ArrayExpress Uploader0mouseC57BL6wildtypeC57BL6wildtypeC57BL6wildtypeC57BL6homozygous LeidenC57BL6homozygous LeidenC57BL6homozygous LeidenBALB/cwildtypeBALB/cwildtypeBALB/cwildtypeBALB/chomozygous LeidenC57BL6heterozygous LeidenC57BL6heterozygous LeidenC57BL6heterozygous LeidenC57BL6heterozygous Leiden7659arrayexpress_sid6We investigated in mouse models how enhanced coagulation activation due to a common disease polymorphism in coagulation factor V (fV...E-GEOD-58328/profile/8773/arrayexpressuploader214bonebone marrowdendriticdiseaselipopolysaccharidemacrophagespleenDec.12, 2014Falseexpression-data-from-mouse-spleen-cd11c-dendriticE-GEOD-58328_A-AFFY-45Expression data from mouse spleen CD11c dendritic cells, bone marrow Gr1DC11b cells, and RAW264.7 cellsNov.12, 2014We investigated in mouse models how enhanced coagulation activation due to a common disease polymorphism in coagulation factor V (fV Leiden Arg506Gln) modifies the host response to infection and inflammation We used microarrays to characterize the in vivo and in vitro inflammatory responses of mouse spleen dendritic cells, macrophage-like RAW264.7 cells, and bone marrow myeloid cells Samples 1-6 were generated by pooling equal amounts of RNA prepared from FACS-enriched spleen dendritic cells isolated from 6 individual mice before (control sample 1) or 16 hours after challenge with lipopolysaccharide. Samples 7-10 were generated by pooling equal amounts of RNA prepared from triplicate cultures of RAW264.7 cells. Samples 10-14 (2 replicas per condition) were prepared from RNA isolated from FACS-enriched bone marrow myeloid cells (pooled from 4 adoptively transferred animals each) 7 days after infection with S.aureus.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-58328http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-58328/samples/