ArrayExpress Uploaderarrayexpress_sid776306Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for...17220892E-GEOD-6681/profile/8773/arrayexpressuploader04cellperipheralproteinDec.12, 2014FalseE-GEOD-6681_A-AFFY-45transcription-profiling-of-mouse-foxp3-ablation-inTranscription profiling of mouse Foxp3 ablation in peripheral mature regulatory T cellsNov.13, 2014Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3. Experiment Overall Design: Compare Cre recombinase treated peripheral regulatory T cells possessing a Cre sensitive Foxp3 locus to Cre treated regulatory T cells with a wild type Foxp3 locus. Cre exposure is observed via the Cre sensitive expression of the yellow flourescent protein molecule.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-6681mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-6681/samples/