ArrayExpress Uploader0mouseno DOXno DOXno DOXno DOXno DOXno DOXDOX treated for 1dose of 15mg/kgDOX treated for 1dose of 15mg/kgDOX treated for 1dose of 15mg/kgDOX treated for 1dose of 15mg/kgDOX treated for 1dose of 15mg/kgDOX treated for 1dose of 15mg/kg7678arrayexpress_sid6The clinical application of doxorubicin as a broad-spectrum anti-tumor antibiotic is limited greatly by its cardiotoxicity. Various...E-GEOD-59672/profile/8773/arrayexpressuploader112cardiomyopathyDec.12, 2014Falseexpression-data-from-doxdoxorubicin-treated-wild-tE-GEOD-59672_A-AFFY-45Expression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5Nov.12, 2014The clinical application of doxorubicin as a broad-spectrum anti-tumor antibiotic is limited greatly by its cardiotoxicity. Various mechanisms have been studied, but little is known about whether genes or pathways relevant with energy metabolism contributes to doxorubicin-induced cardiomyopathy or not. We used microarrays to detail the global expression profiling of acute cardiomyopathy induced by doxorubicin in wild type or CHIP knockout C57BL/6J mice and discovered distinct classes of changed genes during this process. The whole hearts were selected for RNA extraction and hybridization on Affymetrix microarrays at day 5 after a single intraperitoneal injection of doxorubicin at a dose of 15 mg/kg.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-59672http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-59672/samples/