BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Transcription profiling by array of human lung cell lines A549, Beas-2B and MeT5A after treatment with asbestos over a time course

Dataset: Transcription profiling by array of human lung cell lines A549, Beas-2B and MeT5A after treatment with asbestos over a time course

Asbestos has been shown to cause chromosomal damage and DNA aberrations. The fiber is associated with many different lung diseases such...

Registered by ArrayExpress Uploader
View Dataset

Asbestos has been shown to cause chromosomal damage and DNA aberrations. The fiber is associated with many different lung diseases such as asbestosis, malignant mesothelioma, and lung cancer, but the disease-related processes are still largely unknown. Our aim was to identify specific gene expression profiles by using Affymetrix arrays, in human cell lines A549, Beas-2B, and MeT5A exposed to asbestos in a time-dependent manner. The hybridization data was analyzed using an algorithm specifically designed for clustering short time series expression data, a canonical correlation analysis (CCA) for identifying correlations between the cell lines, and a Gene Ontology (GO) analysis method for the identification of enriched differentially expressed biological processes. Samples from three cell lines were collected from asbestos exposed and non-exposed controls at 1h, 6h, 24h, 48h and 7 (168h) days (not all time-points for each cell lines). Replicates were done for one exposed sample of each cell line.

Species:
human

Samples:
27

Source:
E-GEOD-6013

PubMed:
17331233

Updated:
Dec.12, 2014

Registered:
Sep.21, 2014


Factors: (via ArrayExpress)
Sample cell line time compound
GSE6013GSM139640 A549 1 asbestos
GSE6013GSM139643 A549 24 asbestos
GSE6013GSM139644 A549 48 asbestos
GSE6013GSM139644 A549 48 asbestos
GSE6013GSM139641 A549 6 asbestos
GSE6013GSM139642 A549 168 asbestos
GSE6013GSM139646 A549 0 none
GSE6013GSM139647 A549 1 none
GSE6013GSM139653 A549 24 none
GSE6013GSM139652 A549 48 none
GSE6013GSM139648 A549 6 none
GSE6013GSM139649 A549 168 none
GSE6013GSM139654 Beas2B 1 asbestos
GSE6013GSM139656 Beas2B 24 asbestos
GSE6013GSM139656 Beas2B 24 asbestos
GSE6013GSM139659 Beas2B 48 asbestos
GSE6013GSM139655 Beas2B 6 asbestos
GSE6013GSM139660 Beas2B 0 none
GSE6013GSM139661 Beas2B 1 none
GSE6013GSM139664 Beas2B 24 none
GSE6013GSM139666 Beas2B 48 none
GSE6013GSM139663 Beas2B 6 none
GSE6013GSM139760 Met5A 1 asbestos
GSE6013GSM139667 Met5A 48 asbestos
GSE6013GSM139669 Met5A 1 none
GSE6013GSM139761 Met5A 48 none
GSE6013GSM139667 Met5A 48 asbestos

Tags

  • asbestosis
  • cancer
  • cell
  • disease
  • fiber
  • line
  • lung
  • lung cancer
  • malignant mesothelioma

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2023 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use