ArrayExpress Uploader0human4947arrayexpress_sid4bulk breast tumor RNA from patient; Abstract: Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are...E-GEOD-7904/profile/8773/arrayexpressuploader062basalbrca1breastbreast tumorchromosomeclassorganellex chromosomeDec.12, 2014Falsetranscription-profiling-of-human-breast-tissue-tumE-GEOD-7904_A-AFFY-44Transcription profiling of human breast tissue tumors vs. normal tissueSep.22, 2014bulk breast tumor RNA from patient; Abstract: Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic. total 62 sample incudes 43 tumor, 7 normal breast and 12 normal organelle Experiment Overall Design: compare expression of tumor to normal breast tissuehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-7904http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-7904/samples/