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Home › Dataset Library › Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

Dataset: Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

This SuperSeries is composed of the SubSeries listed below. Acquisition of the intestinal microbiota begins at birth, and a stable...

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This SuperSeries is composed of the SubSeries listed below. Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. Refer to individual Series

Species:
mouse

Samples:
19

Source:
E-GEOD-58087

Updated:
Dec.12, 2014

Registered:
Nov.12, 2014


Factors: (via ArrayExpress)
Sample STRAIN AGE TREATMENT DIET SEX
GSM1400505 C57BL6J 8 weeks control D12451: 45% kCAL from fat male
GSM1400505 C57BL6J 8 weeks control D12451: 45% kCAL from fat male
GSM1400505 C57BL6J 8 weeks control D12451: 45% kCAL from fat male
GSM1400508 C57BL6J 8 weeks low-dose pennicillin D12451: 45% kCAL from fat male
GSM1400508 C57BL6J 8 weeks low-dose pennicillin D12451: 45% kCAL from fat male
GSM1400508 C57BL6J 8 weeks low-dose pennicillin D12451: 45% kCAL from fat male
GSM1400508 C57BL6J 8 weeks low-dose pennicillin D12451: 45% kCAL from fat male
GSM1400512 C57BL6J 30 weeks control normal chow (NC, Purina Mills International Diet # 5001, 13.5% kcal from fat) male
GSM1400512 C57BL6J 30 weeks control normal chow (NC, Purina Mills International Diet # 5001, 13.5% kcal from fat) male
GSM1400512 C57BL6J 30 weeks control normal chow (NC, Purina Mills International Diet # 5001, 13.5% kcal from fat) male
GSM1400515 C57BL6J 30 weeks low-dose pennicillin normal chow (NC, Purina Mills International Diet # 5001, 13.5% kcal from fat) male
GSM1400515 C57BL6J 30 weeks low-dose pennicillin normal chow (NC, Purina Mills International Diet # 5001, 13.5% kcal from fat) male
GSM1400515 C57BL6J 30 weeks low-dose pennicillin normal chow (NC, Purina Mills International Diet # 5001, 13.5% kcal from fat) male
GSM1400518 C57BL6J 30 weeks control D12451: 45% kCAL from fat male
GSM1400518 C57BL6J 30 weeks control D12451: 45% kCAL from fat male
GSM1400518 C57BL6J 30 weeks control D12451: 45% kCAL from fat male
GSM140052 C57BL6J 30 weeks low-dose pennicillin D12451: 45% kCAL from fat male
GSM140052 C57BL6J 30 weeks low-dose pennicillin D12451: 45% kCAL from fat male
GSM140052 C57BL6J 30 weeks low-dose pennicillin D12451: 45% kCAL from fat male

Tags

  • body
  • obesity

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