{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM153727": {"genotype": "Dominant negative TGF-beta receptor II (DNR) mice"}}, {"GSM1537272": {"genotype": "wild type (WT)"}}], "id": 7733, "pop_total": 0, "platform": 6, "summary_wrapped": "Donminant negative transform growth factor receptor II (DNR) mice were served as a murine primary biliary cirrhrosis model. CD4+Foxp3+...", "geo_gse_id": "E-GEOD-62964", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 2, "tags": ["genome", "spleen"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiling-of-murine-wt-and-dnr-tre", "geo_id_plat": "E-GEOD-62964_A-AFFY-45", "name": "Gene expression profiling of murine WT and DNR Tregs", "created": "Nov.12, 2014", "summary": "Donminant negative transform growth factor receptor II (DNR) mice were served as a murine primary biliary cirrhrosis model. CD4+Foxp3+ Regulatory T cells (Tregs) play a critical role in self-tolerance and in regulating PBC. In order to determine whether DNR mice derived Tregs processed  defective function compared with WT Tregs, CD4+Foxp3+ Treg cells were sorted from DNR and WT mice, respectively, then gene expression analysis was performed by using the Affymetrix GeneChip Mouse Genome 430 2.0 arrays CD4+Foxp3+ Tregs were sorted from the spleen of 10-week-old DNR mice and B6 wild-type mice, respectively. RNA of each sample was then extracted and hybridized on Affymetrix microarrays to detail differences between DNR Tregs and WT Tregs in gene expression.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-62964", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-62964/samples/"}