Dataset: Transcription profiling of human breast tissue tumors vs. normal tissue
bulk breast tumor RNA from patient; Abstract: Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are...
bulk breast tumor RNA from patient; Abstract: Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic. total 62 sample incudes 43 tumor, 7 normal breast and 12 normal organelle Experiment Overall Design: compare expression of tumor to normal breast tissue
- Species:
- human
- Samples:
- 62
- Source:
- E-GEOD-7904
- Updated:
- Dec.12, 2014
- Registered:
- Sep.22, 2014
Sample |
---|
GSE7904GSM194416 |
GSE7904GSM194417 |
GSE7904GSM194415 |
GSE7904GSM194418 |
GSE7904GSM194407 |
GSE7904GSM194397 |
GSE7904GSM194412 |
GSE7904GSM194409 |
GSE7904GSM194414 |
GSE7904GSM194404 |
GSE7904GSM194398 |
GSE7904GSM194413 |
GSE7904GSM194399 |
GSE7904GSM194400 |
GSE7904GSM194410 |
GSE7904GSM194408 |
GSE7904GSM194401 |
GSE7904GSM194402 |
GSE7904GSM194403 |
GSE7904GSM194405 |
GSE7904GSM194411 |
GSE7904GSM194406 |
GSE7904GSM194421 |
GSE7904GSM194420 |
GSE7904GSM194427 |
GSE7904GSM194426 |
GSE7904GSM194438 |
GSE7904GSM194425 |
GSE7904GSM194422 |
GSE7904GSM194423 |
GSE7904GSM194419 |
GSE7904GSM194428 |
GSE7904GSM194430 |
GSE7904GSM194429 |
GSE7904GSM194434 |
GSE7904GSM194435 |
GSE7904GSM194439 |
GSE7904GSM194433 |
GSE7904GSM194436 |
GSE7904GSM194424 |
GSE7904GSM194432 |
GSE7904GSM194431 |
GSE7904GSM194437 |
GSE7904GSM194452 |
GSE7904GSM194453 |
GSE7904GSM194454 |
GSE7904GSM194455 |
GSE7904GSM194456 |
GSE7904GSM194457 |
GSE7904GSM194458 |
GSE7904GSM194441 |
GSE7904GSM194449 |
GSE7904GSM194442 |
GSE7904GSM194443 |
GSE7904GSM194444 |
GSE7904GSM194445 |
GSE7904GSM194446 |
GSE7904GSM194447 |
GSE7904GSM194450 |
GSE7904GSM194448 |
GSE7904GSM194451 |
GSE7904GSM194440 |