitized the tumor to MTX. This represents a promising novel approach to development of targeted agents in refractory cancer. Keywords: tumor response 10 samples from different time points during course of treatment in a single individual.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-9600", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-9600/samples/"}