Dataset: Expression data from EGFR WT or EGFR mutant NSCLC with or without erlotinib
Non-small cell lung cancers (NSCLCs) harboring activating EGFR mutants show dramatic responses to EGFR TKIs, such as erlotinib and...
Non-small cell lung cancers (NSCLCs) harboring activating EGFR mutants show dramatic responses to EGFR TKIs, such as erlotinib and geffitinib. However, nearly all patients show relapse within 1 year after initial treatment. We used microarrays to detail global gene expression changes in EGFR mutant cells vs. WT cells responding to erlotinib. 4 EGFR mutant and 4 WT NSCLC cells were treated with or without erlotinib for 24 hr, followed by RNA extraction and hybridization on Affymetrix microarrays.
- Species:
- human
- Samples:
- 32
- Source:
- E-GEOD-57156
- Updated:
- Dec.12, 2014
- Registered:
- Jul.10, 2014
Factors:
(via ArrayExpress)
Sample | CELL LINE | TREATMENT | GENOTYPE |
---|---|---|---|
GSM137635 | HCC78 | Erlotinib | EGFR WT |
GSM137635 | HCC78 | Erlotinib | EGFR WT |
GSM1376349 | HCC78 | DMSO | EGFR WT |
GSM1376349 | HCC78 | DMSO | EGFR WT |
GSM1376347 | NCI-H1648 | Erlotinib | EGFR WT |
GSM1376347 | NCI-H1648 | Erlotinib | EGFR WT |
GSM1376345 | NCI-H1648 | DMSO | EGFR WT |
GSM1376345 | NCI-H1648 | DMSO | EGFR WT |
GSM1376343 | NCI-H838 | Erlotinib | EGFR WT |
GSM1376343 | NCI-H838 | Erlotinib | EGFR WT |
GSM137634 | NCI-H838 | DMSO | EGFR WT |
GSM137634 | NCI-H838 | DMSO | EGFR WT |
GSM1376339 | NCI-H23 | Erlotinib | EGFR WT |
GSM1376339 | NCI-H23 | Erlotinib | EGFR WT |
GSM1376337 | NCI-H23 | DMSO | EGFR WT |
GSM1376337 | NCI-H23 | DMSO | EGFR WT |
GSM1376335 | HCC2935 | Erlotinib | EGFR Mutant |
GSM1376335 | HCC2935 | Erlotinib | EGFR Mutant |
GSM1376333 | HCC2935 | DMSO | EGFR Mutant |
GSM1376333 | HCC2935 | DMSO | EGFR Mutant |
GSM137633 | HCC2279 | Erlotinib | EGFR Mutant |
GSM137633 | HCC2279 | Erlotinib | EGFR Mutant |
GSM1376329 | HCC2279 | DMSO | EGFR Mutant |
GSM1376329 | HCC2279 | DMSO | EGFR Mutant |
GSM1376327 | HCC4006 | Erlotinib | EGFR Mutant |
GSM1376327 | HCC4006 | Erlotinib | EGFR Mutant |
GSM1376325 | HCC4006 | DMSO | EGFR Mutant |
GSM1376325 | HCC4006 | DMSO | EGFR Mutant |
GSM1376323 | PC-9 | Erlotinib | EGFR Mutant |
GSM1376323 | PC-9 | Erlotinib | EGFR Mutant |
GSM137632 | PC-9 | DMSO | EGFR Mutant |
GSM137632 | PC-9 | DMSO | EGFR Mutant |