ArrayExpress Uploader0mousenot specifiednone (untreated control)not specifiedLY294002 for 5 daysnot specified2inot specified2i and LY294002not specifiednone (untreated control)c-Myc(wild)-overexpressingnone (untreated control)c-Myc(T58A)-overexpressingnone (untreated control)not specifiedLY294002 for 2 daysc-Myc(wild)-overexpressingLY294002 for 2 daysc-Myc(T58A)-overexpressingLY294002 for 2 daysnot specifiedLY294002 for 5 daysc-Myc(wild)-overexpressingLY294002 for 5 daysc-Myc(T58A)-overexpressingLY294002 for 5 daysMax-nullnone (untreated control)Max-nullDox for 4 daysMax-nullDox for 6 daysp110 alpha-overexpressing Max-nullnone (untreated control)p110 alpha-overexpressing Max-nullDox7691arrayexpress_sid6We explored the relationship between Myc activity and PI3K signaling in ESCs. Our data demonstrate that Myc and PI3K signaling function...E-GEOD-60344/profile/8773/arrayexpressuploader218Dec.12, 2014Falsefunctional-cooperativity-between-myc-and-pi3k-signE-GEOD-60344_A-AFFY-45Functional cooperativity between Myc and PI3K signaling for indefinite self-renewal property of embryonic stem cellsNov.12, 2014We explored the relationship between Myc activity and PI3K signaling in ESCs. Our data demonstrate that Myc and PI3K signaling function cooperatively for supporting pluripotent property of ESCs. Moreover, our data demonstrate that exposure of ESCs to 2i condition render both Myc and PI3K dispensable for preserving ESC status. Effect of PI3K inhibitor, LY4294002 on EBRTcH3 ESCs or their derivatives overexpressing c-Myc (wild-type or T58A mutant) was examined. Effect of LY4294002 on EBRTcH3 ESCs under 2i conditions was also examined. Furthermore, effect of Max expression ablation was compared between ESCs and those overexpressing p110 alpha.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-60344http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-60344/samples/