ArrayExpress Uploader04923TP10controlDCBD3.2not specifiedNone35femaleTP11Late onset IGEDCE1.1Epilimnot specified39maleTP12UnaffectedDCE1.2Nilnot specified39maleTP19Childhood Absence Epilepsy + Febrile SeizuresDCE2.1Nonenot specified42femaleTP20UnaffectedDCE2.2Nonenot specified42femaleTP29Childhood absence epilepsyDCE3.1Epilimnot specified23maleTP30UnaffectedDCE3.2Nonenot specified23maleTP33Childhood absence epilepsyDCE4.1Epilimnot specified26maleTP34UnaffectedDCE4.2Nonenot specified26maleTP37Juvenile Absence Epilepsy + Febrile SeizuresDCE5.1Epilimnot specified27femaleTP38UnaffectedDCE5.2Nonenot specified27femaleTP21Childhood absence epilepsyCCE1.1Epilimnot specified22femaleTP22Childhood Absence Epilepsy + Febrile SeizuresCCE1.2Nonenot specified22femaleTP31Childhood absence epilepsyCCE2.1Nonenot specified34femaleTP32Childhood absence epilepsyCCE2.2Nonenot specified34femaleTP35Childhood absence epilepsyCCE3.1Epilimnot specified57maleTP36Childhood absence epilepsyCCE3.2Nonenot specified57maleTP39Childhood absence epilepsyCCE4.1Epilim & Lamictalnot specified31maleTP40Childhood absence epilepsyCCE4.2Epilimnot specified31maleTP13UnaffectedCCN1.1Nonenot specified37maleTP14UnaffectedCCN1.2Nonenot specified37maleTP15UnaffectedCCN1.1RNonenot specified37maleTP16UnaffectedCCN1.2RNonenot specified37maleTP17UnaffectedCCN2.1Nonenot specified27maleTP18UnaffectedCCN2.2Nonenot specified27maleTP23UnaffectedCCN3.1Nonenot specified25maleTP24UnaffectedCCN3.2Nonenot specified25maleTP25UnaffectedCCN4.1Nonenot specified29femaleTP26UnaffectedCCN4.2Nonenot specified29femaleTP27UnaffectedCCN5.1Nonenot specified34femaleTP28UnaffectedCCN5.2Nonenot specified34femaleTP1Brief Psychotic Disorder-not specifiedthyroxine61femaleTP2Unaffected-not specifiedthyroxine61femaleTP3schizophrenia-not specifiedolanzapine26femaleTP4schizophrenia-not specifiedNil26femalearrayexpress_sid4The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed...17164263E-GEOD-7624/profile/8773/arrayexpressuploader735bipolar disordercellchromosomediseasegenomex chromosomeDec.12, 2014Falseexpression-profiles-of-monozygotic-twinE-GEOD-7624_A-AFFY-44Expression Profiles of Monozygotic TwinSep.22, 2014The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with previous broad sense heritability estimates. The effect of sex on gene expression levels was most noticeable on the X chromosome, which contained 15 of the 20 significantly differentially expressed genes. A high concordance was observed between the sex difference test statistics and surveys of genes escaping X chromosome inactivation. Notably, several autosomal genes showed significant differences in gene expression between the sexes despite much of the cellular environment differences being effectively removed in the cell lines. A publicly available gene expression data set from the CEPH families was used to validate the results. The heritability of gene expression levels as estimated from the two data sets showed a highly significant positive correlation, particularly when both estimates were close to one and thus had the smallest standard error. There was a large concordance between the genes significantly differentially expressed between the sexes in the two data sets. Analysis of the variability of probe binding intensities within a probe set indicated that results are robust to the possible presence of polymorphisms in the target sequences. Keywords: Monozygotic twin pair Expression Profiles Genome-wide gene expression in lymphoblastoid cell lines was determined using microarrays derived from 15 monozygotic (MZ) twin pairs (10 male, 9 female). 10 twin pair are discordant, 4 are concordant for a disease phenotype and their are 5 controls which have no disease phenotype. This data set was analyzed to interrupt replicated effects of sex and genotype, not disease characteristics. Subsets of these samples have been analyzed separately for disease characteristics, (GSE7036 – 3 MZ twins discordant for bipolar disorder) and (GSE7486 - 5 discordant and 4 concordant MZ twin pairs with idiopathic absence epilepsies and 5 unaffected MZ twin pairs).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-7624humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-7624/samples/