ArrayExpress Uploaderarrayexpress_sidrat946309This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD, PCB126 and PeCDF; the non-AhR ligand PCB153 and...16984957E-GEOD-5789/profile/8773/arrayexpressuploader021Feb.09, 2015Falsetranscription-profiling-of-rat-liver-after-13-weekE-GEOD-5789_A-AFFY-18Transcription profiling of rat liver after 13 weeks of subchronic exposure to TCDD, PeCDF, PCB126, PCB153 and PCB126/PCB153Jan.11, 2015This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD, PCB126 and PeCDF; the non-AhR ligand PCB153 and the binary mixture PCB126/PCB153 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg), PeCDF (200ng/kg), PCB126 (1000ng/kg) and PCB153 (1000ug/kg) 5 days a week for 13 weeks. Experiment Overall Design: There are 6 control chips and representing animals treated with vehicle control. There are 3 biological replicates (3 chips) for each treatment group (eg. TCDD, PCB126), each biological replicate is derived from 2 individual animals. A total of 21 chips were analyzed. Intensities were normalized using the GC-Robust Multiarray (GCRMA) method through Genetraffic software package.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-5789http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-5789/samples/