{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1494400": {"RBV-SENSITIVITY STATUS": "sensitive", "CELL LINE": "OL8(3.5Y)"}}, {"GSM149440": {"RBV-SENSITIVITY STATUS": "resistant", "CELL LINE": "OL8(3.5Y)-derived R200#1"}}, {"GSM1494402": {"RBV-SENSITIVITY STATUS": "resistant", "CELL LINE": "OL8(3.5Y)-derived R200#8"}}, {"GSM1494403": {"RBV-SENSITIVITY STATUS": "resistant", "CELL LINE": "OL8(3.5Y)-derived R200#11"}}], "id": 4818, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Ribavirin (RBV) is a potential partner of interferon-based therapy and recently approved therapy using direct acting antivirals for...", "geo_gse_id": "E-GEOD-60948", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 4, "tags": ["cell", "chronic hepatitis", "chronic hepatitis c", "line", "point"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-60948_A-AFFY-44", "slug": "expression-data-of-genome-length-hcv-rna-replicati", "geo_gds_id": "", "name": "Expression data of genome-length HCV RNA-replicating OL8(3.5Y) cells and OL8(3.5Y)-derived ribavirin-resistant cells", "created": "Sep.21, 2014", "summary": "Ribavirin (RBV) is a potential partner of interferon-based therapy and recently approved therapy using direct acting antivirals for patients with chronic hepatitis C, However, the precise mechanisms undelying RBV action against hepatitis C virus (HCV) replication are not yet understood. To clarify this point, we established RBV-resistant cell lines from RBV-sensitive HCV RNA-replicating cell line, OL8(3.5Y), and characterized their features. We used  microarrays to compare the gene expression pattern between OL8(3.5Y) cells and three RBV-resistant cells and identified genes commonly altered by more than four-fold among RBV-resistant cells compared with the OL8(3.5Y) cells. Growing cells  from RBV-sensitive OL8(3.5Y) and three RBV-resistant cell lines were used for RNA extraction and hybridization on Affymetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-60948", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-60948/samples/"}