{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1403920": {"GENOTYPE": "non-transgenic (non-Tg)"}}, {"GSM1403920": {"GENOTYPE": "non-transgenic (non-Tg)"}}, {"GSM1403920": {"GENOTYPE": "non-transgenic (non-Tg)"}}, {"GSM1403923": {"GENOTYPE": "Retnla transgenic (Tg)"}}, {"GSM1403923": {"GENOTYPE": "Retnla transgenic (Tg)"}}, {"GSM1403923": {"GENOTYPE": "Retnla transgenic (Tg)"}}], "id": 7653, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We found that Retnla-Tg mice had significantly lower serum cholesterol levels than non-Tg mice on a high-fat diet (HFD). To explore the...", "geo_gse_id": "E-GEOD-58214", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["genome", "serum"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-liver-of-retnla-transgenic-tg", "geo_id_plat": "E-GEOD-58214_A-AFFY-45", "name": "Expression data from liver of Retnla transgenic (Tg) and non-transgenic (non-Tg) mice.", "created": "Nov.12, 2014", "summary": "We found that Retnla-Tg mice had significantly lower serum cholesterol levels than non-Tg mice on a high-fat diet (HFD). To explore the molecular mechanisms underlying the cholesterol-lowering effects of Retnla under hyperlipidemic conditions, we subjected age- and sex-matched Retnla-Tg and non-Tg mice to a HFD for 4 weeks. Using a microarray approach, we analyzed the hepatic gene expression profiles related to cholesterol metabolism, including catabolism, biosynthesis, and transport. Total RNA was extracted from livers of Retnla-Tg and non-Tg mice after feeding with a HFD for four weeks, and transcriptional profiling was performed on individual samples using Affymetrix Mouse Genome chips (MG 430 2.0 array).", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-58214", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-58214/samples/"}