{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1442228": {"TREATMENT": "no DOX"}}, {"GSM1442228": {"TREATMENT": "no DOX"}}, {"GSM1442228": {"TREATMENT": "no DOX"}}, {"GSM1442228": {"TREATMENT": "no DOX"}}, {"GSM1442228": {"TREATMENT": "no DOX"}}, {"GSM1442228": {"TREATMENT": "no DOX"}}, {"GSM1442234": {"TREATMENT": "DOX treated for 1dose of 15mg/kg"}}, {"GSM1442234": {"TREATMENT": "DOX treated for 1dose of 15mg/kg"}}, {"GSM1442234": {"TREATMENT": "DOX treated for 1dose of 15mg/kg"}}, {"GSM1442234": {"TREATMENT": "DOX treated for 1dose of 15mg/kg"}}, {"GSM1442234": {"TREATMENT": "DOX treated for 1dose of 15mg/kg"}}, {"GSM1442234": {"TREATMENT": "DOX treated for 1dose of 15mg/kg"}}], "id": 7678, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "The clinical application of doxorubicin as a broad-spectrum anti-tumor antibiotic is limited greatly by its cardiotoxicity. Various...", "geo_gse_id": "E-GEOD-59672", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["cardiomyopathy"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-doxdoxorubicin-treated-wild-t", "geo_id_plat": "E-GEOD-59672_A-AFFY-45", "name": "Expression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5", "created": "Nov.12, 2014", "summary": "The clinical application of doxorubicin as a broad-spectrum anti-tumor antibiotic is limited greatly by its cardiotoxicity. Various mechanisms have been studied, but little is known about whether genes or pathways relevant with energy metabolism contributes to doxorubicin-induced cardiomyopathy or not. We used microarrays to detail the global expression profiling of acute cardiomyopathy induced by doxorubicin in wild type or CHIP knockout C57BL/6J mice and discovered distinct classes of changed genes during this process. The whole hearts were selected for RNA extraction and hybridization on Affymetrix microarrays at day 5 after a single intraperitoneal injection of doxorubicin at a dose of 15 mg/kg.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-59672", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-59672/samples/"}