ArrayExpress Uploader0mousenonenonenoneinsulininsulininsulinbiomineralized insulinbiomineralized insulinbiomineralized insulin7642arrayexpress_sid6There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin...E-GEOD-57817/profile/8773/arrayexpressuploader19hyperglycemiainsulinproteinDec.12, 2014Falsetranscription-profiling-by-array-of-livers-from-tyE-GEOD-57817_A-AFFY-45Transcription profiling by array of livers from type 2 diabetes KKAy mice treated with insulin, intranuclear biomineralized insulin against untreated controlsNov.12, 2014There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin resistance. Although the exact mechanism remains unknown, it has been proved that insulin resistance is correlated to low heat shock protein (HSP) expression. We reveal that intranuclear insulin can reduce HSP DNA methylation level to up-regulate HSP protein expression and result in long term cure of hyperglycemia. Type 2 diabetes KKAy mouse were selected in our experiments.Three conditions were compared with three replicates each. These are:(1) Untreated KKAy mouse (2) Insulin treated KKAy mouse(Insulin); (3) Biomineralized insulin treated KKAy mouse(BI).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-57817http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-57817/samples/