{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1382536": {"TREATED WITH": "2ng/ml recombinant TGF-b1"}}, {"GSM1382536": {"TREATED WITH": "2ng/ml recombinant TGF-b1"}}, {"GSM1382536": {"TREATED WITH": "2ng/ml recombinant TGF-b1"}}, {"GSM1382533": {"TREATED WITH": "none (untreated control)"}}, {"GSM1382533": {"TREATED WITH": "none (untreated control)"}}, {"GSM1382533": {"TREATED WITH": "none (untreated control)"}}], "id": 2041, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Aggressive local invasion is the major way of spread in uterine cervical squamous cell carcinoma (CSCC). Although TGF-b facilitates...", "geo_gse_id": "E-GEOD-57441", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cancer", "carcinoma", "cell", "cervical squamous cell carcinoma", "endometrial cancer", "squamous", "squamous cell", "squamous cell carcinoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "genes-expression-of-cervical-squamous-cell-carcino", "geo_id_plat": "E-GEOD-57441_A-AFFY-44", "name": "Genes expression of cervical squamous cell carcinoma, CaSki cells, treated with or without recombinant TGF-b1 (2 ng/mL)", "created": "Jul.10, 2014", "summary": "Aggressive local invasion is the major way of spread in uterine cervical squamous cell carcinoma (CSCC). Although TGF-b facilitates invasion of various types of cancer cells, the role of TGF-b pathway in CSCC is unclear. Through array-based analysis, immunohistochemical staining of human endometrial cancer tissue, it is shown that interaction between CSCC cells and surrounding cancer asscocited fibroblasts (CAFs) activates TGF-b via TSP-1 secretion to facilitate CSCC invade, resulting in up-regulation of pSMAD3 in CSCC cells to promote invasion. These results suggest that activation of TGF-b induced by the interaction between CSCC cells and CAFs could play a key role in the initiation of tumor spreads. We used microarrays to clarify the changes of gene expression along with recombinant TGF-b1 treatment and to confirm whether there are any changes on genes expression related to TGF-b pathway.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-57441", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-57441/samples/"}