6ArrayExpress Uploader0mouselow serum IGF-IB6.C3H-6Tlow serum IGF-IB6.C3H-6Tlow serum IGF-IB6.C3H-6Twild typeC57BL/6Jwild typeC57BL/6Jwild typeC57BL/6J7677arrayexpress_sidhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-5959Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of...17584978/profile/8773/arrayexpressuploader26bonechromosomegenomeliverserumDec.12, 2014Falsetranscription-profiling-of-livers-from-female-c57bE-GEOD-5959_A-AFFY-45Transcription profiling of livers from female C57BL/6J and B6.C3H-6T mice to study differential gene expression in the two strains.Nov.12, 2014Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of genetic and environmental influences. In addition, serum IGF-1 levels have been correlated to both BMD and fracture risk. We previously identified a Quantitative Trait Locus (QTL) for Bone Mineral Density (BMD) on mouse Chromosome (Chr) 6 that overlaps a QTL for serum IGF-1. The B6.C3H-6T (6T) congenic mouse is homozygous for C57BL/6J (B6) alleles across the genome except for a 30 cM region on Chr 6 that is homozygous for C3H/HeJ (C3H) alleles. This mouse was created to study biology behind both the BMD and the serum IGF-1 QTLs and to identify the gene(s) underlying these QTLs. Female 6T mice have lower BMD and lower serum IGF-1 levels at all ages measured. As the liver is the major source of serum IGF-1, we examined differential expression in the livers of fasted female B6 and 6T mice by microarray. Experiment Overall Design: The experimental design of this experiment was a simple two-factor experiment, with three biological replicates of each factor (in this case mouse strain, B6.C3H-6T vs. C57BL/6J). Each sample represented one mouse; no samples were pooled. No technical replicated were done.E-GEOD-5959http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-5959/samples/